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UniProtKB - P02795 (MT2_HUMAN)
Protein
Metallothionein-2
Gene
MT2A
Organism
Homo sapiens (Human)
Status
Functioni
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Miscellaneous
This metallothionein binds zinc.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 5 | Divalent metal cation 1; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 7 | Divalent metal cation 1; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 7 | Divalent metal cation 2; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 13 | Divalent metal cation 2; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 15 | Divalent metal cation 2; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 15 | Divalent metal cation 3; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 19 | Divalent metal cation 3; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 21 | Divalent metal cation 1; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 24 | Divalent metal cation 1; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 24 | Divalent metal cation 3; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 26 | Divalent metal cation 2; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 29 | Divalent metal cation 3; in cluster BCombined sources1 Publication | 1 | |
Metal bindingi | 33 | Divalent metal cation 4; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 34 | Divalent metal cation 4; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 34 | Divalent metal cation 5; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 36 | Divalent metal cation 5; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 37 | Divalent metal cation 5; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 37 | Divalent metal cation 6; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 41 | Divalent metal cation 6; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 44 | Divalent metal cation 4; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 44 | Divalent metal cation 6; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 48 | Divalent metal cation 4; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 50 | Divalent metal cation 5; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 50 | Divalent metal cation 7; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 57 | Divalent metal cation 7; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 59 | Divalent metal cation 7; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 60 | Divalent metal cation 6; in cluster ACombined sources1 Publication | 1 | |
Metal bindingi | 60 | Divalent metal cation 7; in cluster ACombined sources1 Publication | 1 |
GO - Molecular functioni
- metal ion binding Source: GO_Central
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cellular copper ion homeostasis Source: ProtInc
- cellular response to cadmium ion Source: GO_Central
- cellular response to copper ion Source: GO_Central
- cellular response to erythropoietin Source: UniProtKB
- cellular response to interleukin-3 Source: UniProtKB
- cellular response to zinc ion Source: UniProtKB
- cellular zinc ion homeostasis Source: GO_Central
- detoxification of copper ion Source: GO_Central
- negative regulation of growth Source: UniProtKB
Keywordsi
Ligand | Cadmium, Metal-binding, Metal-thiolate cluster, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P02795 |
Reactomei | R-HSA-5661231, Metallothioneins bind metals R-HSA-877300, Interferon gamma signaling |
SignaLinki | P02795 |
Names & Taxonomyi
Protein namesi | Recommended name: Metallothionein-2Short name: MT-2 Alternative name(s): Metallothionein-2A Metallothionein-II Short name: MT-II |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7406, MT2A |
MIMi | 156360, gene |
neXtProti | NX_P02795 |
VEuPathDBi | HostDB:ENSG00000125148 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 4502 |
OpenTargetsi | ENSG00000125148 |
PharmGKBi | PA31214 |
Miscellaneous databases
Pharosi | P02795, Tbio |
Chemistry databases
DrugBanki | DB00958, Carboplatin DB00515, Cisplatin DB09130, Copper DB00526, Oxaliplatin DB12965, Silver DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | MT2A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197245 | 1 – 61 | Metallothionein-2Add BLAST | 61 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 58 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P02795 |
jPOSTi | P02795 |
MassIVEi | P02795 |
MaxQBi | P02795 |
PaxDbi | P02795 |
PeptideAtlasi | P02795 |
PRIDEi | P02795 |
ProteomicsDBi | 51601 |
TopDownProteomicsi | P02795 |
PTM databases
iPTMneti | P02795 |
MetOSitei | P02795 |
PhosphoSitePlusi | P02795 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125148, Expressed in left adrenal gland and 247 other tissues |
ExpressionAtlasi | P02795, baseline and differential |
Genevisiblei | P02795, HS |
Organism-specific databases
HPAi | ENSG00000125148, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Interacts with EOLA1.
1 PublicationBinary interactionsi
P02795
Protein-protein interaction databases
BioGRIDi | 110608, 28 interactors |
DIPi | DIP-35232N |
IntActi | P02795, 39 interactors |
MINTi | P02795 |
STRINGi | 9606.ENSP00000245185 |
Chemistry databases
BindingDBi | P02795 |
Miscellaneous databases
RNActi | P02795, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P02795 |
BMRBi | P02795 |
SMRi | P02795 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02795 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | BetaAdd BLAST | 29 | |
Regioni | 30 – 61 | AlphaAdd BLAST | 32 |
Domaini
Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.1 Publication
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4738, Eukaryota |
GeneTreei | ENSGT00950000182967 |
HOGENOMi | CLU_171204_2_0_1 |
InParanoidi | P02795 |
OMAi | CAGCICK |
PhylomeDBi | P02795 |
TreeFami | TF336054 |
Family and domain databases
Gene3Di | 4.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003019, Metalthion IPR017854, Metalthion_dom_sf IPR023587, Metalthion_dom_sf_vert IPR000006, Metalthion_vert IPR018064, Metalthion_vert_metal_BS |
PANTHERi | PTHR23299, PTHR23299, 1 hit |
Pfami | View protein in Pfam PF00131, Metallothio, 1 hit |
PRINTSi | PR00860, MTVERTEBRATE |
SUPFAMi | SSF57868, SSF57868, 1 hit |
PROSITEi | View protein in PROSITE PS00203, METALLOTHIONEIN_VRT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P02795-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPNCSCAAG DSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCIC
60
KGASDKCSCC A
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BSP9 | H3BSP9_HUMAN | Metallothionein | MT2A | 73 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025840 | 42 | A → V1 PublicationCorresponds to variant dbSNP:rs35109646Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00271 Genomic DNA Translation: AAA59583.1 V00594 mRNA Translation: CAA23841.1 M26637 mRNA Translation: AAA59584.1 Sequence problems. S52379 mRNA Translation: AAB24908.1 X97260 mRNA Translation: CAA65915.1 BT007315 mRNA Translation: AAP35979.1 DQ370420 Genomic DNA Translation: ABC79300.1 BC007034 mRNA Translation: AAH07034.1 BC070289 mRNA Translation: AAH70289.1 |
CCDSi | CCDS10763.1 |
PIRi | A03271, SMHU2 I63131 |
RefSeqi | NP_005944.1, NM_005953.3 |
Genome annotation databases
Ensembli | ENST00000245185.6; ENSP00000245185.5; ENSG00000125148.7 |
GeneIDi | 4502 |
KEGGi | hsa:4502 |
MANE-Selecti | ENST00000245185.6; ENSP00000245185.5; NM_005953.5; NP_005944.1 |
UCSCi | uc002ejh.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00271 Genomic DNA Translation: AAA59583.1 V00594 mRNA Translation: CAA23841.1 M26637 mRNA Translation: AAA59584.1 Sequence problems. S52379 mRNA Translation: AAB24908.1 X97260 mRNA Translation: CAA65915.1 BT007315 mRNA Translation: AAP35979.1 DQ370420 Genomic DNA Translation: ABC79300.1 BC007034 mRNA Translation: AAH07034.1 BC070289 mRNA Translation: AAH70289.1 |
CCDSi | CCDS10763.1 |
PIRi | A03271, SMHU2 I63131 |
RefSeqi | NP_005944.1, NM_005953.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MHU | NMR | - | A | 31-61 | [»] | |
2MHU | NMR | - | A | 1-30 | [»] | |
AlphaFoldDBi | P02795 | |||||
BMRBi | P02795 | |||||
SMRi | P02795 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110608, 28 interactors |
DIPi | DIP-35232N |
IntActi | P02795, 39 interactors |
MINTi | P02795 |
STRINGi | 9606.ENSP00000245185 |
Chemistry databases
BindingDBi | P02795 |
DrugBanki | DB00958, Carboplatin DB00515, Cisplatin DB09130, Copper DB00526, Oxaliplatin DB12965, Silver DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
PTM databases
iPTMneti | P02795 |
MetOSitei | P02795 |
PhosphoSitePlusi | P02795 |
Genetic variation databases
BioMutai | MT2A |
Proteomic databases
EPDi | P02795 |
jPOSTi | P02795 |
MassIVEi | P02795 |
MaxQBi | P02795 |
PaxDbi | P02795 |
PeptideAtlasi | P02795 |
PRIDEi | P02795 |
ProteomicsDBi | 51601 |
TopDownProteomicsi | P02795 |
Protocols and materials databases
Antibodypediai | 58432, 145 antibodies from 19 providers |
DNASUi | 4502 |
Genome annotation databases
Ensembli | ENST00000245185.6; ENSP00000245185.5; ENSG00000125148.7 |
GeneIDi | 4502 |
KEGGi | hsa:4502 |
MANE-Selecti | ENST00000245185.6; ENSP00000245185.5; NM_005953.5; NP_005944.1 |
UCSCi | uc002ejh.4, human |
Organism-specific databases
CTDi | 4502 |
DisGeNETi | 4502 |
GeneCardsi | MT2A |
HGNCi | HGNC:7406, MT2A |
HPAi | ENSG00000125148, Tissue enhanced (liver) |
MIMi | 156360, gene |
neXtProti | NX_P02795 |
OpenTargetsi | ENSG00000125148 |
PharmGKBi | PA31214 |
VEuPathDBi | HostDB:ENSG00000125148 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4738, Eukaryota |
GeneTreei | ENSGT00950000182967 |
HOGENOMi | CLU_171204_2_0_1 |
InParanoidi | P02795 |
OMAi | CAGCICK |
PhylomeDBi | P02795 |
TreeFami | TF336054 |
Enzyme and pathway databases
PathwayCommonsi | P02795 |
Reactomei | R-HSA-5661231, Metallothioneins bind metals R-HSA-877300, Interferon gamma signaling |
SignaLinki | P02795 |
Miscellaneous databases
BioGRID-ORCSi | 4502, 101 hits in 1045 CRISPR screens |
ChiTaRSi | MT2A, human |
EvolutionaryTracei | P02795 |
GeneWikii | Metallothionein_2A |
GenomeRNAii | 4502 |
Pharosi | P02795, Tbio |
PROi | PR:P02795 |
RNActi | P02795, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125148, Expressed in left adrenal gland and 247 other tissues |
ExpressionAtlasi | P02795, baseline and differential |
Genevisiblei | P02795, HS |
Family and domain databases
Gene3Di | 4.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003019, Metalthion IPR017854, Metalthion_dom_sf IPR023587, Metalthion_dom_sf_vert IPR000006, Metalthion_vert IPR018064, Metalthion_vert_metal_BS |
PANTHERi | PTHR23299, PTHR23299, 1 hit |
Pfami | View protein in Pfam PF00131, Metallothio, 1 hit |
PRINTSi | PR00860, MTVERTEBRATE |
SUPFAMi | SSF57868, SSF57868, 1 hit |
PROSITEi | View protein in PROSITE PS00203, METALLOTHIONEIN_VRT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MT2_HUMAN | |
Accessioni | P02795Primary (citable) accession number: P02795 Secondary accession number(s): Q14823, Q2HXR9, Q53XT9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | May 25, 2022 | |
This is version 206 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Metallothioneins
Classification of metallothioneins and list of entries - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families