UniProtKB - P02767 (TTHY_RAT)
Protein
Transthyretin
Gene
Ttr
Organism
Rattus norvegicus (Rat)
Status
Functioni
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.1 Publication
Miscellaneous
This protein binds retinol-binding protein at levels similar to, and the thyroid hormones at levels much higher than, the human protein.
Tetramer dissociation and partial unfolding leads to the formation of aggregates and amyloid fibrils. Small molecules that occupy at least one of the thyroid hormone binding sites stabilize the tetramer, and thereby stabilize the native state and protect against misfolding and the formation of amyloid fibrils (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 35 | Thyroid hormone | 1 | |
Binding sitei | 74 | Thyroid hormone | 1 |
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- hormone binding Source: RGD
- identical protein binding Source: RGD
- protein-containing complex binding Source: RGD
- thyroid hormone binding Source: GO_Central
GO - Biological processi
- purine nucleobase metabolic process Source: GO_Central
- retinol metabolic process Source: InterPro
- thyroid hormone metabolic process Source: RGD
- thyroid hormone transport Source: InterPro
Keywordsi
Molecular function | Hormone, Thyroid hormone |
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-RNO-2453902, The canonical retinoid cycle in rods (twilight vision) R-RNO-3000171, Non-integrin membrane-ECM interactions R-RNO-6798695, Neutrophil degranulation R-RNO-975634, Retinoid metabolism and transport |
Protein family/group databases
TCDBi | 9.B.35.1.1, the putative thyronine-transporting transthyretin (transthyretin) family |
Names & Taxonomyi
Protein namesi | Recommended name: TransthyretinAlternative name(s): Prealbumin TBPA |
Gene namesi | Name:Ttr Synonyms:Tt |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3916, Ttr |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular space Source: RGD
Other locations
- protein-containing complex Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000035764 | 21 – 147 | TransthyretinAdd BLAST | 127 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 62 | 4-carboxyglutamateBy similarity | 1 | |
Modified residuei | 72 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 118 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Gamma-carboxyglutamic acid, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P02767 |
PRIDEi | P02767 |
PTM databases
GlyGeni | P02767, 1 site |
iPTMneti | P02767 |
PhosphoSitePlusi | P02767 |
Expressioni
Tissue specificityi
Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in the choroid plexus. Detected at lower levels in the liver.3 Publications
Gene expression databases
Bgeei | ENSRNOG00000016275, Expressed in liver and 21 other tissues |
Genevisiblei | P02767, RN |
Interactioni
Subunit structurei
Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules.
Interacts with RBP4.
3 PublicationsGO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- identical protein binding Source: RGD
Protein-protein interaction databases
IntActi | P02767, 2 interactors |
MINTi | P02767 |
STRINGi | 10116.ENSRNOP00000022113 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P02767 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02767 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 135 – 139 | Thyroid hormone binding | 5 |
Sequence similaritiesi
Belongs to the transthyretin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3006, Eukaryota |
GeneTreei | ENSGT00940000153229 |
HOGENOMi | CLU_115536_2_0_1 |
InParanoidi | P02767 |
OMAi | EPFATGK |
OrthoDBi | 1453185at2759 |
PhylomeDBi | P02767 |
TreeFami | TF300210 |
Family and domain databases
Gene3Di | 2.60.40.180, 1 hit |
InterProi | View protein in InterPro IPR023418, Thyroxine_BS IPR030178, Transthyretin IPR000895, Transthyretin/HIU_hydrolase IPR023416, Transthyretin/HIU_hydrolase_d IPR036817, Transthyretin/HIU_hydrolase_sf IPR023419, Transthyretin_CS |
PANTHERi | PTHR10395, PTHR10395, 1 hit PTHR10395:SF12, PTHR10395:SF12, 1 hit |
Pfami | View protein in Pfam PF00576, Transthyretin, 1 hit |
PRINTSi | PR00189, TRNSTHYRETIN |
SMARTi | View protein in SMART SM00095, TR_THY, 1 hit |
SUPFAMi | SSF49472, SSF49472, 1 hit |
PROSITEi | View protein in PROSITE PS00768, TRANSTHYRETIN_1, 1 hit PS00769, TRANSTHYRETIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P02767-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASLRLFLLC LAGLIFASEA GPGGAGESKC PLMVKVLDAV RGSPAVDVAV
60 70 80 90 100
KVFKKTADGS WEPFASGKTA ESGELHGLTT DEKFTEGVYR VELDTKSYWK
110 120 130 140
ALGISPFHEY AEVVFTANDS GHRHYTIAAL LSPYSYSTTA VVSNPQN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | K → R in AAA41801 (PubMed:3922975).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K03252 mRNA Translation: AAA41801.1 K03251 Genomic DNA Translation: AAA41802.1 X14876 mRNA Translation: CAA33017.1 AF479660 mRNA Translation: AAL78377.1 BC086946 mRNA Translation: AAH86946.1 M18685 Genomic DNA Translation: AAA40708.1 M20246 Genomic DNA Translation: AAA40709.1 |
PIRi | A92542, VBRT |
RefSeqi | NP_036813.2, NM_012681.2 XP_006254519.1, XM_006254457.1 |
Genome annotation databases
Ensembli | ENSRNOT00000022113; ENSRNOP00000022113; ENSRNOG00000016275 |
GeneIDi | 24856 |
KEGGi | rno:24856 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K03252 mRNA Translation: AAA41801.1 K03251 Genomic DNA Translation: AAA41802.1 X14876 mRNA Translation: CAA33017.1 AF479660 mRNA Translation: AAL78377.1 BC086946 mRNA Translation: AAH86946.1 M18685 Genomic DNA Translation: AAA40708.1 M20246 Genomic DNA Translation: AAA40709.1 |
PIRi | A92542, VBRT |
RefSeqi | NP_036813.2, NM_012681.2 XP_006254519.1, XM_006254457.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GKE | X-ray | 2.50 | A/B/C/D | 28-147 | [»] | |
1IE4 | X-ray | 2.50 | A/B/C/D | 21-147 | [»] | |
1KGI | X-ray | 1.80 | A/B/C/D | 21-147 | [»] | |
1KGJ | X-ray | 2.30 | A/B/C/D | 21-147 | [»] | |
1RVS | NMR | - | A | 125-135 | [»] | |
2M5K | electron microscopy | 12.70 | A/B/C/D/E/F/G/H | 125-135 | [»] | |
2M5M | electron microscopy | 12.20 | A/B/C/D/E/F/G/H/I/J/K/L | 125-135 | [»] | |
3ZPK | NMR | - | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P | 125-135 | [»] | |
SMRi | P02767 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P02767, 2 interactors |
MINTi | P02767 |
STRINGi | 10116.ENSRNOP00000022113 |
Chemistry databases
ChEMBLi | CHEMBL2151 |
Protein family/group databases
TCDBi | 9.B.35.1.1, the putative thyronine-transporting transthyretin (transthyretin) family |
PTM databases
GlyGeni | P02767, 1 site |
iPTMneti | P02767 |
PhosphoSitePlusi | P02767 |
Proteomic databases
PaxDbi | P02767 |
PRIDEi | P02767 |
Genome annotation databases
Ensembli | ENSRNOT00000022113; ENSRNOP00000022113; ENSRNOG00000016275 |
GeneIDi | 24856 |
KEGGi | rno:24856 |
Organism-specific databases
CTDi | 7276 |
RGDi | 3916, Ttr |
Phylogenomic databases
eggNOGi | KOG3006, Eukaryota |
GeneTreei | ENSGT00940000153229 |
HOGENOMi | CLU_115536_2_0_1 |
InParanoidi | P02767 |
OMAi | EPFATGK |
OrthoDBi | 1453185at2759 |
PhylomeDBi | P02767 |
TreeFami | TF300210 |
Enzyme and pathway databases
Reactomei | R-RNO-2453902, The canonical retinoid cycle in rods (twilight vision) R-RNO-3000171, Non-integrin membrane-ECM interactions R-RNO-6798695, Neutrophil degranulation R-RNO-975634, Retinoid metabolism and transport |
Miscellaneous databases
EvolutionaryTracei | P02767 |
PROi | PR:P02767 |
Gene expression databases
Bgeei | ENSRNOG00000016275, Expressed in liver and 21 other tissues |
Genevisiblei | P02767, RN |
Family and domain databases
Gene3Di | 2.60.40.180, 1 hit |
InterProi | View protein in InterPro IPR023418, Thyroxine_BS IPR030178, Transthyretin IPR000895, Transthyretin/HIU_hydrolase IPR023416, Transthyretin/HIU_hydrolase_d IPR036817, Transthyretin/HIU_hydrolase_sf IPR023419, Transthyretin_CS |
PANTHERi | PTHR10395, PTHR10395, 1 hit PTHR10395:SF12, PTHR10395:SF12, 1 hit |
Pfami | View protein in Pfam PF00576, Transthyretin, 1 hit |
PRINTSi | PR00189, TRNSTHYRETIN |
SMARTi | View protein in SMART SM00095, TR_THY, 1 hit |
SUPFAMi | SSF49472, SSF49472, 1 hit |
PROSITEi | View protein in PROSITE PS00768, TRANSTHYRETIN_1, 1 hit PS00769, TRANSTHYRETIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TTHY_RAT | |
Accessioni | P02767Primary (citable) accession number: P02767 Secondary accession number(s): Q547K9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families