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Protein

Beta-lactoglobulin-1

Gene

LGB1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.

GO - Molecular functioni

Keywordsi

Molecular functionMilk protein
Biological processTransport
LigandRetinol-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactoglobulin-1
Short name:
Beta-LG-1
Alternative name(s):
Beta-lactoglobulin I
Short name:
BLGI
Gene namesi
Name:LGB1
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei1499 Equ c BLG

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001790619 – 180Beta-lactoglobulin-1Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 178
Disulfide bondi124 ↔ 137

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP02758
PeptideAtlasiP02758

Expressioni

Gene expression databases

BgeeiENSECAG00000009820

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9796.ENSECAP00000007932

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 334
Helixi47 – 493
Beta strandi117 – 1193
Helixi131 – 1333
Beta strandi143 – 1453
Turni172 – 1743

3D structure databases

ProteinModelPortaliP02758
SMRiP02758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCG3 Eukaryota
ENOG4111386 LUCA
GeneTreeiENSGT00620000088158
HOGENOMiHOG000113272
HOVERGENiHBG104361
InParanoidiP02758
OMAiSMMCQYL
OrthoDBiEOG091G0M2T
TreeFamiTF342475

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR002447 Blactoglobulin
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01172 BLCTOGLOBULN
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCLLLALGL ALMCGIQATN IPQTMQDLDL QEVAGKWHSV AMAASDISLL
60 70 80 90 100
DSESAPLRVY IEKLRPTPED NLEIILREGE NKGCAEKKIF AEKTESPAEF
110 120 130 140 150
KINYLDEDTV FALDTDYKNY LFLCMKNAAT PGQSLVCQYL ARTQMVDEEI
160 170 180
MEKFRRALQP LPGRVQIVPD LTRMAERCRI
Length:180
Mass (Da):20,345
Last modified:July 15, 1998 - v3
Checksum:iA57A477E9D618BFD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54S → E AA sequence (PubMed:6526379).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60356 mRNA Translation: AAB03511.1
PIRiA03222 LGHO
RefSeqiNP_001075962.1, NM_001082493.2
UniGeneiEca.13071

Genome annotation databases

EnsembliENSECAT00000010294; ENSECAP00000007932; ENSECAG00000009820
GeneIDi100034193
KEGGiecb:100034193

Similar proteinsi

Entry informationi

Entry nameiLACB1_HORSE
AccessioniPrimary (citable) accession number: P02758
Secondary accession number(s): Q28394
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 15, 1998
Last modified: January 31, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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