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Protein

Serum albumin

Gene

ALB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.1 Publication

Caution

A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed neurotensin-related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and blood flow.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27CopperBy similarity1
Metal bindingi91Zinc1
Metal bindingi123Zinc1
Sitei223Aspirin-acetylated lysine1
Binding sitei264Bilirubin1
Metal bindingi271Zinc1
Metal bindingi273Zinc1

GO - Molecular functioni

  • antioxidant activity Source: UniProtKB
  • chaperone binding Source: BHF-UCL
  • copper ion binding Source: UniProtKB
  • DNA binding Source: UniProtKB
  • drug binding Source: UniProtKB
  • fatty acid binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • pyridoxal phosphate binding Source: UniProtKB
  • toxic substance binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCopper, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-159418 Recycling of bile acids and salts
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518 Transport of organic anions
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8964058 HDL remodeling
SIGNORiP02768

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:ALB
ORF Names:GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163631.16
HGNCiHGNC:399 ALB
MIMi103600 gene
neXtProtiNX_P02768

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hyperthyroxinemia, familial dysalbuminemic (FDAH)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity.
See also OMIM:615999
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01301190L → P in FDAH. 1 PublicationCorresponds to variant dbSNP:rs77892378EnsemblClinVar.1
Natural variantiVAR_000514242R → H in FDAH. 3 PublicationsCorresponds to variant dbSNP:rs75002628EnsemblClinVar.1
Natural variantiVAR_013013242R → P in FDAH. Corresponds to variant dbSNP:rs75002628EnsemblClinVar.1
Analbuminemia (ANALBA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. Affected individuals manifest mild edema, hypotension, fatigue, and, occasionally, lower body lipodystrophy (mainly in adult females). The most common biochemical finding is hyperlipidemia, with a significant increase in the total and LDL cholesterol concentrations, but normal concentrations of HDL cholesterol and triglycerides.
See also OMIM:616000

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi213
MalaCardsiALB
MIMi615999 phenotype
616000 phenotype
OpenTargetsiENSG00000163631
Orphaneti86816 Congenital analbuminemia
276271 NON RARE IN EUROPE: Familial dysalbuminemic hyperthyroxinemia
PharmGKBiPA24690

Protein family/group databases

Allergomei763 Hom s HSA

Chemistry databases

ChEMBLiCHEMBL3253
DrugBankiDB07517 3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONIC
DB07992 3-SULFOOXY-1H-INDOLE
DB05812 Abiraterone
DB01418 Acenocoumarol
DB01614 Acepromazine
DB00945 Acetylsalicylic acid
DB00459 Acitretin
DB00802 Alfentanil
DB00321 Amitriptyline
DB00415 Ampicillin
DB04557 Arachidonic Acid
DB00995 Auranofin
DB07402 Azapropazone
DB01294 Bismuth Subsalicylate
DB08907 Canagliflozin
DB01197 Captopril
DB00456 Cefalotin
DB01327 Cefazolin
DB00274 Cefmetazole
DB01328 Cefonicid
DB01329 Cefoperazone
DB00493 Cefotaxime
DB01330 Cefotetan
DB00430 Cefpiramide
DB01212 Ceftriaxone
DB00482 Celecoxib
DB00567 Cephalexin
DB00477 Chlorpromazine
DB01242 Clomipramine
DB01068 Clonazepam
DB01147 Cloxacillin
DB03600 Decanoic Acid
DB01189 Desflurane
DB00829 Diazepam
DB00586 Diclofenac
DB00861 Diflunisal
DB01396 Digitoxin
DB04855 Dronedarone
DB00228 Enflurane
DB08899 Enzalutamide
DB00530 Erlotinib
DB00199 Erythromycin
DB00783 Estradiol
DB00655 Estrone
DB04574 Estrone sulfate
DB00903 Etacrynic acid
DB00749 Etodolac
DB00573 Fenoprofen
DB00544 Fluorouracil
DB00472 Fluoxetine
DB00712 Flurbiprofen
DB01320 Fosphenytoin
DB06716 Fospropofol
DB00695 Furosemide
DB00743 Gadobenic acid
DB06705 Gadofosveset trisodium
DB01044 Gatifloxacin
DB00317 Gefitinib
DB01120 Gliclazide
DB01016 Glyburide
DB01159 Halothane
DB00070 Hyaluronidase
DB06205 Hyaluronidase (Human Recombinant)
DB01050 Ibuprofen
DB00619 Imatinib
DB00328 Indomethacin
DB01307 Insulin Detemir
DB04711 Iodipamide
DB00762 Irinotecan
DB00753 Isoflurane
DB08820 Ivacaftor
DB01587 Ketazolam
DB01009 Ketoprofen
DB03017 Lauric Acid
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00678 Losartan
DB09280 Lumacaftor
DB08932 Macitentan
DB01397 Magnesium salicylate
DB00931 Methacycline
DB00563 Methotrexate
DB06710 Methyltestosterone
DB08893 Mirabegron
DB00688 Mycophenolate mofetil
DB08231 MYRISTIC ACID
DB01183 Naloxone
DB00788 Naproxen
DB00731 Nateglinide
DB00717 Norethisterone
DB00540 Nortriptyline
DB00334 Olanzapine
DB04224 Oleic Acid
DB00776 Oxcarbazepine
DB06412 Oxymetholone
DB03585 Oxyphenbutazone
DB03796 Palmitic Acid
DB00454 Pethidine
DB00946 Phenprocoumon
DB00252 Phenytoin
DB01621 Pipotiazine
DB00554 Piroxicam
DB08860 Pitavastatin
DB06209 Prasugrel
DB00635 Prednisone
DB01032 Probenecid
DB00818 Propofol
DB00912 Repaglinide
DB01045 Rifampicin
DB08931 Riociguat
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB06201 Rufinamide
DB00936 Salicylic acid
DB01232 Saquinavir
DB01236 Sevoflurane
DB06290 Simeprevir
DB00815 Sodium lauryl sulfate
DB03193 Stearic acid
DB00364 Sucralfate
DB01581 Sulfamerazine
DB01582 Sulfamethazine
DB00576 Sulfamethizole
DB01015 Sulfamethoxazole
DB00605 Sulindac
DB00864 Tacrolimus
DB05521 Telaprevir
DB00624 Testosterone
DB00759 Tetracycline
DB01622 Thioproperazine
DB01623 Thiothixene
DB01056 Tocainide
DB08895 Tofacitinib
DB08867 Ulipristal
DB00177 Valsartan
DB00512 Vancomycin
DB05294 Vandetanib
DB08881 Vemurafenib
DB08828 Vismodegib
DB00682 Warfarin
DB00137 Xanthophyll
DB00495 Zidovudine

Polymorphism and mutation databases

BioMutaiALB
DMDMi113576

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
PropeptideiPRO_000000106719 – 246
ChainiPRO_000000106825 – 609Serum albuminAdd BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29Phosphoserine; by FAM20C1 Publication1
Glycosylationi36N-linked (Glc) (glycation) lysine1 Publication1
Glycosylationi75N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation1 Publication
Modified residuei82Phosphoserine; by FAM20CCombined sources1 Publication1
Modified residuei89Phosphoserine; by FAM20CCombined sources1 Publication1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation1 Publication
Modified residuei107Phosphothreonine; by FAM20C1 Publication1
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation1 Publication
Disulfide bondi148 ↔ 193PROSITE-ProRule annotation1 Publication
Glycosylationi161N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi186N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation1 Publication
Glycosylationi223N-linked (Glc) (glycation) lysine; in vitro2 Publications1
Disulfide bondi224 ↔ 270PROSITE-ProRule annotation1 Publication
Modified residuei229N6-succinyllysineBy similarity1
Glycosylationi249N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi257N-linked (Glc) (glycation) lysine2 Publications1
Disulfide bondi269 ↔ 277PROSITE-ProRule annotation1 Publication
Disulfide bondi289 ↔ 303PROSITE-ProRule annotation1 Publication
Modified residuei297PhosphoserineBy similarity1
Glycosylationi300N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi302 ↔ 313PROSITE-ProRule annotation1 Publication
Glycosylationi305N-linked (Glc) (glycation) lysine1 Publication1
Glycosylationi337N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi340 ↔ 385PROSITE-ProRule annotation1 Publication
Glycosylationi341N-linked (Glc) (glycation) lysine1 Publication1
GlycosylationiCAR_000226342N-linked (GlcNAc...) asparagine; in variant Redhill1
Glycosylationi347N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi375N-linked (Glc) (glycation) lysine2 Publications1
Disulfide bondi384 ↔ 393PROSITE-ProRule annotation1 Publication
Glycosylationi402N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi416 ↔ 462PROSITE-ProRule annotation1 Publication
Glycosylationi437N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Modified residuei443PhosphoserineCombined sources1
Modified residuei444PhosphothreonineCombined sources1
Modified residuei446PhosphothreonineCombined sources1
Modified residuei460N6-succinyllysineBy similarity1
Disulfide bondi461 ↔ 472PROSITE-ProRule annotation1 Publication
Glycosylationi463N-linked (Glc) (glycation) lysine1 Publication1
Glycosylationi468N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi485 ↔ 501PROSITE-ProRule annotation1 Publication
Disulfide bondi500 ↔ 511PROSITE-ProRule annotation1 Publication
Modified residuei513PhosphoserineCombined sources1
GlycosylationiCAR_000069518N-linked (GlcNAc...) asparagine; in variant Casebrook1
Disulfide bondi538 ↔ 583PROSITE-ProRule annotation1 Publication
Modified residuei543N6-succinyllysineBy similarity1
Glycosylationi549N-linked (Glc) (glycation) lysine4 Publications1
Modified residuei558N6-methyllysine; alternateCombined sources1
Glycosylationi558N-linked (Glc) (glycation) lysine; alternate1 Publication1
Glycosylationi560N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi569N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Disulfide bondi582 ↔ 591PROSITE-ProRule annotation1 Publication
Modified residuei588N6-succinyllysineBy similarity1
Glycosylationi597N-linked (Glc) (glycation) lysine; in vitro1 Publication1

Post-translational modificationi

Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.
Glycated in diabetic patients.
Phosphorylated by FAM20C in the extracellular medium.1 Publication
Acetylated on Lys-223 by acetylsalicylic acid.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei28Not glycated1 Publication1
Sitei44Not glycated1 Publication1
Sitei65Not glycated1 Publication1
Sitei88Not glycated1 Publication1
Sitei97Not glycated1 Publication1
Sitei117Not glycated1 Publication1
Sitei130Not glycated1 Publication1
Sitei160Not glycated1 Publication1
Sitei183Not glycated1 Publication1
Sitei198Not glycated1 Publication1
Sitei205Not glycated1 Publication1
Sitei214Not glycated1 Publication1
Sitei219Not glycated1 Publication1
Sitei229Not glycated1 Publication1
Sitei236Not glycated1 Publication1
Sitei264Not glycated1 Publication1
Sitei286Not glycated1 Publication1
Sitei298Not glycated1 Publication1
Sitei310Not glycated1 Publication1
Sitei383Not glycated1 Publication1
Sitei396Not glycated1 Publication1
Sitei413Not glycated1 Publication1
Sitei426Not glycated1 Publication1
Sitei438Not glycated1 Publication1
Sitei456Not glycated1 Publication1
Sitei460Not glycated1 Publication1
Sitei490Not glycated1 Publication1
Sitei499Not glycated1 Publication1
Sitei524Not glycated1 Publication1
Sitei543Not glycated1 Publication1
Sitei548Not glycated1 Publication1
Sitei562Not glycated1 Publication1
Sitei565Not glycated1 Publication1
Sitei581Not glycated1 Publication1
Sitei584Not glycated1 Publication1
Sitei588Not glycated1 Publication1
Sitei598Not glycated1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycation, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP02768
PeptideAtlasiP02768
PRIDEiP02768
ProteomicsDBi12606 [P02768-2]
51587
51588 [P02768-2]

2D gel databases

DOSAC-COBS-2DPAGEiP02768
OGPiP02768
REPRODUCTION-2DPAGEiIPI00384697
IPI00745872
P02768
SWISS-2DPAGEiP02768
UCD-2DPAGEiP02768

PTM databases

CarbonylDBiP02768
GlyConnecti559
iPTMnetiP02768
PhosphoSitePlusiP02768
SwissPalmiP02768
UniCarbKBiP02768

Miscellaneous databases

PMAP-CutDBiP02768

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSG00000163631 Expressed in 114 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP02768 baseline and differential
GenevisibleiP02768 HS

Organism-specific databases

HPAiCAB006262
HPA031024
HPA031025

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106715, 192 interactors
DIPiDIP-29902N
IntActiP02768, 173 interactors
MINTiP02768
STRINGi9606.ENSP00000295897

Chemistry databases

BindingDBiP02768

Structurei

Secondary structure

1609
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02768
SMRiP02768
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02768

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 210Albumin 1PROSITE-ProRule annotationAdd BLAST192
Domaini211 – 403Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini404 – 601Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
GeneTreeiENSGT00390000000113
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP02768
KOiK16141
OMAiHKECCHG
OrthoDBiEOG091G0F5F
PhylomeDBiP02768
TreeFamiTF335561

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P02768-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA
60 70 80 90 100
FAQYLQQCPF EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT
110 120 130 140 150
VATLRETYGE MADCCAKQEP ERNECFLQHK DDNPNLPRLV RPEVDVMCTA
160 170 180 190 200
FHDNEETFLK KYLYEIARRH PYFYAPELLF FAKRYKAAFT ECCQAADKAA
210 220 230 240 250
CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV ARLSQRFPKA
260 270 280 290 300
EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK
310 320 330 340 350
ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF
360 370 380 390 400
LGMFLYEYAR RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE
410 420 430 440 450
FKPLVEEPQN LIKQNCELFE QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV
460 470 480 490 500
SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV LNQLCVLHEK TPVSDRVTKC
510 520 530 540 550
CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL SEKERQIKKQ
560 570 580 590 600
TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV

AASQAALGL
Length:609
Mass (Da):69,367
Last modified:April 1, 1990 - v2
Checksum:iF88FF61DD242E818
GO
Isoform 2 (identifier: P02768-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-234: Missing.

Show »
Length:417
Mass (Da):47,360
Checksum:i16E764833EEF4E8D
GO
Isoform 3 (identifier: P02768-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-376: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):45,160
Checksum:i756519C096463A9B
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGB6A0A0C4DGB6_HUMAN
Serum albumin
ALB
604Annotation score:
B7WNR0B7WNR0_HUMAN
Serum albumin
ALB
494Annotation score:
C9JKR2C9JKR2_HUMAN
Albumin, isoform CRA_k
ALB hCG_14967
417Annotation score:
A0A087WWT3A0A087WWT3_HUMAN
Serum albumin
ALB
396Annotation score:
D6RHD5D6RHD5_HUMAN
Serum albumin
ALB
459Annotation score:
H7C013H7C013_HUMAN
Serum albumin
ALB
197Annotation score:
H0YA55H0YA55_HUMAN
Serum albumin
ALB
454Annotation score:
D6RCE7D6RCE7_HUMAN
Serum albumin
ALB
105Annotation score:

Sequence cautioni

The sequence AAF22034 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF69644 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAG35503 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55L → P in CAH18185 (PubMed:17974005).Curated1
Sequence conflicti122R → S in AAF01333 (Ref. 4) Curated1
Sequence conflicti155E → Q AA sequence (PubMed:1225573).Curated1
Sequence conflicti174Y → L AA sequence (PubMed:3087352).Curated1
Sequence conflicti174Y → L AA sequence (PubMed:2437111).Curated1
Sequence conflicti194Q → E AA sequence (PubMed:1225573).Curated1
Sequence conflicti327 – 332PSLAAD → MFVLLC in AAF71067 (PubMed:11483580).Curated6
Sequence conflicti405V → A in AAF71067 (PubMed:11483580).Curated1
Sequence conflicti409Q → E in AAH14308 (PubMed:15489334).Curated1
Sequence conflicti441Q → E in CAA23753 (PubMed:6275391).Curated1
Sequence conflicti466E → G in AAF01333 (Ref. 4) Curated1
Sequence conflicti488 – 489HE → EH AA sequence (PubMed:1225573).Curated2
Sequence conflicti490K → R in CAH18185 (PubMed:17974005).Curated1
Sequence conflicti525E → Q AA sequence (PubMed:1225573).Curated1
Sequence conflicti551T → A in CAH18185 (PubMed:17974005).Curated1
Sequence conflicti560K → R in CAH18185 (PubMed:17974005).Curated1
Sequence conflicti604Q → R in AAN17825 (Ref. 5) Curated1

Polymorphismi

A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00049923R → C in Redhill/Malmo-I/Tradate; associated with T-344 in Redhill. 1 PublicationCorresponds to variant dbSNP:rs80008208EnsemblClinVar.1
Natural variantiVAR_00050023R → H in Fukuoka-2/Lille/Taipei/Varese/Komagome-3. 3 PublicationsCorresponds to variant dbSNP:rs72552709EnsemblClinVar.1
Natural variantiVAR_00050124R → L in Jaffna. Corresponds to variant dbSNP:rs74821926EnsemblClinVar.1
Natural variantiVAR_00050224R → P in Takefu/Honolulu-1. 1 PublicationCorresponds to variant dbSNP:rs74821926EnsemblClinVar.1
Natural variantiVAR_00050324R → Q in Christchurch/Honolulu-2. 3 PublicationsCorresponds to variant dbSNP:rs74821926EnsemblClinVar.1
Natural variantiVAR_00050425D → V in Bleinheim/Iowa city-2. 1 PublicationCorresponds to variant dbSNP:rs75353611EnsemblClinVar.1
Natural variantiVAR_00050527H → Q in Nagasaki-3. Corresponds to variant dbSNP:rs76285851EnsemblClinVar.1
Natural variantiVAR_00050627H → Y in Larino. 2 PublicationsCorresponds to variant dbSNP:rs141733599EnsemblClinVar.1
Natural variantiVAR_01065773F → Y1 Publication1
Natural variantiVAR_00050784E → K in Torino. 1 PublicationCorresponds to variant dbSNP:rs77050410EnsemblClinVar.1
Natural variantiVAR_00050887D → N in Malmo-95/Dalakarlia. 1 PublicationCorresponds to variant dbSNP:rs78574148EnsemblClinVar.1
Natural variantiVAR_01301190L → P in FDAH. 1 PublicationCorresponds to variant dbSNP:rs77892378EnsemblClinVar.1
Natural variantiVAR_000509106E → K in Vibo Valentia. 1 PublicationCorresponds to variant dbSNP:rs80296402EnsemblClinVar.1
Natural variantiVAR_014290121E → G1 Publication1
Natural variantiVAR_000510138R → G in Yanomama-2. Corresponds to variant dbSNP:rs77238412EnsemblClinVar.1
Natural variantiVAR_000511143E → K in Nagoya. 1 PublicationCorresponds to variant dbSNP:rs75522063EnsemblClinVar.1
Natural variantiVAR_013012146V → E in Tregasio. Corresponds to variant dbSNP:rs77752336EnsemblClinVar.1
Natural variantiVAR_000512152H → R in Komagome-2. 1 PublicationCorresponds to variant dbSNP:rs80095457EnsemblClinVar.1
Natural variantiVAR_000513201C → F in Hawkes bay. 1 PublicationCorresponds to variant dbSNP:rs77656691EnsemblClinVar.1
Natural variantiVAR_014291215A → T. Corresponds to variant dbSNP:rs3210154Ensembl.1
Natural variantiVAR_014292215A → V. Corresponds to variant dbSNP:rs3204504Ensembl.1
Natural variantiVAR_014293220Q → L. Corresponds to variant dbSNP:rs3210163Ensembl.1
Natural variantiVAR_000514242R → H in FDAH. 3 PublicationsCorresponds to variant dbSNP:rs75002628EnsemblClinVar.1
Natural variantiVAR_013013242R → P in FDAH. Corresponds to variant dbSNP:rs75002628EnsemblClinVar.1
Natural variantiVAR_000515249K → Q in Tradate-2. 1 PublicationCorresponds to variant dbSNP:rs79804069EnsemblClinVar.1
Natural variantiVAR_000516264K → E in Herborn. 1 PublicationCorresponds to variant dbSNP:rs79377490EnsemblClinVar.1
Natural variantiVAR_000517292Q → R in Malmo-10. 1 PublicationCorresponds to variant dbSNP:rs80002911EnsemblClinVar.1
Natural variantiVAR_000518293D → G in Nagasaki-1. 1 PublicationCorresponds to variant dbSNP:rs79744198EnsemblClinVar.1
Natural variantiVAR_000519300K → N in Caserta. 1 PublicationCorresponds to variant dbSNP:rs74718349EnsemblClinVar.1
Natural variantiVAR_000520337K → N in Canterbury/New Guinea/Tagliacozzo/Cuneo/Cooperstown. 3 PublicationsCorresponds to variant dbSNP:rs72552710EnsemblClinVar.1
Natural variantiVAR_013014338D → G in Bergamo. Corresponds to variant dbSNP:rs76242087EnsemblClinVar.1
Natural variantiVAR_013015338D → V in Brest. Corresponds to variant dbSNP:rs76242087EnsemblClinVar.1
Natural variantiVAR_000521342N → K in Malmo-47. 1 PublicationCorresponds to variant dbSNP:rs77544362EnsemblClinVar.1
Natural variantiVAR_000522344A → T in Redhill; associated with C-23. Corresponds to variant dbSNP:rs78953271EnsemblClinVar.1
Natural variantiVAR_000523345E → K in Roma. Corresponds to variant dbSNP:rs72552711EnsemblClinVar.1
Natural variantiVAR_000524357E → K in Sondrio. 1 PublicationCorresponds to variant dbSNP:rs77354753EnsemblClinVar.1
Natural variantiVAR_000525378E → K in Hiroshima-1. 2 PublicationsCorresponds to variant dbSNP:rs76593094EnsemblClinVar.1
Natural variantiVAR_000526382E → K in Coari I/Porto Alegre. Corresponds to variant dbSNP:rs75791663EnsemblClinVar.1
Natural variantiVAR_013016383K → N in Trieste. Corresponds to variant dbSNP:rs75069738Ensembl.1
Natural variantiVAR_000527389D → H in Parklands. Corresponds to variant dbSNP:rs77187142EnsemblClinVar.1
Natural variantiVAR_000528389D → V in Iowa city-1. 1 PublicationCorresponds to variant dbSNP:rs78538497EnsemblClinVar.1
Natural variantiVAR_000529396K → E in Naskapi/Mersin/Komagome-1. 3 PublicationsCorresponds to variant dbSNP:rs78166690EnsemblClinVar.1
Natural variantiVAR_000530399D → N in Nagasaki-2. 1 PublicationCorresponds to variant dbSNP:rs77514449EnsemblClinVar.1
Natural variantiVAR_000531400E → K in Tochigi. 1 PublicationCorresponds to variant dbSNP:rs79047363EnsemblClinVar.1
Natural variantiVAR_000532400E → Q in Malmo-5. 1 PublicationCorresponds to variant dbSNP:rs79047363EnsemblClinVar.1
Natural variantiVAR_000533406E → K in Hiroshima-2. 1 PublicationCorresponds to variant dbSNP:rs76483862EnsemblClinVar.1
Natural variantiVAR_014294420E → K1 Publication1
Natural variantiVAR_013017434R → C in Liprizzi. Corresponds to variant dbSNP:rs78575701EnsemblClinVar.1
Natural variantiVAR_014295490K → E. Corresponds to variant dbSNP:rs1063469Ensembl.1
Natural variantiVAR_000534503E → K in Dublin. Corresponds to variant dbSNP:rs80259813EnsemblClinVar.1
Natural variantiVAR_000535518D → N in Casebrook. 1 PublicationCorresponds to variant dbSNP:rs75920790EnsemblClinVar.1
Natural variantiVAR_000536525E → K in Manaus-1/Adana/Lambadi/Vancouver. 1 PublicationCorresponds to variant dbSNP:rs75523493EnsemblClinVar.1
Natural variantiVAR_000537529E → K in Ortonovo. 1 PublicationCorresponds to variant dbSNP:rs74826639EnsemblClinVar.1
Natural variantiVAR_013018557V → M in Maddaloni. Corresponds to variant dbSNP:rs78284052EnsemblClinVar.1
Natural variantiVAR_000538560K → E in Castel di Sangro. Corresponds to variant dbSNP:rs77645174EnsemblClinVar.1
Natural variantiVAR_000539565K → E in Maku. 1 PublicationCorresponds to variant dbSNP:rs80345158EnsemblClinVar.1
Natural variantiVAR_000541574D → A in Malmo-61. 1 PublicationCorresponds to variant dbSNP:rs79738788EnsemblClinVar.1
Natural variantiVAR_000540574D → G in Mexico. 1 PublicationCorresponds to variant dbSNP:rs79738788EnsemblClinVar.1
Natural variantiVAR_013019584K → E in Church bay. Corresponds to variant dbSNP:rs76671808EnsemblClinVar.1
Natural variantiVAR_000542587D → N in Fukuoka-1/Paris-2. 2 PublicationsCorresponds to variant dbSNP:rs76587671EnsemblClinVar.1
Natural variantiVAR_000543589E → K in Osaka-1. 1 PublicationCorresponds to variant dbSNP:rs75709682EnsemblClinVar.1
Natural variantiVAR_000544594E → K in Osaka-2/Phnom Phen/albumin B/Verona. 3 PublicationsCorresponds to variant dbSNP:rs79228041EnsemblClinVar.1
Natural variantiVAR_000547596 – 609GKKLV…AALGL → PTMRIRERK in Venezia. Add BLAST14
Natural variantiVAR_000545597K → E in Gent/Milano Fast. Corresponds to variant dbSNP:rs80106970EnsemblClinVar.1
Natural variantiVAR_000546598K → N in Vanves. Corresponds to variant dbSNP:rs75738598EnsemblClinVar.1
Natural variantiVAR_012981599 – 609LVAASQAALGL → TCCCKSSCLRLITSHLKASQ PTMRIRERK in Kenitra. Add BLAST11

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02127543 – 234Missing in isoform 2. 2 PublicationsAdd BLAST192
Alternative sequenceiVSP_057389164 – 376Missing in isoform 3. 1 PublicationAdd BLAST213

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00494 mRNA Translation: CAA23753.1
V00495 mRNA Translation: CAA23754.1
M12523 Genomic DNA Translation: AAA98797.1
M12523 Genomic DNA Translation: AAA98798.1
AF190168 mRNA Translation: AAF01333.1
AF542069 mRNA Translation: AAN17825.1
A06977 mRNA Translation: CAA00606.1
AY728024 mRNA Translation: AAU21642.1
DQ986150 mRNA Translation: ABJ16448.1
AY544124 mRNA Translation: AAT11155.1
AY550967 mRNA Translation: AAT52213.1
AF116645 mRNA Translation: AAF71067.1
AF118090 mRNA Translation: AAF22034.1 Different initiation.
AF119840 mRNA Translation: AAF69594.1
AF119890 mRNA Translation: AAF69644.1 Different initiation.
AF130077 mRNA Translation: AAG35503.1 Different initiation.
CR749331 mRNA Translation: CAH18185.1
EF649953 Genomic DNA Translation: ABS29264.1
AC108157 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05676.1
BC014308 mRNA Translation: AAH14308.1
BC034023 mRNA Translation: AAH34023.1
BC035969 mRNA Translation: AAH35969.1
BC036003 mRNA Translation: AAH36003.1
BC041789 mRNA Translation: AAH41789.1
U22961 mRNA Translation: AAA64922.1
AY358313 mRNA Translation: AAQ89947.1
AH002596 Genomic DNA Translation: AAA51688.1
CCDSiCCDS3555.1 [P02768-1]
PIRiA93743 ABHUS
RefSeqiNP_000468.1, NM_000477.6 [P02768-1]
UniGeneiHs.418167
Hs.592379

Genome annotation databases

EnsembliENST00000295897; ENSP00000295897; ENSG00000163631 [P02768-1]
ENST00000621085; ENSP00000483421; ENSG00000163631 [P02768-3]
GeneIDi213
KEGGihsa:213
UCSCiuc003hgs.5 human [P02768-1]
uc062xfr.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Albumin Website
Wikipedia

Serum albumin entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00494 mRNA Translation: CAA23753.1
V00495 mRNA Translation: CAA23754.1
M12523 Genomic DNA Translation: AAA98797.1
M12523 Genomic DNA Translation: AAA98798.1
AF190168 mRNA Translation: AAF01333.1
AF542069 mRNA Translation: AAN17825.1
A06977 mRNA Translation: CAA00606.1
AY728024 mRNA Translation: AAU21642.1
DQ986150 mRNA Translation: ABJ16448.1
AY544124 mRNA Translation: AAT11155.1
AY550967 mRNA Translation: AAT52213.1
AF116645 mRNA Translation: AAF71067.1
AF118090 mRNA Translation: AAF22034.1 Different initiation.
AF119840 mRNA Translation: AAF69594.1
AF119890 mRNA Translation: AAF69644.1 Different initiation.
AF130077 mRNA Translation: AAG35503.1 Different initiation.
CR749331 mRNA Translation: CAH18185.1
EF649953 Genomic DNA Translation: ABS29264.1
AC108157 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05676.1
BC014308 mRNA Translation: AAH14308.1
BC034023 mRNA Translation: AAH34023.1
BC035969 mRNA Translation: AAH35969.1
BC036003 mRNA Translation: AAH36003.1
BC041789 mRNA Translation: AAH41789.1
U22961 mRNA Translation: AAA64922.1
AY358313 mRNA Translation: AAQ89947.1
AH002596 Genomic DNA Translation: AAA51688.1
CCDSiCCDS3555.1 [P02768-1]
PIRiA93743 ABHUS
RefSeqiNP_000468.1, NM_000477.6 [P02768-1]
UniGeneiHs.418167
Hs.592379

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AO6X-ray2.50A/B25-609[»]
1BJ5X-ray2.50A25-609[»]
1BKEX-ray3.15A28-608[»]
1BM0X-ray2.50A/B25-609[»]
1E78X-ray2.60A/B25-609[»]
1E7AX-ray2.20A/B25-609[»]
1E7BX-ray2.38A/B25-609[»]
1E7CX-ray2.40A25-609[»]
1E7EX-ray2.50A25-609[»]
1E7FX-ray2.43A25-609[»]
1E7GX-ray2.50A25-609[»]
1E7HX-ray2.43A25-609[»]
1E7IX-ray2.70A25-609[»]
1GNIX-ray2.40A25-609[»]
1GNJX-ray2.60A25-609[»]
1H9ZX-ray2.50A25-609[»]
1HA2X-ray2.50A25-609[»]
1HK1X-ray2.65A25-609[»]
1HK2X-ray2.80A25-609[»]
1HK3X-ray2.80A25-609[»]
1HK4X-ray2.40A25-609[»]
1HK5X-ray2.70A25-609[»]
1N5UX-ray1.90A25-609[»]
1O9XX-ray3.20A25-609[»]
1TF0X-ray2.70A25-596[»]
1UORX-ray2.80A25-609[»]
1YSXNMR-A409-609[»]
2BX8X-ray2.70A/B25-609[»]
2BXAX-ray2.35A/B25-609[»]
2BXBX-ray3.20A/B25-609[»]
2BXCX-ray3.10A/B25-609[»]
2BXDX-ray3.05A/B25-609[»]
2BXEX-ray2.95A/B25-609[»]
2BXFX-ray2.95A/B25-609[»]
2BXGX-ray2.70A/B25-609[»]
2BXHX-ray2.25A/B25-609[»]
2BXIX-ray2.50A25-609[»]
2BXKX-ray2.40A25-609[»]
2BXLX-ray2.60A25-609[»]
2BXMX-ray2.50A25-609[»]
2BXNX-ray2.65A25-609[»]
2BXOX-ray2.60A25-609[»]
2BXPX-ray2.30A25-609[»]
2BXQX-ray2.60A25-609[»]
2ESGX-ray-C25-609[»]
2I2ZX-ray2.70A25-609[»]
2I30X-ray2.90A25-609[»]
2N0XNMR-A432-447[»]
2VDBX-ray2.52A30-608[»]
2VUEX-ray2.42A/B25-609[»]
2VUFX-ray3.05A/B25-609[»]
2XSIX-ray2.70A25-609[»]
2XVQX-ray2.90A/B25-609[»]
2XVUX-ray2.60A/B25-609[»]
2XVVX-ray2.40A25-609[»]
2XVWX-ray2.65A25-609[»]
2XW0X-ray2.40A/B25-609[»]
2XW1X-ray2.50A/B25-609[»]
2YDFX-ray2.75A/B25-609[»]
3A73X-ray2.19A/B25-609[»]
3B9LX-ray2.60A25-609[»]
3B9MX-ray2.70A25-609[»]
3CX9X-ray2.80A27-608[»]
3JQZX-ray3.30A/B25-609[»]
3JRYX-ray2.30A/B25-609[»]
3LU6X-ray2.70A/B25-609[»]
3LU7X-ray2.80A/B25-609[»]
3LU8X-ray2.60A/B25-609[»]
3SQJX-ray2.05A/B27-608[»]
3TDLX-ray2.60A25-609[»]
3UIVX-ray2.20A/H25-609[»]
4BKEX-ray2.35A1-609[»]
4E99X-ray2.30A25-609[»]
4EMXX-ray2.30A/B25-609[»]
4G03X-ray2.22A/B25-609[»]
4G04X-ray2.30A/B25-609[»]
4HGKX-ray3.04A/B25-609[»]
4HGMX-ray2.34B25-609[»]
4IW1X-ray2.56A25-609[»]
4IW2X-ray2.41A25-609[»]
4K2CX-ray3.23A/B25-609[»]
4K71X-ray2.40A/D25-609[»]
4L8UX-ray2.01A25-609[»]
4L9KX-ray2.40A/B25-609[»]
4L9QX-ray2.70A/B25-609[»]
4LA0X-ray2.40A/B25-609[»]
4LB2X-ray2.80A/B25-609[»]
4LB9X-ray2.70A25-609[»]
4N0FX-ray3.02D/G/J/M25-609[»]
4N0UX-ray3.80D27-609[»]
4S1YX-ray3.16A25-609[»]
4Z69X-ray2.19A/I25-609[»]
5FUOX-ray3.60A25-609[»]
5GIXX-ray2.80A/B27-607[»]
5GIYX-ray2.54A27-607[»]
5ID7X-ray2.26A/B25-609[»]
5IFOX-ray3.20A25-609[»]
5IJFX-ray2.65A25-609[»]
5UJBX-ray2.70A/B1-609[»]
5VNWX-ray2.60A/B25-609[»]
5X52X-ray3.00A/B25-609[»]
5YB1X-ray2.62A/B27-607[»]
5YOQX-ray2.65A/B25-609[»]
6EZQX-ray2.39A25-609[»]
ProteinModelPortaliP02768
SMRiP02768
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106715, 192 interactors
DIPiDIP-29902N
IntActiP02768, 173 interactors
MINTiP02768
STRINGi9606.ENSP00000295897

Chemistry databases

BindingDBiP02768
ChEMBLiCHEMBL3253
DrugBankiDB07517 3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONIC
DB07992 3-SULFOOXY-1H-INDOLE
DB05812 Abiraterone
DB01418 Acenocoumarol
DB01614 Acepromazine
DB00945 Acetylsalicylic acid
DB00459 Acitretin
DB00802 Alfentanil
DB00321 Amitriptyline
DB00415 Ampicillin
DB04557 Arachidonic Acid
DB00995 Auranofin
DB07402 Azapropazone
DB01294 Bismuth Subsalicylate
DB08907 Canagliflozin
DB01197 Captopril
DB00456 Cefalotin
DB01327 Cefazolin
DB00274 Cefmetazole
DB01328 Cefonicid
DB01329 Cefoperazone
DB00493 Cefotaxime
DB01330 Cefotetan
DB00430 Cefpiramide
DB01212 Ceftriaxone
DB00482 Celecoxib
DB00567 Cephalexin
DB00477 Chlorpromazine
DB01242 Clomipramine
DB01068 Clonazepam
DB01147 Cloxacillin
DB03600 Decanoic Acid
DB01189 Desflurane
DB00829 Diazepam
DB00586 Diclofenac
DB00861 Diflunisal
DB01396 Digitoxin
DB04855 Dronedarone
DB00228 Enflurane
DB08899 Enzalutamide
DB00530 Erlotinib
DB00199 Erythromycin
DB00783 Estradiol
DB00655 Estrone
DB04574 Estrone sulfate
DB00903 Etacrynic acid
DB00749 Etodolac
DB00573 Fenoprofen
DB00544 Fluorouracil
DB00472 Fluoxetine
DB00712 Flurbiprofen
DB01320 Fosphenytoin
DB06716 Fospropofol
DB00695 Furosemide
DB00743 Gadobenic acid
DB06705 Gadofosveset trisodium
DB01044 Gatifloxacin
DB00317 Gefitinib
DB01120 Gliclazide
DB01016 Glyburide
DB01159 Halothane
DB00070 Hyaluronidase
DB06205 Hyaluronidase (Human Recombinant)
DB01050 Ibuprofen
DB00619 Imatinib
DB00328 Indomethacin
DB01307 Insulin Detemir
DB04711 Iodipamide
DB00762 Irinotecan
DB00753 Isoflurane
DB08820 Ivacaftor
DB01587 Ketazolam
DB01009 Ketoprofen
DB03017 Lauric Acid
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB00678 Losartan
DB09280 Lumacaftor
DB08932 Macitentan
DB01397 Magnesium salicylate
DB00931 Methacycline
DB00563 Methotrexate
DB06710 Methyltestosterone
DB08893 Mirabegron
DB00688 Mycophenolate mofetil
DB08231 MYRISTIC ACID
DB01183 Naloxone
DB00788 Naproxen
DB00731 Nateglinide
DB00717 Norethisterone
DB00540 Nortriptyline
DB00334 Olanzapine
DB04224 Oleic Acid
DB00776 Oxcarbazepine
DB06412 Oxymetholone
DB03585 Oxyphenbutazone
DB03796 Palmitic Acid
DB00454 Pethidine
DB00946 Phenprocoumon
DB00252 Phenytoin
DB01621 Pipotiazine
DB00554 Piroxicam
DB08860 Pitavastatin
DB06209 Prasugrel
DB00635 Prednisone
DB01032 Probenecid
DB00818 Propofol
DB00912 Repaglinide
DB01045 Rifampicin
DB08931 Riociguat
DB00412 Rosiglitazone
DB01098 Rosuvastatin
DB06201 Rufinamide
DB00936 Salicylic acid
DB01232 Saquinavir
DB01236 Sevoflurane
DB06290 Simeprevir
DB00815 Sodium lauryl sulfate
DB03193 Stearic acid
DB00364 Sucralfate
DB01581 Sulfamerazine
DB01582 Sulfamethazine
DB00576 Sulfamethizole
DB01015 Sulfamethoxazole
DB00605 Sulindac
DB00864 Tacrolimus
DB05521 Telaprevir
DB00624 Testosterone
DB00759 Tetracycline
DB01622 Thioproperazine
DB01623 Thiothixene
DB01056 Tocainide
DB08895 Tofacitinib
DB08867 Ulipristal
DB00177 Valsartan
DB00512 Vancomycin
DB05294 Vandetanib
DB08881 Vemurafenib
DB08828 Vismodegib
DB00682 Warfarin
DB00137 Xanthophyll
DB00495 Zidovudine

Protein family/group databases

Allergomei763 Hom s HSA

PTM databases

CarbonylDBiP02768
GlyConnecti559
iPTMnetiP02768
PhosphoSitePlusiP02768
SwissPalmiP02768
UniCarbKBiP02768

Polymorphism and mutation databases

BioMutaiALB
DMDMi113576

2D gel databases

DOSAC-COBS-2DPAGEiP02768
OGPiP02768
REPRODUCTION-2DPAGEiIPI00384697
IPI00745872
P02768
SWISS-2DPAGEiP02768
UCD-2DPAGEiP02768

Proteomic databases

PaxDbiP02768
PeptideAtlasiP02768
PRIDEiP02768
ProteomicsDBi12606 [P02768-2]
51587
51588 [P02768-2]

Protocols and materials databases

DNASUi213
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295897; ENSP00000295897; ENSG00000163631 [P02768-1]
ENST00000621085; ENSP00000483421; ENSG00000163631 [P02768-3]
GeneIDi213
KEGGihsa:213
UCSCiuc003hgs.5 human [P02768-1]
uc062xfr.1 human

Organism-specific databases

CTDi213
DisGeNETi213
EuPathDBiHostDB:ENSG00000163631.16
GeneCardsiALB
HGNCiHGNC:399 ALB
HPAiCAB006262
HPA031024
HPA031025
MalaCardsiALB
MIMi103600 gene
615999 phenotype
616000 phenotype
neXtProtiNX_P02768
OpenTargetsiENSG00000163631
Orphaneti86816 Congenital analbuminemia
276271 NON RARE IN EUROPE: Familial dysalbuminemic hyperthyroxinemia
PharmGKBiPA24690
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
GeneTreeiENSGT00390000000113
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP02768
KOiK16141
OMAiHKECCHG
OrthoDBiEOG091G0F5F
PhylomeDBiP02768
TreeFamiTF335561

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-159418 Recycling of bile acids and salts
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
R-HSA-879518 Transport of organic anions
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8964058 HDL remodeling
SIGNORiP02768

Miscellaneous databases

ChiTaRSiALB human
EvolutionaryTraceiP02768
GeneWikiiSerum_albumin
GenomeRNAii213
PMAP-CutDBiP02768
PROiPR:P02768
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163631 Expressed in 114 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP02768 baseline and differential
GenevisibleiP02768 HS

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiALBU_HUMAN
AccessioniPrimary (citable) accession number: P02768
Secondary accession number(s): E7ESS9
, O95574, P04277, Q13140, Q645G4, Q68DN5, Q6UXK4, Q86YG0, Q8IUK7, Q9P157, Q9P1I7, Q9UHS3, Q9UJZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 254 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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