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UniProtKB - P02769 (ALBU_BOVIN)

Entry version 183 (07 Apr 2021)
Sequence version 4 (01 Feb 1996)
Previous versions | rss
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Protein

Albumin

Gene

ALB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (PubMed:22677715). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (Probable). The rank order of affinity is zinc > calcium > magnesium (Probable). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017).By similarity1 Publication2 Publications

Caution

A peptide arising from positions 165 to 173 was originally termed neurotensin-related peptide (NRP) and was thought to regulate fat digestion, lipid absorption, and blood flow.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi27CopperBy similarity1
Metal bindingi30Calcium 1Combined sources1 Publication1
Metal bindingi37Calcium 2Combined sources2 Publications1
Metal bindingi91Zinc; via tele nitrogenBy similarity1
Metal bindingi267Calcium 1Combined sources2 Publications1
Metal bindingi270Zinc; via pros nitrogenBy similarity1
Metal bindingi272Calcium 1Combined sources1 Publication1
Metal bindingi272ZincBy similarity1
Metal bindingi275Calcium 1Combined sources2 Publications1
Metal bindingi278Calcium 2Combined sources2 Publications1
Metal bindingi282Calcium 2Combined sources2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Copper, Lipid-binding, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Albumin
Alternative name(s):
BSA
Allergen: Bos d 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section is used for proteins that cause an allergic reaction in mammals. We usually specify in which species the protein is allergenic.<p><a href='/help/allergenic_properties' target='_top'>More...</a></p>Allergenic propertiesi

Can cause allergic reactions in humans.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergome; a platform for allergen knowledge

More...Allergomei		165, Bos d 6
3166, Bos d 6.0101

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3728

DrugCentral

More...DrugCentrali		P02769

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 181 PublicationAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000105719 – 246
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000105825 – 607AlbuminAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi77 ↔ 86PROSITE-ProRule annotationCombined sources4 Publications
Modified residuei82PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotationCombined sources4 Publications
Modified residuei107PhosphothreonineBy similarity1
Disulfide bondi114 ↔ 125PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi147 ↔ 192PROSITE-ProRule annotationCombined sources4 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi151N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi191 ↔ 200PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi223 ↔ 269PROSITE-ProRule annotationCombined sources4 Publications
Modified residuei228N6-succinyllysineBy similarity1
Disulfide bondi268 ↔ 276PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi288 ↔ 302PROSITE-ProRule annotationCombined sources4 Publications
Modified residuei296PhosphoserineBy similarity1
Disulfide bondi301 ↔ 312PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi339 ↔ 384PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi383 ↔ 392PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi415 ↔ 461PROSITE-ProRule annotationCombined sources4 Publications
Modified residuei442PhosphoserineBy similarity1
Modified residuei443PhosphothreonineBy similarity1
Modified residuei445PhosphothreonineBy similarity1
Disulfide bondi460 ↔ 471PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi484 ↔ 500PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi499 ↔ 510PROSITE-ProRule annotationCombined sources4 Publications
Modified residuei512PhosphoserineBy similarity1
Disulfide bondi537 ↔ 582PROSITE-ProRule annotationCombined sources4 Publications
Modified residuei557N6-methyllysineBy similarity1
Modified residuei569PhosphothreonineBy similarity1
Disulfide bondi581 ↔ 590PROSITE-ProRule annotationCombined sources4 Publications
Modified residuei587N6-succinyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycation, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02769

PeptideAtlas

More...PeptideAtlasi		P02769

PRoteomics IDEntifications database

More...PRIDEi		P02769

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P02769

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity).

Interacts with TASOR (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		158123, 5 interactors

Protein interaction database and analysis system

More...IntActi		P02769, 7 interactors

STRING: functional protein association networks

More...STRINGi		9913.ENSBTAP00000022763

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P02769

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P02769

Small Angle Scattering Biological Data Bank

More...SASBDBi		P02769

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P02769

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 209Albumin 1PROSITE-ProRule annotationAdd BLAST191
Domaini210 – 402Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini403 – 600Albumin 3PROSITE-ProRule annotationAdd BLAST198

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R7EA, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030161_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02769

Database of Orthologous Groups

More...OrthoDBi		906547at2759

TreeFam database of animal gene trees

More...TreeFami		TF335561

Family and domain databases

Conserved Domains Database

More...CDDi		cd00015, ALBUMIN, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000264, ALB/AFP/VDB
IPR020858, Serum_albumin-like
IPR021177, Serum_albumin/AFP/Afamin
IPR020857, Serum_albumin_CS
IPR014760, Serum_albumin_N

The PANTHER Classification System

More...PANTHERi		PTHR11385, PTHR11385, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00273, Serum_albumin, 3 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002520, Serum_albumin_subgroup, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00803, AFETOPROTEIN
PR00802, SERUMALBUMIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00103, ALBUMIN, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48552, SSF48552, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00212, ALBUMIN_1, 3 hits
PS51438, ALBUMIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02769-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKWVTFISLL LLFSSAYSRG VFRRDTHKSE IAHRFKDLGE EHFKGLVLIA 
        60         70         80         90        100
FSQYLQQCPF DEHVKLVNEL TEFAKTCVAD ESHAGCEKSL HTLFGDELCK 
       110        120        130        140        150
VASLRETYGD MADCCEKQEP ERNECFLSHK DDSPDLPKLK PDPNTLCDEF 
       160        170        180        190        200
KADEKKFWGK YLYEIARRHP YFYAPELLYY ANKYNGVFQE CCQAEDKGAC 
       210        220        230        240        250
LLPKIETMRE KVLASSARQR LRCASIQKFG ERALKAWSVA RLSQKFPKAE 
       260        270        280        290        300
FVEVTKLVTD LTKVHKECCH GDLLECADDR ADLAKYICDN QDTISSKLKE 
       310        320        330        340        350
CCDKPLLEKS HCIAEVEKDA IPENLPPLTA DFAEDKDVCK NYQEAKDAFL 
       360        370        380        390        400
GSFLYEYSRR HPEYAVSVLL RLAKEYEATL EECCAKDDPH ACYSTVFDKL 
       410        420        430        440        450
KHLVDEPQNL IKQNCDQFEK LGEYGFQNAL IVRYTRKVPQ VSTPTLVEVS 
       460        470        480        490        500
RSLGKVGTRC CTKPESERMP CTEDYLSLIL NRLCVLHEKT PVSEKVTKCC 
       510        520        530        540        550
TESLVNRRPC FSALTPDETY VPKAFDEKLF TFHADICTLP DTEKQIKKQT 
       560        570        580        590        600
ALVELLKHKP KATEEQLKTV MENFVAFVDK CCAADDKEAC FAVEGPKLVV 

STQTALA
Length:607
Mass (Da):69,293
Last modified:February 1, 1996 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39167DFE768585D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58Missing AA sequence (PubMed:2379503).Curated1
Sequence conflicti116E → A in AAI02743 (Ref. 5) Curated1
Sequence conflicti173Y → L AA sequence (PubMed:2437111).Curated1
Sequence conflicti302C → K AA sequence (Ref. 9) Curated1
Sequence conflicti304 – 305KP → PC AA sequence (Ref. 9) Curated2
Sequence conflicti324N → D AA sequence (Ref. 9) Curated1
Sequence conflicti394 – 395ST → TS AA sequence (Ref. 9) Curated2
Sequence conflicti429A → E in AAI02743 (Ref. 5) Curated1
Sequence conflicti437K → R AA sequence (Ref. 16) Curated1
Sequence conflicti472T → A in AAI02743 (Ref. 5) Curated1
Sequence conflicti493 – 494SE → ES AA sequence (Ref. 9) Curated2
Sequence conflicti579D → G in AAI02743 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti214A → T5 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M73993 mRNA Translation: AAA51411.1
X58989 mRNA Translation: CAA41735.1
Y17769 mRNA Translation: CAA76847.1
AF542068 mRNA Translation: AAN17824.1
BC102742 mRNA Translation: AAI02743.1
BC142272 mRNA Translation: AAI42273.1

Protein sequence database of the Protein Information Resource

More...PIRi		A38885, ABBOS

NCBI Reference Sequences

More...RefSeqi		NP_851335.1, NM_180992.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		280717

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bta:280717

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73993 mRNA Translation: AAA51411.1
X58989 mRNA Translation: CAA41735.1
Y17769 mRNA Translation: CAA76847.1
AF542068 mRNA Translation: AAN17824.1
BC102742 mRNA Translation: AAI02743.1
BC142272 mRNA Translation: AAI42273.1
PIRiA38885, ABBOS
RefSeqiNP_851335.1, NM_180992.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L7UNMR-B148-154[»]
3V03X-ray2.70A/B25-607[»]
4F5SX-ray2.47A/B25-607[»]
4JK4X-ray2.65A/B25-607[»]
4OR0X-ray2.58A/B25-607[»]
6QS9X-ray2.80A/B1-607[»]
6RJVX-ray3.21A/B25-607[»]
BMRBiP02769
SASBDBiP02769
SMRiP02769
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi158123, 5 interactors
IntActiP02769, 7 interactors
STRINGi9913.ENSBTAP00000022763

Chemistry databases

BindingDBiP02769
ChEMBLiCHEMBL3728
DrugCentraliP02769

Protein family/group databases

Allergomei165, Bos d 6
3166, Bos d 6.0101

PTM databases

CarbonylDBiP02769

Proteomic databases

PaxDbiP02769
PeptideAtlasiP02769
PRIDEiP02769

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P02769, 3 sequenced antibodies

Genome annotation databases

GeneIDi280717
KEGGibta:280717

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		213

Phylogenomic databases

eggNOGiENOG502R7EA, Eukaryota
HOGENOMiCLU_030161_0_0_1
InParanoidiP02769
OrthoDBi906547at2759
TreeFamiTF335561

Miscellaneous databases

Protein Ontology

More...PROi		PR:P02769

Family and domain databases

CDDicd00015, ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264, ALB/AFP/VDB
IPR020858, Serum_albumin-like
IPR021177, Serum_albumin/AFP/Afamin
IPR020857, Serum_albumin_CS
IPR014760, Serum_albumin_N
PANTHERiPTHR11385, PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273, Serum_albumin, 3 hits
PIRSFiPIRSF002520, Serum_albumin_subgroup, 1 hit
PRINTSiPR00803, AFETOPROTEIN
PR00802, SERUMALBUMIN
SMARTiView protein in SMART
SM00103, ALBUMIN, 3 hits
SUPFAMiSSF48552, SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212, ALBUMIN_1, 3 hits
PS51438, ALBUMIN_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALBU_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02769
Secondary accession number(s): A5PJX3
, O02787, P04277, Q3SZR2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: April 7, 2021
This is version 183 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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