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UniProtKB - P02763 (A1AG1_HUMAN)

Protein

Alpha-1-acid glycoprotein 1

Gene

ORM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAcute phase, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-1-acid glycoprotein 1
Short name:
AGP 1
Alternative name(s):
Orosomucoid-1
Short name:
OMD 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ORM1
Synonyms:AGP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000229314.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:8498 ORM1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		138600 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P02763

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5004

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA260

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4285

Drug and drug target database

More...DrugBanki		DB05812 Abiraterone
DB01418 Acenocoumarol
DB01426 Ajmaline
DB00802 Alfentanil
DB00321 Amitriptyline
DB00543 Amoxapine
DB01429 Aprindine
DB01156 Bupropion
DB08907 Canagliflozin
DB00482 Celecoxib
DB00477 Chlorpromazine
DB01151 Desipramine
DB00280 Disopyramide
DB00590 Doxazosin
DB01142 Doxepin
DB00530 Erlotinib
DB00472 Fluoxetine
DB00317 Gefitinib
DB00619 Imatinib
DB00458 Imipramine
DB08820 Ivacaftor
DB00934 Maprotiline
DB08893 Mirabegron
DB00731 Nateglinide
DB04821 Nomifensine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00497 Oxycodone
DB01359 Penbutolol
DB00454 Pethidine
DB00946 Phenprocoumon
DB08860 Pitavastatin
DB00457 Prazosin
DB00571 Propranolol
DB00908 Quinidine
DB08931 Riociguat
DB01232 Saquinavir
DB00864 Tacrolimus
DB00706 Tamsulosin
DB05521 Telaprevir
DB01041 Thalidomide
DB00656 Trazodone
DB08867 Ulipristal
DB05294 Vandetanib
DB08881 Vemurafenib
DB08828 Vismodegib
DB00682 Warfarin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ORM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		112877

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 181 PublicationAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001786019 – 201Alpha-1-acid glycoprotein 1Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi23 ↔ 1651 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi33N-linked (GlcNAc...) (complex) asparagine8 Publications1
Glycosylationi56N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi72N-linked (GlcNAc...) (complex) asparagine5 Publications1
Disulfide bondi90 ↔ 1831 Publication
Glycosylationi93N-linked (GlcNAc...) asparagine8 Publications1
GlycosylationiCAR_000170103N-linked (GlcNAc...) asparagine4 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).10 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P02763

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P02763

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02763

PeptideAtlas

More...PeptideAtlasi		P02763

PRoteomics IDEntifications database

More...PRIDEi		P02763

ProteomicsDB human proteome resource

More...ProteomicsDBi		51584

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P02763

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P02763

GlyConnect protein glycosylation platform

More...GlyConnecti		718

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P02763

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P02763

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P02763

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000229314 Expressed in 95 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...CleanExi		HS_ORM1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P02763 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB006265
HPA046438
HPA047725
HPA057726

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SERPINE1P051214EBI-976767,EBI-953978

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111046, 16 interactors

Protein interaction database and analysis system

More...IntActi		P02763, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000259396

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P02763

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KQ0X-ray1.80A19-201[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P02763

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P02763

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P02763

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a beta-barrel that binds various ligands in its interior.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IWZI Eukaryota
ENOG4111C49 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000125170

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG000035

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02763

KEGG Orthology (KO)

More...KOi		K17308

Database of Orthologous Groups

More...OrthoDBi		1257041at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P02763

TreeFam database of animal gene trees

More...TreeFami		TF343791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001500 A1A_glycop
IPR012674 Calycin
IPR000566 Lipocln_cytosolic_FA-bd_dom

The PANTHER Classification System

More...PANTHERi		PTHR11967 PTHR11967, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00061 Lipocalin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036899 AGP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00708 A1AGLPROTEIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50814 SSF50814, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02763-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDQIT GKWFYIASAF 
        60         70         80         90        100
RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ 
       110        120        130        140        150
RENGTISRYV GGQEHFAHLL ILRDTKTYML AFDVNDEKNW GLSVYADKPE 
       160        170        180        190        200
TTKEQLGEFY EALDCLRIPK SDVVYTDWKK DKCEPLEKQH EKERKQEEGE 

S
Length:201
Mass (Da):23,512
Last modified:January 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63292233AD6EAD8B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA29229 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti170K → R in AAI43315 (PubMed:15489334).Curated1
Sequence conflicti182Missing AA sequence (PubMed:4561179).Curated1
Sequence conflicti193Missing AA sequence (PubMed:4561179).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and ORM1*S has Arg-38/Val-174. The sequence shown is that of allele ORM1*F1.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01384038Q → R in allele ORM1*S. 4 Publications1
Natural variantiVAR_056166167R → C1 PublicationCorresponds to variant dbSNP:rs3182034Ensembl.1
Natural variantiVAR_013841174V → M in allele ORM1*F2. 2 PublicationsCorresponds to variant dbSNP:rs1126801Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X02544 mRNA Translation: CAA26397.1
M13692 mRNA Translation: AAA35515.1
X05779
, X05780, X05781, X05782, X05783, X05784 Genomic DNA Translation: CAA29229.1 Sequence problems.
X06676 Genomic DNA No translation available.
X06680 Genomic DNA No translation available.
BT019790 mRNA Translation: AAV38593.1
AK312035 mRNA Translation: BAG34972.1
AL356796 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87416.1
BC104818 mRNA Translation: AAI04819.1
BC104820 mRNA Translation: AAI04821.1
BC143313 mRNA Translation: AAI43314.1
BC143314 mRNA Translation: AAI43315.1
BC026238 mRNA Translation: AAH26238.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6803.1

Protein sequence database of the Protein Information Resource

More...PIRi		A28346 OMHU1

NCBI Reference Sequences

More...RefSeqi		NP_000598.2, NM_000607.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.522356

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000259396; ENSP00000259396; ENSG00000229314

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5004

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5004

UCSC genome browser

More...UCSCi		uc004bik.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02544 mRNA Translation: CAA26397.1
M13692 mRNA Translation: AAA35515.1
X05779
, X05780, X05781, X05782, X05783, X05784 Genomic DNA Translation: CAA29229.1 Sequence problems.
X06676 Genomic DNA No translation available.
X06680 Genomic DNA No translation available.
BT019790 mRNA Translation: AAV38593.1
AK312035 mRNA Translation: BAG34972.1
AL356796 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87416.1
BC104818 mRNA Translation: AAI04819.1
BC104820 mRNA Translation: AAI04821.1
BC143313 mRNA Translation: AAI43314.1
BC143314 mRNA Translation: AAI43315.1
BC026238 mRNA Translation: AAH26238.1
CCDSiCCDS6803.1
PIRiA28346 OMHU1
RefSeqiNP_000598.2, NM_000607.2
UniGeneiHs.522356

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KQ0X-ray1.80A19-201[»]
ProteinModelPortaliP02763
SMRiP02763
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111046, 16 interactors
IntActiP02763, 7 interactors
STRINGi9606.ENSP00000259396

Chemistry databases

BindingDBiP02763
ChEMBLiCHEMBL4285
DrugBankiDB05812 Abiraterone
DB01418 Acenocoumarol
DB01426 Ajmaline
DB00802 Alfentanil
DB00321 Amitriptyline
DB00543 Amoxapine
DB01429 Aprindine
DB01156 Bupropion
DB08907 Canagliflozin
DB00482 Celecoxib
DB00477 Chlorpromazine
DB01151 Desipramine
DB00280 Disopyramide
DB00590 Doxazosin
DB01142 Doxepin
DB00530 Erlotinib
DB00472 Fluoxetine
DB00317 Gefitinib
DB00619 Imatinib
DB00458 Imipramine
DB08820 Ivacaftor
DB00934 Maprotiline
DB08893 Mirabegron
DB00731 Nateglinide
DB04821 Nomifensine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00497 Oxycodone
DB01359 Penbutolol
DB00454 Pethidine
DB00946 Phenprocoumon
DB08860 Pitavastatin
DB00457 Prazosin
DB00571 Propranolol
DB00908 Quinidine
DB08931 Riociguat
DB01232 Saquinavir
DB00864 Tacrolimus
DB00706 Tamsulosin
DB05521 Telaprevir
DB01041 Thalidomide
DB00656 Trazodone
DB08867 Ulipristal
DB05294 Vandetanib
DB08881 Vemurafenib
DB08828 Vismodegib
DB00682 Warfarin

PTM databases

CarbonylDBiP02763
GlyConnecti718
iPTMnetiP02763
PhosphoSitePlusiP02763
UniCarbKBiP02763

Polymorphism and mutation databases

BioMutaiORM1
DMDMi112877

2D gel databases

SWISS-2DPAGEiP02763

Proteomic databases

EPDiP02763
jPOSTiP02763
PaxDbiP02763
PeptideAtlasiP02763
PRIDEiP02763
ProteomicsDBi51584

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		5004
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259396; ENSP00000259396; ENSG00000229314
GeneIDi5004
KEGGihsa:5004
UCSCiuc004bik.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5004
DisGeNETi5004
EuPathDBiHostDB:ENSG00000229314.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		ORM1
HGNCiHGNC:8498 ORM1
HPAiCAB006265
HPA046438
HPA047725
HPA057726
MIMi138600 gene
neXtProtiNX_P02763
PharmGKBiPA260

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IWZI Eukaryota
ENOG4111C49 LUCA
HOGENOMiHOG000125170
HOVERGENiHBG000035
InParanoidiP02763
KOiK17308
OrthoDBi1257041at2759
PhylomeDBiP02763
TreeFamiTF343791

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ORM1 human
EvolutionaryTraceiP02763

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ORM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5004

Protein Ontology

More...PROi		PR:P02763

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000229314 Expressed in 95 organ(s), highest expression level in liver
CleanExiHS_ORM1
GenevisibleiP02763 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR001500 A1A_glycop
IPR012674 Calycin
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11967 PTHR11967, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PIRSFiPIRSF036899 AGP, 1 hit
PRINTSiPR00708 A1AGLPROTEIN
SUPFAMiSSF50814 SSF50814, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1AG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02763
Secondary accession number(s): B7ZKQ5
, Q5T539, Q5U067, Q8TC16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: January 16, 2019
This is version 201 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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