PF4

Functionⁱ

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.1 Publication

GO - Molecular functionⁱ

chemokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
CXCR3 chemokine receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12782716
heparin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9531587

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G protein-coupled receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 12782716
antimicrobial humoral immune response mediated by antimicrobial peptide
Source: UniProtKB
Inferred from direct assayⁱ
- 23245326
- 10877842
cellular response to lipopolysaccharide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytokine-mediated signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 12041672
defense response to protozoan
Source: UniProtKB
Inferred from direct assayⁱ
- 23245326
G protein-coupled receptor signaling pathway Source: Reactome
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
killing by host of symbiont cells
Source: UniProtKB
Inferred from direct assayⁱ
- 23245326
killing of cells of other organism
Source: UniProtKB
Inferred from direct assayⁱ
- 10877842
leukocyte chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 6945600
negative regulation of angiogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 1688470
negative regulation of cytolysis
Source: BHF-UCL
Inferred from direct assayⁱ
- 10666185
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Source: BHF-UCL
Inferred from direct assayⁱ
- 10666185
negative regulation of megakaryocyte differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 2140694
negative regulation of MHC class II biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 10666185
neutrophil chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
platelet activation
Source: UniProtKB
Inferred from direct assayⁱ
- 11685038
platelet degranulation Source: Reactome
positive regulation of cAMP-mediated signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 12782716
positive regulation of gene expression
Source: BHF-UCL
Inferred from direct assayⁱ
- 10666185
positive regulation of macrophage derived foam cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17244792
positive regulation of macrophage differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10666185
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 12782716
positive regulation of tumor necrosis factor production
Source: BHF-UCL
Inferred from direct assayⁱ
- 10666185
regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 12782716
regulation of megakaryocyte differentiation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine, Heparin-binding
Biological process	Chemotaxis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-140875 Common Pathway of Fibrin Clot Formation R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Reactomeⁱ

R-HSA-114608 Platelet degranulation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Platelet factor 4 Short name: PF-4 Alternative name(s): C-X-C motif chemokine 4 Iroplact Oncostatin-A Cleaved into the following chain: Platelet factor 4, short form Alternative name(s): Endothelial cell growth inhibitor1 Publication
Gene namesⁱ	Name:PF4 Synonyms:CXCL4, SCYB4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163737.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8861 PF4
MIMⁱ	173460 gene
neXtProtⁱ	NX_P02776

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5196
Open Targets More...OpenTargetsⁱ	ENSG00000163737
PharmGKBⁱ	PA33203

Chemistry databases

ChEMBLⁱ	CHEMBL3286075
Drug and drug target database More...DrugBankⁱ	DB00055 Drotrecogin alfa

Polymorphism and mutation databases

BioMutaⁱ	PF4
DMDMⁱ	130304

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 31	5 PublicationsAdd BLAST	31
ChainⁱPRO_0000005068	32 – 101	Platelet factor 4Add BLAST	70
ChainⁱPRO_0000351217	48 – 101	Platelet factor 4, short form1 PublicationAdd BLAST	54

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	41 ↔ 67	1 Publication
Disulfide bondⁱ	43 ↔ 83	1 Publication
Modified residueⁱ	57	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbⁱ	P02776
PeptideAtlas More...PeptideAtlasⁱ	P02776
PRIDEⁱ	P02776
ProteomicsDBⁱ	51593
TopDownProteomicsⁱ	P02776

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P02776

OGPⁱ

P02776

PTM databases

PhosphoSitePlusⁱ	P02776

PhosphoSitePlusⁱ

P02776

Miscellaneous databases

PMAP-CutDBⁱ	P02776

PMAP-CutDBⁱ

P02776

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163737 Expressed in 105 organ(s), highest expression level in mononuclear cell
CleanExⁱ	HS_PF4
Genevisibleⁱ	P02776 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB026008 HPA052485

HPAⁱ

CAB026008
HPA052485

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
APOH	P02749	2	EBI-2565740,EBI-2114682
CCL11	P51671	2	EBI-2565740,EBI-727357
CCL13	Q99616	2	EBI-2565740,EBI-725342
CCL17	Q92583	2	EBI-2565740,EBI-16640146
CCL2	P13500	2	EBI-2565740,EBI-1034732
CCL20	P78556	2	EBI-2565740,EBI-3913209
CCL21	O00585	2	EBI-2565740,EBI-953695
CCL25	O15444	3	EBI-2565740,EBI-7783341
CCL26	Q9Y258	3	EBI-2565740,EBI-7783416
CCL28	Q9NRJ3	3	EBI-2565740,EBI-7783254
CCL5	P13501	6	EBI-2565740,EBI-2848366
CXCL10	P02778	2	EBI-2565740,EBI-7815386
CXCL11	O14625	2	EBI-2565740,EBI-2871971
CXCL12	P48061	4	EBI-2565740,EBI-3913254
CXCL14	O95715	3	EBI-2565740,EBI-2798068
CXCL17	Q6UXB2	2	EBI-2565740,EBI-16804198
CXCL2	P19875	3	EBI-2565740,EBI-2114901
CXCL6	P80162	2	EBI-2565740,EBI-9214033
CXCL8	P10145	2	EBI-2565740,EBI-3917999
CXCL9	Q07325	3	EBI-2565740,EBI-3911467
XCL1	P47992	2	EBI-2565740,EBI-10209901

GO - Molecular functionⁱ

chemokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
CXCR3 chemokine receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12782716

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111219, 9 interactors
Database of interacting proteins More...DIPⁱ	DIP-56941N
IntActⁱ	P02776, 26 interactors
Molecular INTeraction database More...MINTⁱ	P02776
STRINGⁱ	9606.ENSP00000296029

Chemistry databases

BindingDBⁱ

P02776

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	38 – 40	Combined sources	3
Beta strandⁱ	42 – 44	Combined sources	3
Helixⁱ	52 – 54	Combined sources	3
Beta strandⁱ	55 – 61	Combined sources	7
Beta strandⁱ	64 – 66	Combined sources	3
Beta strandⁱ	67 – 69	Combined sources	3
Beta strandⁱ	71 – 76	Combined sources	6
Beta strandⁱ	77 – 79	Combined sources	3
Beta strandⁱ	81 – 83	Combined sources	3
Beta strandⁱ	86 – 88	Combined sources	3
Helixⁱ	90 – 99	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	P02776
SMRⁱ	P02776
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P02776

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	92 – 98	Heparin-binding		7

Sequence similaritiesⁱ

Belongs to the intercrine alpha (chemokine CxC) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J314 Eukaryota ENOG4111556 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144355
HOGENOMⁱ	HOG000220915
HOVERGENⁱ	HBG107789
InParanoidⁱ	P02776
KEGG Orthology (KO) More...KOⁱ	K05407
OMAⁱ	CAVPQLI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14JD
PhylomeDBⁱ	P02776
TreeFamⁱ	TF333433

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00273 Chemokine_CXC, 1 hit
InterProⁱ	View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR036048 Interleukin_8-like_sf IPR027222 PF4
PANTHERⁱ	PTHR10179 PTHR10179, 1 hit PTHR10179:SF38 PTHR10179:SF38, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
PRINTSⁱ	PR00437 SMALLCYTKCXC
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P02776-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSAAGFCAS RPGLLFLGLL LLPLVVAFAS AEAEEDGDLQ CLCVKTTSQV 
        60         70         80         90        100
RPRHITSLEV IKAGPHCPTA QLIATLKNGR KICLDLQAPL YKKIIKKLLE 

S

Length:101

Mass (Da):10,845

Last modified:July 1, 1989 - v2

Checksum:ⁱE96C2EFE9B944D85

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	78	N → D AA sequence (PubMed:267922).Curated		1
Sequence conflictⁱ	78	N → D AA sequence (PubMed:601757).Curated		1

Mass spectrometryⁱ

Molecular mass is 7765 Da from positions 32 - 101. Determined by ESI. 1 Publication

Molecular mass is 6033 Da from positions 48 - 101. Determined by ESI. Short form.1 Publication

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M25897 mRNA Translation: AAA60066.1 AF349466 Genomic DNA Translation: AAK29643.1 CR407677 mRNA Translation: CAG28605.1 AC097709 Genomic DNA Translation: AAY41003.1 BC093965 mRNA Translation: AAH93965.1 BC112093 mRNA Translation: AAI12094.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3562.1
PIRⁱ	A60161 PFHU4
NCBI Reference Sequences More...RefSeqⁱ	NP_002610.1, NM_002619.3
UniGeneⁱ	Hs.81564

Genome annotation databases

Ensemblⁱ	ENST00000296029; ENSP00000296029; ENSG00000163737
GeneIDⁱ	5196
KEGGⁱ	hsa:5196
UCSC genome browser More...UCSCⁱ	uc003hhi.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P02776	C-X-C motif chemokine		GORGO		101	UniRef100_P02776

Protein	Similar proteins		Species	Score	Length	Source
P02776	C-X-C motif chemokine		GORGO		101	UniRef90_P02776
C-X-C motif chemokine		NOMLE		106
C-X-C motif chemokine		CALJA		102
C-X-C motif chemokine		SAIBB		102
C-X-C motif chemokine		Cebus capucinus imitator		102
+21

Protein	Similar proteins		Species	Score	Length	Source
P02776	Platelet factor 4		RAT		105	UniRef50_P02776
Platelet factor 4 variant	)	HUMAN		104
C-X-C motif chemokine		GORGO		101
C-X-C motif chemokine		NOMLE		106
C-X-C motif chemokine		CALJA		102
+73

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CXCL4 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M25897 mRNA Translation: AAA60066.1 AF349466 Genomic DNA Translation: AAK29643.1 CR407677 mRNA Translation: CAG28605.1 AC097709 Genomic DNA Translation: AAY41003.1 BC093965 mRNA Translation: AAH93965.1 BC112093 mRNA Translation: AAI12094.1
CCDSⁱ	CCDS3562.1
PIRⁱ	A60161 PFHU4
RefSeqⁱ	NP_002610.1, NM_002619.3
UniGeneⁱ	Hs.81564

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1DN3	NMR	-	A	87-101	[»]
	1F9Q	X-ray	2.00	A/B/C/D	32-101	[»]
	1F9R	X-ray	2.00	A/B/C/D	32-101	[»]
	1F9S	X-ray	2.38	A/B/C/D	32-101	[»]
	1PFM	NMR	-	A/B/C/D	39-101	[»]
	1PFN	NMR	-	A/B/C/D	39-101	[»]
	1RHP	X-ray	2.40	A/B/C/D	32-101	[»]
	4R9W	X-ray	2.50	A/B	32-101	[»]
	4R9Y	X-ray	4.11	A/B/C/D	32-101	[»]
	4RAU	X-ray	3.74	C/F/I/L/O/R/U/X	32-101	[»]
ProteinModelPortalⁱ	P02776
SMRⁱ	P02776
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111219, 9 interactors
DIPⁱ	DIP-56941N
IntActⁱ	P02776, 26 interactors
MINTⁱ	P02776
STRINGⁱ	9606.ENSP00000296029

Chemistry databases

BindingDBⁱ	P02776
ChEMBLⁱ	CHEMBL3286075
DrugBankⁱ	DB00055 Drotrecogin alfa

PTM databases

PhosphoSitePlusⁱ	P02776

PhosphoSitePlusⁱ

P02776

Polymorphism and mutation databases

BioMutaⁱ	PF4
DMDMⁱ	130304

2D gel databases

OGPⁱ	P02776

OGPⁱ

P02776

Proteomic databases

PaxDbⁱ	P02776
PeptideAtlasⁱ	P02776
PRIDEⁱ	P02776
ProteomicsDBⁱ	51593
TopDownProteomicsⁱ	P02776

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000296029; ENSP00000296029; ENSG00000163737
GeneIDⁱ	5196
KEGGⁱ	hsa:5196
UCSCⁱ	uc003hhi.4 human

Organism-specific databases

CTDⁱ	5196
DisGeNETⁱ	5196
EuPathDBⁱ	HostDB:ENSG00000163737.3
GeneCardsⁱ	PF4
HGNCⁱ	HGNC:8861 PF4
HPAⁱ	CAB026008 HPA052485
MIMⁱ	173460 gene
neXtProtⁱ	NX_P02776
OpenTargetsⁱ	ENSG00000163737
PharmGKBⁱ	PA33203
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J314 Eukaryota ENOG4111556 LUCA
GeneTreeⁱ	ENSGT00910000144355
HOGENOMⁱ	HOG000220915
HOVERGENⁱ	HBG107789
InParanoidⁱ	P02776
KOⁱ	K05407
OMAⁱ	CAVPQLI
OrthoDBⁱ	EOG091G14JD
PhylomeDBⁱ	P02776
TreeFamⁱ	TF333433

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-140875 Common Pathway of Fibrin Clot Formation R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Reactomeⁱ

R-HSA-114608 Platelet degranulation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

EvolutionaryTraceⁱ	P02776
GeneWikiⁱ	Platelet_factor_4
GenomeRNAiⁱ	5196
PMAP-CutDBⁱ	P02776
Protein Ontology More...PROⁱ	PR:P02776
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163737 Expressed in 105 organ(s), highest expression level in mononuclear cell
CleanExⁱ	HS_PF4
Genevisibleⁱ	P02776 HS

Family and domain databases

CDDⁱ	cd00273 Chemokine_CXC, 1 hit
InterProⁱ	View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR036048 Interleukin_8-like_sf IPR027222 PF4
PANTHERⁱ	PTHR10179 PTHR10179, 1 hit PTHR10179:SF38 PTHR10179:SF38, 1 hit
Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
PRINTSⁱ	PR00437 SMALLCYTKCXC
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLF4_HUMAN
Accessionⁱ	P02776Primary (citable) accession number: P02776 Secondary accession number(s): Q53X61, Q9UC64, Q9UC65
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 1, 1989
	Last modified:	November 7, 2018
	This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P02776 (PLF4_HUMAN)

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Platelet factor 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ