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UniProtKB - P02763 (A1AG1_HUMAN)
Protein
Alpha-1-acid glycoprotein 1
Gene
ORM1
Organism
Homo sapiens (Human)
Status
Functioni
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
2 PublicationsGO - Biological processi
- acute-phase response Source: ProtInc
- inflammatory response Source: ProtInc
- negative regulation of interleukin-6 production Source: CACAO
- negative regulation of tumor necrosis factor production Source: CACAO
- positive regulation of interleukin-1 beta production Source: UniProtKB
- positive regulation of interleukin-1 production Source: UniProtKB
- positive regulation of tumor necrosis factor production Source: UniProtKB
- regulation of immune system process Source: InterPro
Keywordsi
Biological process | Acute phase, Transport |
Enzyme and pathway databases
PathwayCommonsi | P02763 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-6798695, Neutrophil degranulation |
SignaLinki | P02763 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-1-acid glycoprotein 1Short name: AGP 1 Alternative name(s): Orosomucoid-1 Short name: OMD 1 |
Gene namesi | Name:ORM1 Synonyms:AGP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8498, ORM1 |
MIMi | 138600, gene |
neXtProti | NX_P02763 |
VEuPathDBi | HostDB:ENSG00000229314 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: UniProtKB
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- platelet alpha granule lumen Source: Reactome
- specific granule lumen Source: Reactome
- tertiary granule lumen Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5004 |
PharmGKBi | PA260 |
Miscellaneous databases
Pharosi | P02763, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4285 |
DrugBanki | DB12001, Abemaciclib DB05812, Abiraterone DB11703, Acalabrutinib DB01418, Acenocoumarol DB01426, Ajmaline DB00802, Alfentanil DB00346, Alfuzosin DB00404, Alprazolam DB00321, Amitriptyline DB00543, Amoxapine DB00276, Amsacrine DB01429, Aprindine DB09229, Aranidipine DB00278, Argatroban DB09204, Arotinolol DB06216, Asenapine DB01072, Atazanavir DB00289, Atomoxetine DB06237, Avanafil DB16703, Belumosudil DB01086, Benzocaine DB01156, Bupropion DB00490, Buspirone DB11148, Butamben DB08907, Canagliflozin DB00608, Chloroquine DB00477, Chlorpromazine DB01190, Clindamycin DB00907, Cocaine DB00080, Daptomycin DB01264, Darunavir DB11637, Delamanid DB01151, Desipramine DB00343, Diltiazem DB00975, Dipyridamole DB00280, Disopyramide DB01142, Doxepin DB00476, Duloxetine DB01126, Dutasteride DB00530, Erlotinib DB12235, Estetrol DB12466, Favipiravir DB00813, Fentanyl DB00950, Fexofenadine DB01195, Flecainide DB00472, Fluoxetine DB00317, Gefitinib DB00986, Glycopyrronium DB11575, Grazoprevir DB01611, Hydroxychloroquine DB09053, Ibrutinib DB00619, Imatinib DB09262, Imidafenacin DB00458, Imipramine DB00808, Indapamide DB00332, Ipratropium DB01029, Irbesartan DB11757, Istradefylline DB08820, Ivacaftor DB00598, Labetalol DB09236, Lacidipine DB00281, Lidocaine DB01627, Lincomycin DB01601, Lopinavir DB12674, Lurbinectedin DB08932, Macitentan DB00934, Maprotiline DB06234, Maribavir DB00454, Meperidine DB00333, Methadone DB01233, Metoclopramide DB08893, Mirabegron DB01203, Nadolol DB00731, Nateglinide DB11828, Neratinib DB01115, Nifedipine DB04821, Nomifensine DB00540, Nortriptyline DB00334, Olanzapine DB01062, Oxybutynin DB00497, Oxycodone DB14582, Patisiran DB01359, Penbutolol DB12978, Pexidartinib DB00946, Phenprocoumon DB00960, Pindolol DB08860, Pitavastatin DB11642, Pitolisant DB00457, Prazosin DB00396, Progesterone DB00571, Propranolol DB00908, Quinidine DB00481, Raloxifene DB00243, Ranolazine DB11853, Relugolix DB00409, Remoxipride DB01045, Rifampicin DB08931, Riociguat DB14840, Ripretinib DB00734, Risperidone DB00503, Ritonavir DB00938, Salmeterol DB01232, Saquinavir DB11689, Selumetinib DB00877, Sirolimus DB01591, Solifenacin DB00421, Spironolactone DB00864, Tacrolimus DB00706, Tamsulosin DB05521, Telaprevir DB00853, Temozolomide DB15133, Tepotinib DB00857, Terbinafine DB01041, Thalidomide DB01685, Topiroxostat DB08867, Ulipristal DB00512, Vancomycin DB05294, Vandetanib DB08881, Vemurafenib DB00661, Verapamil DB11641, Vinflunine DB08828, Vismodegib DB00682, Warfarin DB00246, Ziprasidone |
DrugCentrali | P02763 |
Genetic variation databases
BioMutai | ORM1 |
DMDMi | 112877 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_0000017860 | 19 – 201 | Alpha-1-acid glycoprotein 1Add BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Disulfide bondi | 23 ↔ 165 | 1 Publication | ||
Glycosylationi | 33 | N-linked (GlcNAc...) (complex) asparagine8 Publications | 1 | |
Glycosylationi | 56 | N-linked (GlcNAc...) asparagine4 Publications | 1 | |
Glycosylationi | 72 | N-linked (GlcNAc...) (complex) asparagine5 Publications | 1 | |
Disulfide bondi | 90 ↔ 183 | 1 Publication | ||
Glycosylationi | 93 | N-linked (GlcNAc...) asparagine8 Publications | 1 | |
GlycosylationiCAR_000170 | 103 | N-linked (GlcNAc...) asparagine4 Publications | 1 |
Post-translational modificationi
N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).10 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acidProteomic databases
EPDi | P02763 |
jPOSTi | P02763 |
MassIVEi | P02763 |
PaxDbi | P02763 |
PeptideAtlasi | P02763 |
PRIDEi | P02763 |
ProteomicsDBi | 51584 |
2D gel databases
SWISS-2DPAGEi | P02763 |
PTM databases
CarbonylDBi | P02763 |
GlyConnecti | 718, 87 N-Linked glycans (5 sites) |
GlyGeni | P02763, 6 sites, 82 N-linked glycans (6 sites) |
iPTMneti | P02763 |
PhosphoSitePlusi | P02763 |
Expressioni
Tissue specificityi
Expressed by the liver and secreted in plasma.
Inductioni
Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.
Gene expression databases
Bgeei | ENSG00000229314, Expressed in liver and 115 other tissues |
Genevisiblei | P02763, HS |
Organism-specific databases
HPAi | ENSG00000229314, Tissue enriched (liver) |
Interactioni
Binary interactionsi
P02763
With | #Exp. | IntAct |
---|---|---|
SERPINE1 [P05121] | 4 | EBI-976767,EBI-953978 |
Protein-protein interaction databases
BioGRIDi | 111046, 78 interactors |
IntActi | P02763, 17 interactors |
MINTi | P02763 |
STRINGi | 9606.ENSP00000259396 |
Chemistry databases
BindingDBi | P02763 |
Miscellaneous databases
RNActi | P02763, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P02763 |
SMRi | P02763 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02763 |
Family & Domainsi
Domaini
Contains a beta-barrel that binds various ligands in its interior.1 Publication
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S0Q2, Eukaryota |
HOGENOMi | CLU_117688_0_0_1 |
InParanoidi | P02763 |
OrthoDBi | 1025450at2759 |
PhylomeDBi | P02763 |
TreeFami | TF343791 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR001500, A1A_glycop IPR012674, Calycin IPR000566, Lipocln_cytosolic_FA-bd_dom |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PIRSFi | PIRSF036899, AGP, 1 hit |
PRINTSi | PR00708, A1AGLPROTEIN |
SUPFAMi | SSF50814, SSF50814, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P02763-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF
60 70 80 90 100
RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ
110 120 130 140 150
RENGTISRYV GGQEHFAHLL ILRDTKTYML AFDVNDEKNW GLSVYADKPE
160 170 180 190 200
TTKEQLGEFY EALDCLRIPK SDVVYTDWKK DKCEPLEKQH EKERKQEEGE
S
Sequence cautioni
The sequence CAA29229 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 170 | K → R in AAI43315 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 182 | Missing AA sequence (PubMed:4561179).Curated | 1 | |
Sequence conflicti | 193 | Missing AA sequence (PubMed:4561179).Curated | 1 |
Polymorphismi
Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and ORM1*S has Arg-38/Val-174. The sequence shown is that of allele ORM1*S.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013840 | 38 | R → Q in allele ORM1*S. 4 Publications | 1 | |
Natural variantiVAR_056166 | 167 | R → C1 PublicationCorresponds to variant dbSNP:rs3182034Ensembl. | 1 | |
Natural variantiVAR_013841 | 174 | V → M in allele ORM1*F2. 2 PublicationsCorresponds to variant dbSNP:rs1126801EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02544 mRNA Translation: CAA26397.1 M13692 mRNA Translation: AAA35515.1 X05779 , X05780, X05781, X05782, X05783, X05784 Genomic DNA Translation: CAA29229.1 Sequence problems. X06676 Genomic DNA No translation available. X06680 Genomic DNA No translation available. BT019790 mRNA Translation: AAV38593.1 AK312035 mRNA Translation: BAG34972.1 AL356796 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87416.1 BC104818 mRNA Translation: AAI04819.1 BC104820 mRNA Translation: AAI04821.1 BC143313 mRNA Translation: AAI43314.1 BC143314 mRNA Translation: AAI43315.1 BC026238 mRNA Translation: AAH26238.1 |
CCDSi | CCDS6803.1 |
PIRi | A28346, OMHU1 |
RefSeqi | NP_000598.2, NM_000607.2 |
Genome annotation databases
Ensembli | ENST00000259396.9; ENSP00000259396.8; ENSG00000229314.6 |
GeneIDi | 5004 |
KEGGi | hsa:5004 |
MANE-Selecti | ENST00000259396.9; ENSP00000259396.8; NM_000607.4; NP_000598.2 |
UCSCi | uc004bik.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02544 mRNA Translation: CAA26397.1 M13692 mRNA Translation: AAA35515.1 X05779 , X05780, X05781, X05782, X05783, X05784 Genomic DNA Translation: CAA29229.1 Sequence problems. X06676 Genomic DNA No translation available. X06680 Genomic DNA No translation available. BT019790 mRNA Translation: AAV38593.1 AK312035 mRNA Translation: BAG34972.1 AL356796 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87416.1 BC104818 mRNA Translation: AAI04819.1 BC104820 mRNA Translation: AAI04821.1 BC143313 mRNA Translation: AAI43314.1 BC143314 mRNA Translation: AAI43315.1 BC026238 mRNA Translation: AAH26238.1 |
CCDSi | CCDS6803.1 |
PIRi | A28346, OMHU1 |
RefSeqi | NP_000598.2, NM_000607.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3KQ0 | X-ray | 1.80 | A | 19-201 | [»] | |
AlphaFoldDBi | P02763 | |||||
SMRi | P02763 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111046, 78 interactors |
IntActi | P02763, 17 interactors |
MINTi | P02763 |
STRINGi | 9606.ENSP00000259396 |
Chemistry databases
BindingDBi | P02763 |
ChEMBLi | CHEMBL4285 |
DrugBanki | DB12001, Abemaciclib DB05812, Abiraterone DB11703, Acalabrutinib DB01418, Acenocoumarol DB01426, Ajmaline DB00802, Alfentanil DB00346, Alfuzosin DB00404, Alprazolam DB00321, Amitriptyline DB00543, Amoxapine DB00276, Amsacrine DB01429, Aprindine DB09229, Aranidipine DB00278, Argatroban DB09204, Arotinolol DB06216, Asenapine DB01072, Atazanavir DB00289, Atomoxetine DB06237, Avanafil DB16703, Belumosudil DB01086, Benzocaine DB01156, Bupropion DB00490, Buspirone DB11148, Butamben DB08907, Canagliflozin DB00608, Chloroquine DB00477, Chlorpromazine DB01190, Clindamycin DB00907, Cocaine DB00080, Daptomycin DB01264, Darunavir DB11637, Delamanid DB01151, Desipramine DB00343, Diltiazem DB00975, Dipyridamole DB00280, Disopyramide DB01142, Doxepin DB00476, Duloxetine DB01126, Dutasteride DB00530, Erlotinib DB12235, Estetrol DB12466, Favipiravir DB00813, Fentanyl DB00950, Fexofenadine DB01195, Flecainide DB00472, Fluoxetine DB00317, Gefitinib DB00986, Glycopyrronium DB11575, Grazoprevir DB01611, Hydroxychloroquine DB09053, Ibrutinib DB00619, Imatinib DB09262, Imidafenacin DB00458, Imipramine DB00808, Indapamide DB00332, Ipratropium DB01029, Irbesartan DB11757, Istradefylline DB08820, Ivacaftor DB00598, Labetalol DB09236, Lacidipine DB00281, Lidocaine DB01627, Lincomycin DB01601, Lopinavir DB12674, Lurbinectedin DB08932, Macitentan DB00934, Maprotiline DB06234, Maribavir DB00454, Meperidine DB00333, Methadone DB01233, Metoclopramide DB08893, Mirabegron DB01203, Nadolol DB00731, Nateglinide DB11828, Neratinib DB01115, Nifedipine DB04821, Nomifensine DB00540, Nortriptyline DB00334, Olanzapine DB01062, Oxybutynin DB00497, Oxycodone DB14582, Patisiran DB01359, Penbutolol DB12978, Pexidartinib DB00946, Phenprocoumon DB00960, Pindolol DB08860, Pitavastatin DB11642, Pitolisant DB00457, Prazosin DB00396, Progesterone DB00571, Propranolol DB00908, Quinidine DB00481, Raloxifene DB00243, Ranolazine DB11853, Relugolix DB00409, Remoxipride DB01045, Rifampicin DB08931, Riociguat DB14840, Ripretinib DB00734, Risperidone DB00503, Ritonavir DB00938, Salmeterol DB01232, Saquinavir DB11689, Selumetinib DB00877, Sirolimus DB01591, Solifenacin DB00421, Spironolactone DB00864, Tacrolimus DB00706, Tamsulosin DB05521, Telaprevir DB00853, Temozolomide DB15133, Tepotinib DB00857, Terbinafine DB01041, Thalidomide DB01685, Topiroxostat DB08867, Ulipristal DB00512, Vancomycin DB05294, Vandetanib DB08881, Vemurafenib DB00661, Verapamil DB11641, Vinflunine DB08828, Vismodegib DB00682, Warfarin DB00246, Ziprasidone |
DrugCentrali | P02763 |
PTM databases
CarbonylDBi | P02763 |
GlyConnecti | 718, 87 N-Linked glycans (5 sites) |
GlyGeni | P02763, 6 sites, 82 N-linked glycans (6 sites) |
iPTMneti | P02763 |
PhosphoSitePlusi | P02763 |
Genetic variation databases
BioMutai | ORM1 |
DMDMi | 112877 |
2D gel databases
SWISS-2DPAGEi | P02763 |
Proteomic databases
EPDi | P02763 |
jPOSTi | P02763 |
MassIVEi | P02763 |
PaxDbi | P02763 |
PeptideAtlasi | P02763 |
PRIDEi | P02763 |
ProteomicsDBi | 51584 |
Protocols and materials databases
Antibodypediai | 29904, 623 antibodies from 39 providers |
DNASUi | 5004 |
Genome annotation databases
Ensembli | ENST00000259396.9; ENSP00000259396.8; ENSG00000229314.6 |
GeneIDi | 5004 |
KEGGi | hsa:5004 |
MANE-Selecti | ENST00000259396.9; ENSP00000259396.8; NM_000607.4; NP_000598.2 |
UCSCi | uc004bik.5, human |
Organism-specific databases
CTDi | 5004 |
DisGeNETi | 5004 |
GeneCardsi | ORM1 |
HGNCi | HGNC:8498, ORM1 |
HPAi | ENSG00000229314, Tissue enriched (liver) |
MIMi | 138600, gene |
neXtProti | NX_P02763 |
PharmGKBi | PA260 |
VEuPathDBi | HostDB:ENSG00000229314 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0Q2, Eukaryota |
HOGENOMi | CLU_117688_0_0_1 |
InParanoidi | P02763 |
OrthoDBi | 1025450at2759 |
PhylomeDBi | P02763 |
TreeFami | TF343791 |
Enzyme and pathway databases
PathwayCommonsi | P02763 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-6798695, Neutrophil degranulation |
SignaLinki | P02763 |
Miscellaneous databases
BioGRID-ORCSi | 5004, 23 hits in 1047 CRISPR screens |
ChiTaRSi | ORM1, human |
EvolutionaryTracei | P02763 |
GeneWikii | ORM1 |
GenomeRNAii | 5004 |
Pharosi | P02763, Tbio |
PROi | PR:P02763 |
RNActi | P02763, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000229314, Expressed in liver and 115 other tissues |
Genevisiblei | P02763, HS |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR001500, A1A_glycop IPR012674, Calycin IPR000566, Lipocln_cytosolic_FA-bd_dom |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PIRSFi | PIRSF036899, AGP, 1 hit |
PRINTSi | PR00708, A1AGLPROTEIN |
SUPFAMi | SSF50814, SSF50814, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A1AG1_HUMAN | |
Accessioni | P02763Primary (citable) accession number: P02763 Secondary accession number(s): B7ZKQ5 Q8TC16 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | February 23, 2022 | |
Last modified: | May 25, 2022 | |
This is version 218 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families