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Entry version 227 (31 Jul 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Ferritin heavy chain

Gene

FTH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi28Iron 11
Metal bindingi63Iron 11
Metal bindingi63Iron 21
Metal bindingi66Iron 11
Metal bindingi108Iron 21
Metal bindingi142Iron 21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.16.3.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation
R-HSA-917937 Iron uptake and transport

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P02794

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
Short name:
Ferritin H subunit
Alternative name(s):
Cell proliferation-inducing gene 15 protein
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FTH1
Synonyms:FTH, FTHL6
ORF Names:OK/SW-cl.84, PIG15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:3976 FTH1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
134770 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02794

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hemochromatosis 5 (HFE5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. In a Japanese family affected by HFE5, a single point mutation has been detected in the iron-responsive element (IRE) in the 5'-UTR of FTH1 mRNA. This mutation leads to an increased binding affinity for iron regulatory protein and thereby to the efficient suppression of mRNA translation.
Disease descriptionA disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
2495

MalaCards human disease database

More...
MalaCardsi
FTH1
MIMi615517 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000167996

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
247790 FTH1-related iron overload

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28392

Chemistry databases

Drug and drug target database

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DrugBanki
DB09147 Ferric pyrophosphate
DB09412 Gallium citrate Ga-67
DB00893 Iron Dextran

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FTH1

Domain mapping of disease mutations (DMDM)

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DMDMi
120516

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002010481 – 183Ferritin heavy chainAdd BLAST183
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004244722 – 183Ferritin heavy chain, N-terminally processedAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in Ferritin heavy chain, N-terminally processedCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P02794

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P02794

MaxQB - The MaxQuant DataBase

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MaxQBi
P02794

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P02794

PeptideAtlas

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PeptideAtlasi
P02794

PRoteomics IDEntifications database

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PRIDEi
P02794

ProteomicsDB human proteome resource

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ProteomicsDBi
51600

Consortium for Top Down Proteomics

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TopDownProteomicsi
P02794

2D gel databases

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P02794

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P02794

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P02794

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P02794

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000167996 Expressed in 224 organ(s), highest expression level in tibial nerve

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P02794 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P02794 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB008623

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. In the human liver, the heavy chain is predominant. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108773, 111 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P02794

Database of interacting proteins

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DIPi
DIP-38301N

Protein interaction database and analysis system

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IntActi
P02794, 44 interactors

Molecular INTeraction database

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MINTi
P02794

STRING: functional protein association networks

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STRINGi
9606.ENSP00000273550

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02794

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P02794

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 160Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2332 Eukaryota
COG1528 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182841

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P02794

KEGG Orthology (KO)

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KOi
K00522

Identification of Orthologs from Complete Genome Data

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OMAi
QALHNFA

Database of Orthologous Groups

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OrthoDBi
1249457at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P02794

TreeFam database of animal gene trees

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TreeFami
TF313885

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1260.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom

The PANTHER Classification System

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PANTHERi
PTHR11431 PTHR11431, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00210 Ferritin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47240 SSF47240, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P02794-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK
60 70 80 90 100
NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD CDDWESGLNA
110 120 130 140 150
MECALHLEKN VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKAIKELG
160 170 180
DHVTNLRKMG APESGLAEYL FDKHTLGDSD NES
Length:183
Mass (Da):21,226
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFEF75640A29CCF56
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQR3E9PQR3_HUMAN
Ferritin
FTH1
50Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKY7E9PKY7_HUMAN
Ferritin
FTH1
114Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRK8E9PRK8_HUMAN
Ferritin
FTH1
95Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPQ4E9PPQ4_HUMAN
Ferritin
FTH1
58Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1D1G3V1D1_HUMAN
Ferritin
FTH1 hCG_1776129
113Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V192G3V192_HUMAN
Ferritin
FTH1 hCG_1776129
153Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKM5E9PKM5_HUMAN
Ferritin heavy chain
FTH1
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK45E9PK45_HUMAN
Ferritin heavy chain
FTH1
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI05803 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti176 – 183LGDSDNES → WETVIMKAKPRANFP in CAA25086 (PubMed:6323167).Curated8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X00318 mRNA Translation: CAA25086.1
M11146 mRNA Translation: AAA52437.1
M12937 mRNA Translation: AAA35830.1
X03487, X03488 Genomic DNA Translation: CAA27205.1
M14212, M14211 Genomic DNA Translation: AAA52438.1
M97164 mRNA Translation: AAA35832.1
L20941 mRNA Translation: AAA35833.1
AF088851 mRNA Translation: AAF89523.1
AY258285 mRNA Translation: AAP82230.1
AB062402 mRNA Translation: BAB93489.1
AK054816 mRNA Translation: BAG51427.1
DQ496108 Genomic DNA Translation: ABF47097.1
CH471076 Genomic DNA Translation: EAW73989.1
BC000857 mRNA Translation: AAH00857.1
BC001399 mRNA Translation: AAH01399.1
BC011359 mRNA Translation: AAH11359.1
BC013724 mRNA Translation: AAH13724.1
BC015156 mRNA Translation: AAH15156.1
BC016009 mRNA Translation: AAH16009.1
BC016857 mRNA Translation: AAH16857.1
BC063514 mRNA Translation: AAH63514.1
BC066961 mRNA Translation: AAH66961.1
BC073750 mRNA Translation: AAH73750.1
BC104643 mRNA Translation: AAI04644.1
BC105802 mRNA Translation: AAI05803.1 Different initiation.
M15383 mRNA Translation: AAA52479.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41655.1

Protein sequence database of the Protein Information Resource

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PIRi
A23517 FRHUH

NCBI Reference Sequences

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RefSeqi
NP_002023.2, NM_002032.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000273550; ENSP00000273550; ENSG00000167996
ENST00000620041; ENSP00000484477; ENSG00000167996

Database of genes from NCBI RefSeq genomes

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GeneIDi
2495

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2495

UCSC genome browser

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UCSCi
uc001nsu.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Ferritin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00318 mRNA Translation: CAA25086.1
M11146 mRNA Translation: AAA52437.1
M12937 mRNA Translation: AAA35830.1
X03487, X03488 Genomic DNA Translation: CAA27205.1
M14212, M14211 Genomic DNA Translation: AAA52438.1
M97164 mRNA Translation: AAA35832.1
L20941 mRNA Translation: AAA35833.1
AF088851 mRNA Translation: AAF89523.1
AY258285 mRNA Translation: AAP82230.1
AB062402 mRNA Translation: BAB93489.1
AK054816 mRNA Translation: BAG51427.1
DQ496108 Genomic DNA Translation: ABF47097.1
CH471076 Genomic DNA Translation: EAW73989.1
BC000857 mRNA Translation: AAH00857.1
BC001399 mRNA Translation: AAH01399.1
BC011359 mRNA Translation: AAH11359.1
BC013724 mRNA Translation: AAH13724.1
BC015156 mRNA Translation: AAH15156.1
BC016009 mRNA Translation: AAH16009.1
BC016857 mRNA Translation: AAH16857.1
BC063514 mRNA Translation: AAH63514.1
BC066961 mRNA Translation: AAH66961.1
BC073750 mRNA Translation: AAH73750.1
BC104643 mRNA Translation: AAI04644.1
BC105802 mRNA Translation: AAI05803.1 Different initiation.
M15383 mRNA Translation: AAA52479.1
CCDSiCCDS41655.1
PIRiA23517 FRHUH
RefSeqiNP_002023.2, NM_002032.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FHAX-ray2.40A1-183[»]
2CEIX-ray1.80A2-183[»]
2CHIX-ray1.60A2-183[»]
2CIHX-ray1.50A2-183[»]
2CLUX-ray2.10A2-183[»]
2CN6X-ray2.20A2-183[»]
2CN7X-ray1.75A2-183[»]
2FHAX-ray1.90A1-183[»]
2IU2X-ray1.80A2-183[»]
2Z6MX-ray2.72A/B/C/D/E/F/G/H/I/J/K/L2-177[»]
3AJOX-ray1.52A2-183[»]
3AJPX-ray1.90A2-183[»]
3AJQX-ray1.58A2-183[»]
3ERZX-ray3.06A/B/C/D/E/F/G/H/I/J/K/L1-183[»]
3ES3X-ray2.79A1-183[»]
4DYXX-ray1.85A6-177[»]
4DYYX-ray1.90A6-177[»]
4DYZX-ray2.30A6-177[»]
4DZ0X-ray2.50A6-177[»]
4OYNX-ray1.43A1-183[»]
4Y08X-ray1.34A1-183[»]
4YKHX-ray1.52A1-183[»]
4ZJKX-ray1.56A2-183[»]
5CMQX-ray1.94A2-183[»]
5CMRX-ray3.79A2-183[»]
5GN8X-ray2.81A2-183[»]
B2-153[»]
5GOUX-ray2.91A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-183[»]
5JKKX-ray1.60A/B/C/D/E/F/G/H1-183[»]
5JKLX-ray1.80A/B/C/D/E/F/G/H/I/J/K/L1-183[»]
5JKMX-ray1.80A/B/C/D/E/F/G/H/I/J/K/L1-183[»]
5N26X-ray2.05A2-183[»]
5N27X-ray1.74A2-183[»]
5UP7X-ray1.79A2-183[»]
5UP8X-ray2.63A2-183[»]
5UP9X-ray2.45A/B/C/D/E/F2-183[»]
5VTDX-ray1.95A2-183[»]
5XB1electron microscopy3.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-160[»]
5YI5electron microscopy3.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-177[»]
5ZNDX-ray3.00A1-134[»]
6B8FX-ray1.06A2-183[»]
6B8GX-ray1.13A2-183[»]
6FTVX-ray1.58A2-183[»]
6GSRelectron microscopy5.50Aa/Ac/Ad/Ae/Af/Ag/Ah/Ai/Aj/Ak/Al/Am/An/Ao/Ap/Ar/As/At/Au/Av/Aw/Ax/Ay/Az2-183[»]
6H5Ielectron microscopy3.90Aa/Ac/Ad/Ae/Af/Ag/Ah/Ai/Aj/Ak/Al/Am/An/Ao/Ap/Ar/As/At/Au/Av/Aw/Ax/Ay/Az6-177[»]
6IPCX-ray4.44A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P2-183[»]
6IPOX-ray3.00A/B2-183[»]
6IPPX-ray2.70A/B2-183[»]
6IPQX-ray3.10A2-183[»]
SMRiP02794
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108773, 111 interactors
CORUMiP02794
DIPiDIP-38301N
IntActiP02794, 44 interactors
MINTiP02794
STRINGi9606.ENSP00000273550

Chemistry databases

DrugBankiDB09147 Ferric pyrophosphate
DB09412 Gallium citrate Ga-67
DB00893 Iron Dextran

PTM databases

iPTMnetiP02794
PhosphoSitePlusiP02794
SwissPalmiP02794

Polymorphism and mutation databases

BioMutaiFTH1
DMDMi120516

2D gel databases

UCD-2DPAGEiP02794

Proteomic databases

EPDiP02794
jPOSTiP02794
MaxQBiP02794
PaxDbiP02794
PeptideAtlasiP02794
PRIDEiP02794
ProteomicsDBi51600
TopDownProteomicsiP02794

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P02794

The DNASU plasmid repository

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DNASUi
2495
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273550; ENSP00000273550; ENSG00000167996
ENST00000620041; ENSP00000484477; ENSG00000167996
GeneIDi2495
KEGGihsa:2495
UCSCiuc001nsu.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2495
DisGeNETi2495

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FTH1
HGNCiHGNC:3976 FTH1
HPAiCAB008623
MalaCardsiFTH1
MIMi134770 gene
615517 phenotype
neXtProtiNX_P02794
OpenTargetsiENSG00000167996
Orphaneti247790 FTH1-related iron overload
PharmGKBiPA28392

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
GeneTreeiENSGT00950000182841
InParanoidiP02794
KOiK00522
OMAiQALHNFA
OrthoDBi1249457at2759
PhylomeDBiP02794
TreeFamiTF313885

Enzyme and pathway databases

BRENDAi1.16.3.1 2681
ReactomeiR-HSA-3000480 Scavenging by Class A Receptors
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation
R-HSA-917937 Iron uptake and transport
SIGNORiP02794

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FTH1 human
EvolutionaryTraceiP02794

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FTH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2495

Protein Ontology

More...
PROi
PR:P02794

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167996 Expressed in 224 organ(s), highest expression level in tibial nerve
ExpressionAtlasiP02794 baseline and differential
GenevisibleiP02794 HS

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRIH_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02794
Secondary accession number(s): B3KNR5, Q3KRA8, Q3SWW1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 31, 2019
This is version 227 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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