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UniProtKB - P02768 (ALBU_HUMAN)

Protein

Serum albumin

Gene

ALB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.1 Publication

Caution

A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed neurotensin-related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and blood flow.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi27CopperBy similarity1
Metal bindingi91Zinc1
Metal bindingi123Zinc1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei223Aspirin-acetylated lysine1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei264Bilirubin1
Metal bindingi271Zinc1
Metal bindingi273Zinc1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • antioxidant activity Source: UniProtKB
  • chaperone binding Source: BHF-UCL
  • copper ion binding Source: UniProtKB
  • DNA binding Source: UniProtKB
  • drug binding Source: UniProtKB
  • fatty acid binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • pyridoxal phosphate binding Source: UniProtKB
  • toxic substance binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCopper, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation
R-HSA-159418 Recycling of bile acids and salts
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518 Transport of organic anions
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8964058 HDL remodeling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P02768

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serum albumin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALB
ORF Names:GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000163631.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:399 ALB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		103600 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P02768

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyperthyroxinemia, familial dysalbuminemic (FDAH)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity.
See also OMIM:615999
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01301190L → P in FDAH. 1 PublicationCorresponds to variant dbSNP:rs77892378EnsemblClinVar.1
Natural variantiVAR_000514242R → H in FDAH. 3 PublicationsCorresponds to variant dbSNP:rs75002628EnsemblClinVar.1
Natural variantiVAR_013013242R → P in FDAH. Corresponds to variant dbSNP:rs75002628EnsemblClinVar.1
Analbuminemia (ANALBA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. Affected individuals manifest mild edema, hypotension, fatigue, and, occasionally, lower body lipodystrophy (mainly in adult females). The most common biochemical finding is hyperlipidemia, with a significant increase in the total and LDL cholesterol concentrations, but normal concentrations of HDL cholesterol and triglycerides.
See also OMIM:616000

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		213

MalaCards human disease database

More...MalaCardsi		ALB
MIMi615999 phenotype
616000 phenotype

Open Targets

More...OpenTargetsi		ENSG00000163631

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		86816 Congenital analbuminemia
276271 NON RARE IN EUROPE: Familial dysalbuminemic hyperthyroxinemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24690

Protein family/group databases

Allergome; a platform for allergen knowledge

More...Allergomei		763 Hom s HSA

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3253

Drug and drug target database

More...DrugBanki		DB07517 3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONIC
DB07992 3-SULFOOXY-1H-INDOLE
DB05812 Abiraterone
DB01418 Acenocoumarol
DB01614 Acepromazine
DB00945 Acetylsalicylic acid
DB00459 Acitretin
DB00802 Alfentanil
DB00321 Amitriptyline
DB00415 Ampicillin
DB04557 Arachidonic Acid
DB00995 Auranofin
DB07402 Azapropazone
DB01294 Bismuth Subsalicylate
DB08907 Canagliflozin
DB01197 Captopril
DB00456 Cefalotin
DB01327 Cefazolin
DB00274 Cefmetazole
DB01328 Cefonicid
DB01329 Cefoperazone
DB00493 Cefotaxime
DB01330 Cefotetan
DB00430 Cefpiramide
DB01212 Ceftriaxone
DB00482 Celecoxib
DB00567 Cephalexin
DB00477 Chlorpromazine
DB01242 Clomipramine
DB01068 Clonazepam
DB01147 Cloxacillin
DB03600 Decanoic Acid
DB01189 Desflurane
DB00829 Diazepam
DB00586 Diclofenac
DB00861 Diflunisal
DB01396 Digitoxin
DB04855 Dronedarone
DB00228 Enflurane
DB08899 Enzalutamide
DB00530 Erlotinib
DB00199 Erythromycin
DB00783 Estradiol
DB00655 Estrone
DB04574 Estrone sulfate
DB00903 Etacrynic acid
DB00749 Etodolac
DB00573 Fenoprofen
DB00544 Fluorouracil
DB00472 Fluoxetine
DB00712 Flurbiprofen
DB01320 Fosphenytoin
DB06716 Fospropofol
DB00695 Furosemide
DB00743 Gadobenic acid
DB06705 Gadofosveset trisodium
DB01044 Gatifloxacin
DB00317 Gefitinib
DB01120 Gliclazide
DB01016 Glyburide
DB01159 Halothane
DB00070 Hyaluronidase
DB06205 Hyaluronidase (Human Recombinant)
DB01050 Ibuprofen
DB00619 Imatinib
DB00328 Indomethacin
DB01307 Insulin Detemir
DB04711 Iodipamide
DB00762 Irinotecan
DB00753 Isoflurane
DB08820 Ivacaftor
DB01587 Ketazolam
DB01009 Ketoprofen
DB03017 Lauric Acid
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00678 Losartan
DB09280 Lumacaftor
DB08932 Macitentan
DB01397 Magnesium salicylate
DB00931 Methacycline
DB00563 Methotrexate
DB06710 Methyltestosterone
DB08893 Mirabegron
DB00688 Mycophenolate mofetil
DB08231 MYRISTIC ACID
DB01183 Naloxone
DB00788 Naproxen
DB00731 Nateglinide
DB00717 Norethisterone
DB00540 Nortriptyline
DB00334 Olanzapine
DB04224 Oleic Acid
DB00776 Oxcarbazepine
DB06412 Oxymetholone
DB03585 Oxyphenbutazone
DB03796 Palmitic Acid
DB00454 Pethidine
DB00946 Phenprocoumon
DB00252 Phenytoin
DB01621 Pipotiazine
DB00554 Piroxicam
DB08860 Pitavastatin
DB06209 Prasugrel
DB00635 Prednisone
DB01032 Probenecid
DB00818 Propofol
DB00912 Repaglinide
DB01045 Rifampicin
DB08931 Riociguat
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB06201 Rufinamide
DB00936 Salicylic acid
DB01232 Saquinavir
DB01236 Sevoflurane
DB06290 Simeprevir
DB00815 Sodium lauryl sulfate
DB03193 Stearic acid
DB00364 Sucralfate
DB01581 Sulfamerazine
DB01582 Sulfamethazine
DB00576 Sulfamethizole
DB01015 Sulfamethoxazole
DB00605 Sulindac
DB00864 Tacrolimus
DB05521 Telaprevir
DB00624 Testosterone
DB00759 Tetracycline
DB01622 Thioproperazine
DB01623 Thiothixene
DB01056 Tocainide
DB08895 Tofacitinib
DB08867 Ulipristal
DB00177 Valsartan
DB00512 Vancomycin
DB05294 Vandetanib
DB08881 Vemurafenib
DB08828 Vismodegib
DB00682 Warfarin
DB00137 Xanthophyll
DB00495 Zidovudine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ALB

Domain mapping of disease mutations (DMDM)

More...DMDMi		113576

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Add BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000106719 – 246
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000106825 – 609Serum albuminAdd BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29Phosphoserine; by FAM20C1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi36N-linked (Glc) (glycation) lysine1 Publication1
Glycosylationi75N-linked (Glc) (glycation) lysine; in vitro1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi77 ↔ 86PROSITE-ProRule annotation1 Publication
Modified residuei82Phosphoserine; by FAM20CCombined sources1 Publication1
Modified residuei89Phosphoserine; by FAM20CCombined sources1 Publication1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation1 Publication
Modified residuei107Phosphothreonine; by FAM20C1 Publication1
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation1 Publication
Disulfide bondi148 ↔ 193PROSITE-ProRule annotation1 Publication
Glycosylationi161N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi186N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation1 Publication
Glycosylationi223N-linked (Glc) (glycation) lysine; in vitro2 Publications1
Disulfide bondi224 ↔ 270PROSITE-ProRule annotation1 Publication
Modified residuei229N6-succinyllysineBy similarity1
Glycosylationi249N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi257N-linked (Glc) (glycation) lysine2 Publications1
Disulfide bondi269 ↔ 277PROSITE-ProRule annotation1 Publication
Disulfide bondi289 ↔ 303PROSITE-ProRule annotation1 Publication
Modified residuei297PhosphoserineBy similarity1
Glycosylationi300N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi302 ↔ 313PROSITE-ProRule annotation1 Publication
Glycosylationi305N-linked (Glc) (glycation) lysine1 Publication1
Glycosylationi337N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi340 ↔ 385PROSITE-ProRule annotation1 Publication
Glycosylationi341N-linked (Glc) (glycation) lysine1 Publication1
GlycosylationiCAR_000226342N-linked (GlcNAc...) asparagine; in variant Redhill1
Glycosylationi347N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi375N-linked (Glc) (glycation) lysine2 Publications1
Disulfide bondi384 ↔ 393PROSITE-ProRule annotation1 Publication
Glycosylationi402N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi416 ↔ 462PROSITE-ProRule annotation1 Publication
Glycosylationi437N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Modified residuei443PhosphoserineCombined sources1
Modified residuei444PhosphothreonineCombined sources1
Modified residuei446PhosphothreonineCombined sources1
Modified residuei460N6-succinyllysineBy similarity1
Disulfide bondi461 ↔ 472PROSITE-ProRule annotation1 Publication
Glycosylationi463N-linked (Glc) (glycation) lysine1 Publication1
Glycosylationi468N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi485 ↔ 501PROSITE-ProRule annotation1 Publication
Disulfide bondi500 ↔ 511PROSITE-ProRule annotation1 Publication
Modified residuei513PhosphoserineCombined sources1
GlycosylationiCAR_000069518N-linked (GlcNAc...) asparagine; in variant Casebrook1
Disulfide bondi538 ↔ 583PROSITE-ProRule annotation1 Publication
Modified residuei543N6-succinyllysineBy similarity1
Glycosylationi549N-linked (Glc) (glycation) lysine4 Publications1
Modified residuei558N6-methyllysine; alternateCombined sources1
Glycosylationi558N-linked (Glc) (glycation) lysine; alternate1 Publication1
Glycosylationi560N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi569N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi582 ↔ 591PROSITE-ProRule annotation1 Publication
Modified residuei588N6-succinyllysineBy similarity1
Glycosylationi597N-linked (Glc) (glycation) lysine; in vitro1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.
Glycated in diabetic patients.
Phosphorylated by FAM20C in the extracellular medium.1 Publication
Acetylated on Lys-223 by acetylsalicylic acid.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei28Not glycated1 Publication1
Sitei44Not glycated1 Publication1
Sitei65Not glycated1 Publication1
Sitei88Not glycated1 Publication1
Sitei97Not glycated1 Publication1
Sitei117Not glycated1 Publication1
Sitei130Not glycated1 Publication1
Sitei160Not glycated1 Publication1
Sitei183Not glycated1 Publication1
Sitei198Not glycated1 Publication1
Sitei205Not glycated1 Publication1
Sitei214Not glycated1 Publication1
Sitei219Not glycated1 Publication1
Sitei229Not glycated1 Publication1
Sitei236Not glycated1 Publication1
Sitei264Not glycated1 Publication1
Sitei286Not glycated1 Publication1
Sitei298Not glycated1 Publication1
Sitei310Not glycated1 Publication1
Sitei383Not glycated1 Publication1
Sitei396Not glycated1 Publication1
Sitei413Not glycated1 Publication1
Sitei426Not glycated1 Publication1
Sitei438Not glycated1 Publication1
Sitei456Not glycated1 Publication1
Sitei460Not glycated1 Publication1
Sitei490Not glycated1 Publication1
Sitei499Not glycated1 Publication1
Sitei524Not glycated1 Publication1
Sitei543Not glycated1 Publication1
Sitei548Not glycated1 Publication1
Sitei562Not glycated1 Publication1
Sitei565Not glycated1 Publication1
Sitei581Not glycated1 Publication1
Sitei584Not glycated1 Publication1
Sitei588Not glycated1 Publication1
Sitei598Not glycated1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycation, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P02768

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02768

PeptideAtlas

More...PeptideAtlasi		P02768

PRoteomics IDEntifications database

More...PRIDEi		P02768

ProteomicsDB human proteome resource

More...ProteomicsDBi		12606 [P02768-2]
51587
51588 [P02768-2]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P02768

USC-OGP 2-DE database

More...OGPi		P02768

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00384697
IPI00745872
P02768

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P02768

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P02768

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P02768

GlyConnect protein glycosylation platform

More...GlyConnecti		559

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P02768

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P02768

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P02768

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P02768

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		P02768

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163631 Expressed in 114 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P02768 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P02768 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB006262
HPA031024
HPA031025

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		106715, 191 interactors

Database of interacting proteins

More...DIPi		DIP-29902N

Protein interaction database and analysis system

More...IntActi		P02768, 176 interactors

Molecular INTeraction database

More...MINTi		P02768

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295897

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P02768

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1609
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AO6X-ray2.50A/B25-609[»]
1BJ5X-ray2.50A25-609[»]
1BKEX-ray3.15A28-608[»]
1BM0X-ray2.50A/B25-609[»]
1E78X-ray2.60A/B25-609[»]
1E7AX-ray2.20A/B25-609[»]
1E7BX-ray2.38A/B25-609[»]
1E7CX-ray2.40A25-609[»]
1E7EX-ray2.50A25-609[»]
1E7FX-ray2.43A25-609[»]
1E7GX-ray2.50A25-609[»]
1E7HX-ray2.43A25-609[»]
1E7IX-ray2.70A25-609[»]
1GNIX-ray2.40A25-609[»]
1GNJX-ray2.60A25-609[»]
1H9ZX-ray2.50A25-609[»]
1HA2X-ray2.50A25-609[»]
1HK1X-ray2.65A25-609[»]
1HK2X-ray2.80A25-609[»]
1HK3X-ray2.80A25-609[»]
1HK4X-ray2.40A25-609[»]
1HK5X-ray2.70A25-609[»]
1N5UX-ray1.90A25-609[»]
1O9XX-ray3.20A25-609[»]
1TF0X-ray2.70A25-596[»]
1UORX-ray2.80A25-609[»]
1YSXNMR-A409-609[»]
2BX8X-ray2.70A/B25-609[»]
2BXAX-ray2.35A/B25-609[»]
2BXBX-ray3.20A/B25-609[»]
2BXCX-ray3.10A/B25-609[»]
2BXDX-ray3.05A/B25-609[»]
2BXEX-ray2.95A/B25-609[»]
2BXFX-ray2.95A/B25-609[»]
2BXGX-ray2.70A/B25-609[»]
2BXHX-ray2.25A/B25-609[»]
2BXIX-ray2.50A25-609[»]
2BXKX-ray2.40A25-609[»]
2BXLX-ray2.60A25-609[»]
2BXMX-ray2.50A25-609[»]
2BXNX-ray2.65A25-609[»]
2BXOX-ray2.60A25-609[»]
2BXPX-ray2.30A25-609[»]
2BXQX-ray2.60A25-609[»]
2ESGX-ray-C25-609[»]
2I2ZX-ray2.70A25-609[»]
2I30X-ray2.90A25-609[»]
2N0XNMR-A432-447[»]
2VDBX-ray2.52A30-608[»]
2VUEX-ray2.42A/B25-609[»]
2VUFX-ray3.05A/B25-609[»]
2XSIX-ray2.70A25-609[»]
2XVQX-ray2.90A/B25-609[»]
2XVUX-ray2.60A/B25-609[»]
2XVVX-ray2.40A25-609[»]
2XVWX-ray2.65A25-609[»]
2XW0X-ray2.40A/B25-609[»]
2XW1X-ray2.50A/B25-609[»]
2YDFX-ray2.75A/B25-609[»]
3A73X-ray2.19A/B25-609[»]
3B9LX-ray2.60A25-609[»]
3B9MX-ray2.70A25-609[»]
3CX9X-ray2.80A27-608[»]
3JQZX-ray3.30A/B25-609[»]
3JRYX-ray2.30A/B25-609[»]
3LU6X-ray2.70A/B25-609[»]
3LU7X-ray2.80A/B25-609[»]
3LU8X-ray2.60A/B25-609[»]
3SQJX-ray2.05A/B27-608[»]
3TDLX-ray2.60A25-609[»]
3UIVX-ray2.20A/H25-609[»]
4BKEX-ray2.35A1-609[»]
4E99X-ray2.30A25-609[»]
4EMXX-ray2.30A/B25-609[»]
4G03X-ray2.22A/B25-609[»]
4G04X-ray2.30A/B25-609[»]
4HGKX-ray3.04A/B25-609[»]
4HGMX-ray2.34B25-609[»]
4IW1X-ray2.56A25-609[»]
4IW2X-ray2.41A25-609[»]
4K2CX-ray3.23A/B25-609[»]
4K71X-ray2.40A/D25-609[»]
4L8UX-ray2.01A25-609[»]
4L9KX-ray2.40A/B25-609[»]
4L9QX-ray2.70A/B25-609[»]
4LA0X-ray2.40A/B25-609[»]
4LB2X-ray2.80A/B25-609[»]
4LB9X-ray2.70A25-609[»]
4N0FX-ray3.02D/G/J/M25-609[»]
4N0UX-ray3.80D27-609[»]
4S1YX-ray3.16A25-609[»]
4Z69X-ray2.19A/I25-609[»]
5FUOX-ray3.60A25-609[»]
5GIXX-ray2.80A/B27-607[»]
5GIYX-ray2.54A27-607[»]
5ID7X-ray2.26A/B25-609[»]
5IFOX-ray3.20A25-609[»]
5IJFX-ray2.65A25-609[»]
5UJBX-ray2.70A/B1-609[»]
5VNWX-ray2.60A/B25-609[»]
5X52X-ray3.00A/B25-609[»]
5YB1X-ray2.62A/B27-607[»]
5YOQX-ray2.65A/B25-609[»]
6A7PX-ray2.28A/B25-609[»]
6EZQX-ray2.39A25-609[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P02768

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P02768

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P02768

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 210Albumin 1PROSITE-ProRule annotationAdd BLAST192
Domaini211 – 403Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini404 – 601Albumin 3PROSITE-ProRule annotationAdd BLAST198

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IIRZ Eukaryota
ENOG410Z40H LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000113

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000293137

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG004207

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02768

KEGG Orthology (KO)

More...KOi		K16141

Identification of Orthologs from Complete Genome Data

More...OMAi		HKECCHG

Database of Orthologous Groups

More...OrthoDBi		1377476at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P02768

TreeFam database of animal gene trees

More...TreeFami		TF335561

Family and domain databases

Conserved Domains Database

More...CDDi		cd00015 ALBUMIN, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N

The PANTHER Classification System

More...PANTHERi		PTHR11385 PTHR11385, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00273 Serum_albumin, 3 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002520 Serum_albumin_subgroup, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00802 SERUMALBUMIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00103 ALBUMIN, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48552 SSF48552, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P02768-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA 
        60         70         80         90        100
FAQYLQQCPF EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT 
       110        120        130        140        150
VATLRETYGE MADCCAKQEP ERNECFLQHK DDNPNLPRLV RPEVDVMCTA 
       160        170        180        190        200
FHDNEETFLK KYLYEIARRH PYFYAPELLF FAKRYKAAFT ECCQAADKAA 
       210        220        230        240        250
CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV ARLSQRFPKA 
       260        270        280        290        300
EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK 
       310        320        330        340        350
ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF 
       360        370        380        390        400
LGMFLYEYAR RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE 
       410        420        430        440        450
FKPLVEEPQN LIKQNCELFE QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV 
       460        470        480        490        500
SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV LNQLCVLHEK TPVSDRVTKC 
       510        520        530        540        550
CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL SEKERQIKKQ 
       560        570        580        590        600
TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV 

AASQAALGL
Length:609
Mass (Da):69,367
Last modified:April 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF88FF61DD242E818
GO
Isoform 2 (identifier: P02768-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-234: Missing.

Show »
Length:417
Mass (Da):47,360
Checksum:i16E764833EEF4E8D
GO
Isoform 3 (identifier: P02768-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-376: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):45,160
Checksum:i756519C096463A9B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGB6A0A0C4DGB6_HUMAN
Serum albumin
ALB
604Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7WNR0B7WNR0_HUMAN
Serum albumin
ALB
494Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKR2C9JKR2_HUMAN
Albumin, isoform CRA_k
ALB hCG_14967
417Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWT3A0A087WWT3_HUMAN
Serum albumin
ALB
396Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHD5D6RHD5_HUMAN
Serum albumin
ALB
459Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA55H0YA55_HUMAN
Serum albumin
ALB
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C013H7C013_HUMAN
Serum albumin
ALB
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCE7D6RCE7_HUMAN
Serum albumin
ALB
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF22034 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF69644 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAG35503 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55L → P in CAH18185 (PubMed:17974005).Curated1
Sequence conflicti122R → S in AAF01333 (Ref. 4) Curated1
Sequence conflicti155E → Q AA sequence (PubMed:1225573).Curated1
Sequence conflicti174Y → L AA sequence (PubMed:3087352).Curated1
Sequence conflicti174Y → L AA sequence (PubMed:2437111).Curated1
Sequence conflicti194Q → E AA sequence (PubMed:1225573).Curated1
Sequence conflicti327 – 332PSLAAD → MFVLLC in AAF71067 (PubMed:11483580).Curated6
Sequence conflicti405V → A in AAF71067 (PubMed:11483580).Curated1
Sequence conflicti409Q → E in AAH14308 (PubMed:15489334).Curated1
Sequence conflicti441Q → E in CAA23753 (PubMed:6275391).Curated1
Sequence conflicti466E → G in AAF01333 (Ref. 4) Curated1
Sequence conflicti488 – 489HE → EH AA sequence (PubMed:1225573).Curated2
Sequence conflicti490K → R in CAH18185 (PubMed:17974005).Curated1
Sequence conflicti525E → Q AA sequence (PubMed:1225573).Curated1
Sequence conflicti551T → A in CAH18185 (PubMed:17974005).Curated1
Sequence conflicti560K → R in CAH18185 (PubMed:17974005).Curated1
Sequence conflicti604Q → R in AAN17825 (Ref. 5) Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00049923R → C in Redhill/Malmo-I/Tradate; associated with T-344 in Redhill. 1 PublicationCorresponds to variant dbSNP:rs80008208EnsemblClinVar.1
Natural variantiVAR_00050023R → H in Fukuoka-2/Lille/Taipei/Varese/Komagome-3. 3 PublicationsCorresponds to variant dbSNP:rs72552709EnsemblClinVar.1
Natural variantiVAR_00050124R → L in Jaffna. Corresponds to variant dbSNP:rs74821926EnsemblClinVar.1
Natural variantiVAR_00050224R → P in Takefu/Honolulu-1. 1 PublicationCorresponds to variant dbSNP:rs74821926EnsemblClinVar.1
Natural variantiVAR_00050324R → Q in Christchurch/Honolulu-2. 3 PublicationsCorresponds to variant dbSNP:rs74821926EnsemblClinVar.1
Natural variantiVAR_00050425D → V in Bleinheim/Iowa city-2. 1 PublicationCorresponds to variant dbSNP:rs75353611EnsemblClinVar.1
Natural variantiVAR_00050527H → Q in Nagasaki-3. Corresponds to variant dbSNP:rs76285851EnsemblClinVar.1
Natural variantiVAR_00050627H → Y in Larino. 2 PublicationsCorresponds to variant dbSNP:rs141733599EnsemblClinVar.1
Natural variantiVAR_01065773F → Y1 Publication1
Natural variantiVAR_00050784E → K in Torino. 1 PublicationCorresponds to variant dbSNP:rs77050410EnsemblClinVar.1
Natural variantiVAR_00050887D → N in Malmo-95/Dalakarlia. 1 PublicationCorresponds to variant dbSNP:rs78574148EnsemblClinVar.1
Natural variantiVAR_01301190L → P in FDAH. 1 PublicationCorresponds to variant dbSNP:rs77892378EnsemblClinVar.1
Natural variantiVAR_000509106E → K in Vibo Valentia. 1 PublicationCorresponds to variant dbSNP:rs80296402EnsemblClinVar.1
Natural variantiVAR_014290121E → G1 Publication1
Natural variantiVAR_000510138R → G in Yanomama-2. Corresponds to variant dbSNP:rs77238412EnsemblClinVar.1
Natural variantiVAR_000511143E → K in Nagoya. 1 PublicationCorresponds to variant dbSNP:rs75522063EnsemblClinVar.1
Natural variantiVAR_013012146V → E in Tregasio. Corresponds to variant dbSNP:rs77752336EnsemblClinVar.1
Natural variantiVAR_000512152H → R in Komagome-2. 1 PublicationCorresponds to variant dbSNP:rs80095457EnsemblClinVar.1
Natural variantiVAR_000513201C → F in Hawkes bay. 1 PublicationCorresponds to variant dbSNP:rs77656691EnsemblClinVar.1
Natural variantiVAR_014291215A → T. Corresponds to variant dbSNP:rs3210154Ensembl.1
Natural variantiVAR_014292215A → V. Corresponds to variant dbSNP:rs3204504Ensembl.1
Natural variantiVAR_014293220Q → L. Corresponds to variant dbSNP:rs3210163Ensembl.1
Natural variantiVAR_000514242R → H in FDAH. 3 PublicationsCorresponds to variant dbSNP:rs75002628EnsemblClinVar.1
Natural variantiVAR_013013242R → P in FDAH. Corresponds to variant dbSNP:rs75002628EnsemblClinVar.1
Natural variantiVAR_000515249K → Q in Tradate-2. 1 PublicationCorresponds to variant dbSNP:rs79804069EnsemblClinVar.1
Natural variantiVAR_000516264K → E in Herborn. 1 PublicationCorresponds to variant dbSNP:rs79377490EnsemblClinVar.1
Natural variantiVAR_000517292Q → R in Malmo-10. 1 PublicationCorresponds to variant dbSNP:rs80002911EnsemblClinVar.1
Natural variantiVAR_000518293D → G in Nagasaki-1. 1 PublicationCorresponds to variant dbSNP:rs79744198EnsemblClinVar.1
Natural variantiVAR_000519300K → N in Caserta. 1 PublicationCorresponds to variant dbSNP:rs74718349EnsemblClinVar.1
Natural variantiVAR_000520337K → N in Canterbury/New Guinea/Tagliacozzo/Cuneo/Cooperstown. 3 PublicationsCorresponds to variant dbSNP:rs72552710EnsemblClinVar.1
Natural variantiVAR_013014338D → G in Bergamo. Corresponds to variant dbSNP:rs76242087EnsemblClinVar.1
Natural variantiVAR_013015338D → V in Brest. Corresponds to variant dbSNP:rs76242087EnsemblClinVar.1
Natural variantiVAR_000521342N → K in Malmo-47. 1 PublicationCorresponds to variant dbSNP:rs77544362EnsemblClinVar.1
Natural variantiVAR_000522344A → T in Redhill; associated with C-23. Corresponds to variant dbSNP:rs78953271EnsemblClinVar.1
Natural variantiVAR_000523345E → K in Roma. Corresponds to variant dbSNP:rs72552711EnsemblClinVar.1
Natural variantiVAR_000524357E → K in Sondrio. 1 PublicationCorresponds to variant dbSNP:rs77354753EnsemblClinVar.1
Natural variantiVAR_000525378E → K in Hiroshima-1. 2 PublicationsCorresponds to variant dbSNP:rs76593094EnsemblClinVar.1
Natural variantiVAR_000526382E → K in Coari I/Porto Alegre. Corresponds to variant dbSNP:rs75791663EnsemblClinVar.1
Natural variantiVAR_013016383K → N in Trieste. Corresponds to variant dbSNP:rs75069738Ensembl.1
Natural variantiVAR_000527389D → H in Parklands. Corresponds to variant dbSNP:rs77187142EnsemblClinVar.1
Natural variantiVAR_000528389D → V in Iowa city-1. 1 PublicationCorresponds to variant dbSNP:rs78538497EnsemblClinVar.1
Natural variantiVAR_000529396K → E in Naskapi/Mersin/Komagome-1. 3 PublicationsCorresponds to variant dbSNP:rs78166690EnsemblClinVar.1
Natural variantiVAR_000530399D → N in Nagasaki-2. 1 PublicationCorresponds to variant dbSNP:rs77514449EnsemblClinVar.1
Natural variantiVAR_000531400E → K in Tochigi. 1 PublicationCorresponds to variant dbSNP:rs79047363EnsemblClinVar.1
Natural variantiVAR_000532400E → Q in Malmo-5. 1 PublicationCorresponds to variant dbSNP:rs79047363EnsemblClinVar.1
Natural variantiVAR_000533406E → K in Hiroshima-2. 1 PublicationCorresponds to variant dbSNP:rs76483862EnsemblClinVar.1
Natural variantiVAR_014294420E → K1 Publication1
Natural variantiVAR_013017434R → C in Liprizzi. Corresponds to variant dbSNP:rs78575701EnsemblClinVar.1
Natural variantiVAR_014295490K → E. Corresponds to variant dbSNP:rs1063469Ensembl.1
Natural variantiVAR_000534503E → K in Dublin. Corresponds to variant dbSNP:rs80259813EnsemblClinVar.1
Natural variantiVAR_000535518D → N in Casebrook. 1 PublicationCorresponds to variant dbSNP:rs75920790EnsemblClinVar.1
Natural variantiVAR_000536525E → K in Manaus-1/Adana/Lambadi/Vancouver. 1 PublicationCorresponds to variant dbSNP:rs75523493EnsemblClinVar.1
Natural variantiVAR_000537529E → K in Ortonovo. 1 PublicationCorresponds to variant dbSNP:rs74826639EnsemblClinVar.1
Natural variantiVAR_013018557V → M in Maddaloni. Corresponds to variant dbSNP:rs78284052EnsemblClinVar.1
Natural variantiVAR_000538560K → E in Castel di Sangro. Corresponds to variant dbSNP:rs77645174EnsemblClinVar.1
Natural variantiVAR_000539565K → E in Maku. 1 PublicationCorresponds to variant dbSNP:rs80345158EnsemblClinVar.1
Natural variantiVAR_000541574D → A in Malmo-61. 1 PublicationCorresponds to variant dbSNP:rs79738788EnsemblClinVar.1
Natural variantiVAR_000540574D → G in Mexico. 1 PublicationCorresponds to variant dbSNP:rs79738788EnsemblClinVar.1
Natural variantiVAR_013019584K → E in Church bay. Corresponds to variant dbSNP:rs76671808EnsemblClinVar.1
Natural variantiVAR_000542587D → N in Fukuoka-1/Paris-2. 2 PublicationsCorresponds to variant dbSNP:rs76587671EnsemblClinVar.1
Natural variantiVAR_000543589E → K in Osaka-1. 1 PublicationCorresponds to variant dbSNP:rs75709682EnsemblClinVar.1
Natural variantiVAR_000544594E → K in Osaka-2/Phnom Phen/albumin B/Verona. 3 PublicationsCorresponds to variant dbSNP:rs79228041EnsemblClinVar.1
Natural variantiVAR_000547596 – 609GKKLV…AALGL → PTMRIRERK in Venezia. Add BLAST14
Natural variantiVAR_000545597K → E in Gent/Milano Fast. Corresponds to variant dbSNP:rs80106970EnsemblClinVar.1
Natural variantiVAR_000546598K → N in Vanves. Corresponds to variant dbSNP:rs75738598EnsemblClinVar.1
Natural variantiVAR_012981599 – 609LVAASQAALGL → TCCCKSSCLRLITSHLKASQ PTMRIRERK in Kenitra. Add BLAST11

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02127543 – 234Missing in isoform 2. 2 PublicationsAdd BLAST192
Alternative sequenceiVSP_057389164 – 376Missing in isoform 3. 1 PublicationAdd BLAST213

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
V00494 mRNA Translation: CAA23753.1
V00495 mRNA Translation: CAA23754.1
M12523 Genomic DNA Translation: AAA98797.1
M12523 Genomic DNA Translation: AAA98798.1
AF190168 mRNA Translation: AAF01333.1
AF542069 mRNA Translation: AAN17825.1
A06977 mRNA Translation: CAA00606.1
AY728024 mRNA Translation: AAU21642.1
DQ986150 mRNA Translation: ABJ16448.1
AY544124 mRNA Translation: AAT11155.1
AY550967 mRNA Translation: AAT52213.1
AF116645 mRNA Translation: AAF71067.1
AF118090 mRNA Translation: AAF22034.1 Different initiation.
AF119840 mRNA Translation: AAF69594.1
AF119890 mRNA Translation: AAF69644.1 Different initiation.
AF130077 mRNA Translation: AAG35503.1 Different initiation.
CR749331 mRNA Translation: CAH18185.1
EF649953 Genomic DNA Translation: ABS29264.1
AC108157 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05676.1
BC014308 mRNA Translation: AAH14308.1
BC034023 mRNA Translation: AAH34023.1
BC035969 mRNA Translation: AAH35969.1
BC036003 mRNA Translation: AAH36003.1
BC041789 mRNA Translation: AAH41789.1
U22961 mRNA Translation: AAA64922.1
AY358313 mRNA Translation: AAQ89947.1
AH002596 Genomic DNA Translation: AAA51688.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3555.1 [P02768-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A93743 ABHUS

NCBI Reference Sequences

More...RefSeqi		NP_000468.1, NM_000477.6 [P02768-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.418167
Hs.592379

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295897; ENSP00000295897; ENSG00000163631 [P02768-1]
ENST00000621085; ENSP00000483421; ENSG00000163631 [P02768-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		213

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:213

UCSC genome browser

More...UCSCi		uc003hgs.5 human [P02768-1]
uc062xfr.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Albumin Website
Wikipedia

Serum albumin entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00494 mRNA Translation: CAA23753.1
V00495 mRNA Translation: CAA23754.1
M12523 Genomic DNA Translation: AAA98797.1
M12523 Genomic DNA Translation: AAA98798.1
AF190168 mRNA Translation: AAF01333.1
AF542069 mRNA Translation: AAN17825.1
A06977 mRNA Translation: CAA00606.1
AY728024 mRNA Translation: AAU21642.1
DQ986150 mRNA Translation: ABJ16448.1
AY544124 mRNA Translation: AAT11155.1
AY550967 mRNA Translation: AAT52213.1
AF116645 mRNA Translation: AAF71067.1
AF118090 mRNA Translation: AAF22034.1 Different initiation.
AF119840 mRNA Translation: AAF69594.1
AF119890 mRNA Translation: AAF69644.1 Different initiation.
AF130077 mRNA Translation: AAG35503.1 Different initiation.
CR749331 mRNA Translation: CAH18185.1
EF649953 Genomic DNA Translation: ABS29264.1
AC108157 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05676.1
BC014308 mRNA Translation: AAH14308.1
BC034023 mRNA Translation: AAH34023.1
BC035969 mRNA Translation: AAH35969.1
BC036003 mRNA Translation: AAH36003.1
BC041789 mRNA Translation: AAH41789.1
U22961 mRNA Translation: AAA64922.1
AY358313 mRNA Translation: AAQ89947.1
AH002596 Genomic DNA Translation: AAA51688.1
CCDSiCCDS3555.1 [P02768-1]
PIRiA93743 ABHUS
RefSeqiNP_000468.1, NM_000477.6 [P02768-1]
UniGeneiHs.418167
Hs.592379

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AO6X-ray2.50A/B25-609[»]
1BJ5X-ray2.50A25-609[»]
1BKEX-ray3.15A28-608[»]
1BM0X-ray2.50A/B25-609[»]
1E78X-ray2.60A/B25-609[»]
1E7AX-ray2.20A/B25-609[»]
1E7BX-ray2.38A/B25-609[»]
1E7CX-ray2.40A25-609[»]
1E7EX-ray2.50A25-609[»]
1E7FX-ray2.43A25-609[»]
1E7GX-ray2.50A25-609[»]
1E7HX-ray2.43A25-609[»]
1E7IX-ray2.70A25-609[»]
1GNIX-ray2.40A25-609[»]
1GNJX-ray2.60A25-609[»]
1H9ZX-ray2.50A25-609[»]
1HA2X-ray2.50A25-609[»]
1HK1X-ray2.65A25-609[»]
1HK2X-ray2.80A25-609[»]
1HK3X-ray2.80A25-609[»]
1HK4X-ray2.40A25-609[»]
1HK5X-ray2.70A25-609[»]
1N5UX-ray1.90A25-609[»]
1O9XX-ray3.20A25-609[»]
1TF0X-ray2.70A25-596[»]
1UORX-ray2.80A25-609[»]
1YSXNMR-A409-609[»]
2BX8X-ray2.70A/B25-609[»]
2BXAX-ray2.35A/B25-609[»]
2BXBX-ray3.20A/B25-609[»]
2BXCX-ray3.10A/B25-609[»]
2BXDX-ray3.05A/B25-609[»]
2BXEX-ray2.95A/B25-609[»]
2BXFX-ray2.95A/B25-609[»]
2BXGX-ray2.70A/B25-609[»]
2BXHX-ray2.25A/B25-609[»]
2BXIX-ray2.50A25-609[»]
2BXKX-ray2.40A25-609[»]
2BXLX-ray2.60A25-609[»]
2BXMX-ray2.50A25-609[»]
2BXNX-ray2.65A25-609[»]
2BXOX-ray2.60A25-609[»]
2BXPX-ray2.30A25-609[»]
2BXQX-ray2.60A25-609[»]
2ESGX-ray-C25-609[»]
2I2ZX-ray2.70A25-609[»]
2I30X-ray2.90A25-609[»]
2N0XNMR-A432-447[»]
2VDBX-ray2.52A30-608[»]
2VUEX-ray2.42A/B25-609[»]
2VUFX-ray3.05A/B25-609[»]
2XSIX-ray2.70A25-609[»]
2XVQX-ray2.90A/B25-609[»]
2XVUX-ray2.60A/B25-609[»]
2XVVX-ray2.40A25-609[»]
2XVWX-ray2.65A25-609[»]
2XW0X-ray2.40A/B25-609[»]
2XW1X-ray2.50A/B25-609[»]
2YDFX-ray2.75A/B25-609[»]
3A73X-ray2.19A/B25-609[»]
3B9LX-ray2.60A25-609[»]
3B9MX-ray2.70A25-609[»]
3CX9X-ray2.80A27-608[»]
3JQZX-ray3.30A/B25-609[»]
3JRYX-ray2.30A/B25-609[»]
3LU6X-ray2.70A/B25-609[»]
3LU7X-ray2.80A/B25-609[»]
3LU8X-ray2.60A/B25-609[»]
3SQJX-ray2.05A/B27-608[»]
3TDLX-ray2.60A25-609[»]
3UIVX-ray2.20A/H25-609[»]
4BKEX-ray2.35A1-609[»]
4E99X-ray2.30A25-609[»]
4EMXX-ray2.30A/B25-609[»]
4G03X-ray2.22A/B25-609[»]
4G04X-ray2.30A/B25-609[»]
4HGKX-ray3.04A/B25-609[»]
4HGMX-ray2.34B25-609[»]
4IW1X-ray2.56A25-609[»]
4IW2X-ray2.41A25-609[»]
4K2CX-ray3.23A/B25-609[»]
4K71X-ray2.40A/D25-609[»]
4L8UX-ray2.01A25-609[»]
4L9KX-ray2.40A/B25-609[»]
4L9QX-ray2.70A/B25-609[»]
4LA0X-ray2.40A/B25-609[»]
4LB2X-ray2.80A/B25-609[»]
4LB9X-ray2.70A25-609[»]
4N0FX-ray3.02D/G/J/M25-609[»]
4N0UX-ray3.80D27-609[»]
4S1YX-ray3.16A25-609[»]
4Z69X-ray2.19A/I25-609[»]
5FUOX-ray3.60A25-609[»]
5GIXX-ray2.80A/B27-607[»]
5GIYX-ray2.54A27-607[»]
5ID7X-ray2.26A/B25-609[»]
5IFOX-ray3.20A25-609[»]
5IJFX-ray2.65A25-609[»]
5UJBX-ray2.70A/B1-609[»]
5VNWX-ray2.60A/B25-609[»]
5X52X-ray3.00A/B25-609[»]
5YB1X-ray2.62A/B27-607[»]
5YOQX-ray2.65A/B25-609[»]
6A7PX-ray2.28A/B25-609[»]
6EZQX-ray2.39A25-609[»]
ProteinModelPortaliP02768
SMRiP02768
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106715, 191 interactors
DIPiDIP-29902N
IntActiP02768, 176 interactors
MINTiP02768
STRINGi9606.ENSP00000295897

Chemistry databases

BindingDBiP02768
ChEMBLiCHEMBL3253
DrugBankiDB07517 3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONIC
DB07992 3-SULFOOXY-1H-INDOLE
DB05812 Abiraterone
DB01418 Acenocoumarol
DB01614 Acepromazine
DB00945 Acetylsalicylic acid
DB00459 Acitretin
DB00802 Alfentanil
DB00321 Amitriptyline
DB00415 Ampicillin
DB04557 Arachidonic Acid
DB00995 Auranofin
DB07402 Azapropazone
DB01294 Bismuth Subsalicylate
DB08907 Canagliflozin
DB01197 Captopril
DB00456 Cefalotin
DB01327 Cefazolin
DB00274 Cefmetazole
DB01328 Cefonicid
DB01329 Cefoperazone
DB00493 Cefotaxime
DB01330 Cefotetan
DB00430 Cefpiramide
DB01212 Ceftriaxone
DB00482 Celecoxib
DB00567 Cephalexin
DB00477 Chlorpromazine
DB01242 Clomipramine
DB01068 Clonazepam
DB01147 Cloxacillin
DB03600 Decanoic Acid
DB01189 Desflurane
DB00829 Diazepam
DB00586 Diclofenac
DB00861 Diflunisal
DB01396 Digitoxin
DB04855 Dronedarone
DB00228 Enflurane
DB08899 Enzalutamide
DB00530 Erlotinib
DB00199 Erythromycin
DB00783 Estradiol
DB00655 Estrone
DB04574 Estrone sulfate
DB00903 Etacrynic acid
DB00749 Etodolac
DB00573 Fenoprofen
DB00544 Fluorouracil
DB00472 Fluoxetine
DB00712 Flurbiprofen
DB01320 Fosphenytoin
DB06716 Fospropofol
DB00695 Furosemide
DB00743 Gadobenic acid
DB06705 Gadofosveset trisodium
DB01044 Gatifloxacin
DB00317 Gefitinib
DB01120 Gliclazide
DB01016 Glyburide
DB01159 Halothane
DB00070 Hyaluronidase
DB06205 Hyaluronidase (Human Recombinant)
DB01050 Ibuprofen
DB00619 Imatinib
DB00328 Indomethacin
DB01307 Insulin Detemir
DB04711 Iodipamide
DB00762 Irinotecan
DB00753 Isoflurane
DB08820 Ivacaftor
DB01587 Ketazolam
DB01009 Ketoprofen
DB03017 Lauric Acid
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00678 Losartan
DB09280 Lumacaftor
DB08932 Macitentan
DB01397 Magnesium salicylate
DB00931 Methacycline
DB00563 Methotrexate
DB06710 Methyltestosterone
DB08893 Mirabegron
DB00688 Mycophenolate mofetil
DB08231 MYRISTIC ACID
DB01183 Naloxone
DB00788 Naproxen
DB00731 Nateglinide
DB00717 Norethisterone
DB00540 Nortriptyline
DB00334 Olanzapine
DB04224 Oleic Acid
DB00776 Oxcarbazepine
DB06412 Oxymetholone
DB03585 Oxyphenbutazone
DB03796 Palmitic Acid
DB00454 Pethidine
DB00946 Phenprocoumon
DB00252 Phenytoin
DB01621 Pipotiazine
DB00554 Piroxicam
DB08860 Pitavastatin
DB06209 Prasugrel
DB00635 Prednisone
DB01032 Probenecid
DB00818 Propofol
DB00912 Repaglinide
DB01045 Rifampicin
DB08931 Riociguat
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB06201 Rufinamide
DB00936 Salicylic acid
DB01232 Saquinavir
DB01236 Sevoflurane
DB06290 Simeprevir
DB00815 Sodium lauryl sulfate
DB03193 Stearic acid
DB00364 Sucralfate
DB01581 Sulfamerazine
DB01582 Sulfamethazine
DB00576 Sulfamethizole
DB01015 Sulfamethoxazole
DB00605 Sulindac
DB00864 Tacrolimus
DB05521 Telaprevir
DB00624 Testosterone
DB00759 Tetracycline
DB01622 Thioproperazine
DB01623 Thiothixene
DB01056 Tocainide
DB08895 Tofacitinib
DB08867 Ulipristal
DB00177 Valsartan
DB00512 Vancomycin
DB05294 Vandetanib
DB08881 Vemurafenib
DB08828 Vismodegib
DB00682 Warfarin
DB00137 Xanthophyll
DB00495 Zidovudine

Protein family/group databases

Allergomei763 Hom s HSA

PTM databases

CarbonylDBiP02768
GlyConnecti559
iPTMnetiP02768
PhosphoSitePlusiP02768
SwissPalmiP02768
UniCarbKBiP02768

Polymorphism and mutation databases

BioMutaiALB
DMDMi113576

2D gel databases

DOSAC-COBS-2DPAGEiP02768
OGPiP02768
REPRODUCTION-2DPAGEiIPI00384697
IPI00745872
P02768
SWISS-2DPAGEiP02768
UCD-2DPAGEiP02768

Proteomic databases

jPOSTiP02768
PaxDbiP02768
PeptideAtlasiP02768
PRIDEiP02768
ProteomicsDBi12606 [P02768-2]
51587
51588 [P02768-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		213
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295897; ENSP00000295897; ENSG00000163631 [P02768-1]
ENST00000621085; ENSP00000483421; ENSG00000163631 [P02768-3]
GeneIDi213
KEGGihsa:213
UCSCiuc003hgs.5 human [P02768-1]
uc062xfr.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		213
DisGeNETi213
EuPathDBiHostDB:ENSG00000163631.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		ALB
HGNCiHGNC:399 ALB
HPAiCAB006262
HPA031024
HPA031025
MalaCardsiALB
MIMi103600 gene
615999 phenotype
616000 phenotype
neXtProtiNX_P02768
OpenTargetsiENSG00000163631
Orphaneti86816 Congenital analbuminemia
276271 NON RARE IN EUROPE: Familial dysalbuminemic hyperthyroxinemia
PharmGKBiPA24690

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
GeneTreeiENSGT00390000000113
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP02768
KOiK16141
OMAiHKECCHG
OrthoDBi1377476at2759
PhylomeDBiP02768
TreeFamiTF335561

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-159418 Recycling of bile acids and salts
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518 Transport of organic anions
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8964058 HDL remodeling
SIGNORiP02768

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ALB human
EvolutionaryTraceiP02768

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Serum_albumin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		213
PMAP-CutDBiP02768

Protein Ontology

More...PROi		PR:P02768

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163631 Expressed in 114 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP02768 baseline and differential
GenevisibleiP02768 HS

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALBU_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02768
Secondary accession number(s): E7ESS9
, O95574, P04277, Q13140, Q645G4, Q68DN5, Q6UXK4, Q86YG0, Q8IUK7, Q9P157, Q9P1I7, Q9UHS3, Q9UJZ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1990
Last modified: January 16, 2019
This is version 256 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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