UniProtKB - P02761 (MUP_RAT)
Major urinary protein
Functioni
Major urinary proteins (Mups) bind and release pheromones. They may also protect pheromones from oxidation. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice.
GO - Molecular functioni
- insulin-activated receptor activity Source: UniProtKB
- odorant binding Source: GO_Central
- pheromone binding Source: UniProtKB
- small molecule binding Source: InterPro
GO - Biological processi
- aerobic respiration Source: UniProtKB
- cellular response to lipid Source: UniProtKB
- energy reserve metabolic process Source: UniProtKB
- glucose homeostasis Source: UniProtKB
- heat generation Source: UniProtKB
- locomotor rhythm Source: UniProtKB
- mitochondrion morphogenesis Source: UniProtKB
- negative regulation of gluconeogenesis Source: UniProtKB
- negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
- negative regulation of lipid biosynthetic process Source: UniProtKB
- negative regulation of lipid storage Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of glucose metabolic process Source: UniProtKB
- positive regulation of lipid metabolic process Source: UniProtKB
- positive regulation of protein kinase B signaling Source: UniProtKB
Keywordsi
Biological process | Behavior, Transport |
Ligand | Pheromone-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Major urinary proteinShort name: MUP Alternative name(s): Allergen Rat n I Alpha(2)-euglobulin Alpha-2u-globulin alpha-2u globulin PGCL1 Allergen: Rat n 1 Cleaved into the following chain: |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 708506, LOC259246 |
Subcellular locationi
Cytoplasm and Cytosol
Note: It is probably taken up from the urinary lumen by endocytosis.
Extracellular region or secreted
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular space Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, SecretedPathology & Biotechi
Allergenic propertiesi
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 3464, Rat n 1.0101 611, Rat n 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 2 PublicationsAdd BLAST | 19 | |
ChainiPRO_0000017925 | 20 – 181 | Major urinary proteinAdd BLAST | 162 | |
ChainiPRO_0000017926 | 29 – 179 | 15.5 kDa fatty acid-binding proteinAdd BLAST | 151 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Disulfide bondi | 83 ↔ 176 | 1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P02761 |
PRIDEi | P02761 |
PTM databases
GlyGeni | P02761, 1 site |
Expressioni
Tissue specificityi
Inductioni
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P02761 |
SMRi | P02761 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02761 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S6GK, Eukaryota |
InParanoidi | P02761 |
PhylomeDBi | P02761 |
TreeFami | TF338197 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR002345, Lipocalin IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom IPR002971, Maj_urinary |
PANTHERi | PTHR11430, PTHR11430, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR01221, MAJORURINARY |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MKLLLLLLCL GLTLVCGHAE EASSTRGNLD VAKLNGDWFS IVVASNKREK
60 70 80 90 100
IEENGSMRVF MQHIDVLENS LGFKFRIKEN GECRELYLVA YKTPEDGEYF
110 120 130 140 150
VEYDGGNTFT ILKTDYDRYV MFHLINFKNG ETFQLMVLYG RTKDLSSDIK
160 170 180
EKFAKLCEAH GITRDNIIDL TKTDRCLQAR G
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9JJH9 | Q9JJH9_RAT | Alpha-2u globulin | Mup4 LOC100909412, LOC500473, rCG_31930 | 181 | Annotation score: | ||
Q9JJI3 | Q9JJI3_RAT | Alpha-2u globulin | LOC259244 LOC500473, Obp3, rCG_31988 | 181 | Annotation score: | ||
F7ET54 | F7ET54_RAT | Major urinary protein-like | LOC259244 LOC120102889, LOC259245 | 181 | Annotation score: | ||
F1LQM1 | F1LQM1_RAT | Major urinary protein-like | LOC120102889 | 181 | Annotation score: | ||
M0RBS2 | M0RBS2_RAT | Major urinary protein-like | LOC120102889 | 181 | Annotation score: | ||
A0A096MIX6 | A0A096MIX6_RAT | Major urinary protein-like | LOC120102889 | 202 | Annotation score: | ||
A0A0G2JTN2 | A0A0G2JTN2_RAT | Alpha-2u globulin PGCL3 | LOC500473 | 181 | Annotation score: | ||
A0A096MJW3 | A0A096MJW3_RAT | Major urinary protein-like | LOC120102889 | 179 | Annotation score: | ||
M0R8N5 | M0R8N5_RAT | Uncharacterized protein | Mup4 | 198 | Annotation score: | ||
A0A096MK41 | A0A096MK41_RAT | Similar to alpha-2u globulin PGCL2 | LOC500473 | 181 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | R → S in AAA41198 (PubMed:6167987).Curated | 1 | |
Sequence conflicti | 55 | G → D in CAA24531 (PubMed:6163771).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26835 mRNA Translation: AAA40643.1 M26837 mRNA Translation: AAA40641.1 AB039822 mRNA Translation: BAA96479.1 BC088109 mRNA Translation: AAH88109.1 BC098654 mRNA Translation: AAH98654.1 BC105816 mRNA Translation: AAI05817.1 U31287 mRNA Translation: AAA75511.1 V01220 mRNA Translation: CAA24531.1 J00737 mRNA Translation: AAA41198.1 |
PIRi | A92317, UART |
RefSeqi | NP_671747.1, NM_147214.2 |
Genome annotation databases
Ensembli | ENSRNOT00000100434; ENSRNOP00000080129; ENSRNOG00000067602 ENSRNOT00000120034; ENSRNOP00000092008; ENSRNOG00000067602 |
GeneIDi | 259246 |
UCSCi | RGD:708506, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26835 mRNA Translation: AAA40643.1 M26837 mRNA Translation: AAA40641.1 AB039822 mRNA Translation: BAA96479.1 BC088109 mRNA Translation: AAH88109.1 BC098654 mRNA Translation: AAH98654.1 BC105816 mRNA Translation: AAI05817.1 U31287 mRNA Translation: AAA75511.1 V01220 mRNA Translation: CAA24531.1 J00737 mRNA Translation: AAA41198.1 |
PIRi | A92317, UART |
RefSeqi | NP_671747.1, NM_147214.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2A2G | X-ray | 2.90 | A/B/C/D | 1-181 | [»] | |
2A2U | X-ray | 2.50 | A/B/C/D | 1-181 | [»] | |
AlphaFoldDBi | P02761 | |||||
SMRi | P02761 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000068097 |
Protein family/group databases
Allergomei | 3464, Rat n 1.0101 611, Rat n 1 |
PTM databases
GlyGeni | P02761, 1 site |
Proteomic databases
PaxDbi | P02761 |
PRIDEi | P02761 |
Genome annotation databases
Ensembli | ENSRNOT00000100434; ENSRNOP00000080129; ENSRNOG00000067602 ENSRNOT00000120034; ENSRNOP00000092008; ENSRNOG00000067602 |
GeneIDi | 259246 |
UCSCi | RGD:708506, rat |
Organism-specific databases
RGDi | 708506, LOC259246 |
Phylogenomic databases
eggNOGi | ENOG502S6GK, Eukaryota |
InParanoidi | P02761 |
PhylomeDBi | P02761 |
TreeFami | TF338197 |
Miscellaneous databases
EvolutionaryTracei | P02761 |
PROi | PR:P02761 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR002345, Lipocalin IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom IPR002971, Maj_urinary |
PANTHERi | PTHR11430, PTHR11430, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR01221, MAJORURINARY |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MUP_RAT | |
Accessioni | P02761Primary (citable) accession number: P02761 Secondary accession number(s): Q54AE7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Allergens
Nomenclature of allergens and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families