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Protein

Ferritin light chain

Gene

FTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi54Iron1
Metal bindingi57Iron1
Metal bindingi58Iron1
Metal bindingi61Iron1
Metal bindingi64Iron1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ferric iron binding Source: GO_Central
  • ferrous iron binding Source: GO_Central
  • identical protein binding Source: IntAct
  • iron ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation
R-HSA-917937 Iron uptake and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ferritin light chain
Short name:
Ferritin L subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FTL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000087086.13

Human Gene Nomenclature Database

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HGNCi
HGNC:3999 FTL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
134790 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P02792

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperferritinemia with or without cataract (HRFTC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by elevated level of ferritin in serum and tissues, and early-onset bilateral cataract. Cataracts may be subclinical in some patients.
See also OMIM:600886
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07094830T → I in HRFTC. 1 PublicationCorresponds to variant dbSNP:rs397514540EnsemblClinVar.1
Neurodegeneration with brain iron accumulation 3 (NBIA3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild non-progressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
See also OMIM:606159
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02663396A → T in NBIA3. 1 PublicationCorresponds to variant dbSNP:rs104894685EnsemblClinVar.1
L-ferritin deficiency (LFTD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by low levels of ferritin in serum and tissues in the absence of other hematological symptoms. Seizures and mild neuropsychologic impairment may manifest in individuals with complete ferritin deficiency.
See also OMIM:615604

Keywords - Diseasei

Cataract, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

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DisGeNETi
2512

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
FTL

MalaCards human disease database

More...
MalaCardsi
FTL
MIMi600886 phenotype
606159 phenotype
615604 phenotype

Open Targets

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OpenTargetsi
ENSG00000087086

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
254704 Genetic hyperferritinemia without iron overload
163 Hereditary hyperferritinemia-cataract syndrome
440731 L-ferritin deficiency
157846 Neuroferritinopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28412

Chemistry databases

Drug and drug target database

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DrugBanki
DB09412 Gallium citrate Ga-67
DB00893 Iron Dextran
DB02285 Protoporphyrin Ix

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FTL

Domain mapping of disease mutations (DMDM)

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DMDMi
120523

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002010602 – 175Ferritin light chainAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P02792

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P02792

MaxQB - The MaxQuant DataBase

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MaxQBi
P02792

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P02792

PeptideAtlas

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PeptideAtlasi
P02792

PRoteomics IDEntifications database

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PRIDEi
P02792

ProteomicsDB human proteome resource

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ProteomicsDBi
51599

Consortium for Top Down Proteomics

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TopDownProteomicsi
P02792

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P02792

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P02792

SwissPalm database of S-palmitoylation events

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SwissPalmi
P02792

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000087086 Expressed in 90 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_FTL

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P02792 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB020769
HPA041602

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Iron enters the spherical protein shell through pores that are formed between subunits. Mutations leading to truncation or the addition of extra residues at the C-terminus interfere with normal pore formation and with iron accumulation.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108789, 49 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P02792

Database of interacting proteins

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DIPi
DIP-31248N

Protein interaction database and analysis system

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IntActi
P02792, 31 interactors

Molecular INTeraction database

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MINTi
P02792

STRING: functional protein association networks

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STRINGi
9606.ENSP00000366525

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FFXX-ray1.90J2-174[»]
2FG4X-ray2.10A2-175[»]
2FG8X-ray2.50A/B/C/D/E/F/G/H2-175[»]
3KXUX-ray1.85A1-166[»]
4V6BX-ray2.85A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v/w/x1-166[»]
5LG8X-ray1.98A1-175[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P02792

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02792

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P02792

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 156Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni54 – 61Catalytic site for iron oxidation8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDTV Eukaryota
ENOG4111WYH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153096

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000410

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P02792

KEGG Orthology (KO)

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KOi
K13625

Identification of Orthologs from Complete Genome Data

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OMAi
VNLYLRA

Database of Orthologous Groups

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OrthoDBi
323029at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P02792

TreeFam database of animal gene trees

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TreeFami
TF313885

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1260.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom

The PANTHER Classification System

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PANTHERi
PTHR11431 PTHR11431, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00210 Ferritin, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47240 SSF47240, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02792-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSQIRQNYS TDVEAAVNSL VNLYLQASYT YLSLGFYFDR DDVALEGVSH
60 70 80 90 100
FFRELAEEKR EGYERLLKMQ NQRGGRALFQ DIKKPAEDEW GKTPDAMKAA
110 120 130 140 150
MALEKKLNQA LLDLHALGSA RTDPHLCDFL ETHFLDEEVK LIKKMGDHLT
160 170
NLHRLGGPEA GLGEYLFERL TLKHD
Length:175
Mass (Da):20,020
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DB98081FF976BC2
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAE11873 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54E → Q AA sequence (PubMed:6653779).Curated1
Sequence conflicti87E → Q AA sequence (PubMed:6653779).Curated1
Sequence conflicti89E → W AA sequence (PubMed:8706699).Curated1
Sequence conflicti102A → T in AAA35831 (PubMed:3858810).Curated1
Sequence conflicti154R → A AA sequence (PubMed:8706699).Curated1
Sequence conflicti175D → N AA sequence (PubMed:6653779).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07094830T → I in HRFTC. 1 PublicationCorresponds to variant dbSNP:rs397514540EnsemblClinVar.1
Natural variantiVAR_02663396A → T in NBIA3. 1 PublicationCorresponds to variant dbSNP:rs104894685EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M11147 mRNA Translation: AAA52439.1
M10119 mRNA Translation: AAA35831.1
M12938 mRNA Translation: AAA52440.1
AY207005 mRNA Translation: AAO52739.1
CR456715 mRNA Translation: CAG32996.1
AK311773 mRNA Translation: BAG34716.1
BX571748 mRNA Translation: CAE11873.1 Different initiation.
AC026803 Genomic DNA No translation available.
BC002991 mRNA Translation: AAH02991.2
BC004245 mRNA Translation: AAH04245.1
BC008439 mRNA Translation: AAH08439.1
BC013928 mRNA Translation: AAH13928.1
BC016715 mRNA Translation: AAH16715.1
BC016346 mRNA Translation: AAH16346.1
BC016354 mRNA Translation: AAH16354.1
BC018990 mRNA Translation: AAH18990.1
BC021670 mRNA Translation: AAH21670.1
BC058820 mRNA Translation: AAH58820.1
BC062708 mRNA Translation: AAH62708.1
X03742 Genomic DNA Translation: CAA27382.1
X03743 Genomic DNA Translation: CAA27383.1
X03743 Genomic DNA Translation: CAA27384.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33070.1

Protein sequence database of the Protein Information Resource

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PIRi
B23920 FRHUL

NCBI Reference Sequences

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RefSeqi
NP_000137.2, NM_000146.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.433670
Hs.728304

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331825; ENSP00000366525; ENSG00000087086

Database of genes from NCBI RefSeq genomes

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GeneIDi
2512

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2512

UCSC genome browser

More...
UCSCi
uc002plo.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Ferritin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11147 mRNA Translation: AAA52439.1
M10119 mRNA Translation: AAA35831.1
M12938 mRNA Translation: AAA52440.1
AY207005 mRNA Translation: AAO52739.1
CR456715 mRNA Translation: CAG32996.1
AK311773 mRNA Translation: BAG34716.1
BX571748 mRNA Translation: CAE11873.1 Different initiation.
AC026803 Genomic DNA No translation available.
BC002991 mRNA Translation: AAH02991.2
BC004245 mRNA Translation: AAH04245.1
BC008439 mRNA Translation: AAH08439.1
BC013928 mRNA Translation: AAH13928.1
BC016715 mRNA Translation: AAH16715.1
BC016346 mRNA Translation: AAH16346.1
BC016354 mRNA Translation: AAH16354.1
BC018990 mRNA Translation: AAH18990.1
BC021670 mRNA Translation: AAH21670.1
BC058820 mRNA Translation: AAH58820.1
BC062708 mRNA Translation: AAH62708.1
X03742 Genomic DNA Translation: CAA27382.1
X03743 Genomic DNA Translation: CAA27383.1
X03743 Genomic DNA Translation: CAA27384.1
CCDSiCCDS33070.1
PIRiB23920 FRHUL
RefSeqiNP_000137.2, NM_000146.3
UniGeneiHs.433670
Hs.728304

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FFXX-ray1.90J2-174[»]
2FG4X-ray2.10A2-175[»]
2FG8X-ray2.50A/B/C/D/E/F/G/H2-175[»]
3KXUX-ray1.85A1-166[»]
4V6BX-ray2.85A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v/w/x1-166[»]
5LG8X-ray1.98A1-175[»]
ProteinModelPortaliP02792
SMRiP02792
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108789, 49 interactors
CORUMiP02792
DIPiDIP-31248N
IntActiP02792, 31 interactors
MINTiP02792
STRINGi9606.ENSP00000366525

Chemistry databases

DrugBankiDB09412 Gallium citrate Ga-67
DB00893 Iron Dextran
DB02285 Protoporphyrin Ix

PTM databases

iPTMnetiP02792
PhosphoSitePlusiP02792
SwissPalmiP02792

Polymorphism and mutation databases

BioMutaiFTL
DMDMi120523

Proteomic databases

EPDiP02792
jPOSTiP02792
MaxQBiP02792
PaxDbiP02792
PeptideAtlasiP02792
PRIDEiP02792
ProteomicsDBi51599
TopDownProteomicsiP02792

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2512
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331825; ENSP00000366525; ENSG00000087086
GeneIDi2512
KEGGihsa:2512
UCSCiuc002plo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2512
DisGeNETi2512
EuPathDBiHostDB:ENSG00000087086.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FTL
GeneReviewsiFTL
HGNCiHGNC:3999 FTL
HPAiCAB020769
HPA041602
MalaCardsiFTL
MIMi134790 gene
600886 phenotype
606159 phenotype
615604 phenotype
neXtProtiNX_P02792
OpenTargetsiENSG00000087086
Orphaneti254704 Genetic hyperferritinemia without iron overload
163 Hereditary hyperferritinemia-cataract syndrome
440731 L-ferritin deficiency
157846 Neuroferritinopathy
PharmGKBiPA28412

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KDTV Eukaryota
ENOG4111WYH LUCA
GeneTreeiENSGT00940000153096
HOVERGENiHBG000410
InParanoidiP02792
KOiK13625
OMAiVNLYLRA
OrthoDBi323029at2759
PhylomeDBiP02792
TreeFamiTF313885

Enzyme and pathway databases

ReactomeiR-HSA-3000480 Scavenging by Class A Receptors
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation
R-HSA-917937 Iron uptake and transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FTL human
EvolutionaryTraceiP02792

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Ferritin_light_chain

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2512

Protein Ontology

More...
PROi
PR:P02792

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000087086 Expressed in 90 organ(s), highest expression level in blood
CleanExiHS_FTL
GenevisibleiP02792 HS

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRIL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02792
Secondary accession number(s): B2R4B9
, Q6IBT7, Q7Z2W1, Q86WI9, Q8WU07, Q96AU9, Q96CU0, Q9BTZ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 202 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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