UniProtKB - P02771 (FETA_HUMAN)

BLAST

>sp|P02771|FETA_HUMAN Alpha-fetoprotein OS=Homo sapiens OX=9606 GN=AFP PE=1 SV=1
MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATY
KEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEG
RHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTILL
WAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRTFQAITV
TKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCLQDGEKIMSYICSQQDTLSNKIT
ECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASFVHEYSR
RHPQLAVSVILRVAKGYQELLEKCFQTENPLECQDKGEEELQKYIQESQALAKRSCGLFQ
KLGEYYLQNAFLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDKLLACGEGAADII
IGHLCIRHEMTPVNPGVGQCCTSSYANRRPCFSSLVVDETYVPPAFSDDKFIFHKDLCQA
QGVALQTMKQEFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQEQEVCFAEEGQKLI
SKTRAALGV

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History
Entry version 190 (12 Sep 2018)
Sequence version 1 (21 Jul 1986)
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Protein

Alpha-fetoprotein

Gene

AFP

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	22	Copper or nickel1 Publication		1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
ovulation from ovarian follicle Source: Ensembl
post-translational protein modification Source: Reactome
progesterone metabolic process Source: Ensembl
SMAD protein signal transduction Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Copper, Metal-binding, Nickel

Ligand

Copper, Metal-binding, Nickel

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation
SIGNORⁱ	P02771

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-fetoprotein Alternative name(s): Alpha-1-fetoprotein Alpha-fetoglobulin
Gene namesⁱ	Name:AFP Synonyms:HPAFP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000081051.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:317 AFP
MIMⁱ	104150 gene
neXtProtⁱ	NX_P02771

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Alpha-fetoprotein deficiency (AFPD)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development.

Alpha-fetoprotein, hereditary persistence (HPAFP)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	174
MalaCards human disease database More...MalaCardsⁱ	AFP
MIMⁱ	615969 phenotype 615970 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000081051
Orphanetⁱ	168612 Congenital deficiency in alpha-fetoprotein 168615 Hereditary persistence of alpha-fetoprotein
PharmGKBⁱ	PA24614

Chemistry databases

ChEMBLⁱ	CHEMBL3712864

ChEMBLⁱ

CHEMBL3712864

Polymorphism and mutation databases

BioMutaⁱ	AFP
DMDMⁱ	120042

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	1 PublicationAdd BLAST		18
ChainⁱPRO_0000001097	19 – 609	Alpha-fetoproteinAdd BLAST		591

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	99 ↔ 114
Modified residueⁱ	111	Phosphoserine; by FAM20C1 Publication	1
Disulfide bondⁱ	113 ↔ 124
Modified residueⁱ	115	Phosphoserine; by FAM20C1 Publication	1
Modified residueⁱ	117	Phosphoserine; by FAM20C1 Publication	1
Disulfide bondⁱ	148 ↔ 193
Disulfide bondⁱ	192 ↔ 201
Disulfide bondⁱ	224 ↔ 270
GlycosylationⁱCAR_000070	251	N-linked (GlcNAc...) asparagine	1
Disulfide bondⁱ	269 ↔ 277
Disulfide bondⁱ	289 ↔ 303
Disulfide bondⁱ	302 ↔ 313
Modified residueⁱ	344	Phosphoserine; by FAM20C1 Publication	1
Disulfide bondⁱ	384 ↔ 393
Disulfide bondⁱ	416 ↔ 462
Modified residueⁱ	444	Phosphoserine; by FAM20C1 Publication	1
Modified residueⁱ	445	Phosphoserine; by FAM20C1 Publication	1
Disulfide bondⁱ	461 ↔ 472
Disulfide bondⁱ	485 ↔ 501
Disulfide bondⁱ	500 ↔ 511
Disulfide bondⁱ	538 ↔ 583
Disulfide bondⁱ	582 ↔ 591

Post-translational modificationⁱ

Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.

Sulfated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P02771
PaxDbⁱ	P02771
PeptideAtlas More...PeptideAtlasⁱ	P02771
PRIDEⁱ	P02771
ProteomicsDBⁱ	51589
TopDownProteomicsⁱ	P02771

PTM databases

GlyConnectⁱ	41
iPTMnetⁱ	P02771
PhosphoSitePlusⁱ	P02771
UniCarbKBⁱ	P02771

Expressionⁱ

Tissue specificityⁱ

Plasma. Synthesized by the fetal liver and yolk sac.

Developmental stageⁱ

Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.

Gene expression databases

Bgeeⁱ	ENSG00000081051 Expressed in 68 organ(s), highest expression level in embryo
CleanExⁱ	HS_AFP
ExpressionAtlasⁱ	P02771 baseline and differential
Genevisibleⁱ	P02771 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB024283 CAB025339 HPA010607 HPA023600

HPAⁱ

CAB024283
CAB025339
HPA010607
HPA023600

Interactionⁱ

Subunit structureⁱ

Dimeric and trimeric forms have been found in addition to the monomeric form.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	Q99IB8	2	EBI-722498,EBI-6901449	From Hepatitis C virus genotype 2a (isolate JFH-1).

With

Entry

#Exp.

IntAct

Notes

Q99IB8

EBI-722498,EBI-6901449

From Hepatitis C virus genotype 2a (isolate JFH-1).

Protein-protein interaction databases

BioGridⁱ	106682, 11 interactors
IntActⁱ	P02771, 10 interactors
STRINGⁱ	9606.ENSP00000379138

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P02771
SMRⁱ	P02771
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	19 – 210	Albumin 1PROSITE-ProRule annotationAdd BLAST	192
Domainⁱ	211 – 402	Albumin 2PROSITE-ProRule annotationAdd BLAST	192
Domainⁱ	403 – 601	Albumin 3PROSITE-ProRule annotationAdd BLAST	199

Sequence similaritiesⁱ

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IIRZ Eukaryota ENOG410Z40H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000113
HOGENOMⁱ	HOG000293137
HOVERGENⁱ	HBG004207
InParanoidⁱ	P02771
KEGG Orthology (KO) More...KOⁱ	K16144
PhylomeDBⁱ	P02771
TreeFamⁱ	TF335561

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00015 ALBUMIN, 3 hits
InterProⁱ	View protein in InterPro IPR000264 ALB/AFP/VDB IPR020858 Serum_albumin-like IPR021177 Serum_albumin/AFP/Afamin IPR020857 Serum_albumin_CS IPR014760 Serum_albumin_N
PANTHERⁱ	PTHR11385 PTHR11385, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00273 Serum_albumin, 3 hits
PIRSFⁱ	PIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSⁱ	PR00803 AFETOPROTEIN PR00802 SERUMALBUMIN
SMARTⁱ	View protein in SMART SM00103 ALBUMIN, 3 hits
SUPFAMⁱ	SSF48552 SSF48552, 3 hits
PROSITEⁱ	View protein in PROSITE PS00212 ALBUMIN_1, 2 hits PS51438 ALBUMIN_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P02771-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MKWVESIFLI FLLNFTESRT LHRNEYGIAS ILDSYQCTAE ISLADLATIF 
        60         70         80         90        100
FAQFVQEATY KEVSKMVKDA LTAIEKPTGD EQSSGCLENQ LPAFLEELCH 
       110        120        130        140        150
EKEILEKYGH SDCCSQSEEG RHNCFLAHKK PTPASIPLFQ VPEPVTSCEA 
       160        170        180        190        200
YEEDRETFMN KFIYEIARRH PFLYAPTILL WAARYDKIIP SCCKAENAVE 
       210        220        230        240        250
CFQTKAATVT KELRESSLLN QHACAVMKNF GTRTFQAITV TKLSQKFTKV 
       260        270        280        290        300
NFTEIQKLVL DVAHVHEHCC RGDVLDCLQD GEKIMSYICS QQDTLSNKIT 
       310        320        330        340        350
ECCKLTTLER GQCIIHAEND EKPEGLSPNL NRFLGDRDFN QFSSGEKNIF 
       360        370        380        390        400
LASFVHEYSR RHPQLAVSVI LRVAKGYQEL LEKCFQTENP LECQDKGEEE 
       410        420        430        440        450
LQKYIQESQA LAKRSCGLFQ KLGEYYLQNA FLVAYTKKAP QLTSSELMAI 
       460        470        480        490        500
TRKMAATAAT CCQLSEDKLL ACGEGAADII IGHLCIRHEM TPVNPGVGQC 
       510        520        530        540        550
CTSSYANRRP CFSSLVVDET YVPPAFSDDK FIFHKDLCQA QGVALQTMKQ 
       560        570        580        590        600
EFLINLVKQK PQITEEQLEA VIADFSGLLE KCCQGQEQEV CFAEEGQKLI 

SKTRAALGV

Length:609

Mass (Da):68,678

Last modified:July 21, 1986 - v1

Checksum:ⁱ4D4E45820E1C2D4F

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	J3KMX3	J3KMX3_HUMAN		Alpha-fetoprotein Alpha-fetoprotein	AFP	622	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033928	187	K → Q. Corresponds to variant dbSNP:rs35765619Ensembl.		1
Natural variantⁱVAR_012049	570	A → G1 PublicationCorresponds to variant dbSNP:rs7790Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	V01514 mRNA Translation: CAA24758.1 M16110 Genomic DNA Translation: AAB58754.1 AK314817 mRNA Translation: BAG37340.1 BC027881 mRNA Translation: AAH27881.1 M10949 Genomic DNA Translation: AAA51674.1 M10950 Genomic DNA Translation: AAA51675.1 Z19532 Genomic DNA Translation: CAA79592.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3556.1
PIRⁱ	A26624 FPHU
NCBI Reference Sequences More...RefSeqⁱ	NP_001125.1, NM_001134.2
UniGeneⁱ	Hs.518808

Genome annotation databases

Ensemblⁱ	ENST00000395792; ENSP00000379138; ENSG00000081051
GeneIDⁱ	174
KEGGⁱ	hsa:174
UCSC genome browser More...UCSCⁱ	uc003hgz.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P02771	Alpha-fetoprotein		PANTR		609	UniRef90_P02771
Alpha-fetoprotein		GORGO		609
Uncharacterized protein		COLAP		635
Alpha-fetoprotein (Fragment)		MACMU		13
Alpha-fetoprotein (Fragment)		MACFA		13
+50

Protein	Similar proteins		Species	Score	Length	Source
P02771	Alpha-fetoprotein		PANTR		609	UniRef50_P02771
Alpha-fetoprotein		GORGO		609
Alpha-fetoprotein		RAT		611
Alpha-fetoprotein		PIG		610
Alpha-fetoprotein		BOVIN		610
+154

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Alpha-fetoprotein entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	V01514 mRNA Translation: CAA24758.1 M16110 Genomic DNA Translation: AAB58754.1 AK314817 mRNA Translation: BAG37340.1 BC027881 mRNA Translation: AAH27881.1 M10949 Genomic DNA Translation: AAA51674.1 M10950 Genomic DNA Translation: AAA51675.1 Z19532 Genomic DNA Translation: CAA79592.1
CCDSⁱ	CCDS3556.1
PIRⁱ	A26624 FPHU
RefSeqⁱ	NP_001125.1, NM_001134.2
UniGeneⁱ	Hs.518808

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3MRK	X-ray	1.40	P	137-145	[»]
ProteinModelPortalⁱ	P02771
SMRⁱ	P02771
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106682, 11 interactors
IntActⁱ	P02771, 10 interactors
STRINGⁱ	9606.ENSP00000379138

Chemistry databases

ChEMBLⁱ	CHEMBL3712864

ChEMBLⁱ

CHEMBL3712864

PTM databases

GlyConnectⁱ	41
iPTMnetⁱ	P02771
PhosphoSitePlusⁱ	P02771
UniCarbKBⁱ	P02771

Polymorphism and mutation databases

BioMutaⁱ	AFP
DMDMⁱ	120042

Proteomic databases

MaxQBⁱ	P02771
PaxDbⁱ	P02771
PeptideAtlasⁱ	P02771
PRIDEⁱ	P02771
ProteomicsDBⁱ	51589
TopDownProteomicsⁱ	P02771

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	174
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000395792; ENSP00000379138; ENSG00000081051
GeneIDⁱ	174
KEGGⁱ	hsa:174
UCSCⁱ	uc003hgz.3 human

Organism-specific databases

CTDⁱ	174
DisGeNETⁱ	174
EuPathDBⁱ	HostDB:ENSG00000081051.7
GeneCardsⁱ	AFP
HGNCⁱ	HGNC:317 AFP
HPAⁱ	CAB024283 CAB025339 HPA010607 HPA023600
MalaCardsⁱ	AFP
MIMⁱ	104150 gene 615969 phenotype 615970 phenotype
neXtProtⁱ	NX_P02771
OpenTargetsⁱ	ENSG00000081051
Orphanetⁱ	168612 Congenital deficiency in alpha-fetoprotein 168615 Hereditary persistence of alpha-fetoprotein
PharmGKBⁱ	PA24614
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIRZ Eukaryota ENOG410Z40H LUCA
GeneTreeⁱ	ENSGT00390000000113
HOGENOMⁱ	HOG000293137
HOVERGENⁱ	HBG004207
InParanoidⁱ	P02771
KOⁱ	K16144
PhylomeDBⁱ	P02771
TreeFamⁱ	TF335561

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation
SIGNORⁱ	P02771

Miscellaneous databases

ChiTaRSⁱ	AFP human
GeneWikiⁱ	Alpha-fetoprotein
GenomeRNAiⁱ	174
Protein Ontology More...PROⁱ	PR:P02771
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000081051 Expressed in 68 organ(s), highest expression level in embryo
CleanExⁱ	HS_AFP
ExpressionAtlasⁱ	P02771 baseline and differential
Genevisibleⁱ	P02771 HS

Family and domain databases

CDDⁱ	cd00015 ALBUMIN, 3 hits
InterProⁱ	View protein in InterPro IPR000264 ALB/AFP/VDB IPR020858 Serum_albumin-like IPR021177 Serum_albumin/AFP/Afamin IPR020857 Serum_albumin_CS IPR014760 Serum_albumin_N
PANTHERⁱ	PTHR11385 PTHR11385, 1 hit
Pfamⁱ	View protein in Pfam PF00273 Serum_albumin, 3 hits
PIRSFⁱ	PIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSⁱ	PR00803 AFETOPROTEIN PR00802 SERUMALBUMIN
SMARTⁱ	View protein in SMART SM00103 ALBUMIN, 3 hits
SUPFAMⁱ	SSF48552 SSF48552, 3 hits
PROSITEⁱ	View protein in PROSITE PS00212 ALBUMIN_1, 2 hits PS51438 ALBUMIN_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FETA_HUMAN
Accessionⁱ	P02771Primary (citable) accession number: P02771 Secondary accession number(s): B2RBU3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	September 12, 2018
	This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - P02771 (FETA_HUMAN)

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Alpha-fetoprotein

AFP

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ