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Protein

Ferritin light chain 1

Gene

Ftl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54IronPROSITE-ProRule annotation1
Metal bindingi57IronPROSITE-ProRule annotation1
Metal bindingi58IronPROSITE-ProRule annotation1
Metal bindingi61IronPROSITE-ProRule annotation1
Metal bindingi64IronPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: RGD
  • intracellular sequestering of iron ion Source: GO_Central
  • iron ion transport Source: InterPro
  • response to lead ion Source: RGD

Keywordsi

Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-432722 Golgi Associated Vesicle Biogenesis
R-RNO-6798695 Neutrophil degranulation
R-RNO-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin light chain 1
Alternative name(s):
Ferritin L subunit 1
Gene namesi
Name:Ftl1
Synonyms:Ftl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 1, Chromosome 5

Organism-specific databases

RGDi61813 Ftl1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010661 – 183Ferritin light chain 1Add BLAST183

Proteomic databases

PaxDbiP02793
PRIDEiP02793

2D gel databases

World-2DPAGEi0004:P02793

PTM databases

iPTMnetiP02793
PhosphoSitePlusiP02793

Expressioni

Tissue specificityi

In rat liver, the light chain is the major chain.

Gene expression databases

BgeeiENSRNOG00000020843 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
GenevisibleiP02793 RN

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Protein-protein interaction databases

IntActiP02793, 2 interactors
STRINGi10116.ENSRNOP00000064683

Structurei

3D structure databases

ProteinModelPortaliP02793
SMRiP02793
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 156Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Domaini

The rat light chain has an octopeptide insertion after residue 158 compared with other light chains.

Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

eggNOGiENOG410KDTW Eukaryota
ENOG4111Q1M LUCA
GeneTreeiENSGT00760000119129
HOGENOMiHOG000223383
HOVERGENiHBG000410
InParanoidiP02793
KOiK13625
OMAiVNLYLRA
OrthoDBiEOG091G0J20
PhylomeDBiP02793
TreeFamiTF313885

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P02793-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSQIRQNYS TEVEAAVNRL VNLHLRASYT YLSLGFFFDR DDVALEGVGH
60 70 80 90 100
FFRELAEEKR EGAERLLKLQ NERGGRALFQ DVQKPSQDEW GKTLEAMEAA
110 120 130 140 150
LALEKNLNQA LLDLHALGSA RTDPHLCDFL ESHFLDKEVK LIKKMGNHLT
160 170 180
NLRRVAGPQP AQTGVAQASL GEYLFERLTL KHD
Length:183
Mass (Da):20,749
Last modified:January 23, 2007 - v3
Checksum:iE6AB306251D55106
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98E → K in AAA41154 (PubMed:6546756).Curated1
Sequence conflicti121 – 122RT → QA in AAA41154 (PubMed:6546756).Curated2
Sequence conflicti126L → F in AAA41152 (PubMed:1555892).Curated1
Sequence conflicti155V → W in AAA41154 (PubMed:6546756).Curated1
Sequence conflicti156A → Q in AAA41154 (PubMed:6546756).Curated1
Sequence conflicti156A → Q in AAA41155 (PubMed:3584116).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01930 mRNA Translation: AAA41154.1
J02741 Genomic DNA Translation: AAA41155.1
L01122 mRNA Translation: AAA41152.1
BC061525 mRNA Translation: AAH61525.1
BC086583 mRNA Translation: AAH86583.1
BC088756 mRNA Translation: AAH88756.1
PIRiA29575 FRRTL
I54774
RefSeqiNP_071945.3, NM_022500.4
XP_002726683.1, XM_002726637.5
XP_002729599.1, XM_002729553.5
UniGeneiRn.119282
Rn.1905

Genome annotation databases

EnsembliENSRNOT00000028315; ENSRNOP00000028315; ENSRNOG00000020843
ENSRNOT00000044711; ENSRNOP00000064683; ENSRNOG00000031506
GeneIDi100360087
29292
KEGGirno:100360087
rno:29292
UCSCiRGD:61813 rat

Similar proteinsi

Entry informationi

Entry nameiFRIL1_RAT
AccessioniPrimary (citable) accession number: P02793
Secondary accession number(s): Q6P7T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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