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UniProtKB - P02769 (ALBU_BOVIN)

Protein

Serum albumin

Gene

ALB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Caution

A peptide arising from positions 165 to 173 was originally termed neurotensin-related peptide (NRP) and was thought to regulate fat digestion, lipid absorption, and blood flow.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27CopperBy similarity1
Metal bindingi91ZincBy similarity1
Metal bindingi123ZincBy similarity1
Metal bindingi270ZincBy similarity1
Metal bindingi272ZincBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

LigandCopper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Alternative name(s):
BSA
Allergen: Bos d 6
Gene namesi
Name:ALB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei165 Bos d 6
3166 Bos d 6.0101

Chemistry databases

ChEMBLiCHEMBL3728

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
PropeptideiPRO_000000105719 – 246
ChainiPRO_000000105825 – 607Serum albuminAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation1 Publication
Modified residuei82PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation1 Publication
Modified residuei107PhosphothreonineBy similarity1
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation1 Publication
Disulfide bondi147 ↔ 192PROSITE-ProRule annotation1 Publication
Disulfide bondi191 ↔ 200PROSITE-ProRule annotation1 Publication
Disulfide bondi223 ↔ 269PROSITE-ProRule annotation1 Publication
Modified residuei228N6-succinyllysineBy similarity1
Disulfide bondi268 ↔ 276PROSITE-ProRule annotation1 Publication
Disulfide bondi288 ↔ 302PROSITE-ProRule annotation1 Publication
Modified residuei296PhosphoserineBy similarity1
Disulfide bondi301 ↔ 312PROSITE-ProRule annotation1 Publication
Disulfide bondi339 ↔ 384PROSITE-ProRule annotation1 Publication
Disulfide bondi383 ↔ 392PROSITE-ProRule annotation1 Publication
Disulfide bondi415 ↔ 461PROSITE-ProRule annotation1 Publication
Modified residuei442PhosphoserineBy similarity1
Modified residuei443PhosphothreonineBy similarity1
Modified residuei445PhosphothreonineBy similarity1
Disulfide bondi460 ↔ 471PROSITE-ProRule annotation1 Publication
Disulfide bondi484 ↔ 500PROSITE-ProRule annotation1 Publication
Disulfide bondi499 ↔ 510PROSITE-ProRule annotation1 Publication
Modified residuei512PhosphoserineBy similarity1
Disulfide bondi537 ↔ 582PROSITE-ProRule annotation1 Publication
Modified residuei557N6-methyllysineBy similarity1
Modified residuei569PhosphothreonineBy similarity1
Disulfide bondi581 ↔ 590PROSITE-ProRule annotation1 Publication
Modified residuei587N6-succinyllysineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP02769
PeptideAtlasiP02769
PRIDEiP02769

PTM databases

CarbonylDBiP02769

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

BioGridi158123, 5 interactors
IntActiP02769, 1 interactor
STRINGi9913.ENSBTAP00000022763

Chemistry databases

BindingDBiP02769

Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02769
SMRiP02769
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 209Albumin 1PROSITE-ProRule annotationAdd BLAST191
Domaini210 – 402Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini403 – 600Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP02769
KOiK16141
TreeFamiTF335561

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00803 AFETOPROTEIN
PR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02769-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKWVTFISLL LLFSSAYSRG VFRRDTHKSE IAHRFKDLGE EHFKGLVLIA 
        60         70         80         90        100
FSQYLQQCPF DEHVKLVNEL TEFAKTCVAD ESHAGCEKSL HTLFGDELCK 
       110        120        130        140        150
VASLRETYGD MADCCEKQEP ERNECFLSHK DDSPDLPKLK PDPNTLCDEF 
       160        170        180        190        200
KADEKKFWGK YLYEIARRHP YFYAPELLYY ANKYNGVFQE CCQAEDKGAC 
       210        220        230        240        250
LLPKIETMRE KVLASSARQR LRCASIQKFG ERALKAWSVA RLSQKFPKAE 
       260        270        280        290        300
FVEVTKLVTD LTKVHKECCH GDLLECADDR ADLAKYICDN QDTISSKLKE 
       310        320        330        340        350
CCDKPLLEKS HCIAEVEKDA IPENLPPLTA DFAEDKDVCK NYQEAKDAFL 
       360        370        380        390        400
GSFLYEYSRR HPEYAVSVLL RLAKEYEATL EECCAKDDPH ACYSTVFDKL 
       410        420        430        440        450
KHLVDEPQNL IKQNCDQFEK LGEYGFQNAL IVRYTRKVPQ VSTPTLVEVS 
       460        470        480        490        500
RSLGKVGTRC CTKPESERMP CTEDYLSLIL NRLCVLHEKT PVSEKVTKCC 
       510        520        530        540        550
TESLVNRRPC FSALTPDETY VPKAFDEKLF TFHADICTLP DTEKQIKKQT 
       560        570        580        590        600
ALVELLKHKP KATEEQLKTV MENFVAFVDK CCAADDKEAC FAVEGPKLVV 

STQTALA
Length:607
Mass (Da):69,293
Last modified:February 1, 1996 - v4
Checksum:i39167DFE768585D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58Missing AA sequence (PubMed:2379503).Curated1
Sequence conflicti116E → A in AAI02743 (Ref. 5) Curated1
Sequence conflicti173Y → L AA sequence (PubMed:2437111).Curated1
Sequence conflicti302C → K AA sequence (Ref. 9) Curated1
Sequence conflicti304 – 305KP → PC AA sequence (Ref. 9) Curated2
Sequence conflicti324N → D AA sequence (Ref. 9) Curated1
Sequence conflicti394 – 395ST → TS AA sequence (Ref. 9) Curated2
Sequence conflicti429A → E in AAI02743 (Ref. 5) Curated1
Sequence conflicti437K → R AA sequence (Ref. 16) Curated1
Sequence conflicti472T → A in AAI02743 (Ref. 5) Curated1
Sequence conflicti493 – 494SE → ES AA sequence (Ref. 9) Curated2
Sequence conflicti579D → G in AAI02743 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti214A → T4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73993 mRNA Translation: AAA51411.1
X58989 mRNA Translation: CAA41735.1
Y17769 mRNA Translation: CAA76847.1
AF542068 mRNA Translation: AAN17824.1
BC102742 mRNA Translation: AAI02743.1
BC142272 mRNA Translation: AAI42273.1
PIRiA38885 ABBOS
RefSeqiNP_851335.1, NM_180992.2
UniGeneiBt.106669

Genome annotation databases

GeneIDi280717
KEGGibta:280717

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73993 mRNA Translation: AAA51411.1
X58989 mRNA Translation: CAA41735.1
Y17769 mRNA Translation: CAA76847.1
AF542068 mRNA Translation: AAN17824.1
BC102742 mRNA Translation: AAI02743.1
BC142272 mRNA Translation: AAI42273.1
PIRiA38885 ABBOS
RefSeqiNP_851335.1, NM_180992.2
UniGeneiBt.106669

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L7UNMR-B148-154[»]
3V03X-ray2.70A/B25-607[»]
4F5SX-ray2.47A/B25-607[»]
4JK4X-ray2.65A/B25-607[»]
4OR0X-ray2.58A/B25-607[»]
ProteinModelPortaliP02769
SMRiP02769
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi158123, 5 interactors
IntActiP02769, 1 interactor
STRINGi9913.ENSBTAP00000022763

Chemistry databases

BindingDBiP02769
ChEMBLiCHEMBL3728

Protein family/group databases

Allergomei165 Bos d 6
3166 Bos d 6.0101

PTM databases

CarbonylDBiP02769

Proteomic databases

PaxDbiP02769
PeptideAtlasiP02769
PRIDEiP02769

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280717
KEGGibta:280717

Organism-specific databases

CTDi213

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP02769
KOiK16141
TreeFamiTF335561

Miscellaneous databases

PROiPR:P02769

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00803 AFETOPROTEIN
PR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiALBU_BOVIN
AccessioniPrimary (citable) accession number: P02769
Secondary accession number(s): A5PJX3
, O02787, P04277, Q3SZR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: April 25, 2018
This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Allergens
    Nomenclature of allergens and list of entries
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