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Protein

Vitamin D-binding protein

Gene

GC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • calcidiol binding Source: UniProtKB
  • vitamin D binding Source: ProtInc
  • vitamin transmembrane transporter activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processTransport
LigandVitamin D

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196791 Vitamin D (calciferol) metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vitamin D-binding protein
Short name:
DBP
Short name:
VDB
Alternative name(s):
Gc protein-derived macrophage activating factor1 Publication
Short name:
Gc-MAF
Short name:
GcMAF1 Publication
Gc-globulin
Group-specific component
Short name:
Gc1 Publication
Vitamin D-binding protein-macrophage activating factor
Short name:
DBP-maf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145321.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4187 GC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
139200 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02774

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2638

Open Targets

More...
OpenTargetsi
ENSG00000145321

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28601

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2259

Drug and drug target database

More...
DrugBanki
DB01436 Alfacalcidol
DB00169 Cholecalciferol
DB04224 Oleic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
139641

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 162 PublicationsAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000110217 – 474Vitamin D-binding proteinAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 75
Disulfide bondi74 ↔ 83PROSITE-ProRule annotation
Disulfide bondi96 ↔ 112
Disulfide bondi111 ↔ 122
Disulfide bondi145 ↔ 190
Disulfide bondi189 ↔ 198
Disulfide bondi220 ↔ 266
Disulfide bondi265 ↔ 273
Disulfide bondi286 ↔ 300
Disulfide bondi299 ↔ 311
Disulfide bondi335 ↔ 376
Disulfide bondi375 ↔ 384
Disulfide bondi407 ↔ 453
Disulfide bondi452 ↔ 462

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Allele GC*1S is O-glycosylated at Thr-436 (PubMed:20079467). The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated (PubMed:17360250). The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.1 Publication2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02774

PeptideAtlas

More...
PeptideAtlasi
P02774

PRoteomics IDEntifications database

More...
PRIDEi
P02774

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51590
51591 [P02774-2]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P02774

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00555812
P02774

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P02774

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P02774

GlyConnect protein glycosylation platform

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GlyConnecti
619

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02774

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02774

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P02774

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.1 Publication2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145321 Expressed in 91 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_GC

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P02774 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02774 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008596
HPA001526
HPA019855

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Interacts with LRP2; the interaction is required for renal uptake of GC in complex with 25-hydroxyvitamin D3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108908, 22 interactors

Database of interacting proteins

More...
DIPi
DIP-17038N

Protein interaction database and analysis system

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IntActi
P02774, 8 interactors

Molecular INTeraction database

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MINTi
P02774

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000421725

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P02774

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1474
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P02774

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02774

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02774

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 208Albumin 1PROSITE-ProRule annotationAdd BLAST192
Domaini209 – 394Albumin 2PROSITE-ProRule annotationAdd BLAST186
Domaini395 – 474Albumin 3PROSITE-ProRule annotationAdd BLAST80

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II89 Eukaryota
ENOG4111PH6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000113

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000140946

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG009729

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02774

KEGG Orthology (KO)

More...
KOi
K12258

Database of Orthologous Groups

More...
OrthoDBi
EOG091G059U

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02774

TreeFam database of animal gene trees

More...
TreeFami
TF335561

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00015 ALBUMIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
IPR000213 VitD-bd
IPR015247 VitD-bind_III

The PANTHER Classification System

More...
PANTHERi
PTHR11385 PTHR11385, 1 hit
PTHR11385:SF11 PTHR11385:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00273 Serum_albumin, 2 hits
PF09164 VitD-bind_III, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00802 SERUMALBUMIN
PR00804 VITAMNDBNDNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00103 ALBUMIN, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48552 SSF48552, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00212 ALBUMIN_1, 1 hit
PS51438 ALBUMIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P02774-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR
60 70 80 90 100
KFPSGTFEQV SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS
110 120 130 140 150
PFPVHPGTAE CCTKEGLERK LCMAALKHQP QEFPTYVEPT NDEICEAFRK
160 170 180 190 200
DPKEYANQFM WEYSTNYGQA PLSLLVSYTK SYLSMVGSCC TSASPTVCFL
210 220 230 240 250
KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA QKVPTADLED
260 270 280 290 300
VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC
310 320 330 340 350
QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL
360 370 380 390 400
SRRTHLPEVF LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI
410 420 430 440 450
DKGQELCADY SENTFTEYKK KLAERLKAKL PDATPTELAK LVNKHSDFAS
460 470
NCCSINSPPL YCDSEIDAEL KNIL
Length:474
Mass (Da):52,918
Last modified:September 12, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i484BF163B54A43E6
GO
Isoform 2 (identifier: P02774-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:352
Mass (Da):39,496
Checksum:i31840DD8F9920143
GO
Isoform 3 (identifier: P02774-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLWSWSEERGGAARLSGRKM

Note: No experimental confirmation available.
Show »
Length:493
Mass (Da):55,077
Checksum:iE6E08F41F3ACD511
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF35D6RF35_HUMAN
Vitamin D-binding protein
GC
476Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBJ7D6RBJ7_HUMAN
Vitamin D-binding protein
GC
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF20D6RF20_HUMAN
Vitamin D-binding protein
GC
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG60654 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti168G → E in AAA52173 (PubMed:2416779).Curated1
Sequence conflicti183L → P in AK309595 (PubMed:14702039).Curated1
Sequence conflicti327E → R in AAA52173 (PubMed:2416779).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Over 80 variants of human DBP have been identified. The three most common alleles are called GC*1F, GC*1S, and GC*2. The sequence shown is that of the GC*1A1 allele.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_000548432D → E in allele GC*1S. 8 PublicationsCorresponds to variant dbSNP:rs7041EnsemblClinVar.1
Natural variantiVAR_000549436T → K in allele GC*2, allele GC*2A9. 4 PublicationsCorresponds to variant dbSNP:rs4588EnsemblClinVar.1
Natural variantiVAR_014120445H → C in allele GC*2A9; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_014121445H → R in allele GC*1F, allele GC*2 and allele GC*1S. 11 PublicationsCorresponds to variant dbSNP:rs9016Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0384271 – 122Missing in isoform 2. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_0445231M → MLWSWSEERGGAARLSGRKM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M12654 mRNA Translation: AAA52173.1
X03178 mRNA Translation: CAA26938.1
S67480
, S67474, S67476, S67478, S67479, S67526 Genomic DNA Translation: AAB29423.1
L10641 Genomic DNA Translation: AAA61704.1
AK290827 mRNA Translation: BAF83516.1
AK298433 mRNA Translation: BAG60654.1 Sequence problems.
AK309595 mRNA No translation available.
AK315853 mRNA Translation: BAF98744.1
AK223458 mRNA Translation: BAD97178.1
AC024722 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05645.1
BC057228 mRNA Translation: AAH57228.1
M17156 Genomic DNA Translation: AAA19662.2
S77129 Genomic DNA Translation: AAD14249.1 Sequence problems.
S77130 Genomic DNA Translation: AAD14250.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3550.1 [P02774-1]
CCDS56332.1 [P02774-3]

Protein sequence database of the Protein Information Resource

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PIRi
A94076 VYHUD

NCBI Reference Sequences

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RefSeqi
NP_000574.2, NM_000583.3 [P02774-1]
NP_001191235.1, NM_001204306.1 [P02774-1]
NP_001191236.1, NM_001204307.1 [P02774-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.418497

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000273951; ENSP00000273951; ENSG00000145321 [P02774-1]
ENST00000504199; ENSP00000421725; ENSG00000145321 [P02774-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2638

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2638

UCSC genome browser

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UCSCi
uc003hge.4 human [P02774-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12654 mRNA Translation: AAA52173.1
X03178 mRNA Translation: CAA26938.1
S67480
, S67474, S67476, S67478, S67479, S67526 Genomic DNA Translation: AAB29423.1
L10641 Genomic DNA Translation: AAA61704.1
AK290827 mRNA Translation: BAF83516.1
AK298433 mRNA Translation: BAG60654.1 Sequence problems.
AK309595 mRNA No translation available.
AK315853 mRNA Translation: BAF98744.1
AK223458 mRNA Translation: BAD97178.1
AC024722 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05645.1
BC057228 mRNA Translation: AAH57228.1
M17156 Genomic DNA Translation: AAA19662.2
S77129 Genomic DNA Translation: AAD14249.1 Sequence problems.
S77130 Genomic DNA Translation: AAD14250.1 Sequence problems.
CCDSiCCDS3550.1 [P02774-1]
CCDS56332.1 [P02774-3]
PIRiA94076 VYHUD
RefSeqiNP_000574.2, NM_000583.3 [P02774-1]
NP_001191235.1, NM_001204306.1 [P02774-1]
NP_001191236.1, NM_001204307.1 [P02774-3]
UniGeneiHs.418497

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J78X-ray2.31A/B17-474[»]
1J7EX-ray2.55A/B17-474[»]
1KW2X-ray2.15A/B17-474[»]
1KXPX-ray2.10D17-474[»]
1LOTX-ray2.50A17-474[»]
1MA9X-ray2.40A17-474[»]
ProteinModelPortaliP02774
SMRiP02774
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108908, 22 interactors
DIPiDIP-17038N
IntActiP02774, 8 interactors
MINTiP02774
STRINGi9606.ENSP00000421725

Chemistry databases

BindingDBiP02774
ChEMBLiCHEMBL2259
DrugBankiDB01436 Alfacalcidol
DB00169 Cholecalciferol
DB04224 Oleic Acid

PTM databases

CarbonylDBiP02774
GlyConnecti619
iPTMnetiP02774
PhosphoSitePlusiP02774
UniCarbKBiP02774

Polymorphism and mutation databases

BioMutaiGC
DMDMi139641

2D gel databases

DOSAC-COBS-2DPAGEiP02774
REPRODUCTION-2DPAGEiIPI00555812
P02774
SWISS-2DPAGEiP02774

Proteomic databases

PaxDbiP02774
PeptideAtlasiP02774
PRIDEiP02774
ProteomicsDBi51590
51591 [P02774-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273951; ENSP00000273951; ENSG00000145321 [P02774-1]
ENST00000504199; ENSP00000421725; ENSG00000145321 [P02774-3]
GeneIDi2638
KEGGihsa:2638
UCSCiuc003hge.4 human [P02774-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2638
DisGeNETi2638
EuPathDBiHostDB:ENSG00000145321.12

GeneCards: human genes, protein and diseases

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GeneCardsi
GC
HGNCiHGNC:4187 GC
HPAiCAB008596
HPA001526
HPA019855
MIMi139200 gene
neXtProtiNX_P02774
OpenTargetsiENSG00000145321
PharmGKBiPA28601

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II89 Eukaryota
ENOG4111PH6 LUCA
GeneTreeiENSGT00390000000113
HOGENOMiHOG000140946
HOVERGENiHBG009729
InParanoidiP02774
KOiK12258
OrthoDBiEOG091G059U
PhylomeDBiP02774
TreeFamiTF335561

Enzyme and pathway databases

ReactomeiR-HSA-196791 Vitamin D (calciferol) metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GC human
EvolutionaryTraceiP02774

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Vitamin_D-binding_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2638

Protein Ontology

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PROi
PR:P02774

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145321 Expressed in 91 organ(s), highest expression level in liver
CleanExiHS_GC
ExpressionAtlasiP02774 baseline and differential
GenevisibleiP02774 HS

Family and domain databases

CDDicd00015 ALBUMIN, 1 hit
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
IPR000213 VitD-bd
IPR015247 VitD-bind_III
PANTHERiPTHR11385 PTHR11385, 1 hit
PTHR11385:SF11 PTHR11385:SF11, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 2 hits
PF09164 VitD-bind_III, 1 hit
PRINTSiPR00802 SERUMALBUMIN
PR00804 VITAMNDBNDNG
SMARTiView protein in SMART
SM00103 ALBUMIN, 2 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 1 hit
PS51438 ALBUMIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVTDB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02774
Secondary accession number(s): B4DPP2
, D6RAK8, Q16309, Q16310, Q53F31, Q6GTG1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 12, 2018
Last modified: December 5, 2018
This is version 208 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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