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Protein

Alpha-fetoprotein

Gene

Afp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds estrogens, fatty acids and metals.

GO - Molecular functioni

GO - Biological processi

  • ovulation from ovarian follicle Source: MGI
  • progesterone metabolic process Source: MGI
  • sexual reproduction Source: MGI
  • SMAD protein signal transduction Source: MGI

Keywordsi

LigandCopper, Metal-binding, Nickel

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-fetoprotein
Alternative name(s):
Alpha-1-fetoprotein
Alpha-fetoglobulin
Gene namesi
Name:Afp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:87951 Afp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000109819 – 605Alpha-fetoproteinAdd BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi95 ↔ 110PROSITE-ProRule annotation
Modified residuei107PhosphoserineBy similarity1
Disulfide bondi109 ↔ 120PROSITE-ProRule annotation
Modified residuei111PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Disulfide bondi144 ↔ 189PROSITE-ProRule annotation
Disulfide bondi188 ↔ 197PROSITE-ProRule annotation
Disulfide bondi220 ↔ 266PROSITE-ProRule annotation
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi265 ↔ 273PROSITE-ProRule annotation
Disulfide bondi285 ↔ 299PROSITE-ProRule annotation
Disulfide bondi298 ↔ 309PROSITE-ProRule annotation
Modified residuei340PhosphoserineBy similarity1
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi412 ↔ 458PROSITE-ProRule annotation
Modified residuei440PhosphoserineBy similarity1
Disulfide bondi457 ↔ 468PROSITE-ProRule annotation
Disulfide bondi481 ↔ 497PROSITE-ProRule annotation
Disulfide bondi496 ↔ 507PROSITE-ProRule annotation
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi534 ↔ 579PROSITE-ProRule annotation
Disulfide bondi578 ↔ 587PROSITE-ProRule annotation

Post-translational modificationi

Glycosylated; contains two glycans.
Sulfated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

MaxQBiP02772
PaxDbiP02772
PeptideAtlasiP02772
PRIDEiP02772

2D gel databases

REPRODUCTION-2DPAGEiIPI00113163

PTM databases

iPTMnetiP02772
PhosphoSitePlusiP02772

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSMUSG00000054932 Expressed in 150 organ(s), highest expression level in embryo
CleanExiMM_AFP
ExpressionAtlasiP02772 baseline and differential
GenevisibleiP02772 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041006

Structurei

3D structure databases

ProteinModelPortaliP02772
SMRiP02772
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 207Albumin 1PROSITE-ProRule annotationAdd BLAST189
Domaini208 – 398Albumin 2PROSITE-ProRule annotationAdd BLAST191
Domaini399 – 597Albumin 3PROSITE-ProRule annotationAdd BLAST199

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
GeneTreeiENSGT00390000000113
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP02772
KOiK16144
OMAiAECCKLP
OrthoDBiEOG091G0F5F
PhylomeDBiP02772
TreeFamiTF335561

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00803 AFETOPROTEIN
PR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 2 hits
PS51438 ALBUMIN_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02772-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKWITPASLI LLLHFAASKA LHENEFGIAS TLDSSQCVTE KNVLSIATIT
60 70 80 90 100
FTQFVPEATE EEVNKMTSDV LAAMKKNSGD GCLESQLSVF LDEICHETEL
110 120 130 140 150
SNKYGLSGCC SQSGVERHQC LLARKKTAPA SVPPFQFPEP AESCKAHEEN
160 170 180 190 200
RAVFMNRFIY EVSRRNPFMY APAILSLAAQ YDKVVLACCK ADNKEECFQT
210 220 230 240 250
KRASIAKELR EGSMLNEHVC SVIRKFGSRN LQATTIIKLS QKLTEANFTE
260 270 280 290 300
IQKLALDVAH IHEECCQGNS LECLQDGEKV MTYICSQQNI LSSKIAECCK
310 320 330 340 350
LPMIQLGFCI IHAENGVKPE GLSLNPSQFL GDRNFAQFSS EEKIMFMASF
360 370 380 390 400
LHEYSRTHPN LPVSVILRIA KTYQEILEKC SQSGNLPGCQ DNLEEELQKH
410 420 430 440 450
IEESQALSKQ SCALYQTLGD YKLQNLFLIG YTRKAPQLTS AELIDLTGKM
460 470 480 490 500
VSIASTCCQL SEEKWSGCGE GMADIFIGHL CIRNEASPVN SGISHCCNSS
510 520 530 540 550
YSNRRLCITS FLRDETYAPP PFSEDKFIFH KDLCQAQGKA LQTMKQELLI
560 570 580 590 600
NLVKQKPELT EEQLAAVTAD FSGLLEKCCK AQDQEVCFTE EGPKLISKTR

DALGV
Length:605
Mass (Da):67,337
Last modified:July 21, 1986 - v1
Checksum:iCE09E9F50D74619A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YU60A0A0J9YU60_MOUSE
Alpha-fetoprotein
Afp
121Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti533 – 536LCQA → RAKL no nucleotide entry (PubMed:6161929).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00743 mRNA Translation: CAA24118.1
M16394
, M16381, M16382, M16383, M16384, M16385, M16386, M16387, M16388, M16389, M16390, M16391, M16392, M16393 Genomic DNA Translation: AAA37189.1
AK010934 mRNA Translation: BAB27278.1
AK145975 mRNA Translation: BAE26798.1
AK146513 mRNA Translation: BAE27225.1
AK146524 mRNA Translation: BAE27233.1
AK167549 mRNA Translation: BAE39615.1
AK168574 mRNA Translation: BAE40444.1
AK168576 mRNA Translation: BAE40446.1
AK168751 mRNA Translation: BAE40591.1
AK168883 mRNA Translation: BAE40701.1
AK169046 mRNA Translation: BAE40834.1
AK169054 mRNA Translation: BAE40842.1
AK169147 mRNA Translation: BAE40926.1
BC066206 mRNA Translation: AAH66206.1
CCDSiCCDS19413.1
PIRiA93254 FPMS
RefSeqiNP_031449.3, NM_007423.4
UniGeneiMm.358570

Genome annotation databases

EnsembliENSMUST00000042755; ENSMUSP00000041006; ENSMUSG00000054932
GeneIDi11576
KEGGimmu:11576
UCSCiuc008yba.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00743 mRNA Translation: CAA24118.1
M16394
, M16381, M16382, M16383, M16384, M16385, M16386, M16387, M16388, M16389, M16390, M16391, M16392, M16393 Genomic DNA Translation: AAA37189.1
AK010934 mRNA Translation: BAB27278.1
AK145975 mRNA Translation: BAE26798.1
AK146513 mRNA Translation: BAE27225.1
AK146524 mRNA Translation: BAE27233.1
AK167549 mRNA Translation: BAE39615.1
AK168574 mRNA Translation: BAE40444.1
AK168576 mRNA Translation: BAE40446.1
AK168751 mRNA Translation: BAE40591.1
AK168883 mRNA Translation: BAE40701.1
AK169046 mRNA Translation: BAE40834.1
AK169054 mRNA Translation: BAE40842.1
AK169147 mRNA Translation: BAE40926.1
BC066206 mRNA Translation: AAH66206.1
CCDSiCCDS19413.1
PIRiA93254 FPMS
RefSeqiNP_031449.3, NM_007423.4
UniGeneiMm.358570

3D structure databases

ProteinModelPortaliP02772
SMRiP02772
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041006

PTM databases

iPTMnetiP02772
PhosphoSitePlusiP02772

2D gel databases

REPRODUCTION-2DPAGEiIPI00113163

Proteomic databases

MaxQBiP02772
PaxDbiP02772
PeptideAtlasiP02772
PRIDEiP02772

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042755; ENSMUSP00000041006; ENSMUSG00000054932
GeneIDi11576
KEGGimmu:11576
UCSCiuc008yba.2 mouse

Organism-specific databases

CTDi174
MGIiMGI:87951 Afp

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
GeneTreeiENSGT00390000000113
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP02772
KOiK16144
OMAiAECCKLP
OrthoDBiEOG091G0F5F
PhylomeDBiP02772
TreeFamiTF335561

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiAfp mouse
PROiPR:P02772
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054932 Expressed in 150 organ(s), highest expression level in embryo
CleanExiMM_AFP
ExpressionAtlasiP02772 baseline and differential
GenevisibleiP02772 MM

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00803 AFETOPROTEIN
PR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 2 hits
PS51438 ALBUMIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFETA_MOUSE
AccessioniPrimary (citable) accession number: P02772
Secondary accession number(s): Q3UJD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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