ORM1

Functionⁱ

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.2 Publications

GO - Biological processⁱ

acute-phase response
Source: ProtInc
Traceable author statementⁱ
- 2822385
inflammatory response
Source: ProtInc
Traceable author statementⁱ
- 3360326
negative regulation of interleukin-6 production
Source: CACAO
Inferred from direct assayⁱ
- 23973664
negative regulation of tumor necrosis factor production
Source: CACAO
Inferred from direct assayⁱ
- 23973664
neutrophil degranulation Source: Reactome
platelet degranulation Source: Reactome
positive regulation of interleukin-1 beta secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 8774350
positive regulation of interleukin-1 secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 8774350
positive regulation of tumor necrosis factor secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 8774350
regulation of immune system process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Acute phase, Transport

Biological process

Acute phase, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-1-acid glycoprotein 1 Short name: AGP 1 Alternative name(s): Orosomucoid-1 Short name: OMD 1
Gene namesⁱ	Name:ORM1 Synonyms:AGP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000229314.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8498 ORM1
MIMⁱ	138600 gene
neXtProtⁱ	NX_P02763

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5004
PharmGKBⁱ	PA260

Chemistry databases

ChEMBLⁱ	CHEMBL4285
Drug and drug target database More...DrugBankⁱ	DB05812 Abiraterone DB01418 Acenocoumarol DB01426 Ajmaline DB00802 Alfentanil DB00321 Amitriptyline DB00543 Amoxapine DB01429 Aprindine DB01156 Bupropion DB08907 Canagliflozin DB00482 Celecoxib DB00477 Chlorpromazine DB01151 Desipramine DB00280 Disopyramide DB00590 Doxazosin DB01142 Doxepin DB00530 Erlotinib DB00472 Fluoxetine DB00317 Gefitinib DB00619 Imatinib DB00458 Imipramine DB08820 Ivacaftor DB00934 Maprotiline DB08893 Mirabegron DB00731 Nateglinide DB04821 Nomifensine DB00540 Nortriptyline DB00334 Olanzapine DB00497 Oxycodone DB01359 Penbutolol DB00454 Pethidine DB00946 Phenprocoumon DB08860 Pitavastatin DB00457 Prazosin DB00571 Propranolol DB00908 Quinidine DB08931 Riociguat DB01232 Saquinavir DB00864 Tacrolimus DB00706 Tamsulosin DB05521 Telaprevir DB01041 Thalidomide DB00656 Trazodone DB08867 Ulipristal DB05294 Vandetanib DB08881 Vemurafenib DB08828 Vismodegib DB00682 Warfarin

ChEMBLⁱ

CHEMBL4285

DrugBankⁱ

DB05812 Abiraterone
DB01418 Acenocoumarol
DB01426 Ajmaline
DB00802 Alfentanil
DB00321 Amitriptyline
DB00543 Amoxapine
DB01429 Aprindine
DB01156 Bupropion
DB08907 Canagliflozin
DB00482 Celecoxib
DB00477 Chlorpromazine
DB01151 Desipramine
DB00280 Disopyramide
DB00590 Doxazosin
DB01142 Doxepin
DB00530 Erlotinib
DB00472 Fluoxetine
DB00317 Gefitinib
DB00619 Imatinib
DB00458 Imipramine
DB08820 Ivacaftor
DB00934 Maprotiline
DB08893 Mirabegron
DB00731 Nateglinide
DB04821 Nomifensine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00497 Oxycodone
DB01359 Penbutolol
DB00454 Pethidine
DB00946 Phenprocoumon
DB08860 Pitavastatin
DB00457 Prazosin
DB00571 Propranolol
DB00908 Quinidine
DB08931 Riociguat
DB01232 Saquinavir
DB00864 Tacrolimus
DB00706 Tamsulosin
DB05521 Telaprevir
DB01041 Thalidomide
DB00656 Trazodone
DB08867 Ulipristal
DB05294 Vandetanib
DB08881 Vemurafenib
DB08828 Vismodegib
DB00682 Warfarin

Polymorphism and mutation databases

BioMutaⁱ	ORM1
DMDMⁱ	112877

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	1 PublicationAdd BLAST		18
ChainⁱPRO_0000017860	19 – 201	Alpha-1-acid glycoprotein 1Add BLAST		183

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	19	Pyrrolidone carboxylic acid1 Publication	1
Disulfide bondⁱ	23 ↔ 165	1 Publication
Glycosylationⁱ	33	N-linked (GlcNAc...) (complex) asparagine8 Publications	1
Glycosylationⁱ	56	N-linked (GlcNAc...) asparagine4 Publications	1
Glycosylationⁱ	72	N-linked (GlcNAc...) (complex) asparagine5 Publications	1
Disulfide bondⁱ	90 ↔ 183	1 Publication
Glycosylationⁱ	93	N-linked (GlcNAc...) asparagine8 Publications	1
GlycosylationⁱCAR_000170	103	N-linked (GlcNAc...) asparagine4 Publications	1

Post-translational modificationⁱ

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).10 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDⁱ	P02763
PaxDbⁱ	P02763
PeptideAtlas More...PeptideAtlasⁱ	P02763
PRIDEⁱ	P02763
ProteomicsDBⁱ	51584

2D gel databases

SWISS-2DPAGEⁱ	P02763

SWISS-2DPAGEⁱ

P02763

PTM databases

CarbonylDBⁱ	P02763
GlyConnectⁱ	718
iPTMnetⁱ	P02763
PhosphoSitePlusⁱ	P02763
UniCarbKBⁱ	P02763

Expressionⁱ

Tissue specificityⁱ

Expressed by the liver and secreted in plasma.

Inductionⁱ

Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.

Gene expression databases

Bgeeⁱ	ENSG00000229314 Expressed in 95 organ(s), highest expression level in liver
CleanExⁱ	HS_ORM1
Genevisibleⁱ	P02763 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB006265 HPA046438 HPA047725 HPA057726

HPAⁱ

CAB006265
HPA046438
HPA047725
HPA057726

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SERPINE1	P05121	4	EBI-976767,EBI-953978

With

Entry

#Exp.

IntAct

Notes

SERPINE1

P05121

4

EBI-976767,EBI-953978

Protein-protein interaction databases

BioGridⁱ	111046, 16 interactors
IntActⁱ	P02763, 7 interactors
STRINGⁱ	9606.ENSP00000259396

Chemistry databases

BindingDBⁱ

P02763

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	24 – 26	Combined sources	3
Helixⁱ	33 – 39	Combined sources	7
Beta strandⁱ	41 – 52	Combined sources	12
Helixⁱ	53 – 59	Combined sources	7
Beta strandⁱ	62 – 72	Combined sources	11
Turnⁱ	73 – 76	Combined sources	4
Beta strandⁱ	77 – 86	Combined sources	10
Beta strandⁱ	89 – 100	Combined sources	12
Turnⁱ	101 – 104	Combined sources	4
Beta strandⁱ	105 – 110	Combined sources	6
Beta strandⁱ	113 – 121	Combined sources	9
Beta strandⁱ	127 – 132	Combined sources	6
Helixⁱ	137 – 139	Combined sources	3
Beta strandⁱ	141 – 149	Combined sources	9
Turnⁱ	153 – 156	Combined sources	4
Helixⁱ	157 – 166	Combined sources	10
Helixⁱ	170 – 172	Combined sources	3
Helixⁱ	178 – 180	Combined sources	3
Helixⁱ	184 – 192	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P02763
SMRⁱ	P02763
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02763

EvolutionaryTraceⁱ

P02763

Family & Domainsⁱ

Domainⁱ

Contains a beta-barrel that binds various ligands in its interior.1 Publication

Sequence similaritiesⁱ

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IWZI Eukaryota ENOG4111C49 LUCA
HOGENOMⁱ	HOG000125170
HOVERGENⁱ	HBG000035
InParanoidⁱ	P02763
KEGG Orthology (KO) More...KOⁱ	K17308
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NAQ
PhylomeDBⁱ	P02763
TreeFamⁱ	TF343791

Family and domain databases

Gene3Dⁱ	2.40.128.20, 1 hit
InterProⁱ	View protein in InterPro IPR001500 A1A_glycop IPR012674 Calycin IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERⁱ	PTHR11967 PTHR11967, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00061 Lipocalin, 1 hit
PIRSFⁱ	PIRSF036899 AGP, 1 hit
PRINTSⁱ	PR00708 A1AGLPROTEIN
SUPFAMⁱ	SSF50814 SSF50814, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P02763-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDQIT GKWFYIASAF 
        60         70         80         90        100
RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ 
       110        120        130        140        150
RENGTISRYV GGQEHFAHLL ILRDTKTYML AFDVNDEKNW GLSVYADKPE 
       160        170        180        190        200
TTKEQLGEFY EALDCLRIPK SDVVYTDWKK DKCEPLEKQH EKERKQEEGE 

S

Length:201

Mass (Da):23,512

Last modified:January 1, 1988 - v1

Checksum:ⁱ63292233AD6EAD8B

GO

Sequence cautionⁱ

The sequence CAA29229 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	170	K → R in AAI43315 (PubMed:15489334).Curated	1
Sequence conflictⁱ	182	Missing AA sequence (PubMed:4561179).Curated	1
Sequence conflictⁱ	193	Missing AA sequence (PubMed:4561179).Curated	1

Polymorphismⁱ

Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and ORM1*S has Arg-38/Val-174. The sequence shown is that of allele ORM1*F1.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013840	38	Q → R in allele ORM1*S. 4 Publications	1
Natural variantⁱVAR_056166	167	R → C1 PublicationCorresponds to variant dbSNP:rs3182034Ensembl.	1
Natural variantⁱVAR_013841	174	V → M in allele ORM1*F2. 2 PublicationsCorresponds to variant dbSNP:rs1126801Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X02544 mRNA Translation: CAA26397.1 M13692 mRNA Translation: AAA35515.1 X05779 X05784 Genomic DNA Translation: CAA29229.1 Sequence problems. X06676 Genomic DNA No translation available. X06680 Genomic DNA No translation available. BT019790 mRNA Translation: AAV38593.1 AK312035 mRNA Translation: BAG34972.1 AL356796 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87416.1 BC104818 mRNA Translation: AAI04819.1 BC104820 mRNA Translation: AAI04821.1 BC143313 mRNA Translation: AAI43314.1 BC143314 mRNA Translation: AAI43315.1 BC026238 mRNA Translation: AAH26238.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6803.1
PIRⁱ	A28346 OMHU1
NCBI Reference Sequences More...RefSeqⁱ	NP_000598.2, NM_000607.2
UniGeneⁱ	Hs.522356

Genome annotation databases

Ensemblⁱ	ENST00000259396; ENSP00000259396; ENSG00000229314
GeneIDⁱ	5004
KEGGⁱ	hsa:5004
UCSC genome browser More...UCSCⁱ	uc004bik.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P02763	Alpha-1-acid glycoprotein		HUMAN		201	UniRef100_P02763

Protein	Similar proteins		Species	Score	Length	Source
P02763	Alpha-1-acid glycoprotein 2	)	HUMAN		201	UniRef90_P02763
Alpha-1-acid glycoprotein		PANTR		201
Alpha-1-acid glycoprotein		PONAB		201
Alpha-1-acid glycoprotein		NOMLE		201
Alpha-1-acid glycoprotein		GORGO		201
+8

Protein	Similar proteins		Species	Score	Length	Source
P02763	Alpha-1-acid glycoprotein 2	)	HUMAN		201	UniRef50_P02763
Alpha-1-acid glycoprotein		RABIT		201
Alpha-1-acid glycoprotein		BOVIN		202
Alpha-1-acid glycoprotein		NOMLE		201
Alpha-1-acid glycoprotein		GORGO		201
+107

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X02544 mRNA Translation: CAA26397.1 M13692 mRNA Translation: AAA35515.1 X05779 X05784 Genomic DNA Translation: CAA29229.1 Sequence problems. X06676 Genomic DNA No translation available. X06680 Genomic DNA No translation available. BT019790 mRNA Translation: AAV38593.1 AK312035 mRNA Translation: BAG34972.1 AL356796 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87416.1 BC104818 mRNA Translation: AAI04819.1 BC104820 mRNA Translation: AAI04821.1 BC143313 mRNA Translation: AAI43314.1 BC143314 mRNA Translation: AAI43315.1 BC026238 mRNA Translation: AAH26238.1
CCDSⁱ	CCDS6803.1
PIRⁱ	A28346 OMHU1
RefSeqⁱ	NP_000598.2, NM_000607.2
UniGeneⁱ	Hs.522356

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3KQ0	X-ray	1.80	A	19-201	[»]
ProteinModelPortalⁱ	P02763
SMRⁱ	P02763
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111046, 16 interactors
IntActⁱ	P02763, 7 interactors
STRINGⁱ	9606.ENSP00000259396

Chemistry databases

BindingDBⁱ	P02763
ChEMBLⁱ	CHEMBL4285
DrugBankⁱ	DB05812 Abiraterone DB01418 Acenocoumarol DB01426 Ajmaline DB00802 Alfentanil DB00321 Amitriptyline DB00543 Amoxapine DB01429 Aprindine DB01156 Bupropion DB08907 Canagliflozin DB00482 Celecoxib DB00477 Chlorpromazine DB01151 Desipramine DB00280 Disopyramide DB00590 Doxazosin DB01142 Doxepin DB00530 Erlotinib DB00472 Fluoxetine DB00317 Gefitinib DB00619 Imatinib DB00458 Imipramine DB08820 Ivacaftor DB00934 Maprotiline DB08893 Mirabegron DB00731 Nateglinide DB04821 Nomifensine DB00540 Nortriptyline DB00334 Olanzapine DB00497 Oxycodone DB01359 Penbutolol DB00454 Pethidine DB00946 Phenprocoumon DB08860 Pitavastatin DB00457 Prazosin DB00571 Propranolol DB00908 Quinidine DB08931 Riociguat DB01232 Saquinavir DB00864 Tacrolimus DB00706 Tamsulosin DB05521 Telaprevir DB01041 Thalidomide DB00656 Trazodone DB08867 Ulipristal DB05294 Vandetanib DB08881 Vemurafenib DB08828 Vismodegib DB00682 Warfarin

PTM databases

CarbonylDBⁱ	P02763
GlyConnectⁱ	718
iPTMnetⁱ	P02763
PhosphoSitePlusⁱ	P02763
UniCarbKBⁱ	P02763

Polymorphism and mutation databases

BioMutaⁱ	ORM1
DMDMⁱ	112877

2D gel databases

SWISS-2DPAGEⁱ	P02763

SWISS-2DPAGEⁱ

P02763

Proteomic databases

EPDⁱ	P02763
PaxDbⁱ	P02763
PeptideAtlasⁱ	P02763
PRIDEⁱ	P02763
ProteomicsDBⁱ	51584

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5004
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000259396; ENSP00000259396; ENSG00000229314
GeneIDⁱ	5004
KEGGⁱ	hsa:5004
UCSCⁱ	uc004bik.5 human

Organism-specific databases

CTDⁱ	5004
DisGeNETⁱ	5004
EuPathDBⁱ	HostDB:ENSG00000229314.5
GeneCardsⁱ	ORM1
HGNCⁱ	HGNC:8498 ORM1
HPAⁱ	CAB006265 HPA046438 HPA047725 HPA057726
MIMⁱ	138600 gene
neXtProtⁱ	NX_P02763
PharmGKBⁱ	PA260
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWZI Eukaryota ENOG4111C49 LUCA
HOGENOMⁱ	HOG000125170
HOVERGENⁱ	HBG000035
InParanoidⁱ	P02763
KOⁱ	K17308
OrthoDBⁱ	EOG091G0NAQ
PhylomeDBⁱ	P02763
TreeFamⁱ	TF343791

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	ORM1 human
EvolutionaryTraceⁱ	P02763
GeneWikiⁱ	ORM1
GenomeRNAiⁱ	5004
Protein Ontology More...PROⁱ	PR:P02763
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000229314 Expressed in 95 organ(s), highest expression level in liver
CleanExⁱ	HS_ORM1
Genevisibleⁱ	P02763 HS

Family and domain databases

Gene3Dⁱ	2.40.128.20, 1 hit
InterProⁱ	View protein in InterPro IPR001500 A1A_glycop IPR012674 Calycin IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERⁱ	PTHR11967 PTHR11967, 1 hit
Pfamⁱ	View protein in Pfam PF00061 Lipocalin, 1 hit
PIRSFⁱ	PIRSF036899 AGP, 1 hit
PRINTSⁱ	PR00708 A1AGLPROTEIN
SUPFAMⁱ	SSF50814 SSF50814, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A1AG1_HUMAN
Accessionⁱ	P02763Primary (citable) accession number: P02763 Secondary accession number(s): B7ZKQ5 , Q5T539, Q5U067, Q8TC16
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	January 1, 1988
	Last modified:	October 10, 2018
	This is version 200 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P02763 (A1AG1_HUMAN)

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Alpha-1-acid glycoprotein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ