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UniProtKB - P02776 (PLF4_HUMAN)

Protein

Platelet factor 4

Gene

PF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chemokine activity Source: GO_Central
  • CXCR3 chemokine receptor binding Source: UniProtKB
  • heparin binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet factor 4
Short name:
PF-4
Alternative name(s):
C-X-C motif chemokine 4
Iroplact
Oncostatin-A
Cleaved into the following chain:
Platelet factor 4, short form
Alternative name(s):
Endothelial cell growth inhibitor1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PF4
Synonyms:CXCL4, SCYB4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000163737.3

Human Gene Nomenclature Database

More...HGNCi		HGNC:8861 PF4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		173460 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P02776

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5196

Open Targets

More...OpenTargetsi		ENSG00000163737

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33203

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3286075

Drug and drug target database

More...DrugBanki		DB00055 Drotrecogin alfa

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PF4

Domain mapping of disease mutations (DMDM)

More...DMDMi		130304

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 315 PublicationsAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000506832 – 101Platelet factor 4Add BLAST70
ChainiPRO_000035121748 – 101Platelet factor 4, short form1 PublicationAdd BLAST54

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 671 Publication
Disulfide bondi43 ↔ 831 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei57PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P02776

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02776

PeptideAtlas

More...PeptideAtlasi		P02776

PRoteomics IDEntifications database

More...PRIDEi		P02776

ProteomicsDB human proteome resource

More...ProteomicsDBi		51593

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P02776

2D gel databases

USC-OGP 2-DE database

More...OGPi		P02776

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P02776

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		P02776

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163737 Expressed in 105 organ(s), highest expression level in mononuclear cell

CleanEx database of gene expression profiles

More...CleanExi		HS_PF4

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P02776 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB026008
HPA052485

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111219, 9 interactors

Database of interacting proteins

More...DIPi		DIP-56941N

Protein interaction database and analysis system

More...IntActi		P02776, 26 interactors

Molecular INTeraction database

More...MINTi		P02776

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296029

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P02776

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DN3NMR-A87-101[»]
1F9QX-ray2.00A/B/C/D32-101[»]
1F9RX-ray2.00A/B/C/D32-101[»]
1F9SX-ray2.38A/B/C/D32-101[»]
1PFMNMR-A/B/C/D39-101[»]
1PFNNMR-A/B/C/D39-101[»]
1RHPX-ray2.40A/B/C/D32-101[»]
4R9WX-ray2.50A/B32-101[»]
4R9YX-ray4.11A/B/C/D32-101[»]
4RAUX-ray3.74C/F/I/L/O/R/U/X32-101[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P02776

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P02776

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P02776

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni92 – 98Heparin-binding7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J314 Eukaryota
ENOG4111556 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163666

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000220915

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG107789

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02776

KEGG Orthology (KO)

More...KOi		K05407

Identification of Orthologs from Complete Genome Data

More...OMAi		CAVPQLI

Database of Orthologous Groups

More...OrthoDBi		1618797at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P02776

TreeFam database of animal gene trees

More...TreeFami		TF333433

Family and domain databases

Conserved Domains Database

More...CDDi		cd00273 Chemokine_CXC, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
IPR027222 PF4

The PANTHER Classification System

More...PANTHERi		PTHR10179 PTHR10179, 1 hit
PTHR10179:SF38 PTHR10179:SF38, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00048 IL8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00437 SMALLCYTKCXC

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00199 SCY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54117 SSF54117, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02776-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAAGFCAS RPGLLFLGLL LLPLVVAFAS AEAEEDGDLQ CLCVKTTSQV 
        60         70         80         90        100
RPRHITSLEV IKAGPHCPTA QLIATLKNGR KICLDLQAPL YKKIIKKLLE 

S
Length:101
Mass (Da):10,845
Last modified:July 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE96C2EFE9B944D85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78N → D AA sequence (PubMed:267922).Curated1
Sequence conflicti78N → D AA sequence (PubMed:601757).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 7765 Da from positions 32 - 101. Determined by ESI. 1 Publication
Molecular mass is 6033 Da from positions 48 - 101. Determined by ESI. Short form.1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M25897 mRNA Translation: AAA60066.1
AF349466 Genomic DNA Translation: AAK29643.1
CR407677 mRNA Translation: CAG28605.1
AC097709 Genomic DNA Translation: AAY41003.1
BC093965 mRNA Translation: AAH93965.1
BC112093 mRNA Translation: AAI12094.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3562.1

Protein sequence database of the Protein Information Resource

More...PIRi		A60161 PFHU4

NCBI Reference Sequences

More...RefSeqi		NP_002610.1, NM_002619.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.81564

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296029; ENSP00000296029; ENSG00000163737

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5196

UCSC genome browser

More...UCSCi		uc003hhi.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CXCL4 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25897 mRNA Translation: AAA60066.1
AF349466 Genomic DNA Translation: AAK29643.1
CR407677 mRNA Translation: CAG28605.1
AC097709 Genomic DNA Translation: AAY41003.1
BC093965 mRNA Translation: AAH93965.1
BC112093 mRNA Translation: AAI12094.1
CCDSiCCDS3562.1
PIRiA60161 PFHU4
RefSeqiNP_002610.1, NM_002619.3
UniGeneiHs.81564

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DN3NMR-A87-101[»]
1F9QX-ray2.00A/B/C/D32-101[»]
1F9RX-ray2.00A/B/C/D32-101[»]
1F9SX-ray2.38A/B/C/D32-101[»]
1PFMNMR-A/B/C/D39-101[»]
1PFNNMR-A/B/C/D39-101[»]
1RHPX-ray2.40A/B/C/D32-101[»]
4R9WX-ray2.50A/B32-101[»]
4R9YX-ray4.11A/B/C/D32-101[»]
4RAUX-ray3.74C/F/I/L/O/R/U/X32-101[»]
ProteinModelPortaliP02776
SMRiP02776
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111219, 9 interactors
DIPiDIP-56941N
IntActiP02776, 26 interactors
MINTiP02776
STRINGi9606.ENSP00000296029

Chemistry databases

BindingDBiP02776
ChEMBLiCHEMBL3286075
DrugBankiDB00055 Drotrecogin alfa

PTM databases

PhosphoSitePlusiP02776

Polymorphism and mutation databases

BioMutaiPF4
DMDMi130304

2D gel databases

OGPiP02776

Proteomic databases

jPOSTiP02776
PaxDbiP02776
PeptideAtlasiP02776
PRIDEiP02776
ProteomicsDBi51593
TopDownProteomicsiP02776

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296029; ENSP00000296029; ENSG00000163737
GeneIDi5196
KEGGihsa:5196
UCSCiuc003hhi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5196
DisGeNETi5196
EuPathDBiHostDB:ENSG00000163737.3

GeneCards: human genes, protein and diseases

More...GeneCardsi		PF4
HGNCiHGNC:8861 PF4
HPAiCAB026008
HPA052485
MIMi173460 gene
neXtProtiNX_P02776
OpenTargetsiENSG00000163737
PharmGKBiPA33203

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J314 Eukaryota
ENOG4111556 LUCA
GeneTreeiENSGT00940000163666
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP02776
KOiK05407
OMAiCAVPQLI
OrthoDBi1618797at2759
PhylomeDBiP02776
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

EvolutionaryTraceiP02776

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Platelet_factor_4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5196
PMAP-CutDBiP02776

Protein Ontology

More...PROi		PR:P02776

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163737 Expressed in 105 organ(s), highest expression level in mononuclear cell
CleanExiHS_PF4
GenevisibleiP02776 HS

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
IPR027222 PF4
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF38 PTHR10179:SF38, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLF4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02776
Secondary accession number(s): Q53X61, Q9UC64, Q9UC65
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: January 16, 2019
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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