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Entry version 206 (08 May 2019)
Sequence version 2 (12 Sep 2018)
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Protein

Alpha-2-HS-glycoprotein

Gene

AHSG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: InterPro
  • kinase inhibitor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processMineral balance

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-6798695 Neutrophil degranulation
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I25.020

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-2-HS-glycoprotein
Alternative name(s):
Alpha-2-Z-globulin
Ba-alpha-2-glycoprotein
Fetuin-A
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AHSG
Synonyms:FETUA
ORF Names:PRO2743
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:349 AHSG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
138680 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02765

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Alopecia-mental retardation syndrome 1 (APMR1)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive form of alopecia. APMR1 patients show loss of hair on the scalp, absence of eyebrows, eyelashes, axillary and pubic hair, and mild to severe mental retardation.
See also OMIM:203650
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080645317R → H in APMR1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201849460EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hypotrichosis, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
197

MalaCards human disease database

More...
MalaCardsi
AHSG
MIMi203650 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000145192

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2850 Alopecia-intellectual disability syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24642

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AHSG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
112910

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 182 PublicationsAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000888719 – 300Alpha-2-HS-glycoprotein chain A1 PublicationAdd BLAST282
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000008888301 – 340Connecting peptide1 PublicationAdd BLAST40
ChainiPRO_0000008889341 – 367Alpha-2-HS-glycoprotein chain BAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 358Interchain (between A and B chains)
Disulfide bondi89 ↔ 100PROSITE-ProRule annotation1 Publication
Disulfide bondi114 ↔ 132PROSITE-ProRule annotation1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei134PhosphoserineCombined sources1
Modified residuei135Phosphoserine; by FAM20C1 Publication1
Modified residuei138Phosphoserine; by FAM20CCombined sources2 Publications1
Disulfide bondi146 ↔ 149PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_000064156N-linked (GlcNAc...) (complex) asparagine7 Publications1
GlycosylationiCAR_000065176N-linked (GlcNAc...) (complex) asparagine5 Publications1
Disulfide bondi208 ↔ 219PROSITE-ProRule annotation1 Publication
Disulfide bondi230 ↔ 247PROSITE-ProRule annotation1 Publication
GlycosylationiCAR_000067270O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi280O-linked (GalNAc...) serineSequence analysis1
Glycosylationi293O-linked (GalNAc...) serineSequence analysis1
Modified residuei319Phosphothreonine; by FAM20CCombined sources1 Publication1
Modified residuei325Phosphoserine; by FAM20C1 Publication1
Modified residuei328Phosphoserine; by FAM20C1 Publication1
Modified residuei330Phosphoserine; by FAM20CCombined sources2 Publications1
Glycosylationi339O-linked (GalNAc...) threonineBy similarity1
Glycosylationi341O-linked (GalNAc...) threonineSequence analysis1
GlycosylationiCAR_000068346O-linked (GalNAc...) serine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.2 Publications
O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor).8 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P02765

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P02765

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02765

PeptideAtlas

More...
PeptideAtlasi
P02765

PRoteomics IDEntifications database

More...
PRIDEi
P02765

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51585

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P02765

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P02765

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P02765

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P02765

GlyConnect protein glycosylation platform

More...
GlyConnecti
23

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02765

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02765

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P02765

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P02765

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145192 Expressed in 115 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P02765 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02765 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026209
HPA001524
HPA001525

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106700, 24 interactors

Protein interaction database and analysis system

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IntActi
P02765, 18 interactors

Molecular INTeraction database

More...
MINTi
P02765

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000393887

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02765

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 133Cystatin fetuin-A-type 1PROSITE-ProRule annotationAdd BLAST107
Domaini144 – 255Cystatin fetuin-A-type 2PROSITE-ProRule annotationAdd BLAST112

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fetuin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK8F Eukaryota
ENOG4111RIP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182930

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02765

Database of Orthologous Groups

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OrthoDBi
913381at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02765

TreeFam database of animal gene trees

More...
TreeFami
TF333729

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00042 CY, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000010 Cystatin_dom
IPR025760 Cystatin_Fetuin_A
IPR001363 Prot_inh_fetuin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00031 Cystatin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00043 CY, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51529 CYSTATIN_FETUIN_A, 2 hits
PS01254 FETUIN_1, 1 hit
PS01255 FETUIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02765-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSLVLLLCL AQLWGCHSAP HGPGLIYRQP NCDDPETEEA ALVAIDYINQ
60 70 80 90 100
NLPWGYKHTL NQIDEVKVWP QQPSGELFEI EIDTLETTCH VLDPTPVARC
110 120 130 140 150
SVRQLKEHAV EGDCDFQLLK LDGKFSVVYA KCDSSPDSAE DVRKVCQDCP
160 170 180 190 200
LLAPLNDTRV VHAAKAALAA FNAQNNGSNF QLEEISRAQL VPLPPSTYVE
210 220 230 240 250
FTVSGTDCVA KEATEAAKCN LLAEKQYGFC KATLSEKLGG AEVAVTCMVF
260 270 280 290 300
QTQPVSSQPQ PEGANEAVPT PVVDPDAPPS PPLGAPGLPP AGSPPDSHVL
310 320 330 340 350
LAAPPGHQLH RAHYDLRHTF MGVVSLGSPS GEVSHPRKTR TVVQPSVGAA
360
AGPVVPPCPG RIRHFKV
Length:367
Mass (Da):39,341
Last modified:September 12, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FE60C8D6B6272D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JV77C9JV77_HUMAN
Alpha-2-HS-glycoprotein
AHSG
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16C → W in BAA22652 (PubMed:9322749).Curated1
Sequence conflicti54W → K AA sequence (PubMed:3944104).Curated1
Sequence conflicti125F → S in BAA22651 (PubMed:9003486).Curated1
Sequence conflicti150 – 182PLLAP…SNFQL → MVGWQEGANHKNGAGRSQKQ EMAEKMVPEVASG in AAF69649 (Ref. 12) CuratedAdd BLAST33
Sequence conflicti204S → C in BAA22652 (PubMed:9322749).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055802142V → L. Corresponds to variant dbSNP:rs7633550Ensembl.1
Natural variantiVAR_002388248M → T in allele AHSG*1. 1 PublicationCorresponds to variant dbSNP:rs4917EnsemblClinVar.1
Natural variantiVAR_002389256S → T in allele AHSG*1. 2 PublicationsCorresponds to variant dbSNP:rs4918EnsemblClinVar.1
Natural variantiVAR_012474276D → N in allele AHSG*5. 1 PublicationCorresponds to variant dbSNP:rs70961709Ensembl.1
Natural variantiVAR_012475317R → C in allele AHSG*3. 1 PublicationCorresponds to variant dbSNP:rs35457250Ensembl.1
Natural variantiVAR_080645317R → H in APMR1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201849460EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M16961 mRNA Translation: AAA51683.1
D67013 Genomic DNA Translation: BAA22652.1
AB038689 Genomic DNA Translation: BAA92189.1
AK292751 mRNA Translation: BAF85440.1
AK312969 mRNA Translation: BAG35808.1
AC068631 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78189.1
BC048198 mRNA Translation: AAH48198.1
BC052590 mRNA Translation: AAH52590.1
D67012 mRNA Translation: BAA22651.1
AF119895 mRNA Translation: AAF69649.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3278.1

Protein sequence database of the Protein Information Resource

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PIRi
A29081 WOHU

NCBI Reference Sequences

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RefSeqi
NP_001613.2, NM_001622.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000411641; ENSP00000393887; ENSG00000145192

Database of genes from NCBI RefSeq genomes

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GeneIDi
197

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:197

UCSC genome browser

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UCSCi
uc003fqk.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16961 mRNA Translation: AAA51683.1
D67013 Genomic DNA Translation: BAA22652.1
AB038689 Genomic DNA Translation: BAA92189.1
AK292751 mRNA Translation: BAF85440.1
AK312969 mRNA Translation: BAG35808.1
AC068631 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78189.1
BC048198 mRNA Translation: AAH48198.1
BC052590 mRNA Translation: AAH52590.1
D67012 mRNA Translation: BAA22651.1
AF119895 mRNA Translation: AAF69649.1
CCDSiCCDS3278.1
PIRiA29081 WOHU
RefSeqiNP_001613.2, NM_001622.2

3D structure databases

SMRiP02765
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106700, 24 interactors
IntActiP02765, 18 interactors
MINTiP02765
STRINGi9606.ENSP00000393887

Protein family/group databases

MEROPSiI25.020

PTM databases

CarbonylDBiP02765
GlyConnecti23
iPTMnetiP02765
PhosphoSitePlusiP02765
UniCarbKBiP02765

Polymorphism and mutation databases

BioMutaiAHSG
DMDMi112910

2D gel databases

DOSAC-COBS-2DPAGEiP02765
SWISS-2DPAGEiP02765

Proteomic databases

jPOSTiP02765
MaxQBiP02765
PaxDbiP02765
PeptideAtlasiP02765
PRIDEiP02765
ProteomicsDBi51585
TopDownProteomicsiP02765

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
197
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000411641; ENSP00000393887; ENSG00000145192
GeneIDi197
KEGGihsa:197
UCSCiuc003fqk.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
197
DisGeNETi197

GeneCards: human genes, protein and diseases

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GeneCardsi
AHSG

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0024338
HGNCiHGNC:349 AHSG
HPAiCAB026209
HPA001524
HPA001525
MalaCardsiAHSG
MIMi138680 gene
203650 phenotype
neXtProtiNX_P02765
OpenTargetsiENSG00000145192
Orphaneti2850 Alopecia-intellectual disability syndrome
PharmGKBiPA24642

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IK8F Eukaryota
ENOG4111RIP LUCA
GeneTreeiENSGT00950000182930
InParanoidiP02765
OrthoDBi913381at2759
PhylomeDBiP02765
TreeFamiTF333729

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-6798695 Neutrophil degranulation
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AHSG human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Alpha-2-HS-glycoprotein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
197
PMAP-CutDBiP02765

Protein Ontology

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PROi
PR:P02765

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145192 Expressed in 115 organ(s), highest expression level in liver
ExpressionAtlasiP02765 baseline and differential
GenevisibleiP02765 HS

Family and domain databases

CDDicd00042 CY, 2 hits
InterProiView protein in InterPro
IPR000010 Cystatin_dom
IPR025760 Cystatin_Fetuin_A
IPR001363 Prot_inh_fetuin_CS
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 2 hits
PROSITEiView protein in PROSITE
PS51529 CYSTATIN_FETUIN_A, 2 hits
PS01254 FETUIN_1, 1 hit
PS01255 FETUIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFETUA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02765
Secondary accession number(s): A8K9N6
, B2R7G1, O14961, O14962, Q9P152
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 12, 2018
Last modified: May 8, 2019
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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