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Protein

Beta-lactoglobulin

Gene

LGB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.

Miscellaneous

The B variant sequence is shown.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • long-chain fatty acid binding Source: CAFA
  • retinol binding Source: UniProtKB-KW

Keywordsi

Molecular functionMilk protein
Biological processTransport
LigandRetinol-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactoglobulin
Short name:
Beta-LG
Alternative name(s):
Allergen: Bos d 5
Gene namesi
Name:LGB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Is one of the causes of cow's milk allergy.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei164 Bos d 5
2739 Bos d 5.0101

Chemistry databases

ChEMBLiCHEMBL1075053

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 162 PublicationsAdd BLAST16
ChainiPRO_000001790317 – 178Beta-lactoglobulinAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 1762 Publications
Disulfide bondi122 ↔ 137Alternate1 Publication
Disulfide bondi122 ↔ 1352 Publications

Post-translational modificationi

Alternate disulfide bonds occur in equal amounts in all variants examined.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP02754
PeptideAtlasiP02754
PRIDEiP02754

PTM databases

CarbonylDBiP02754
GlyConnecti70
UniCarbKBiP02754

Expressioni

Tissue specificityi

Synthesized in mammary gland and secreted in milk.

Interactioni

Subunit structurei

Under physiological conditions beta-lactoglobulin exists as an equilibrium mixture of monomeric and dimeric forms.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-9697387,EBI-9697387

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29525N
MINTiP02754
STRINGi9913.ENSBTAP00000019538

Chemistry databases

BindingDBiP02754

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00193
ProteinModelPortaliP02754
SMRiP02754
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02754

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCG3 Eukaryota
ENOG4111386 LUCA
HOGENOMiHOG000113272
HOVERGENiHBG104361
InParanoidiP02754

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR002447 Blactoglobulin
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01172 BLCTOGLOBULN
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02754-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKCLLLALAL TCGAQALIVT QTMKGLDIQK VAGTWYSLAM AASDISLLDA
60 70 80 90 100
QSAPLRVYVE ELKPTPEGDL EILLQKWENG ECAQKKIIAE KTKIPAVFKI
110 120 130 140 150
DALNENKVLV LDTDYKKYLL FCMENSAEPE QSLACQCLVR TPEVDDEALE
160 170
KFDKALKALP MHIRLSFNPT QLEEQCHI
Length:178
Mass (Da):19,883
Last modified:August 1, 1991 - v3
Checksum:i225F10A78C63A6B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121F → V in CAA32835 (PubMed:2701948).Curated1
Sequence conflicti136Q → E (PubMed:6897774).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti61E → Q in variant D. 1 Publication1
Natural varianti72I → L in variant W. 1 Publication1
Natural varianti75Q → H in variant C; found only in the Jersey breed. 1 Publication1
Natural varianti80G → D in variant A. 3 Publications1
Natural varianti134A → V in variant A. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14712 mRNA Translation: CAA32835.1
Z48305 Genomic DNA Translation: CAA88303.1
DQ489319 Genomic DNA Translation: ABF48380.1
BC108213 mRNA Translation: AAI08214.1
X52581 Genomic DNA Translation: CAA36812.1
M19088 Genomic DNA Translation: AAA30411.1
M27732 mRNA Translation: AAA30412.1
K01086 mRNA Translation: AAA30413.1
PIRiS10179 LGBO
RefSeqiNP_776354.2, NM_173929.3
XP_015329083.1, XM_015473597.1
UniGeneiBt.385

Genome annotation databases

GeneIDi280838
KEGGibta:280838

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14712 mRNA Translation: CAA32835.1
Z48305 Genomic DNA Translation: CAA88303.1
DQ489319 Genomic DNA Translation: ABF48380.1
BC108213 mRNA Translation: AAI08214.1
X52581 Genomic DNA Translation: CAA36812.1
M19088 Genomic DNA Translation: AAA30411.1
M27732 mRNA Translation: AAA30412.1
K01086 mRNA Translation: AAA30413.1
PIRiS10179 LGBO
RefSeqiNP_776354.2, NM_173929.3
XP_015329083.1, XM_015473597.1
UniGeneiBt.385

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B0OX-ray2.50A17-178[»]
1B8EX-ray1.95A17-178[»]
1BEBX-ray1.80A/B17-178[»]
1BSOX-ray2.23A17-178[»]
1BSQX-ray2.22A17-178[»]
1BSYX-ray2.24A17-178[»]
1CJ5NMR-A19-178[»]
1DV9NMR-A17-178[»]
1GX8X-ray2.40A17-178[»]
1GX9X-ray2.34A17-178[»]
1GXAX-ray2.35A17-178[»]
1QG5X-ray2.00A17-178[»]
1UZ2X-ray1.95X17-178[»]
1YUPX-ray2.10D18-176[»]
2AKQX-ray3.00A/B/C/D17-178[»]
2BLGX-ray2.46A17-178[»]
2GJ5X-ray2.40A17-178[»]
2Q2MX-ray2.10A17-178[»]
2Q2PX-ray2.96A17-178[»]
2Q39X-ray2.50A/B17-178[»]
2R56X-ray2.80A/B17-178[»]
3BLGX-ray2.56A17-178[»]
3KZAX-ray2.00A/B33-169[»]
3NPOX-ray2.20A17-178[»]
3NQ3X-ray1.90A17-178[»]
3NQ9X-ray1.90A17-178[»]
3PH5X-ray2.40A/B18-178[»]
3PH6X-ray2.53A/B18-178[»]
3UEUX-ray2.10A17-178[»]
3UEVX-ray1.90A17-178[»]
3UEWX-ray2.00A17-178[»]
3UEXX-ray2.10A17-178[»]
4DQ3X-ray1.95A17-178[»]
4DQ4X-ray1.90A17-178[»]
4GNYX-ray1.64A17-178[»]
4IB6X-ray2.20A17-178[»]
4IB7X-ray2.20A17-178[»]
4IB8X-ray2.30A17-178[»]
4IB9X-ray2.20A17-178[»]
4IBAX-ray2.30A17-178[»]
4KIIX-ray1.85A17-178[»]
4LZUX-ray2.40A17-178[»]
4LZVX-ray2.44A17-178[»]
4Y0PX-ray2.20A17-178[»]
4Y0QX-ray2.00A17-178[»]
4Y0RX-ray2.30A17-178[»]
5EEEX-ray1.95A17-178[»]
5HTDX-ray2.50A17-178[»]
5HTEX-ray2.40A17-178[»]
5IO5X-ray2.85A17-178[»]
5IO7X-ray2.85A17-178[»]
5K06X-ray2.50A17-178[»]
5LKEX-ray2.80A17-178[»]
5LKFX-ray2.50A17-178[»]
5NUJX-ray2.60A17-178[»]
5NUKX-ray1.70A17-178[»]
5NUMX-ray2.30A17-178[»]
5NUNX-ray1.95A17-178[»]
5Y5CX-ray2.61A/B17-178[»]
6GE7X-ray2.30A17-178[»]
6GF9X-ray2.10A17-178[»]
6GFSX-ray2.00A17-178[»]
6GHHX-ray1.90A17-178[»]
DisProtiDP00193
ProteinModelPortaliP02754
SMRiP02754
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29525N
MINTiP02754
STRINGi9913.ENSBTAP00000019538

Chemistry databases

BindingDBiP02754
ChEMBLiCHEMBL1075053

Protein family/group databases

Allergomei164 Bos d 5
2739 Bos d 5.0101

PTM databases

CarbonylDBiP02754
GlyConnecti70
UniCarbKBiP02754

Proteomic databases

PaxDbiP02754
PeptideAtlasiP02754
PRIDEiP02754

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280838
KEGGibta:280838

Organism-specific databases

CTDi5047

Phylogenomic databases

eggNOGiENOG410JCG3 Eukaryota
ENOG4111386 LUCA
HOGENOMiHOG000113272
HOVERGENiHBG104361
InParanoidiP02754

Miscellaneous databases

EvolutionaryTraceiP02754
PROiPR:P02754

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR002447 Blactoglobulin
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01172 BLCTOGLOBULN
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLACB_BOVIN
AccessioniPrimary (citable) accession number: P02754
Secondary accession number(s): Q32P89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1991
Last modified: October 10, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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