MT2A

Functionⁱ

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Miscellaneous

This metallothionein binds zinc.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	5	Divalent metal cation; cluster B1 Publication	1
Metal bindingⁱ	7	Divalent metal cation; cluster B1 Publication	1
Metal bindingⁱ	13	Divalent metal cation; cluster B1 Publication	1
Metal bindingⁱ	15	Divalent metal cation; cluster B1 Publication	1
Metal bindingⁱ	19	Divalent metal cation; cluster B	1
Metal bindingⁱ	21	Divalent metal cation; cluster B	1
Metal bindingⁱ	24	Divalent metal cation; cluster B	1
Metal bindingⁱ	26	Divalent metal cation; cluster B	1
Metal bindingⁱ	29	Divalent metal cation; cluster B	1
Metal bindingⁱ	33	Divalent metal cation; cluster A	1
Metal bindingⁱ	34	Divalent metal cation; cluster A	1
Metal bindingⁱ	36	Divalent metal cation; cluster A	1
Metal bindingⁱ	37	Divalent metal cation; cluster A	1
Metal bindingⁱ	41	Divalent metal cation; cluster A	1
Metal bindingⁱ	44	Divalent metal cation; cluster A	1
Metal bindingⁱ	48	Divalent metal cation; cluster A	1
Metal bindingⁱ	50	Divalent metal cation; cluster A	1
Metal bindingⁱ	57	Divalent metal cation; cluster A	1
Metal bindingⁱ	59	Divalent metal cation; cluster A	1
Metal bindingⁱ	60	Divalent metal cation; cluster A	1

GO - Molecular functionⁱ

drug binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19536566
zinc ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19536566

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular copper ion homeostasis
Source: ProtInc
Traceable author statementⁱ
- 6719135
cellular response to drug
Source: UniProtKB
Inferred from direct assayⁱ
- 19536566
cellular response to erythropoietin
Source: UniProtKB
Inferred from expression patternⁱ
- 11168427
cellular response to interleukin-3
Source: UniProtKB
Inferred from expression patternⁱ
- 11168427
cellular response to zinc ion
Source: UniProtKB
Inferred from expression patternⁱ
- 11168427
interferon-gamma-mediated signaling pathway Source: Reactome
negative regulation of growth Source: UniProtKB
response to metal ion Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Metal-thiolate cluster, Zinc

Ligand

Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5661231 Metallothioneins bind metals R-HSA-877300 Interferon gamma signaling

Reactomeⁱ

R-HSA-5661231 Metallothioneins bind metals
R-HSA-877300 Interferon gamma signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metallothionein-2 Short name: MT-2 Alternative name(s): Metallothionein-2A Metallothionein-II Short name: MT-II
Gene namesⁱ	Name:MT2A Synonyms:CES1, MT2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125148.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7406 MT2A
MIMⁱ	156360 gene
neXtProtⁱ	NX_P02795

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4502
Open Targets More...OpenTargetsⁱ	ENSG00000125148
PharmGKBⁱ	PA31214

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00958 Carboplatin DB00515 Cisplatin DB00526 Oxaliplatin

DrugBankⁱ

DB00958 Carboplatin
DB00515 Cisplatin
DB00526 Oxaliplatin

Polymorphism and mutation databases

BioMutaⁱ	MT2A

BioMutaⁱ

MT2A

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197245	1 – 61	Metallothionein-2Add BLAST		61

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1
Modified residueⁱ	58	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P02795
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P02795
PaxDbⁱ	P02795
PeptideAtlas More...PeptideAtlasⁱ	P02795
PRIDEⁱ	P02795
ProteomicsDBⁱ	51601
TopDownProteomicsⁱ	P02795

PTM databases

iPTMnetⁱ	P02795
PhosphoSitePlusⁱ	P02795

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000125148
CleanExⁱ	HS_CES1 HS_MT2A
ExpressionAtlasⁱ	P02795 baseline and differential
Genevisibleⁱ	P02795 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CXorf40A	Q8TE69	2	EBI-996616,EBI-996609
GPR50	Q13585	2	EBI-996616,EBI-8550965
PRKD1	Q15139	7	EBI-996616,EBI-1181072
SPINK7	P58062	7	EBI-996616,EBI-1182445

Show more details

Protein-protein interaction databases

BioGridⁱ	110608, 19 interactors
Database of interacting proteins More...DIPⁱ	DIP-35232N
IntActⁱ	P02795, 20 interactors
Molecular INTeraction database More...MINTⁱ	P02795
STRINGⁱ	9606.ENSP00000245185

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	7 – 11	Combined sources	5
Helixⁱ	27 – 29	Combined sources	3
Beta strandⁱ	35 – 37	Combined sources	3
Helixⁱ	42 – 44	Combined sources	3

3D structure databases

ProteinModelPortalⁱ	P02795
SMRⁱ	P02795
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02795

EvolutionaryTraceⁱ

P02795

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 29	BetaAdd BLAST		29
Regionⁱ	30 – 61	AlphaAdd BLAST		32

Domainⁱ

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesⁱ

Belongs to the metallothionein superfamily. Type 1 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410JFS1 Eukaryota ENOG41113QR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110883
HOGENOMⁱ	HOG000236262
HOVERGENⁱ	HBG094456
InParanoidⁱ	P02795
KEGG Orthology (KO) More...KOⁱ	K14739
OMAⁱ	CKKSCCT
PhylomeDBⁱ	P02795
TreeFamⁱ	TF336054

Family and domain databases

Gene3Dⁱ	4.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR003019 Metalthion IPR017854 Metalthion_dom_sf IPR023587 Metalthion_dom_sf_vert IPR000006 Metalthion_vert IPR018064 Metalthion_vert_metal_BS
PANTHERⁱ	PTHR23299 PTHR23299, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00131 Metallothio, 1 hit
PRINTSⁱ	PR00860 MTVERTEBRATE
SUPFAMⁱ	SSF57868 SSF57868, 1 hit
PROSITEⁱ	View protein in PROSITE PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P02795-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDPNCSCAAG DSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCIC 
        60 
KGASDKCSCC A

Length:61

Mass (Da):6,042

Last modified:July 21, 1986 - v1

Checksum:ⁱ7B0A7E1F99843078

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_025840	42	A → V1 PublicationCorresponds to variant dbSNP:rs35109646Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00271 Genomic DNA Translation: AAA59583.1 V00594 mRNA Translation: CAA23841.1 M26637 mRNA Translation: AAA59584.1 Sequence problems. S52379 mRNA Translation: AAB24908.1 X97260 mRNA Translation: CAA65915.1 BT007315 mRNA Translation: AAP35979.1 DQ370420 Genomic DNA Translation: ABC79300.1 BC007034 mRNA Translation: AAH07034.1 BC070289 mRNA Translation: AAH70289.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10763.1
PIRⁱ	A03271 SMHU2 I63131
NCBI Reference Sequences More...RefSeqⁱ	NP_005944.1, NM_005953.3
UniGeneⁱ	Hs.534330

Genome annotation databases

Ensemblⁱ	ENST00000245185; ENSP00000245185; ENSG00000125148
GeneIDⁱ	4502
KEGGⁱ	hsa:4502
UCSC genome browser More...UCSCⁱ	uc002ejh.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length
P02795	Metallothionein-2		PONAB		61
Metallothionein		PANTR		61
Metallothionein		PANPA		61
Metallothionein		NOMLE		61
Metallothionein		GORGO		61
+1

Protein	Similar proteins		Species	Score	Length
P02795	Metallothionein-2		PONAB		61
Metallothionein		PANTR		61
Metallothionein		PANPA		61
Metallothionein		NOMLE		61
Metallothionein		GORGO		61
+10

Protein	Similar proteins		Species	Score	Length
P02795	Metallothionein-3		HORSE		68
Metallothionein (Fragment)		MUSPF		72
Metallothionein		CANLF		68
Metallothionein		FELCA		68
Metallothionein-3		PIG		68
+91

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00271 Genomic DNA Translation: AAA59583.1 V00594 mRNA Translation: CAA23841.1 M26637 mRNA Translation: AAA59584.1 Sequence problems. S52379 mRNA Translation: AAB24908.1 X97260 mRNA Translation: CAA65915.1 BT007315 mRNA Translation: AAP35979.1 DQ370420 Genomic DNA Translation: ABC79300.1 BC007034 mRNA Translation: AAH07034.1 BC070289 mRNA Translation: AAH70289.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10763.1
PIRⁱ	A03271 SMHU2 I63131
NCBI Reference Sequences More...RefSeqⁱ	NP_005944.1, NM_005953.3
UniGeneⁱ	Hs.534330

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1MHU	NMR	-	A	31-61	[»]
	2MHU	NMR	-	A	1-30	[»]
ProteinModelPortalⁱ	P02795
SMRⁱ	P02795
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110608, 19 interactors
Database of interacting proteins More...DIPⁱ	DIP-35232N
IntActⁱ	P02795, 20 interactors
Molecular INTeraction database More...MINTⁱ	P02795
STRINGⁱ	9606.ENSP00000245185

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00958 Carboplatin DB00515 Cisplatin DB00526 Oxaliplatin

DrugBankⁱ

DB00958 Carboplatin
DB00515 Cisplatin
DB00526 Oxaliplatin

PTM databases

iPTMnetⁱ	P02795
PhosphoSitePlusⁱ	P02795

Polymorphism and mutation databases

BioMutaⁱ	MT2A

BioMutaⁱ

MT2A

Proteomic databases

EPDⁱ	P02795
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P02795
PaxDbⁱ	P02795
PeptideAtlas More...PeptideAtlasⁱ	P02795
PRIDEⁱ	P02795
ProteomicsDBⁱ	51601
TopDownProteomicsⁱ	P02795

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4502
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000245185; ENSP00000245185; ENSG00000125148
GeneIDⁱ	4502
KEGGⁱ	hsa:4502
UCSC genome browser More...UCSCⁱ	uc002ejh.4 human

Organism-specific databases

CTDⁱ	4502
DisGeNET More...DisGeNETⁱ	4502
EuPathDBⁱ	HostDB:ENSG00000125148.6
GeneCardsⁱ	MT2A
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7406 MT2A
MIMⁱ	156360 gene
neXtProtⁱ	NX_P02795
Open Targets More...OpenTargetsⁱ	ENSG00000125148
PharmGKBⁱ	PA31214
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JFS1 Eukaryota ENOG41113QR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110883
HOGENOMⁱ	HOG000236262
HOVERGENⁱ	HBG094456
InParanoidⁱ	P02795
KEGG Orthology (KO) More...KOⁱ	K14739
OMAⁱ	CKKSCCT
PhylomeDBⁱ	P02795
TreeFamⁱ	TF336054

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5661231 Metallothioneins bind metals R-HSA-877300 Interferon gamma signaling

Reactomeⁱ

R-HSA-5661231 Metallothioneins bind metals
R-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRSⁱ	MT2A human
EvolutionaryTraceⁱ	P02795
GeneWikiⁱ	Metallothionein_2A
GenomeRNAiⁱ	4502
Protein Ontology More...PROⁱ	PR:P02795
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125148
CleanExⁱ	HS_CES1 HS_MT2A
ExpressionAtlasⁱ	P02795 baseline and differential
Genevisibleⁱ	P02795 HS

Family and domain databases

Gene3Dⁱ	4.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR003019 Metalthion IPR017854 Metalthion_dom_sf IPR023587 Metalthion_dom_sf_vert IPR000006 Metalthion_vert IPR018064 Metalthion_vert_metal_BS
PANTHERⁱ	PTHR23299 PTHR23299, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00131 Metallothio, 1 hit
PRINTSⁱ	PR00860 MTVERTEBRATE
SUPFAMⁱ	SSF57868 SSF57868, 1 hit
PROSITEⁱ	View protein in PROSITE PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MT2_HUMAN
Accessionⁱ	P02795Primary (citable) accession number: P02795 Secondary accession number(s): Q14823, Q2HXR9, Q53XT9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	June 20, 2018
	This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Metallothioneins
Classification of metallothioneins and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P02795 (MT2_HUMAN)

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Metallothionein-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ