UniProtKB - P02786 (TFR1_HUMAN)
Protein
Transferrin receptor protein 1
Gene
TFRC
Organism
Homo sapiens (Human)
Status
Functioni
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738).By similarity3 Publications
(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.2 Publications
Miscellaneous
Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.
GO - Molecular functioni
- double-stranded RNA binding Source: MGI
- identical protein binding Source: IntAct
- protein-containing complex binding Source: ARUK-UCL
- protein homodimerization activity Source: BHF-UCL
- protein kinase binding Source: ARUK-UCL
- RNA binding Source: UniProtKB
- transferrin receptor activity Source: UniProtKB
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- cellular iron ion homeostasis Source: GO_Central
- cellular response to drug Source: MGI
- cellular response to leukemia inhibitory factor Source: Ensembl
- intracellular signal transduction Source: UniProtKB
- iron ion transport Source: UniProtKB
- membrane organization Source: Reactome
- negative regulation of apoptotic process Source: ARUK-UCL
- negative regulation of mitochondrial fusion Source: UniProtKB
- osteoclast differentiation Source: Ensembl
- positive regulation of B cell proliferation Source: UniProtKB
- positive regulation of bone resorption Source: Ensembl
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: ARUK-UCL
- positive regulation of isotype switching Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: ARUK-UCL
- positive regulation of peptidyl-serine phosphorylation Source: ARUK-UCL
- positive regulation of protein-containing complex assembly Source: ARUK-UCL
- positive regulation of protein localization to nucleus Source: ARUK-UCL
- positive regulation of protein phosphorylation Source: ARUK-UCL
- positive regulation of T cell proliferation Source: UniProtKB
- receptor internalization Source: UniProtKB
- transferrin transport Source: UniProtKB
- transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor, Transducer |
Biological process | Endocytosis, Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P02786 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-917977, Transferrin endocytosis and recycling |
SIGNORi | P02786 |
Protein family/group databases
MEROPSi | M28.972 |
TCDBi | 9.B.229.1.1, the transferrin receptor, cd71, (tfr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transferrin receptor protein 1Short name: TR Short name: TfR Short name: TfR1 Short name: Trfr Alternative name(s): T9 p90 CD_antigen: CD71 Cleaved into the following chain: |
Gene namesi | Name:TFRC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11763, TFRC |
MIMi | 190010, gene |
neXtProti | NX_P02786 |
VEuPathDBi | HostDB:ENSG00000072274.12 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Other locations
- Melanosome 1 Publication
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Endosome
- early endosome Source: Ensembl
- endosome Source: MGI
- endosome membrane Source: CAFA
- recycling endosome Source: UniProtKB
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: UniProtKB
- extracellular space Source: UniProtKB
- extracellular vesicle Source: UniProtKB
Plasma Membrane
- basolateral plasma membrane Source: BHF-UCL
- clathrin-coated pit Source: UniProtKB
- external side of plasma membrane Source: BHF-UCL
- HFE-transferrin receptor complex Source: BHF-UCL
- integral component of plasma membrane Source: BHF-UCL
- plasma membrane Source: ARUK-UCL
Other locations
- cell surface Source: UniProtKB
- clathrin-coated endocytic vesicle membrane Source: Reactome
- cytoplasmic vesicle Source: MGI
- intracellular membrane-bounded organelle Source: UniProtKB
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: CAFA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 67 | CytoplasmicSequence analysisAdd BLAST | 67 | |
Transmembranei | 68 – 88 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 89 – 760 | ExtracellularSequence analysisAdd BLAST | 672 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Immunodeficiency 46 (IMD46)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076365 | 20 | Y → H in IMD46; increases protein expression; increases cell surface expression on T and B cells; increases soluble form level; impairs receptor internalization; impairs transferrin transport; impairs T and B cell proliferation as well as B cell class-switching; interacts with STEAP3; doesn't affect receptor internalization in erythroid precursor cells. 1 PublicationCorresponds to variant dbSNP:rs863225436EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 9 – 12 | FSNL → YTRF: Only 80% as active as wild-type receptor. | 4 | |
Mutagenesisi | 20 – 34 | YTRFS…DGDNS → PPGYSLARQVDYTRF: No influence on endocytic uptake of the receptor. Add BLAST | 15 | |
Mutagenesisi | 20 – 23 | YTRF → PPGY: Only 16% as active as wild-type receptor. 1 Publication | 4 | |
Mutagenesisi | 20 | Y → C: Only 35% as active as wild-type receptor. 3 Publications | 1 | |
Mutagenesisi | 20 | Y → G: Only 20% as active as wild-type receptor. 3 Publications | 1 | |
Mutagenesisi | 21 | T → F: Only 88% as active as wild-type receptor. 1 Publication | 1 | |
Mutagenesisi | 21 | T → TA: Only 14% as active as wild-type receptor. 1 Publication | 1 | |
Mutagenesisi | 21 | T → TAA: Only 19% as active as wild-type receptor. 1 Publication | 1 | |
Mutagenesisi | 23 | F → Y: Only 48% as active as wild-type receptor. 1 Publication | 1 | |
Mutagenesisi | 31 – 34 | GDNS → YTRF: 2-fold increase of the endocytic uptake of the receptor. | 4 | |
Mutagenesisi | 47 – 50 | NADN → YTRF: 1.27-fold increase of the endocytic uptake of the receptor. | 4 | |
Mutagenesisi | 619 | L → A: 20-fold reduced affinity for transferrin receptor. No binding to HFE. | 1 | |
Mutagenesisi | 622 | V → A: No significant effect on binding to transferrin nor HFE. | 1 | |
Mutagenesisi | 623 | R → A: No significant effect on binding to transferrin nor HFE. | 1 | |
Mutagenesisi | 629 | R → A: >5-fold reduced affinity for transferrin. >10-fold reduced affinity for HFE. | 1 | |
Mutagenesisi | 640 | Q → A: No effect on binding to transferrin. >10-fold reduced affinity for HFE. | 1 | |
Mutagenesisi | 641 | W → A: No significant effect on binding to transferrin nor HFE. | 1 | |
Mutagenesisi | 643 | Y → A: 20-fold reduced affinity for transferrin. No binding to HFE. | 1 | |
Mutagenesisi | 644 | S → A: No significant effect on binding to transferrin nor HFE. | 1 | |
Mutagenesisi | 646 | R → A or H: No binding to transferrin. 1 Publication | 1 | |
Mutagenesisi | 646 | R → K: 5% binding to transferrin. 1 Publication | 1 | |
Mutagenesisi | 647 | G → A: Large effect on affinity for transferrin. 4-fold reduced affinity for HFE. 1 Publication | 1 | |
Mutagenesisi | 648 | D → A: 16% binding to transferrin. 1 Publication | 1 | |
Mutagenesisi | 648 | D → E: 57% binding to transferrin. 1 Publication | 1 | |
Mutagenesisi | 650 | F → Q: >5-fold reduced affinity for transferrin. >10-fold reduced affinity for HFE. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 7037 |
MalaCardsi | TFRC |
MIMi | 616740, phenotype |
OpenTargetsi | ENSG00000072274 |
Orphaneti | 476113, Combined immunodeficiency due to TFRC deficiency |
PharmGKBi | PA36478 |
Miscellaneous databases
Pharosi | P02786, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3712860 |
DrugBanki | DB13949, Ferric cation DB15617, Ferric derisomaltose DB14490, Ferrous ascorbate DB14491, Ferrous fumarate DB14488, Ferrous gluconate DB14501, Ferrous glycine sulfate DB14489, Ferrous succinate DB13257, Ferrous sulfate anhydrous DB06784, Gallium citrate Ga-67 DB05260, Gallium nitrate DB01592, Iron DB14520, Tetraferric tricitrate decahydrate |
Genetic variation databases
BioMutai | TFRC |
DMDMi | 108935939 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000174132 | 1 – 760 | Transferrin receptor protein 1Add BLAST | 760 | |
ChainiPRO_0000292265 | 101 – 760 | Transferrin receptor protein 1, serum formAdd BLAST | 660 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 19 | PhosphoserineBy similarity | 1 | |
Modified residuei | 20 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 21 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 24 | Phosphoserine1 Publication | 1 | |
Lipidationi | 62 | S-palmitoyl cysteine1 Publication | 1 | |
Lipidationi | 67 | S-palmitoyl cysteine1 Publication | 1 | |
Disulfide bondi | 89 | Interchain1 Publication | ||
Disulfide bondi | 98 | Interchain1 Publication | ||
GlycosylationiCAR_000072 | 104 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Glycosylationi | 251 | N-linked (GlcNAc...) asparagineCombined sources4 Publications | 1 | |
Glycosylationi | 317 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
GlycosylationiCAR_000173 | 727 | N-linked (GlcNAc...) asparagineCombined sources3 Publications | 1 |
Post-translational modificationi
Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (PubMed:26214738). Stearoylation does not affect iron uptake (PubMed:26214738).1 Publication
N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.6 Publications
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 100 – 101 | Cleavage; by trypsin; to produce soluble form | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-2704 |
EPDi | P02786 |
jPOSTi | P02786 |
MassIVEi | P02786 |
MaxQBi | P02786 |
PaxDbi | P02786 |
PeptideAtlasi | P02786 |
PRIDEi | P02786 |
ProteomicsDBi | 51595 |
PTM databases
GlyConnecti | 607, 36 N-Linked glycans (5 sites), 5 O-Linked glycans (1 site) |
GlyGeni | P02786, 10 sites, 9 N-linked glycans (3 sites), 6 O-linked glycans (1 site) |
iPTMneti | P02786 |
MetOSitei | P02786 |
PhosphoSitePlusi | P02786 |
SwissPalmi | P02786 |
Expressioni
Inductioni
Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.
Gene expression databases
Bgeei | ENSG00000072274, Expressed in liver and 255 other tissues |
ExpressionAtlasi | P02786, baseline and differential |
Genevisiblei | P02786, HS |
Organism-specific databases
HPAi | ENSG00000072274, Tissue enhanced (placenta) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1.
Interacts with SH3BP3.
Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (PubMed:26642240).
2 PublicationsBinary interactionsi
Hide detailsP02786
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein homodimerization activity Source: BHF-UCL
- protein kinase binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 112895, 205 interactors |
CORUMi | P02786 |
DIPi | DIP-2736N |
ELMi | P02786 |
IntActi | P02786, 119 interactors |
MINTi | P02786 |
STRINGi | 9606.ENSP00000353224 |
Miscellaneous databases
RNActi | P02786, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P02786 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02786 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 223 – 313 | PAAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 67 | Mediates interaction with SH3BP41 PublicationAdd BLAST | 67 | |
Regioni | 569 – 760 | Ligand-bindingAdd BLAST | 192 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 20 – 23 | Endocytosis signal1 Publication | 4 | |
Motifi | 58 – 61 | Stop-transfer sequence1 Publication | 4 | |
Motifi | 646 – 648 | Cell attachment site; required for binding to transferrin | 3 |
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2195, Eukaryota |
GeneTreei | ENSGT01010000222495 |
InParanoidi | P02786 |
OMAi | VEPKTEC |
OrthoDBi | 804230at2759 |
PhylomeDBi | P02786 |
TreeFami | TF312981 |
Family and domain databases
CDDi | cd02128, PA_TfR, 1 hit |
Gene3Di | 1.20.930.40, 1 hit |
InterProi | View protein in InterPro IPR003137, PA_domain IPR007484, Peptidase_M28 IPR039373, Peptidase_M28B IPR029513, TfR IPR007365, TFR-like_dimer_dom IPR036757, TFR-like_dimer_dom_sf IPR037324, TfR1/2_PA |
PANTHERi | PTHR10404, PTHR10404, 1 hit PTHR10404:SF26, PTHR10404:SF26, 1 hit |
Pfami | View protein in Pfam PF02225, PA, 1 hit PF04389, Peptidase_M28, 1 hit PF04253, TFR_dimer, 1 hit |
SUPFAMi | SSF47672, SSF47672, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P02786-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL AVDEEENADN
60 70 80 90 100
NTKANVTKPK RCSGSICYGT IAVIVFFLIG FMIGYLGYCK GVEPKTECER
110 120 130 140 150
LAGTESPVRE EPGEDFPAAR RLYWDDLKRK LSEKLDSTDF TGTIKLLNEN
160 170 180 190 200
SYVPREAGSQ KDENLALYVE NQFREFKLSK VWRDQHFVKI QVKDSAQNSV
210 220 230 240 250
IIVDKNGRLV YLVENPGGYV AYSKAATVTG KLVHANFGTK KDFEDLYTPV
260 270 280 290 300
NGSIVIVRAG KITFAEKVAN AESLNAIGVL IYMDQTKFPI VNAELSFFGH
310 320 330 340 350
AHLGTGDPYT PGFPSFNHTQ FPPSRSSGLP NIPVQTISRA AAEKLFGNME
360 370 380 390 400
GDCPSDWKTD STCRMVTSES KNVKLTVSNV LKEIKILNIF GVIKGFVEPD
410 420 430 440 450
HYVVVGAQRD AWGPGAAKSG VGTALLLKLA QMFSDMVLKD GFQPSRSIIF
460 470 480 490 500
ASWSAGDFGS VGATEWLEGY LSSLHLKAFT YINLDKAVLG TSNFKVSASP
510 520 530 540 550
LLYTLIEKTM QNVKHPVTGQ FLYQDSNWAS KVEKLTLDNA AFPFLAYSGI
560 570 580 590 600
PAVSFCFCED TDYPYLGTTM DTYKELIERI PELNKVARAA AEVAGQFVIK
610 620 630 640 650
LTHDVELNLD YERYNSQLLS FVRDLNQYRA DIKEMGLSLQ WLYSARGDFF
660 670 680 690 700
RATSRLTTDF GNAEKTDRFV MKKLNDRVMR VEYHFLSPYV SPKESPFRHV
710 720 730 740 750
FWGSGSHTLP ALLENLKLRK QNNGAFNETL FRNQLALATW TIQGAANALS
760
GDVWDIDNEF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WBE5 | F8WBE5_HUMAN | Transferrin receptor protein 1 | TFRC | 81 | Annotation score: | ||
G3V0E5 | G3V0E5_HUMAN | Transferrin receptor protein 1 | TFRC hCG_22086 | 679 | Annotation score: | ||
H7C3V5 | H7C3V5_HUMAN | Transferrin receptor protein 1 | TFRC | 118 | Annotation score: |
Sequence cautioni
The sequence BAD92491 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 104 | T → K AA sequence (PubMed:1871153).Curated | 1 | |
Sequence conflicti | 109 | R → V AA sequence (PubMed:1871153).Curated | 1 | |
Sequence conflicti | 123 | Y → T AA sequence (PubMed:1871153).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076365 | 20 | Y → H in IMD46; increases protein expression; increases cell surface expression on T and B cells; increases soluble form level; impairs receptor internalization; impairs transferrin transport; impairs T and B cell proliferation as well as B cell class-switching; interacts with STEAP3; doesn't affect receptor internalization in erythroid precursor cells. 1 PublicationCorresponds to variant dbSNP:rs863225436EnsemblClinVar. | 1 | |
Natural variantiVAR_012737 | 142 | G → S3 PublicationsCorresponds to variant dbSNP:rs3817672Ensembl. | 1 | |
Natural variantiVAR_051806 | 212 | L → V. Corresponds to variant dbSNP:rs41301381Ensembl. | 1 | |
Natural variantiVAR_051807 | 420 | G → S. Corresponds to variant dbSNP:rs41295879EnsemblClinVar. | 1 | |
Natural variantiVAR_051808 | 677 | R → H. Corresponds to variant dbSNP:rs41298067Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01060 mRNA Translation: CAA25527.1 M11507 mRNA Translation: AAA61153.1 AF187320 Genomic DNA Translation: AAF04564.1 AB209254 mRNA Translation: BAD92491.1 Different initiation. DQ496099 Genomic DNA Translation: ABF47088.1 CH471191 Genomic DNA Translation: EAW53670.1 CH471191 Genomic DNA Translation: EAW53673.1 BC001188 mRNA Translation: AAH01188.1 |
CCDSi | CCDS3312.1 |
PIRi | A93343, JXHU |
RefSeqi | NP_001121620.1, NM_001128148.2 NP_001300894.1, NM_001313965.1 NP_001300895.1, NM_001313966.1 NP_003225.2, NM_003234.3 |
Genome annotation databases
Ensembli | ENST00000360110; ENSP00000353224; ENSG00000072274 ENST00000392396; ENSP00000376197; ENSG00000072274 |
GeneIDi | 7037 |
KEGGi | hsa:7037 |
UCSCi | uc003fvz.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01060 mRNA Translation: CAA25527.1 M11507 mRNA Translation: AAA61153.1 AF187320 Genomic DNA Translation: AAF04564.1 AB209254 mRNA Translation: BAD92491.1 Different initiation. DQ496099 Genomic DNA Translation: ABF47088.1 CH471191 Genomic DNA Translation: EAW53670.1 CH471191 Genomic DNA Translation: EAW53673.1 BC001188 mRNA Translation: AAH01188.1 |
CCDSi | CCDS3312.1 |
PIRi | A93343, JXHU |
RefSeqi | NP_001121620.1, NM_001128148.2 NP_001300894.1, NM_001313965.1 NP_001300895.1, NM_001313966.1 NP_003225.2, NM_003234.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CX8 | X-ray | 3.20 | A/B/C/D/E/F/G/H | 122-760 | [»] | |
1DE4 | X-ray | 2.80 | C/F/I | 121-760 | [»] | |
1SUV | electron microscopy | 7.50 | A/B | 122-760 | [»] | |
2NSU | electron microscopy | 27.00 | A/B | 122-760 | [»] | |
3KAS | X-ray | 2.40 | A | 121-760 | [»] | |
3S9L | X-ray | 3.22 | A/B | 120-760 | [»] | |
3S9M | X-ray | 3.32 | A/B | 120-760 | [»] | |
3S9N | X-ray | 3.25 | A/B | 120-760 | [»] | |
6D03 | electron microscopy | 3.68 | A/B | 121-760 | [»] | |
6D04 | electron microscopy | 3.74 | A/B | 121-760 | [»] | |
6D05 | electron microscopy | 3.80 | A/B | 121-760 | [»] | |
6GSR | electron microscopy | 5.50 | Ab/Aq | 121-760 | [»] | |
6H5I | electron microscopy | 3.90 | Ab/Aq | 121-760 | [»] | |
6OKD | X-ray | 1.85 | A/B | 121-760 | [»] | |
6W3H | X-ray | 3.38 | C/D | 296-326 | [»] | |
6Y76 | X-ray | 1.98 | A/B | 197-378 | [»] | |
SMRi | P02786 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112895, 205 interactors |
CORUMi | P02786 |
DIPi | DIP-2736N |
ELMi | P02786 |
IntActi | P02786, 119 interactors |
MINTi | P02786 |
STRINGi | 9606.ENSP00000353224 |
Chemistry databases
ChEMBLi | CHEMBL3712860 |
DrugBanki | DB13949, Ferric cation DB15617, Ferric derisomaltose DB14490, Ferrous ascorbate DB14491, Ferrous fumarate DB14488, Ferrous gluconate DB14501, Ferrous glycine sulfate DB14489, Ferrous succinate DB13257, Ferrous sulfate anhydrous DB06784, Gallium citrate Ga-67 DB05260, Gallium nitrate DB01592, Iron DB14520, Tetraferric tricitrate decahydrate |
Protein family/group databases
MEROPSi | M28.972 |
TCDBi | 9.B.229.1.1, the transferrin receptor, cd71, (tfr) family |
PTM databases
GlyConnecti | 607, 36 N-Linked glycans (5 sites), 5 O-Linked glycans (1 site) |
GlyGeni | P02786, 10 sites, 9 N-linked glycans (3 sites), 6 O-linked glycans (1 site) |
iPTMneti | P02786 |
MetOSitei | P02786 |
PhosphoSitePlusi | P02786 |
SwissPalmi | P02786 |
Genetic variation databases
BioMutai | TFRC |
DMDMi | 108935939 |
Proteomic databases
CPTACi | non-CPTAC-2704 |
EPDi | P02786 |
jPOSTi | P02786 |
MassIVEi | P02786 |
MaxQBi | P02786 |
PaxDbi | P02786 |
PeptideAtlasi | P02786 |
PRIDEi | P02786 |
ProteomicsDBi | 51595 |
Protocols and materials databases
ABCDi | P02786, 98 sequenced antibodies |
Antibodypediai | 4559, 2956 antibodies |
DNASUi | 7037 |
Genome annotation databases
Ensembli | ENST00000360110; ENSP00000353224; ENSG00000072274 ENST00000392396; ENSP00000376197; ENSG00000072274 |
GeneIDi | 7037 |
KEGGi | hsa:7037 |
UCSCi | uc003fvz.5, human |
Organism-specific databases
CTDi | 7037 |
DisGeNETi | 7037 |
GeneCardsi | TFRC |
HGNCi | HGNC:11763, TFRC |
HPAi | ENSG00000072274, Tissue enhanced (placenta) |
MalaCardsi | TFRC |
MIMi | 190010, gene 616740, phenotype |
neXtProti | NX_P02786 |
OpenTargetsi | ENSG00000072274 |
Orphaneti | 476113, Combined immunodeficiency due to TFRC deficiency |
PharmGKBi | PA36478 |
VEuPathDBi | HostDB:ENSG00000072274.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2195, Eukaryota |
GeneTreei | ENSGT01010000222495 |
InParanoidi | P02786 |
OMAi | VEPKTEC |
OrthoDBi | 804230at2759 |
PhylomeDBi | P02786 |
TreeFami | TF312981 |
Enzyme and pathway databases
PathwayCommonsi | P02786 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-917977, Transferrin endocytosis and recycling |
SIGNORi | P02786 |
Miscellaneous databases
BioGRID-ORCSi | 7037, 544 hits in 1006 CRISPR screens |
ChiTaRSi | TFRC, human |
EvolutionaryTracei | P02786 |
GeneWikii | TFRC |
GenomeRNAii | 7037 |
Pharosi | P02786, Tbio |
PROi | PR:P02786 |
RNActi | P02786, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000072274, Expressed in liver and 255 other tissues |
ExpressionAtlasi | P02786, baseline and differential |
Genevisiblei | P02786, HS |
Family and domain databases
CDDi | cd02128, PA_TfR, 1 hit |
Gene3Di | 1.20.930.40, 1 hit |
InterProi | View protein in InterPro IPR003137, PA_domain IPR007484, Peptidase_M28 IPR039373, Peptidase_M28B IPR029513, TfR IPR007365, TFR-like_dimer_dom IPR036757, TFR-like_dimer_dom_sf IPR037324, TfR1/2_PA |
PANTHERi | PTHR10404, PTHR10404, 1 hit PTHR10404:SF26, PTHR10404:SF26, 1 hit |
Pfami | View protein in Pfam PF02225, PA, 1 hit PF04389, Peptidase_M28, 1 hit PF04253, TFR_dimer, 1 hit |
SUPFAMi | SSF47672, SSF47672, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TFR1_HUMAN | |
Accessioni | P02786Primary (citable) accession number: P02786 Secondary accession number(s): D3DXB0 Q9UK21 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | May 30, 2006 | |
Last modified: | April 7, 2021 | |
This is version 248 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Peptidase families
Classification of peptidase families and list of entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families