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Protein

Protein AMBP

Gene

AMBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.1 Publication
Trypstatin is a trypsin inhibitor.By similarity

Miscellaneous

In vitro, the first twelve residues of the amino end of the inhibitor appear to have a reactive site capable of inhibiting the activity of a number of enzymes. Its in vivo function is not known.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei53Multimeric 3-hydroxykynurenine chromophore (covalent)1
Binding sitei111Multimeric 3-hydroxykynurenine chromophore (covalent)1
Binding sitei137Multimeric 3-hydroxykynurenine chromophore (covalent)1
Binding sitei149Multimeric 3-hydroxykynurenine chromophore (covalent)1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei241 – 242Inhibitory (P1) (chymotrypsin, elastase)By similarity2
Sitei297 – 298Inhibitory (P1) (trypsin)By similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium channel inhibitor activity Source: UniProtKB
  • calcium oxalate binding Source: UniProtKB
  • heme binding Source: UniProtKB
  • IgA binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processHost-virus interaction
LigandChromophore

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2168880 Scavenging of heme from plasma

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein AMBP
Cleaved into the following 3 chains:
Alpha-1-microglobulin
Short name:
Protein HC
Alternative name(s):
Alpha-1 microglycoprotein
Complex-forming glycoprotein heterogeneous in charge
Alternative name(s):
Bikunin
EDC1
HI-30
Uronic-acid-rich protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMBP
Synonyms:HCP, ITIL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000106927.11

Human Gene Nomenclature Database

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HGNCi
HGNC:453 AMBP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
176870 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02760

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
259

Open Targets

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OpenTargetsi
ENSG00000106927

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24759

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00062 Human Serum Albumin
DB00064 Serum albumin iodonated

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AMBP

Domain mapping of disease mutations (DMDM)

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DMDMi
122801

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 193 PublicationsAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001788620 – 203Alpha-1-microglobulinAdd BLAST184
ChainiPRO_0000017887206 – 352Inter-alpha-trypsin inhibitor light chainAdd BLAST147
ChainiPRO_0000318926284 – 344TrypstatinBy similarityAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00017224O-linked (GalNAc...) threonine1 Publication1
Glycosylationi36N-linked (GlcNAc...) (complex) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi91 ↔ 188
Glycosylationi115N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi215O-linked (Xyl...) (chondroitin sulfate) serine3 Publications1
Disulfide bondi231 ↔ 281
Disulfide bondi240 ↔ 264
Glycosylationi250N-linked (GlcNAc...) (complex) asparagine2 Publications1
Disulfide bondi256 ↔ 277
Disulfide bondi287 ↔ 337
Disulfide bondi296 ↔ 320
Disulfide bondi312 ↔ 333

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is proteolytically processed into separately functioning proteins.
3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross-links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.
Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate.By similarity
N- and O-glycosylated. N-glycan heterogeneity at Asn-115: Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor). N-glycan at Asn-250: Hex5HexNAc4. O-linkage of the glycosaminoglycan, chondroitin sulfate, at Ser-215 allows cross-linking between the three polypeptide chains.5 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P02760

MaxQB - The MaxQuant DataBase

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MaxQBi
P02760

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02760

PeptideAtlas

More...
PeptideAtlasi
P02760

PRoteomics IDEntifications database

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PRIDEi
P02760

ProteomicsDB human proteome resource

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ProteomicsDBi
51583

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P02760

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P02760

GlyConnect protein glycosylation platform

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GlyConnecti
21

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P02760

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P02760

UniCarbKB; an annotated and curated database of glycan structures

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UniCarbKBi
P02760

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P02760

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000106927 Expressed in 93 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

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CleanExi
HS_AMBP

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P02760 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P02760 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB069436
HPA001497

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. Alpha-1-microglobulin occurs as a monomer and also in complexes with IgA and albumin. Alpha-1-microglobulin interacts with FN1. Trypstatin is a monomer and also occurs as a complex with tryptase in mast cells (By similarity).By similarity
(Microbial infection) Alpha-1-microglobulin and bikunin interact (via SH3 domain) with hepatitis E virus/HEV protein ORF3.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106757, 13 interactors

Protein interaction database and analysis system

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IntActi
P02760, 12 interactors

Molecular INTeraction database

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MINTi
P02760

STRING: functional protein association networks

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STRINGi
9606.ENSP00000265132

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1352
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BIKX-ray2.50A206-352[»]
3QKGX-ray2.30A20-202[»]
4ES7X-ray2.00A27-193[»]
4U30X-ray2.50W/X/Y/Z283-340[»]
6EJ7X-ray2.00B210-221[»]
6EJ8X-ray2.09B210-221[»]
6EJ9X-ray2.02B210-220[»]
6EJAX-ray1.94B210-221[»]
6EJBX-ray2.56B210-221[»]
6EJCX-ray2.06B210-221[»]
6EJDX-ray2.68B210-221[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P02760

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02760

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P02760

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini231 – 281BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini287 – 337BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni206 – 226Glycopeptide (secretory piece)Add BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4295 Eukaryota
ENOG410XQNP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160109

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000225

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P02760

Database of Orthologous Groups

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OrthoDBi
131191at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P02760

TreeFam database of animal gene trees

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TreeFami
TF351222

Family and domain databases

Conserved Domains Database

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CDDi
cd00109 KU, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.128.20, 1 hit
4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002968 A1-microglobln
IPR029856 AMBP
IPR012674 Calycin
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR020901 Prtase_inh_Kunz-CS

The PANTHER Classification System

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PANTHERi
PTHR10083:SF18 PTHR10083:SF18, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00014 Kunitz_BPTI, 2 hits
PF00061 Lipocalin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01215 A1MCGLOBULIN
PR00759 BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00131 KU, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50814 SSF50814, 1 hit
SSF57362 SSF57362, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280 BPTI_KUNITZ_1, 2 hits
PS50279 BPTI_KUNITZ_2, 2 hits
PS00213 LIPOCALIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P02760-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSLGALLLL LSACLAVSAG PVPTPPDNIQ VQENFNISRI YGKWYNLAIG
60 70 80 90 100
STCPWLKKIM DRMTVSTLVL GEGATEAEIS MTSTRWRKGV CEETSGAYEK
110 120 130 140 150
TDTDGKFLYH KSKWNITMES YVVHTNYDEY AIFLTKKFSR HHGPTITAKL
160 170 180 190 200
YGRAPQLRET LLQDFRVVAQ GVGIPEDSIF TMADRGECVP GEQEPEPILI
210 220 230 240 250
PRVRRAVLPQ EEEGSGGGQL VTEVTKKEDS CQLGYSAGPC MGMTSRYFYN
260 270 280 290 300
GTSMACETFQ YGGCMGNGNN FVTEKECLQT CRTVAACNLP IVRGPCRAFI
310 320 330 340 350
QLWAFDAVKG KCVLFPYGGC QGNGNKFYSE KECREYCGVP GDGDEELLRF

SN
Length:352
Mass (Da):38,999
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC001780094CBD06
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3Y4S4R3Y4_HUMAN
Protein AMBP
AMBP
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R471S4R471_HUMAN
Protein AMBP
AMBP
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48 – 57Missing AA sequence (PubMed:6164372).Curated10
Sequence conflicti57Missing AA sequence (PubMed:6198962).Curated1
Sequence conflicti57Missing AA sequence (Ref. 12) Curated1
Sequence conflicti137Missing AA sequence (PubMed:6164372).Curated1
Sequence conflicti142H → T AA sequence (PubMed:6164372).Curated1
Sequence conflicti145Missing AA sequence (PubMed:6164372).Curated1
Sequence conflicti194E → Q AA sequence (PubMed:6164372).Curated1
Sequence conflicti215S → T AA sequence (PubMed:7676539).Curated1
Sequence conflicti218G → T AA sequence (PubMed:7676539).Curated1
Sequence conflicti291 – 292IV → VI AA sequence (PubMed:2408638).Curated2
Sequence conflicti291 – 292IV → VI AA sequence (PubMed:1469060).Curated2
Sequence conflicti295Missing AA sequence (PubMed:1469060).Curated1
Sequence conflicti343G → E AA sequence (PubMed:2408638).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X04225 mRNA Translation: CAA27803.1
X04494 mRNA Translation: CAA28182.1
X54816, X54817, X54818 Genomic DNA Translation: CAA38585.1
X54817 Genomic DNA Translation: CAA38586.1
X54818 Genomic DNA Translation: CAA38587.1
M88249
, M88165, M88243, M88244, M88246, M88247 Genomic DNA Translation: AAA59196.1
AY544123 mRNA Translation: AAT11154.1
AK290837 mRNA Translation: BAF83526.1
AL137850 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87404.1
BC041593 mRNA Translation: AAH41593.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6800.1

Protein sequence database of the Protein Information Resource

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PIRi
S13433 HCHU

NCBI Reference Sequences

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RefSeqi
NP_001624.1, NM_001633.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.436911

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265132; ENSP00000265132; ENSG00000106927

Database of genes from NCBI RefSeq genomes

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GeneIDi
259

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:259

UCSC genome browser

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UCSCi
uc004bie.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04225 mRNA Translation: CAA27803.1
X04494 mRNA Translation: CAA28182.1
X54816, X54817, X54818 Genomic DNA Translation: CAA38585.1
X54817 Genomic DNA Translation: CAA38586.1
X54818 Genomic DNA Translation: CAA38587.1
M88249
, M88165, M88243, M88244, M88246, M88247 Genomic DNA Translation: AAA59196.1
AY544123 mRNA Translation: AAT11154.1
AK290837 mRNA Translation: BAF83526.1
AL137850 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87404.1
BC041593 mRNA Translation: AAH41593.1
CCDSiCCDS6800.1
PIRiS13433 HCHU
RefSeqiNP_001624.1, NM_001633.3
UniGeneiHs.436911

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BIKX-ray2.50A206-352[»]
3QKGX-ray2.30A20-202[»]
4ES7X-ray2.00A27-193[»]
4U30X-ray2.50W/X/Y/Z283-340[»]
6EJ7X-ray2.00B210-221[»]
6EJ8X-ray2.09B210-221[»]
6EJ9X-ray2.02B210-220[»]
6EJAX-ray1.94B210-221[»]
6EJBX-ray2.56B210-221[»]
6EJCX-ray2.06B210-221[»]
6EJDX-ray2.68B210-221[»]
ProteinModelPortaliP02760
SMRiP02760
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106757, 13 interactors
IntActiP02760, 12 interactors
MINTiP02760
STRINGi9606.ENSP00000265132

Chemistry databases

DrugBankiDB00062 Human Serum Albumin
DB00064 Serum albumin iodonated

Protein family/group databases

MEROPSiI02.005

PTM databases

CarbonylDBiP02760
GlyConnecti21
iPTMnetiP02760
PhosphoSitePlusiP02760
UniCarbKBiP02760

Polymorphism and mutation databases

BioMutaiAMBP
DMDMi122801

2D gel databases

SWISS-2DPAGEiP02760

Proteomic databases

jPOSTiP02760
MaxQBiP02760
PaxDbiP02760
PeptideAtlasiP02760
PRIDEiP02760
ProteomicsDBi51583

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
259
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265132; ENSP00000265132; ENSG00000106927
GeneIDi259
KEGGihsa:259
UCSCiuc004bie.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
259
DisGeNETi259
EuPathDBiHostDB:ENSG00000106927.11

GeneCards: human genes, protein and diseases

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GeneCardsi
AMBP
HGNCiHGNC:453 AMBP
HPAiCAB069436
HPA001497
MIMi176870 gene
neXtProtiNX_P02760
OpenTargetsiENSG00000106927
PharmGKBiPA24759

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4295 Eukaryota
ENOG410XQNP LUCA
GeneTreeiENSGT00940000160109
HOVERGENiHBG000225
InParanoidiP02760
OrthoDBi131191at2759
PhylomeDBiP02760
TreeFamiTF351222

Enzyme and pathway databases

ReactomeiR-HSA-2168880 Scavenging of heme from plasma

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AMBP human
EvolutionaryTraceiP02760

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Alpha-1-microglobulin/bikunin_precursor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
259
PMAP-CutDBiP02760

Protein Ontology

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PROi
PR:P02760

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106927 Expressed in 93 organ(s), highest expression level in liver
CleanExiHS_AMBP
ExpressionAtlasiP02760 baseline and differential
GenevisibleiP02760 HS

Family and domain databases

CDDicd00109 KU, 2 hits
Gene3Di2.40.128.20, 1 hit
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR002968 A1-microglobln
IPR029856 AMBP
IPR012674 Calycin
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR020901 Prtase_inh_Kunz-CS
PANTHERiPTHR10083:SF18 PTHR10083:SF18, 1 hit
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 2 hits
PF00061 Lipocalin, 1 hit
PRINTSiPR01215 A1MCGLOBULIN
PR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 2 hits
SUPFAMiSSF50814 SSF50814, 1 hit
SSF57362 SSF57362, 2 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 2 hits
PS50279 BPTI_KUNITZ_2, 2 hits
PS00213 LIPOCALIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMBP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02760
Secondary accession number(s): P00977
, P02759, P78491, Q2TU33, Q5TBD7, Q9UC58, Q9UDI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: January 16, 2019
This is version 219 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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