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UniProtKB - P02771 (FETA_HUMAN)

Entry version 207 (02 Jun 2021)
Sequence version 1 (21 Jul 1986)
Previous versions | rss
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Protein

Alpha-fetoprotein

Gene

AFP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi22Cu(2+)1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCopper, Metal-binding, Nickel

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P02771

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P02771

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-fetoprotein
Alternative name(s):
Alpha-1-fetoprotein
Alpha-fetoglobulin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFP
Synonyms:HPAFP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:317, AFP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		104150, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P02771

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000081051.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Alpha-fetoprotein deficiency (AFPD)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development.
Related information in OMIM
Alpha-fetoprotein, hereditary persistence (HPAFP)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		174

MalaCards human disease database

More...MalaCardsi		AFP
MIMi615969, phenotype
615970, phenotype

Open Targets

More...OpenTargetsi		ENSG00000081051

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		168612, Congenital deficiency in alpha-fetoprotein
168615, Hereditary persistence of alpha-fetoprotein

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24614

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P02771, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3712864

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AFP

Domain mapping of disease mutations (DMDM)

More...DMDMi		120042

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 181 PublicationAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000109719 – 609Alpha-fetoproteinAdd BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi99 ↔ 114
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei111Phosphoserine; by FAM20C1 Publication1
Disulfide bondi113 ↔ 124
Modified residuei115Phosphoserine; by FAM20C1 Publication1
Modified residuei117Phosphoserine; by FAM20C1 Publication1
Disulfide bondi148 ↔ 193
Disulfide bondi192 ↔ 201
Disulfide bondi224 ↔ 270
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_000070251N-linked (GlcNAc...) asparagine1
Disulfide bondi269 ↔ 277
Disulfide bondi289 ↔ 303
Disulfide bondi302 ↔ 313
Modified residuei344Phosphoserine; by FAM20C1 Publication1
Disulfide bondi384 ↔ 393
Disulfide bondi416 ↔ 462
Modified residuei444Phosphoserine; by FAM20C1 Publication1
Modified residuei445Phosphoserine; by FAM20C1 Publication1
Disulfide bondi461 ↔ 472
Disulfide bondi485 ↔ 501
Disulfide bondi500 ↔ 511
Disulfide bondi538 ↔ 583
Disulfide bondi582 ↔ 591

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.
Sulfated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P02771

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P02771

MaxQB - The MaxQuant DataBase

More...MaxQBi		P02771

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02771

PeptideAtlas

More...PeptideAtlasi		P02771

PRoteomics IDEntifications database

More...PRIDEi		P02771

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51589

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P02771

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		41, 31 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P02771, 1 site, 26 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P02771

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P02771

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma. Synthesized by the fetal liver and yolk sac.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000081051, Expressed in embryo and 98 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P02771, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P02771, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000081051, Group enriched (heart muscle, liver, lung)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimeric and trimeric forms have been found in addition to the monomeric form.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106682, 16 interactors

Protein interaction database and analysis system

More...IntActi		P02771, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379138

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P02771, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P02771

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 210Albumin 1PROSITE-ProRule annotationAdd BLAST192
Domaini211 – 402Albumin 2PROSITE-ProRule annotationAdd BLAST192
Domaini403 – 601Albumin 3PROSITE-ProRule annotationAdd BLAST199

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R7EA, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000113

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030161_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02771

Database of Orthologous Groups

More...OrthoDBi		906547at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P02771

TreeFam database of animal gene trees

More...TreeFami		TF335561

Family and domain databases

Conserved Domains Database

More...CDDi		cd00015, ALBUMIN, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000264, ALB/AFP/VDB
IPR020858, Serum_albumin-like
IPR021177, Serum_albumin/AFP/Afamin
IPR020857, Serum_albumin_CS
IPR014760, Serum_albumin_N

The PANTHER Classification System

More...PANTHERi		PTHR11385, PTHR11385, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00273, Serum_albumin, 3 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002520, Serum_albumin_subgroup, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00803, AFETOPROTEIN
PR00802, SERUMALBUMIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00103, ALBUMIN, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48552, SSF48552, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00212, ALBUMIN_1, 2 hits
PS51438, ALBUMIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02771-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKWVESIFLI FLLNFTESRT LHRNEYGIAS ILDSYQCTAE ISLADLATIF 
        60         70         80         90        100
FAQFVQEATY KEVSKMVKDA LTAIEKPTGD EQSSGCLENQ LPAFLEELCH 
       110        120        130        140        150
EKEILEKYGH SDCCSQSEEG RHNCFLAHKK PTPASIPLFQ VPEPVTSCEA 
       160        170        180        190        200
YEEDRETFMN KFIYEIARRH PFLYAPTILL WAARYDKIIP SCCKAENAVE 
       210        220        230        240        250
CFQTKAATVT KELRESSLLN QHACAVMKNF GTRTFQAITV TKLSQKFTKV 
       260        270        280        290        300
NFTEIQKLVL DVAHVHEHCC RGDVLDCLQD GEKIMSYICS QQDTLSNKIT 
       310        320        330        340        350
ECCKLTTLER GQCIIHAEND EKPEGLSPNL NRFLGDRDFN QFSSGEKNIF 
       360        370        380        390        400
LASFVHEYSR RHPQLAVSVI LRVAKGYQEL LEKCFQTENP LECQDKGEEE 
       410        420        430        440        450
LQKYIQESQA LAKRSCGLFQ KLGEYYLQNA FLVAYTKKAP QLTSSELMAI 
       460        470        480        490        500
TRKMAATAAT CCQLSEDKLL ACGEGAADII IGHLCIRHEM TPVNPGVGQC 
       510        520        530        540        550
CTSSYANRRP CFSSLVVDET YVPPAFSDDK FIFHKDLCQA QGVALQTMKQ 
       560        570        580        590        600
EFLINLVKQK PQITEEQLEA VIADFSGLLE KCCQGQEQEV CFAEEGQKLI 

SKTRAALGV
Length:609
Mass (Da):68,678
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D4E45820E1C2D4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KMX3J3KMX3_HUMAN
Alpha-fetoprotein
AFP
622Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033928187K → Q. Corresponds to variant dbSNP:rs35765619Ensembl.1
Natural variantiVAR_012049570A → G1 PublicationCorresponds to variant dbSNP:rs7790Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
V01514 mRNA Translation: CAA24758.1
M16110 Genomic DNA Translation: AAB58754.1
AK314817 mRNA Translation: BAG37340.1
BC027881 mRNA Translation: AAH27881.1
M10949 Genomic DNA Translation: AAA51674.1
M10950 Genomic DNA Translation: AAA51675.1
Z19532 Genomic DNA Translation: CAA79592.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3556.1

Protein sequence database of the Protein Information Resource

More...PIRi		A26624, FPHU

NCBI Reference Sequences

More...RefSeqi		NP_001125.1, NM_001134.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000395792; ENSP00000379138; ENSG00000081051

Database of genes from NCBI RefSeq genomes

More...GeneIDi		174

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:174

UCSC genome browser

More...UCSCi		uc003hgz.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Alpha-fetoprotein entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01514 mRNA Translation: CAA24758.1
M16110 Genomic DNA Translation: AAB58754.1
AK314817 mRNA Translation: BAG37340.1
BC027881 mRNA Translation: AAH27881.1
M10949 Genomic DNA Translation: AAA51674.1
M10950 Genomic DNA Translation: AAA51675.1
Z19532 Genomic DNA Translation: CAA79592.1
CCDSiCCDS3556.1
PIRiA26624, FPHU
RefSeqiNP_001125.1, NM_001134.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MRKX-ray1.40P137-145[»]
SMRiP02771
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106682, 16 interactors
IntActiP02771, 10 interactors
STRINGi9606.ENSP00000379138

Chemistry databases

ChEMBLiCHEMBL3712864

PTM databases

GlyConnecti41, 31 N-Linked glycans (2 sites)
GlyGeniP02771, 1 site, 26 N-linked glycans (1 site)
iPTMnetiP02771
PhosphoSitePlusiP02771

Genetic variation databases

BioMutaiAFP
DMDMi120042

Proteomic databases

jPOSTiP02771
MassIVEiP02771
MaxQBiP02771
PaxDbiP02771
PeptideAtlasiP02771
PRIDEiP02771
ProteomicsDBi51589
TopDownProteomicsiP02771

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P02771, 16 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1359, 3457 antibodies

The DNASU plasmid repository

More...DNASUi		174

Genome annotation databases

EnsembliENST00000395792; ENSP00000379138; ENSG00000081051
GeneIDi174
KEGGihsa:174
UCSCiuc003hgz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		174
DisGeNETi174

GeneCards: human genes, protein and diseases

More...GeneCardsi		AFP
HGNCiHGNC:317, AFP
HPAiENSG00000081051, Group enriched (heart muscle, liver, lung)
MalaCardsiAFP
MIMi104150, gene
615969, phenotype
615970, phenotype
neXtProtiNX_P02771
OpenTargetsiENSG00000081051
Orphaneti168612, Congenital deficiency in alpha-fetoprotein
168615, Hereditary persistence of alpha-fetoprotein
PharmGKBiPA24614
VEuPathDBiHostDB:ENSG00000081051.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502R7EA, Eukaryota
GeneTreeiENSGT00390000000113
HOGENOMiCLU_030161_1_0_1
InParanoidiP02771
OrthoDBi906547at2759
PhylomeDBiP02771
TreeFamiTF335561

Enzyme and pathway databases

PathwayCommonsiP02771
ReactomeiR-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation
SIGNORiP02771

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		174, 6 hits in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AFP, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Alpha-fetoprotein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		174
PharosiP02771, Tbio

Protein Ontology

More...PROi		PR:P02771
RNActiP02771, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000081051, Expressed in embryo and 98 other tissues
ExpressionAtlasiP02771, baseline and differential
GenevisibleiP02771, HS

Family and domain databases

CDDicd00015, ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264, ALB/AFP/VDB
IPR020858, Serum_albumin-like
IPR021177, Serum_albumin/AFP/Afamin
IPR020857, Serum_albumin_CS
IPR014760, Serum_albumin_N
PANTHERiPTHR11385, PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273, Serum_albumin, 3 hits
PIRSFiPIRSF002520, Serum_albumin_subgroup, 1 hit
PRINTSiPR00803, AFETOPROTEIN
PR00802, SERUMALBUMIN
SMARTiView protein in SMART
SM00103, ALBUMIN, 3 hits
SUPFAMiSSF48552, SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212, ALBUMIN_1, 2 hits
PS51438, ALBUMIN_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFETA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02771
Secondary accession number(s): B2RBU3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 2, 2021
This is version 207 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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