UniProtKB - P02769 (ALBU_BOVIN)
Albumin
ALB
Functioni
Binds water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity).
Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (PubMed:22677715).
The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (Probable). The rank order of affinity is zinc > calcium > magnesium (Probable). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017).
Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017).
By similarity1 Publication2 PublicationsCaution
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 27 | CopperBy similarity | 1 | |
Metal bindingi | 30 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 37 | Calcium 2Combined sources2 Publications | 1 | |
Metal bindingi | 91 | Zinc; via tele nitrogenBy similarity | 1 | |
Metal bindingi | 267 | Calcium 1Combined sources2 Publications | 1 | |
Metal bindingi | 270 | Zinc; via pros nitrogenBy similarity | 1 | |
Metal bindingi | 272 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 272 | ZincBy similarity | 1 | |
Metal bindingi | 275 | Calcium 1Combined sources2 Publications | 1 | |
Metal bindingi | 278 | Calcium 2Combined sources2 Publications | 1 | |
Metal bindingi | 282 | Calcium 2Combined sources2 Publications | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- enterobactin binding Source: UniProtKB
- fatty acid binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- pyridoxal phosphate binding Source: UniProtKB
- toxic substance binding Source: UniProtKB
GO - Biological processi
- cellular response to starvation Source: UniProtKB
- maintenance of mitochondrion location Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
Keywordsi
Ligand | Calcium, Copper, Lipid-binding, Metal-binding, Zinc |
Enzyme and pathway databases
SABIO-RKi | P02769 |
Names & Taxonomyi
Protein namesi | Recommended name: AlbuminAlternative name(s): BSA Allergen: Bos d 6 |
Gene namesi | Name:ALB |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: InterPro
Other locations
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Allergenic propertiesi
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 165, Bos d 6 3166, Bos d 6.0101 |
Chemistry databases
ChEMBLi | CHEMBL3728 |
DrugCentrali | P02769 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
PropeptideiPRO_0000001057 | 19 – 24 | 6 | ||
ChainiPRO_0000001058 | 25 – 607 | AlbuminAdd BLAST | 583 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 29 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 77 ↔ 86 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Modified residuei | 82 | PhosphoserineBy similarity | 1 | |
Modified residuei | 89 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 99 ↔ 115 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Modified residuei | 107 | PhosphothreonineBy similarity | 1 | |
Disulfide bondi | 114 ↔ 125 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 147 ↔ 192 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Glycosylationi | 151 | N-linked (Glc) (glycation) lysine; in vitro1 Publication | 1 | |
Disulfide bondi | 191 ↔ 200 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 223 ↔ 269 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Modified residuei | 228 | N6-succinyllysineBy similarity | 1 | |
Disulfide bondi | 268 ↔ 276 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 288 ↔ 302 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Modified residuei | 296 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 301 ↔ 312 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 339 ↔ 384 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 383 ↔ 392 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 415 ↔ 461 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Modified residuei | 442 | PhosphoserineBy similarity | 1 | |
Modified residuei | 443 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 445 | PhosphothreonineBy similarity | 1 | |
Disulfide bondi | 460 ↔ 471 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 484 ↔ 500 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 499 ↔ 510 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Modified residuei | 512 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 537 ↔ 582 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Modified residuei | 557 | N6-methyllysineBy similarity | 1 | |
Modified residuei | 569 | PhosphothreonineBy similarity | 1 | |
Disulfide bondi | 581 ↔ 590 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Modified residuei | 587 | N6-succinyllysineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycation, Glycoprotein, Methylation, PhosphoproteinProteomic databases
PaxDbi | P02769 |
PeptideAtlasi | P02769 |
PRIDEi | P02769 |
PTM databases
CarbonylDBi | P02769 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity).
Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.
By similarityBinary interactionsi
P02769
With | #Exp. | IntAct |
---|---|---|
CFH [P08603] from Homo sapiens. | 10 | EBI-2296927,EBI-1223708 |
Ficolin-1 (PRO_0000009136) from Homo sapiens. | 2 | EBI-2296927,EBI-11784425 |
Protein-protein interaction databases
BioGRIDi | 158123, 5 interactors |
IntActi | P02769, 8 interactors |
STRINGi | 9913.ENSBTAP00000022763 |
Chemistry databases
BindingDBi | P02769 |
Structurei
Secondary structure
3D structure databases
BMRBi | P02769 |
SASBDBi | P02769 |
SMRi | P02769 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 209 | Albumin 1PROSITE-ProRule annotationAdd BLAST | 191 | |
Domaini | 210 – 402 | Albumin 2PROSITE-ProRule annotationAdd BLAST | 193 | |
Domaini | 403 – 600 | Albumin 3PROSITE-ProRule annotationAdd BLAST | 198 |
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502R7EA, Eukaryota |
HOGENOMi | CLU_030161_0_0_1 |
InParanoidi | P02769 |
OrthoDBi | 906547at2759 |
TreeFami | TF335561 |
Family and domain databases
CDDi | cd00015, ALBUMIN, 3 hits |
InterProi | View protein in InterPro IPR000264, ALB/AFP/VDB IPR020858, Serum_albumin-like IPR021177, Serum_albumin/AFP/Afamin IPR020857, Serum_albumin_CS IPR014760, Serum_albumin_N |
PANTHERi | PTHR11385, PTHR11385, 1 hit |
Pfami | View protein in Pfam PF00273, Serum_albumin, 3 hits |
PIRSFi | PIRSF002520, Serum_albumin_subgroup, 1 hit |
PRINTSi | PR00803, AFETOPROTEIN PR00802, SERUMALBUMIN |
SMARTi | View protein in SMART SM00103, ALBUMIN, 3 hits |
SUPFAMi | SSF48552, SSF48552, 3 hits |
PROSITEi | View protein in PROSITE PS00212, ALBUMIN_1, 3 hits PS51438, ALBUMIN_2, 3 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MKWVTFISLL LLFSSAYSRG VFRRDTHKSE IAHRFKDLGE EHFKGLVLIA
60 70 80 90 100
FSQYLQQCPF DEHVKLVNEL TEFAKTCVAD ESHAGCEKSL HTLFGDELCK
110 120 130 140 150
VASLRETYGD MADCCEKQEP ERNECFLSHK DDSPDLPKLK PDPNTLCDEF
160 170 180 190 200
KADEKKFWGK YLYEIARRHP YFYAPELLYY ANKYNGVFQE CCQAEDKGAC
210 220 230 240 250
LLPKIETMRE KVLASSARQR LRCASIQKFG ERALKAWSVA RLSQKFPKAE
260 270 280 290 300
FVEVTKLVTD LTKVHKECCH GDLLECADDR ADLAKYICDN QDTISSKLKE
310 320 330 340 350
CCDKPLLEKS HCIAEVEKDA IPENLPPLTA DFAEDKDVCK NYQEAKDAFL
360 370 380 390 400
GSFLYEYSRR HPEYAVSVLL RLAKEYEATL EECCAKDDPH ACYSTVFDKL
410 420 430 440 450
KHLVDEPQNL IKQNCDQFEK LGEYGFQNAL IVRYTRKVPQ VSTPTLVEVS
460 470 480 490 500
RSLGKVGTRC CTKPESERMP CTEDYLSLIL NRLCVLHEKT PVSEKVTKCC
510 520 530 540 550
TESLVNRRPC FSALTPDETY VPKAFDEKLF TFHADICTLP DTEKQIKKQT
560 570 580 590 600
ALVELLKHKP KATEEQLKTV MENFVAFVDK CCAADDKEAC FAVEGPKLVV
STQTALA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 | Missing AA sequence (PubMed:2379503).Curated | 1 | |
Sequence conflicti | 116 | E → A in AAI02743 (Ref. 5) Curated | 1 | |
Sequence conflicti | 173 | Y → L AA sequence (PubMed:2437111).Curated | 1 | |
Sequence conflicti | 302 | C → K AA sequence (Ref. 9) Curated | 1 | |
Sequence conflicti | 304 – 305 | KP → PC AA sequence (Ref. 9) Curated | 2 | |
Sequence conflicti | 324 | N → D AA sequence (Ref. 9) Curated | 1 | |
Sequence conflicti | 394 – 395 | ST → TS AA sequence (Ref. 9) Curated | 2 | |
Sequence conflicti | 429 | A → E in AAI02743 (Ref. 5) Curated | 1 | |
Sequence conflicti | 437 | K → R AA sequence (Ref. 16) Curated | 1 | |
Sequence conflicti | 472 | T → A in AAI02743 (Ref. 5) Curated | 1 | |
Sequence conflicti | 493 – 494 | SE → ES AA sequence (Ref. 9) Curated | 2 | |
Sequence conflicti | 579 | D → G in AAI02743 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 214 | A → T5 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73993 mRNA Translation: AAA51411.1 X58989 mRNA Translation: CAA41735.1 Y17769 mRNA Translation: CAA76847.1 AF542068 mRNA Translation: AAN17824.1 BC102742 mRNA Translation: AAI02743.1 BC142272 mRNA Translation: AAI42273.1 |
PIRi | A38885, ABBOS |
RefSeqi | NP_851335.1, NM_180992.2 |
Genome annotation databases
GeneIDi | 280717 |
KEGGi | bta:280717 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73993 mRNA Translation: AAA51411.1 X58989 mRNA Translation: CAA41735.1 Y17769 mRNA Translation: CAA76847.1 AF542068 mRNA Translation: AAN17824.1 BC102742 mRNA Translation: AAI02743.1 BC142272 mRNA Translation: AAI42273.1 |
PIRi | A38885, ABBOS |
RefSeqi | NP_851335.1, NM_180992.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2L7U | NMR | - | B | 148-154 | [»] | |
3V03 | X-ray | 2.70 | A/B | 25-607 | [»] | |
4F5S | X-ray | 2.47 | A/B | 25-607 | [»] | |
4JK4 | X-ray | 2.65 | A/B | 25-607 | [»] | |
4OR0 | X-ray | 2.58 | A/B | 25-607 | [»] | |
6QS9 | X-ray | 2.80 | A/B | 1-607 | [»] | |
6RJV | X-ray | 3.21 | A/B | 25-607 | [»] | |
BMRBi | P02769 | |||||
SASBDBi | P02769 | |||||
SMRi | P02769 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 158123, 5 interactors |
IntActi | P02769, 8 interactors |
STRINGi | 9913.ENSBTAP00000022763 |
Chemistry databases
BindingDBi | P02769 |
ChEMBLi | CHEMBL3728 |
DrugCentrali | P02769 |
Protein family/group databases
Allergomei | 165, Bos d 6 3166, Bos d 6.0101 |
PTM databases
CarbonylDBi | P02769 |
Proteomic databases
PaxDbi | P02769 |
PeptideAtlasi | P02769 |
PRIDEi | P02769 |
Protocols and materials databases
ABCDi | P02769, 3 sequenced antibodies |
Genome annotation databases
GeneIDi | 280717 |
KEGGi | bta:280717 |
Organism-specific databases
CTDi | 213 |
Phylogenomic databases
eggNOGi | ENOG502R7EA, Eukaryota |
HOGENOMi | CLU_030161_0_0_1 |
InParanoidi | P02769 |
OrthoDBi | 906547at2759 |
TreeFami | TF335561 |
Enzyme and pathway databases
SABIO-RKi | P02769 |
Miscellaneous databases
PROi | PR:P02769 |
Family and domain databases
CDDi | cd00015, ALBUMIN, 3 hits |
InterProi | View protein in InterPro IPR000264, ALB/AFP/VDB IPR020858, Serum_albumin-like IPR021177, Serum_albumin/AFP/Afamin IPR020857, Serum_albumin_CS IPR014760, Serum_albumin_N |
PANTHERi | PTHR11385, PTHR11385, 1 hit |
Pfami | View protein in Pfam PF00273, Serum_albumin, 3 hits |
PIRSFi | PIRSF002520, Serum_albumin_subgroup, 1 hit |
PRINTSi | PR00803, AFETOPROTEIN PR00802, SERUMALBUMIN |
SMARTi | View protein in SMART SM00103, ALBUMIN, 3 hits |
SUPFAMi | SSF48552, SSF48552, 3 hits |
PROSITEi | View protein in PROSITE PS00212, ALBUMIN_1, 3 hits PS51438, ALBUMIN_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ALBU_BOVIN | |
Accessioni | P02769Primary (citable) accession number: P02769 Secondary accession number(s): A5PJX3 Q3SZR2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 186 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Allergens
Nomenclature of allergens and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families