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Protein

Metallothionein-1

Gene

Mt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

  • metal ion binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandMetal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Alternative name(s):
Metallothionein-I
Short name:
MT-I
Gene namesi
Name:Mt1
Synonyms:Mt1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi3117 Mt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972211 – 61Metallothionein-1Add BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02803
PRIDEiP02803

PTM databases

iPTMnetiP02803
PhosphoSitePlusiP02803

Expressioni

Gene expression databases

BgeeiENSRNOG00000038047 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiP02803 baseline and differential
GenevisibleiP02803 RN

Structurei

3D structure databases

ProteinModelPortaliP02803
SMRiP02803
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
HOVERGENiHBG095667
InParanoidiP02803
KOiK14739
OMAiCTCGNNC
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

P02803-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPNCSCSTG GSCTCSSSCG CKNCKCTSCK KSCCSCCPVG CSKCAQGCVC
60
KGASDKCTCC A
Length:61
Mass (Da):6,006
Last modified:July 21, 1986 - v1
Checksum:i4460B3720B9ABC18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00750 mRNA Translation: AAA41590.1
M11794 Genomic DNA Translation: AAA41641.1
BC058442 mRNA Translation: AAH58442.1
M24327 mRNA Translation: AAA41589.1
PIRiA93079 SMRT1
RefSeqiNP_620181.1, NM_138826.4
UniGeneiRn.16133
Rn.54397

Genome annotation databases

EnsembliENSRNOT00000057898; ENSRNOP00000054706; ENSRNOG00000038047
GeneIDi24567
KEGGirno:24567
UCSCiRGD:3117 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00750 mRNA Translation: AAA41590.1
M11794 Genomic DNA Translation: AAA41641.1
BC058442 mRNA Translation: AAH58442.1
M24327 mRNA Translation: AAA41589.1
PIRiA93079 SMRT1
RefSeqiNP_620181.1, NM_138826.4
UniGeneiRn.16133
Rn.54397

3D structure databases

ProteinModelPortaliP02803
SMRiP02803
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP02803
PhosphoSitePlusiP02803

Proteomic databases

PaxDbiP02803
PRIDEiP02803

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057898; ENSRNOP00000054706; ENSRNOG00000038047
GeneIDi24567
KEGGirno:24567
UCSCiRGD:3117 rat

Organism-specific databases

CTDi17748
RGDi3117 Mt1

Phylogenomic databases

GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
HOVERGENiHBG095667
InParanoidiP02803
KOiK14739
OMAiCTCGNNC
TreeFamiTF336054

Miscellaneous databases

PROiPR:P02803

Gene expression databases

BgeeiENSRNOG00000038047 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiP02803 baseline and differential
GenevisibleiP02803 RN

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT1_RAT
AccessioniPrimary (citable) accession number: P02803
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
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Main funding by: National Institutes of Health

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