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Protein

Platelet basic protein

Gene

PPBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chemokine activity Source: GO_Central
  • glucose transmembrane transporter activity Source: ProtInc
  • growth factor activity Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Cytokine, Growth factor, Mitogen
Biological processChemotaxis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet basic protein
Short name:
PBP
Alternative name(s):
C-X-C motif chemokine 7
Leukocyte-derived growth factor
Short name:
LDGF
Macrophage-derived growth factor
Short name:
MDGF
Small-inducible cytokine B7
Cleaved into the following 10 chains:
Alternative name(s):
LA-PF4
Low-affinity platelet factor IV
Beta-thromboglobulin
Short name:
Beta-TG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPBP
Synonyms:CTAP3, CXCL7, SCYB7, TGB1, THBGB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163736.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9240 PPBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
121010 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02775

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5473

Open Targets

More...
OpenTargetsi
ENSG00000163736

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33561

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03635 Ethanesulfonic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPBP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
129874

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 342 PublicationsAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000508835 – 128Platelet basic proteinAdd BLAST94
ChainiPRO_000000508944 – 128Connective tissue-activating peptide IIIAdd BLAST85
ChainiPRO_000000509044 – 126TC-2Add BLAST83
ChainiPRO_000004194944 – 124Connective tissue-activating peptide III(1-81)Add BLAST81
ChainiPRO_000000509148 – 128Beta-thromboglobulinAdd BLAST81
ChainiPRO_000000509255 – 128Neutrophil-activating peptide 2(74)Add BLAST74
ChainiPRO_000000509356 – 128Neutrophil-activating peptide 2(73)Add BLAST73
ChainiPRO_000000509459 – 128Neutrophil-activating peptide 2Add BLAST70
ChainiPRO_000000509559 – 126TC-1Add BLAST68
ChainiPRO_000000509659 – 124Neutrophil-activating peptide 2(1-66)Add BLAST66
ChainiPRO_000004195059 – 121Neutrophil-activating peptide 2(1-63)Add BLAST63

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi63 ↔ 89
Disulfide bondi65 ↔ 105

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)).
Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor.
NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils.1 Publication
NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02775

PeptideAtlas

More...
PeptideAtlasi
P02775

PRoteomics IDEntifications database

More...
PRIDEi
P02775

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51592

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P02775

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P02775

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02775

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02775

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P02775

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163736 Expressed in 125 organ(s), highest expression level in mononuclear cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_PPBP

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02775 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017624
HPA008354

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Beta-thromboglobulin is a homotetramer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111469, 15 interactors

Database of interacting proteins

More...
DIPi
DIP-5913N

Protein interaction database and analysis system

More...
IntActi
P02775, 32 interactors

Molecular INTeraction database

More...
MINTi
P02775

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296028

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P02775

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02775

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02775

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JG75 Eukaryota
ENOG4111BTH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162559

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220915

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107789

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02775

KEGG Orthology (KO)

More...
KOi
K10029

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMKTTSG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G10E9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02775

TreeFam database of animal gene trees

More...
TreeFami
TF333433

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00273 Chemokine_CXC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10179 PTHR10179, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00048 IL8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00437 SMALLCYTKCXC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00199 SCY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54117 SSF54117, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02775-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLRLDTTPS CNSARPLHAL QVLLLLSLLL TALASSTKGQ TKRNLAKGKE
60 70 80 90 100
ESLDSDLYAE LRCMCIKTTS GIHPKNIQSL EVIGKGTHCN QVEVIATLKD
110 120
GRKICLDPDA PRIKKIVQKK LAGDESAD
Length:128
Mass (Da):13,894
Last modified:November 1, 1991 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEAB7B75916723D9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M54995 mRNA Translation: AAA62836.1
AF349466 Genomic DNA Translation: AAK29642.1
CR456805 mRNA Translation: CAG33086.1
AC097709 Genomic DNA Translation: AAY41004.1
AK312166 mRNA Translation: BAG35100.1
CH471057 Genomic DNA Translation: EAX05695.1
BC028217 mRNA Translation: AAH28217.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3563.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A39546 TGHU

NCBI Reference Sequences

More...
RefSeqi
NP_002695.1, NM_002704.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2164

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296028; ENSP00000296028; ENSG00000163736

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5473

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5473

UCSC genome browser

More...
UCSCi
uc003hhj.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CXCL7 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54995 mRNA Translation: AAA62836.1
AF349466 Genomic DNA Translation: AAK29642.1
CR456805 mRNA Translation: CAG33086.1
AC097709 Genomic DNA Translation: AAY41004.1
AK312166 mRNA Translation: BAG35100.1
CH471057 Genomic DNA Translation: EAX05695.1
BC028217 mRNA Translation: AAH28217.1
CCDSiCCDS3563.1
PIRiA39546 TGHU
RefSeqiNP_002695.1, NM_002704.3
UniGeneiHs.2164

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F9PX-ray1.93A44-128[»]
1NAPX-ray1.90A/B/C/D59-128[»]
1TVXX-ray1.75A/B/C/D54-128[»]
ProteinModelPortaliP02775
SMRiP02775
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111469, 15 interactors
DIPiDIP-5913N
IntActiP02775, 32 interactors
MINTiP02775
STRINGi9606.ENSP00000296028

Chemistry databases

DrugBankiDB03635 Ethanesulfonic Acid

PTM databases

iPTMnetiP02775
PhosphoSitePlusiP02775

Polymorphism and mutation databases

BioMutaiPPBP
DMDMi129874

2D gel databases

SWISS-2DPAGEiP02775

Proteomic databases

PaxDbiP02775
PeptideAtlasiP02775
PRIDEiP02775
ProteomicsDBi51592
TopDownProteomicsiP02775

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5473
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296028; ENSP00000296028; ENSG00000163736
GeneIDi5473
KEGGihsa:5473
UCSCiuc003hhj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5473
DisGeNETi5473
EuPathDBiHostDB:ENSG00000163736.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPBP

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0031528
HGNCiHGNC:9240 PPBP
HPAiCAB017624
HPA008354
MIMi121010 gene
neXtProtiNX_P02775
OpenTargetsiENSG00000163736
PharmGKBiPA33561

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JG75 Eukaryota
ENOG4111BTH LUCA
GeneTreeiENSGT00940000162559
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP02775
KOiK10029
OMAiCMKTTSG
OrthoDBiEOG091G10E9
PhylomeDBiP02775
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceiP02775

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CXCL7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5473
PMAP-CutDBiP02775

Protein Ontology

More...
PROi
PR:P02775

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163736 Expressed in 125 organ(s), highest expression level in mononuclear cell
CleanExiHS_PPBP
GenevisibleiP02775 HS

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCXCL7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02775
Secondary accession number(s): B2R5F3, Q6IBJ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1991
Last modified: December 5, 2018
This is version 195 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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