UniProtKB - P02787 (TRFE_HUMAN)
Serotransferrin
TF
Functioni
Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
(Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use.
2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 82 | Fe(3+) 1Combined sources1 Publication | 1 | |
Metal bindingi | 114 | Fe(3+) 1Combined sources1 Publication | 1 | |
Binding sitei | 139 | Carbonate 1 | 1 | |
Binding sitei | 143 | Carbonate 1 | 1 | |
Binding sitei | 145 | Carbonate 1; via amide nitrogen | 1 | |
Binding sitei | 146 | Carbonate 1; via amide nitrogen | 1 | |
Metal bindingi | 207 | Fe(3+) 1Combined sources1 Publication | 1 | |
Metal bindingi | 268 | Fe(3+) 1Combined sources1 Publication | 1 | |
Metal bindingi | 411 | Fe(3+) 2PROSITE-ProRule annotationCombined sources2 Publications | 1 | |
Metal bindingi | 445 | Fe(3+) 2PROSITE-ProRule annotationCombined sources2 Publications | 1 | |
Binding sitei | 471 | Carbonate 2PROSITE-ProRule annotation | 1 | |
Binding sitei | 475 | Carbonate 2PROSITE-ProRule annotation | 1 | |
Binding sitei | 477 | Carbonate 2; via amide nitrogenPROSITE-ProRule annotation | 1 | |
Binding sitei | 478 | Carbonate 2; via amide nitrogenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 536 | Fe(3+) 2PROSITE-ProRule annotationCombined sources2 Publications | 1 | |
Metal bindingi | 604 | Fe(3+) 2PROSITE-ProRule annotationCombined sources2 Publications | 1 |
GO - Molecular functioni
- ferric iron binding Source: InterPro
- ferrous iron binding Source: BHF-UCL
- iron chaperone activity Source: BHF-UCL
- transferrin receptor binding Source: BHF-UCL
GO - Biological processi
- actin filament organization Source: Ensembl
- antibacterial humoral response Source: GO_Central
- cellular iron ion homeostasis Source: InterPro
- cellular response to iron ion Source: BHF-UCL
- ERK1 and ERK2 cascade Source: Ensembl
- iron ion homeostasis Source: BHF-UCL
- iron ion transport Source: GO_Central
- osteoclast differentiation Source: Ensembl
- positive regulation of bone resorption Source: Ensembl
- positive regulation of cell motility Source: Ensembl
- positive regulation of phosphorylation Source: Ensembl
- positive regulation of receptor-mediated endocytosis Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: Ensembl
- regulation of iron ion transport Source: BHF-UCL
- regulation of protein stability Source: BHF-UCL
- retina homeostasis Source: UniProtKB
- SMAD protein signal transduction Source: Ensembl
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P02787 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8957275, Post-translational protein phosphorylation R-HSA-917937, Iron uptake and transport R-HSA-917977, Transferrin endocytosis and recycling |
SignaLinki | P02787 |
SIGNORi | P02787 |
Protein family/group databases
MEROPSi | S60.972 |
Names & Taxonomyi
Protein namesi | Recommended name: SerotransferrinShort name: Transferrin Alternative name(s): Beta-1 metal-binding globulin Siderophilin |
Gene namesi | Name:TF ORF Names:PRO1400 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11740, TF |
MIMi | 190000, gene |
neXtProti | NX_P02787 |
VEuPathDBi | HostDB:ENSG00000091513 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Endosome
- early endosome Source: UniProtKB
- endosome membrane Source: Reactome
- late endosome Source: UniProtKB
- recycling endosome Source: UniProtKB
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- basal plasma membrane Source: UniProtKB
- clathrin-coated pit Source: UniProtKB
- extrinsic component of external side of plasma membrane Source: BHF-UCL
- HFE-transferrin receptor complex Source: BHF-UCL
- plasma membrane Source: GO_Central
Other locations
- basal part of cell Source: UniProtKB
- cell surface Source: UniProtKB
- clathrin-coated endocytic vesicle membrane Source: Reactome
- cytoplasmic vesicle Source: UniProtKB
- endocytic vesicle Source: MGI
- perinuclear region of cytoplasm Source: UniProtKB
- secretory granule lumen Source: Reactome
- vesicle Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Atransferrinemia (ATRAF)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038810 | 77 | D → N in ATRAF. 1 PublicationCorresponds to variant dbSNP:rs121918681EnsemblClinVar. | 1 | |
Natural variantiVAR_012997 | 477 | A → P in ATRAF. 1 PublicationCorresponds to variant dbSNP:rs121918679EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 7018 |
MalaCardsi | TF |
MIMi | 209300, phenotype |
OpenTargetsi | ENSG00000091513 |
Orphaneti | 1195, Congenital atransferrinemia |
PharmGKBi | PA36457 |
Miscellaneous databases
Pharosi | P02787, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4865 |
DrugBanki | DB01370, Aluminium DB14517, Aluminium phosphate DB14518, Aluminum acetate DB01294, Bismuth subsalicylate DB14526, Chromic citrate DB14527, Chromic nitrate DB11136, Chromium DB14528, Chromium gluconate DB14529, Chromium nicotinate DB14530, Chromous sulfate DB00515, Cisplatin DB09130, Copper DB11397, Dichlorvos DB13949, Ferric cation DB14490, Ferrous ascorbate DB14491, Ferrous fumarate DB14488, Ferrous gluconate DB14501, Ferrous glycine sulfate DB14489, Ferrous succinate DB13257, Ferrous sulfate anhydrous DB06215, Ferumoxytol DB05260, Gallium nitrate DB01592, Iron DB00893, Iron Dextran DB00677, Isoflurophate DB06757, Manganese DB11182, Rose bengal DB14520, Tetraferric tricitrate decahydrate DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | TF |
DMDMi | 313104271 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000035715 | 20 – 698 | SerotransferrinAdd BLAST | 679 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 67 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 38 ↔ 58 | PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 42 | Dimethylated arginineBy similarity | 1 | |
GlycosylationiCAR_000073 | 51 | O-linked (GalNAc...) serine | 1 | |
Disulfide bondi | 137 ↔ 213 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 156 ↔ 350 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 177 ↔ 193 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 180 ↔ 196 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 190 ↔ 198 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 246 ↔ 260 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 358 ↔ 615 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 364 ↔ 396 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 374 ↔ 387 | PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 389 | Phosphoserine; by FAM20C1 Publication | 1 | |
Disulfide bondi | 421 ↔ 693 | PROSITE-ProRule annotation1 Publication | ||
GlycosylationiCAR_000074 | 432 | N-linked (GlcNAc...) (complex) asparagine7 Publications | 1 | |
Disulfide bondi | 437 ↔ 656 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 469 ↔ 542 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 491 | N-linked (GlcNAc...) asparagine; atypical; partial1 Publication | 1 | |
Disulfide bondi | 493 ↔ 684 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 503 ↔ 517 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 514 ↔ 525 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 582 ↔ 596 | PROSITE-ProRule annotation1 Publication | ||
GlycosylationiCAR_000075 | 630 | N-linked (GlcNAc...) (complex) asparagine9 Publications | 1 | |
Disulfide bondi | 634 ↔ 639 | PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 685 | Phosphoserine; by FAM20C1 Publication | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Methylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-1157 non-CPTAC-1159 |
EPDi | P02787 |
jPOSTi | P02787 |
MassIVEi | P02787 |
MaxQBi | P02787 |
PaxDbi | P02787 |
PeptideAtlasi | P02787 |
PRIDEi | P02787 |
ProteomicsDBi | 51596 |
TopDownProteomicsi | P02787 |
2D gel databases
DOSAC-COBS-2DPAGEi | P02787 |
REPRODUCTION-2DPAGEi | IPI00022463 P02787 |
SWISS-2DPAGEi | P02787 |
UCD-2DPAGEi | P02787 |
PTM databases
CarbonylDBi | P02787 |
GlyConnecti | 558, 125 N-Linked glycans (3 sites), 3 O-Linked glycans (1 site) |
GlyGeni | P02787, 8 sites, 145 N-linked glycans (6 sites), 6 O-linked glycans (2 sites) |
iPTMneti | P02787 |
PhosphoSitePlusi | P02787 |
SwissPalmi | P02787 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000091513, Expressed in inferior vagus X ganglion and 210 other tissues |
ExpressionAtlasi | P02787, baseline and differential |
Genevisiblei | P02787, HS |
Organism-specific databases
HPAi | ENSG00000091513, Group enriched (liver, retina) |
Interactioni
Subunit structurei
Monomer.
1 Publication1 Publication(Microbial infection) Binds to Neisseria transferrin-binding protein A (tbpA or tbp1).
Forms a large complex with TbpA and TbpB.
1 Publication(Microbial infection) Binds to Neisseria transferrin-binding protein B (tbpb or tbp2).
2 PublicationsBinary interactionsi
P02787
GO - Molecular functioni
- transferrin receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112876, 152 interactors |
CORUMi | P02787 |
DIPi | DIP-2738N |
IntActi | P02787, 82 interactors |
MINTi | P02787 |
STRINGi | 9606.ENSP00000385834 |
Miscellaneous databases
RNActi | P02787, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P02787 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02787 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 347 | Transferrin-like 1PROSITE-ProRule annotationAdd BLAST | 323 | |
Domaini | 361 – 683 | Transferrin-like 2PROSITE-ProRule annotationAdd BLAST | 323 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QT0C, Eukaryota |
GeneTreei | ENSGT00940000154388 |
HOGENOMi | CLU_011309_1_0_1 |
InParanoidi | P02787 |
OMAi | KWCAIGH |
OrthoDBi | 232859at2759 |
PhylomeDBi | P02787 |
TreeFami | TF324013 |
Family and domain databases
InterProi | View protein in InterPro IPR030685, Serotransferrin_mammal IPR016357, Transferrin IPR001156, Transferrin-like_dom IPR018195, Transferrin_Fe_BS |
Pfami | View protein in Pfam PF00405, Transferrin, 2 hits |
PIRSFi | PIRSF500682, Serotransferrin, 1 hit PIRSF002549, Transferrin, 1 hit |
PRINTSi | PR00422, TRANSFERRIN |
SMARTi | View protein in SMART SM00094, TR_FER, 2 hits |
PROSITEi | View protein in PROSITE PS00205, TRANSFERRIN_LIKE_1, 1 hit PS00206, TRANSFERRIN_LIKE_2, 2 hits PS00207, TRANSFERRIN_LIKE_3, 2 hits PS51408, TRANSFERRIN_LIKE_4, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MRLAVGALLV CAVLGLCLAV PDKTVRWCAV SEHEATKCQS FRDHMKSVIP
60 70 80 90 100
SDGPSVACVK KASYLDCIRA IAANEADAVT LDAGLVYDAY LAPNNLKPVV
110 120 130 140 150
AEFYGSKEDP QTFYYAVAVV KKDSGFQMNQ LRGKKSCHTG LGRSAGWNIP
160 170 180 190 200
IGLLYCDLPE PRKPLEKAVA NFFSGSCAPC ADGTDFPQLC QLCPGCGCST
210 220 230 240 250
LNQYFGYSGA FKCLKDGAGD VAFVKHSTIF ENLANKADRD QYELLCLDNT
260 270 280 290 300
RKPVDEYKDC HLAQVPSHTV VARSMGGKED LIWELLNQAQ EHFGKDKSKE
310 320 330 340 350
FQLFSSPHGK DLLFKDSAHG FLKVPPRMDA KMYLGYEYVT AIRNLREGTC
360 370 380 390 400
PEAPTDECKP VKWCALSHHE RLKCDEWSVN SVGKIECVSA ETTEDCIAKI
410 420 430 440 450
MNGEADAMSL DGGFVYIAGK CGLVPVLAEN YNKSDNCEDT PEAGYFAIAV
460 470 480 490 500
VKKSASDLTW DNLKGKKSCH TAVGRTAGWN IPMGLLYNKI NHCRFDEFFS
510 520 530 540 550
EGCAPGSKKD SSLCKLCMGS GLNLCEPNNK EGYYGYTGAF RCLVEKGDVA
560 570 580 590 600
FVKHQTVPQN TGGKNPDPWA KNLNEKDYEL LCLDGTRKPV EEYANCHLAR
610 620 630 640 650
APNHAVVTRK DKEACVHKIL RQQQHLFGSN VTDCSGNFCL FRSETKDLLF
660 670 680 690
RDDTVCLAKL HDRNTYEKYL GEEYVKAVGN LRKCSTSSLL EACTFRRP
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WCI6 | F8WCI6_HUMAN | Serotransferrin | TF | 120 | Annotation score: | ||
H7C5E8 | H7C5E8_HUMAN | Serotransferrin | TF | 143 | Annotation score: | ||
F8WC57 | F8WC57_HUMAN | Serotransferrin | TF | 102 | Annotation score: | ||
F8WEK9 | F8WEK9_HUMAN | Serotransferrin | TF | 115 | Annotation score: | ||
C9JVG0 | C9JVG0_HUMAN | Serotransferrin | TF | 134 | Annotation score: | ||
C9JB55 | C9JB55_HUMAN | Serotransferrin | TF | 75 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 | D → N in AAH59367 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 264 | Q → E AA sequence (PubMed:6833213).Curated | 1 | |
Sequence conflicti | 329 | D → N AA sequence (PubMed:6833213).Curated | 1 | |
Sequence conflicti | 329 | D → N in AAA61141 (PubMed:3858812).Curated | 1 | |
Sequence conflicti | 351 | P → Q in AAH59367 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 380 – 381 | NS → SD AA sequence (PubMed:6833213).Curated | 2 | |
Sequence conflicti | 436 | N → D AA sequence (PubMed:6833213).Curated | 1 | |
Sequence conflicti | 558 – 561 | PQNT → TQNP AA sequence (PubMed:6833213).Curated | 4 | |
Sequence conflicti | 591 | E → Q AA sequence (PubMed:6833213).Curated | 1 | |
Sequence conflicti | 672 | E → Q AA sequence (PubMed:6833213).Curated | 1 | |
Sequence conflicti | 691 | E → G in AAA61142 (PubMed:6322780).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034569 | 42 | R → L. Corresponds to variant dbSNP:rs41298293EnsemblClinVar. | 1 | |
Natural variantiVAR_029280 | 55 | S → R1 PublicationCorresponds to variant dbSNP:rs8177318EnsemblClinVar. | 1 | |
Natural variantiVAR_034570 | 76 | A → V. Corresponds to variant dbSNP:rs41298977EnsemblClinVar. | 1 | |
Natural variantiVAR_038810 | 77 | D → N in ATRAF. 1 PublicationCorresponds to variant dbSNP:rs121918681EnsemblClinVar. | 1 | |
Natural variantiVAR_011997 | 142 | G → S1 PublicationCorresponds to variant dbSNP:rs1799830Ensembl. | 1 | |
Natural variantiVAR_011998 | 277 | G → S in allele TF*C3; associated with a reduction in total iron binding capacity; risk factor for iron deficiency anemia in menstruating white women. 3 PublicationsCorresponds to variant dbSNP:rs1799899EnsemblClinVar. | 1 | |
Natural variantiVAR_007544 | 296 | D → G in allele TF*D1. 1 PublicationCorresponds to variant dbSNP:rs8177238EnsemblClinVar. | 1 | |
Natural variantiVAR_007545 | 319 | H → R in allele TF*CHI. Corresponds to variant dbSNP:rs41295774EnsemblClinVar. | 1 | |
Natural variantiVAR_011999 | 377 | W → C. Corresponds to variant dbSNP:rs1804498Ensembl. | 1 | |
Natural variantiVAR_058199 | 448 | I → VCombined sources12 PublicationsCorresponds to variant dbSNP:rs2692696Ensembl. | 1 | |
Natural variantiVAR_012997 | 477 | A → P in ATRAF. 1 PublicationCorresponds to variant dbSNP:rs121918679EnsemblClinVar. | 1 | |
Natural variantiVAR_034571 | 562 | G → V. Corresponds to variant dbSNP:rs41296590EnsemblClinVar. | 1 | |
Natural variantiVAR_012000 | 589 | P → S in allele TF*C2. 4 PublicationsCorresponds to variant dbSNP:rs1049296EnsemblClinVar. | 1 | |
Natural variantiVAR_012001 | 645 | T → P. Corresponds to variant dbSNP:rs1130537Ensembl. | 1 | |
Natural variantiVAR_012998 | 646 | K → E in allele TF*BV. 1 PublicationCorresponds to variant dbSNP:rs121918678EnsemblClinVar. | 1 | |
Natural variantiVAR_012999 | 671 | G → E in allele TF*B2. 1 PublicationCorresponds to variant dbSNP:rs121918677EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M12530 mRNA Translation: AAA61140.1 M17611, M17610 Genomic DNA Translation: AAA61147.1 M17614, M17612, M17613 Genomic DNA Translation: AAA61148.1 S95936 mRNA Translation: AAB22049.1 AF288144 , AF294270, AF294271, AF288139, AF288140, AF288141, AF288142, AF288143 Genomic DNA Translation: AAK77664.1 AY308797 Genomic DNA Translation: AAP45055.1 DQ525716 Genomic DNA Translation: ABF47110.1 AC080128 mRNA No translation available. AC083905 mRNA No translation available. CH471052 Genomic DNA Translation: EAW79167.1 BC059367 mRNA Translation: AAH59367.1 M21569, M15673 Genomic DNA Translation: AAA61143.2 M21570 Genomic DNA Translation: AAA61145.1 X04600 Genomic DNA Translation: CAA28265.1 AJ252279 mRNA Translation: CAB96907.1 M11372 , M11361, M11362, M11363, M11364, M11365, M11366, M11367, M11368, M11369, M11370, M11371 Genomic DNA Translation: AAA61141.1 AF118063 mRNA Translation: AAF22007.1 Different initiation. M12525 mRNA Translation: AAA61142.1 U88581 mRNA Translation: AAB97880.1 AF058327 Genomic DNA Translation: AAC63506.1 M26641 mRNA Translation: AAA61233.1 |
CCDSi | CCDS3080.1 |
PIRi | A20981, TFHUP |
RefSeqi | NP_001054.1, NM_001063.3 XP_016862578.1, XM_017007089.1 XP_016862579.1, XM_017007090.1 |
Genome annotation databases
Ensembli | ENST00000402696; ENSP00000385834; ENSG00000091513 |
GeneIDi | 7018 |
KEGGi | hsa:7018 |
MANE-Selecti | ENST00000402696.9; ENSP00000385834.3; NM_001063.4; NP_001054.2 |
UCSCi | uc003epv.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Transferrin entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M12530 mRNA Translation: AAA61140.1 M17611, M17610 Genomic DNA Translation: AAA61147.1 M17614, M17612, M17613 Genomic DNA Translation: AAA61148.1 S95936 mRNA Translation: AAB22049.1 AF288144 , AF294270, AF294271, AF288139, AF288140, AF288141, AF288142, AF288143 Genomic DNA Translation: AAK77664.1 AY308797 Genomic DNA Translation: AAP45055.1 DQ525716 Genomic DNA Translation: ABF47110.1 AC080128 mRNA No translation available. AC083905 mRNA No translation available. CH471052 Genomic DNA Translation: EAW79167.1 BC059367 mRNA Translation: AAH59367.1 M21569, M15673 Genomic DNA Translation: AAA61143.2 M21570 Genomic DNA Translation: AAA61145.1 X04600 Genomic DNA Translation: CAA28265.1 AJ252279 mRNA Translation: CAB96907.1 M11372 , M11361, M11362, M11363, M11364, M11365, M11366, M11367, M11368, M11369, M11370, M11371 Genomic DNA Translation: AAA61141.1 AF118063 mRNA Translation: AAF22007.1 Different initiation. M12525 mRNA Translation: AAA61142.1 U88581 mRNA Translation: AAB97880.1 AF058327 Genomic DNA Translation: AAC63506.1 M26641 mRNA Translation: AAA61233.1 |
CCDSi | CCDS3080.1 |
PIRi | A20981, TFHUP |
RefSeqi | NP_001054.1, NM_001063.3 XP_016862578.1, XM_017007089.1 XP_016862579.1, XM_017007090.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A8E | X-ray | 1.60 | A | 22-350 | [»] | |
1A8F | X-ray | 1.80 | A | 22-350 | [»] | |
1B3E | X-ray | 2.50 | A | 23-352 | [»] | |
1BP5 | X-ray | 2.20 | A/B/C/D | 20-356 | [»] | |
1BTJ | X-ray | 3.20 | A/B | 20-356 | [»] | |
1D3K | X-ray | 1.80 | A | 22-350 | [»] | |
1D4N | X-ray | 2.00 | A | 22-350 | [»] | |
1DTG | X-ray | 2.40 | A | 20-353 | [»] | |
1FQE | X-ray | 1.80 | A | 20-350 | [»] | |
1FQF | X-ray | 2.10 | A | 20-350 | [»] | |
1JQF | X-ray | 1.85 | A | 20-353 | [»] | |
1N7W | X-ray | 2.20 | A | 22-350 | [»] | |
1N7X | X-ray | 2.10 | A | 20-350 | [»] | |
1N84 | X-ray | 2.05 | A | 20-350 | [»] | |
1OQG | X-ray | 1.90 | A | 20-354 | [»] | |
1OQH | X-ray | 2.40 | A | 20-354 | [»] | |
1RYO | X-ray | 1.20 | A | 20-346 | [»] | |
1SUV | electron microscopy | 7.50 | C/D | 22-350 | [»] | |
2HAU | X-ray | 2.70 | A/B | 23-698 | [»] | |
2HAV | X-ray | 2.70 | A/B | 23-698 | [»] | |
2O7U | X-ray | 2.80 | A/B/C/D/E/F/G/H/I | 20-356 | [»] | |
2O84 | X-ray | 2.60 | X | 20-356 | [»] | |
3FGS | X-ray | 1.80 | A | 20-356 | [»] | |
3QYT | X-ray | 2.80 | A | 20-698 | [»] | |
3S9L | X-ray | 3.22 | C/D | 20-698 | [»] | |
3S9M | X-ray | 3.32 | C/D | 20-698 | [»] | |
3S9N | X-ray | 3.25 | C/D | 20-698 | [»] | |
3SKP | X-ray | 1.70 | A | 358-698 | [»] | |
3V83 | X-ray | 2.10 | A/B/C/D/E/F | 1-698 | [»] | |
3V89 | X-ray | 3.10 | B | 356-698 | [»] | |
3V8X | X-ray | 2.60 | B | 1-698 | [»] | |
3VE1 | X-ray | 2.96 | B/D | 20-698 | [»] | |
4H0W | X-ray | 2.40 | A | 20-698 | [»] | |
4X1B | X-ray | 2.45 | A | 20-698 | [»] | |
4X1D | X-ray | 2.80 | A/B | 20-698 | [»] | |
5DYH | X-ray | 2.68 | A/B | 1-698 | [»] | |
5H52 | X-ray | 3.00 | A | 20-698 | [»] | |
5WTD | X-ray | 2.50 | A | 20-698 | [»] | |
5X5P | X-ray | 2.70 | A | 20-698 | [»] | |
5Y6K | X-ray | 2.86 | A | 20-698 | [»] | |
6CTC | X-ray | 2.60 | A | 20-698 | [»] | |
6D03 | electron microscopy | 3.68 | C/D | 1-698 | [»] | |
6D04 | electron microscopy | 3.74 | C/D | 1-698 | [»] | |
6D05 | electron microscopy | 3.80 | C/D | 1-698 | [»] | |
6JAS | X-ray | 2.50 | A | 20-698 | [»] | |
6SOY | X-ray | 2.75 | C | 22-698 | [»] | |
6SOZ | X-ray | 3.42 | C | 22-698 | [»] | |
6UJ6 | X-ray | 2.68 | A | 1-698 | [»] | |
SMRi | P02787 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112876, 152 interactors |
CORUMi | P02787 |
DIPi | DIP-2738N |
IntActi | P02787, 82 interactors |
MINTi | P02787 |
STRINGi | 9606.ENSP00000385834 |
Chemistry databases
ChEMBLi | CHEMBL4865 |
DrugBanki | DB01370, Aluminium DB14517, Aluminium phosphate DB14518, Aluminum acetate DB01294, Bismuth subsalicylate DB14526, Chromic citrate DB14527, Chromic nitrate DB11136, Chromium DB14528, Chromium gluconate DB14529, Chromium nicotinate DB14530, Chromous sulfate DB00515, Cisplatin DB09130, Copper DB11397, Dichlorvos DB13949, Ferric cation DB14490, Ferrous ascorbate DB14491, Ferrous fumarate DB14488, Ferrous gluconate DB14501, Ferrous glycine sulfate DB14489, Ferrous succinate DB13257, Ferrous sulfate anhydrous DB06215, Ferumoxytol DB05260, Gallium nitrate DB01592, Iron DB00893, Iron Dextran DB00677, Isoflurophate DB06757, Manganese DB11182, Rose bengal DB14520, Tetraferric tricitrate decahydrate DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Protein family/group databases
MEROPSi | S60.972 |
PTM databases
CarbonylDBi | P02787 |
GlyConnecti | 558, 125 N-Linked glycans (3 sites), 3 O-Linked glycans (1 site) |
GlyGeni | P02787, 8 sites, 145 N-linked glycans (6 sites), 6 O-linked glycans (2 sites) |
iPTMneti | P02787 |
PhosphoSitePlusi | P02787 |
SwissPalmi | P02787 |
Genetic variation databases
BioMutai | TF |
DMDMi | 313104271 |
2D gel databases
DOSAC-COBS-2DPAGEi | P02787 |
REPRODUCTION-2DPAGEi | IPI00022463 P02787 |
SWISS-2DPAGEi | P02787 |
UCD-2DPAGEi | P02787 |
Proteomic databases
CPTACi | non-CPTAC-1157 non-CPTAC-1159 |
EPDi | P02787 |
jPOSTi | P02787 |
MassIVEi | P02787 |
MaxQBi | P02787 |
PaxDbi | P02787 |
PeptideAtlasi | P02787 |
PRIDEi | P02787 |
ProteomicsDBi | 51596 |
TopDownProteomicsi | P02787 |
Protocols and materials databases
ABCDi | P02787, 1 sequenced antibody |
Antibodypediai | 873, 1763 antibodies from 43 providers |
DNASUi | 7018 |
Genome annotation databases
Ensembli | ENST00000402696; ENSP00000385834; ENSG00000091513 |
GeneIDi | 7018 |
KEGGi | hsa:7018 |
MANE-Selecti | ENST00000402696.9; ENSP00000385834.3; NM_001063.4; NP_001054.2 |
UCSCi | uc003epv.2, human |
Organism-specific databases
CTDi | 7018 |
DisGeNETi | 7018 |
GeneCardsi | TF |
HGNCi | HGNC:11740, TF |
HPAi | ENSG00000091513, Group enriched (liver, retina) |
MalaCardsi | TF |
MIMi | 190000, gene 209300, phenotype |
neXtProti | NX_P02787 |
OpenTargetsi | ENSG00000091513 |
Orphaneti | 1195, Congenital atransferrinemia |
PharmGKBi | PA36457 |
VEuPathDBi | HostDB:ENSG00000091513 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT0C, Eukaryota |
GeneTreei | ENSGT00940000154388 |
HOGENOMi | CLU_011309_1_0_1 |
InParanoidi | P02787 |
OMAi | KWCAIGH |
OrthoDBi | 232859at2759 |
PhylomeDBi | P02787 |
TreeFami | TF324013 |
Enzyme and pathway databases
PathwayCommonsi | P02787 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-8957275, Post-translational protein phosphorylation R-HSA-917937, Iron uptake and transport R-HSA-917977, Transferrin endocytosis and recycling |
SignaLinki | P02787 |
SIGNORi | P02787 |
Miscellaneous databases
BioGRID-ORCSi | 7018, 8 hits in 1044 CRISPR screens |
ChiTaRSi | TF, human |
EvolutionaryTracei | P02787 |
GeneWikii | Transferrin |
GenomeRNAii | 7018 |
Pharosi | P02787, Tbio |
PROi | PR:P02787 |
RNActi | P02787, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000091513, Expressed in inferior vagus X ganglion and 210 other tissues |
ExpressionAtlasi | P02787, baseline and differential |
Genevisiblei | P02787, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030685, Serotransferrin_mammal IPR016357, Transferrin IPR001156, Transferrin-like_dom IPR018195, Transferrin_Fe_BS |
Pfami | View protein in Pfam PF00405, Transferrin, 2 hits |
PIRSFi | PIRSF500682, Serotransferrin, 1 hit PIRSF002549, Transferrin, 1 hit |
PRINTSi | PR00422, TRANSFERRIN |
SMARTi | View protein in SMART SM00094, TR_FER, 2 hits |
PROSITEi | View protein in PROSITE PS00205, TRANSFERRIN_LIKE_1, 1 hit PS00206, TRANSFERRIN_LIKE_2, 2 hits PS00207, TRANSFERRIN_LIKE_3, 2 hits PS51408, TRANSFERRIN_LIKE_4, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TRFE_HUMAN | |
Accessioni | P02787Primary (citable) accession number: P02787 Secondary accession number(s): O43890 Q9UHV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 23, 2022 | |
This is version 250 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families