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Protein

Retinol-binding protein 4

Gene

RBP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).Curated1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei116SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein heterodimerization activity Source: Ensembl
  • retinal binding Source: UniProtKB-KW
  • retinol binding Source: BHF-UCL
  • retinol transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSensory transduction, Transport, Vision
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000138207-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2453864 Retinoid cycle disease events
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-6809583 Retinoid metabolism disease events
R-HSA-975634 Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retinol-binding protein 4
Alternative name(s):
Plasma retinol-binding protein
Short name:
PRBP
Short name:
RBP
Cleaved into the following 4 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBP4
ORF Names:PRO2222
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000138207.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9922 RBP4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
180250 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02753

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Retinal dystrophy, iris coloboma, and comedogenic acne syndrome (RDCCAS)3 Publications
The disease is caused by mutations affecting the gene represented in this entry. Loss of functional RBP4 protein results in serum retinol deficiency. Lack of normal levels of retinol impairs the visual cycle leading to night blindness at early stages; prolonged deficiency may lead to retinal degeneration. Additionally, retinol deficiency may result in dry skin, increased susceptibility to infection and acne (PubMed:23189188).1 Publication
Disease descriptionA disease characterized by retinal degeneration, ocular colobomas involving both the anterior and posterior segment, impaired night vision and loss of visual acuity. Additional characteristic features include developmental abnormalities and severe acne.
See also OMIM:615147
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00927659I → N in RDCCAS. 2 PublicationsCorresponds to variant dbSNP:rs121918584EnsemblClinVar.1
Natural variantiVAR_00927793G → D in RDCCAS. 2 PublicationsCorresponds to variant dbSNP:rs121918585EnsemblClinVar.1
Microphthalmia, isolated, with coloboma, 10 (MCOPCB10)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure).
See also OMIM:616428
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07385673A → T in MCOPCB10; dramatic reduction in retinol binding; has greater affinity for the STRA6 receptor. 1 PublicationCorresponds to variant dbSNP:rs794726862EnsemblClinVar.1
Natural variantiVAR_07385775A → T in MCOPCB10; dramatic reduction in retinol binding; has greater affinity for the STRA6 receptor. 1 PublicationCorresponds to variant dbSNP:rs794726861EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Microphthalmia

Organism-specific databases

DisGeNET

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DisGeNETi
5950

MalaCards human disease database

More...
MalaCardsi
RBP4
MIMi615147 phenotype
616428 phenotype

Open Targets

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OpenTargetsi
ENSG00000138207

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98938 Colobomatous microphthalmia
352718 Progressive retinal dystrophy due to retinol transport defect

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34289

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3100

Drug and drug target database

More...
DrugBanki
DB06985 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid
DB05076 Fenretinide
DB03917 N-Ethyl Retinamide
DB00162 Vitamin A

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2549

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RBP4

Domain mapping of disease mutations (DMDM)

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DMDMi
62298174

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 183 PublicationsAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001796119 – 201Retinol-binding protein 4Add BLAST183
ChainiPRO_000001796219 – 200Plasma retinol-binding protein(1-182)Add BLAST182
ChainiPRO_000001796319 – 199Plasma retinol-binding protein(1-181)Add BLAST181
ChainiPRO_000001796419 – 197Plasma retinol-binding protein(1-179)Add BLAST179
ChainiPRO_000001796519 – 194Plasma retinol-binding protein(1-176)Add BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi22 ↔ 1781 Publication
Disulfide bondi88 ↔ 1921 Publication
Disulfide bondi138 ↔ 1471 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei139Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P02753

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P02753

PeptideAtlas

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PeptideAtlasi
P02753

PRoteomics IDEntifications database

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PRIDEi
P02753

ProteomicsDB human proteome resource

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ProteomicsDBi
12699
51582

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P02753

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P02753

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P02753

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in blood plasma and in urine (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138207 Expressed in 178 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

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CleanExi
HS_RBP4

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P02753 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P02753 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB004555
HPA001641

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TTR (PubMed:5541771, PubMed:7754382, PubMed:10052934, PubMed:19021760). Interaction with TTR prevents its loss by filtration through the kidney glomeruli (Probable). Interacts with STRA6 (PubMed:22665496, PubMed:25910211).Curated6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111884, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P02753

Protein interaction database and analysis system

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IntActi
P02753, 5 interactors

Molecular INTeraction database

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MINTi
P02753

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360519

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P02753

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P02753

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02753

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02753

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJHC Eukaryota
ENOG4111K1Y LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000047107

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004493

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P02753

KEGG Orthology (KO)

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KOi
K18271

Identification of Orthologs from Complete Genome Data

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OMAi
HWVIDTD

Database of Orthologous Groups

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OrthoDBi
EOG091G0KIM

Database for complete collections of gene phylogenies

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PhylomeDBi
P02753

TreeFam database of animal gene trees

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TreeFami
TF331445

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012674 Calycin
IPR022271 Lipocalin_ApoD
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002449 Retinol-bd/Purpurin

The PANTHER Classification System

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PANTHERi
PTHR11873 PTHR11873, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00061 Lipocalin, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF036893 Lipocalin_ApoD, 1 hit
PIRSF500204 RBP_purpurin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01174 RETINOLBNDNG

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50814 SSF50814, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00213 LIPOCALIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02753-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKWVWALLLL AALGSGRAER DCRVSSFRVK ENFDKARFSG TWYAMAKKDP
60 70 80 90 100
EGLFLQDNIV AEFSVDETGQ MSATAKGRVR LLNNWDVCAD MVGTFTDTED
110 120 130 140 150
PAKFKMKYWG VASFLQKGND DHWIVDTDYD TYAVQYSCRL LNLDGTCADS
160 170 180 190 200
YSFVFSRDPN GLPPEAQKIV RQRQEELCLA RQYRLIVHNG YCDGRSERNL

L
Length:201
Mass (Da):23,010
Last modified:March 29, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i660C6DD8CC9B811A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VY30Q5VY30_HUMAN
Retinol-binding protein
RBP4 hCG_37964
199Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF69622 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8L → F in AAH20633 (PubMed:15489334).Curated1
Sequence conflicti13 – 17LGSGR → WAA in CAA24959 (PubMed:6316270).Curated5
Sequence conflicti13 – 17LGSGR → WAA in CAA26553 (PubMed:2998779).Curated5

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 21063.46±1.88 Da from positions 17 - 199. Determined by ESI. 1 Publication
Molecular mass is 20534 Da from positions 19 - 197. Determined by MALDI. 1 Publication
Molecular mass is 20162 Da from positions 19 - 194. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00927659I → N in RDCCAS. 2 PublicationsCorresponds to variant dbSNP:rs121918584EnsemblClinVar.1
Natural variantiVAR_07385673A → T in MCOPCB10; dramatic reduction in retinol binding; has greater affinity for the STRA6 receptor. 1 PublicationCorresponds to variant dbSNP:rs794726862EnsemblClinVar.1
Natural variantiVAR_07385775A → T in MCOPCB10; dramatic reduction in retinol binding; has greater affinity for the STRA6 receptor. 1 PublicationCorresponds to variant dbSNP:rs794726861EnsemblClinVar.1
Natural variantiVAR_00927793G → D in RDCCAS. 2 PublicationsCorresponds to variant dbSNP:rs121918585EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X00129 mRNA Translation: CAA24959.1
AL356214 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50065.1
CH471066 Genomic DNA Translation: EAW50066.1
CH471066 Genomic DNA Translation: EAW50067.1
BC020633 mRNA Translation: AAH20633.1
X02775 Genomic DNA Translation: CAA26553.1
X02824 Genomic DNA Translation: CAB46489.1
AF119868 mRNA Translation: AAF69622.1 Different initiation.
AF025334 Genomic DNA Translation: AAC02945.1
AF025335 Genomic DNA Translation: AAC02946.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31249.1

Protein sequence database of the Protein Information Resource

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PIRi
A93494 VAHU

NCBI Reference Sequences

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RefSeqi
NP_001310446.1, NM_001323517.1
NP_001310447.1, NM_001323518.1
NP_006735.2, NM_006744.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.50223

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000371464; ENSP00000360519; ENSG00000138207
ENST00000371467; ENSP00000360522; ENSG00000138207

Database of genes from NCBI RefSeq genomes

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GeneIDi
5950

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5950

UCSC genome browser

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UCSCi
uc001kit.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mutations of the RBP4 gene

Retina International's Scientific Newsletter

Wikipedia

Retinol-binding protein 4 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00129 mRNA Translation: CAA24959.1
AL356214 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50065.1
CH471066 Genomic DNA Translation: EAW50066.1
CH471066 Genomic DNA Translation: EAW50067.1
BC020633 mRNA Translation: AAH20633.1
X02775 Genomic DNA Translation: CAA26553.1
X02824 Genomic DNA Translation: CAB46489.1
AF119868 mRNA Translation: AAF69622.1 Different initiation.
AF025334 Genomic DNA Translation: AAC02945.1
AF025335 Genomic DNA Translation: AAC02946.1
CCDSiCCDS31249.1
PIRiA93494 VAHU
RefSeqiNP_001310446.1, NM_001323517.1
NP_001310447.1, NM_001323518.1
NP_006735.2, NM_006744.3
UniGeneiHs.50223

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BRPX-ray2.50A19-200[»]
1BRQX-ray2.50A19-200[»]
1JYDX-ray1.70A19-200[»]
1JYJX-ray2.00A19-200[»]
1QABX-ray3.20E/F22-201[»]
1RBPX-ray2.00A19-200[»]
1RLBX-ray3.10E/F19-192[»]
2WQ9X-ray1.65A19-192[»]
2WQAX-ray2.85E/F19-194[»]
2WR6X-ray1.80A19-192[»]
3BSZX-ray3.38E/F19-194[»]
3FMZX-ray2.90A/B19-201[»]
4O9SX-ray2.30A/B19-201[»]
4PSQX-ray2.40A/B19-201[»]
5NTYX-ray2.00A19-200[»]
5NU2X-ray1.50A19-200[»]
5NU6X-ray1.68A19-200[»]
5NU7X-ray1.50A19-200[»]
5NU8X-ray1.59A19-200[»]
5NU9X-ray1.50A19-200[»]
5NUAX-ray1.60A19-200[»]
5NUBX-ray1.60A19-200[»]
ProteinModelPortaliP02753
SMRiP02753
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111884, 13 interactors
CORUMiP02753
IntActiP02753, 5 interactors
MINTiP02753
STRINGi9606.ENSP00000360519

Chemistry databases

BindingDBiP02753
ChEMBLiCHEMBL3100
DrugBankiDB06985 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid
DB05076 Fenretinide
DB03917 N-Ethyl Retinamide
DB00162 Vitamin A
GuidetoPHARMACOLOGYi2549

PTM databases

iPTMnetiP02753
PhosphoSitePlusiP02753

Polymorphism and mutation databases

BioMutaiRBP4
DMDMi62298174

2D gel databases

SWISS-2DPAGEiP02753

Proteomic databases

MaxQBiP02753
PaxDbiP02753
PeptideAtlasiP02753
PRIDEiP02753
ProteomicsDBi12699
51582

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371464; ENSP00000360519; ENSG00000138207
ENST00000371467; ENSP00000360522; ENSG00000138207
GeneIDi5950
KEGGihsa:5950
UCSCiuc001kit.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5950
DisGeNETi5950
EuPathDBiHostDB:ENSG00000138207.12

GeneCards: human genes, protein and diseases

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GeneCardsi
RBP4

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0009047
HGNCiHGNC:9922 RBP4
HPAiCAB004555
HPA001641
MalaCardsiRBP4
MIMi180250 gene
615147 phenotype
616428 phenotype
neXtProtiNX_P02753
OpenTargetsiENSG00000138207
Orphaneti98938 Colobomatous microphthalmia
352718 Progressive retinal dystrophy due to retinol transport defect
PharmGKBiPA34289

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJHC Eukaryota
ENOG4111K1Y LUCA
GeneTreeiENSGT00510000047107
HOVERGENiHBG004493
InParanoidiP02753
KOiK18271
OMAiHWVIDTD
OrthoDBiEOG091G0KIM
PhylomeDBiP02753
TreeFamiTF331445

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000138207-MONOMER
ReactomeiR-HSA-2453864 Retinoid cycle disease events
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-6809583 Retinoid metabolism disease events
R-HSA-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBP4 human
EvolutionaryTraceiP02753

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Retinol_binding_protein_4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5950

Protein Ontology

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PROi
PR:P02753

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138207 Expressed in 178 organ(s), highest expression level in liver
CleanExiHS_RBP4
ExpressionAtlasiP02753 baseline and differential
GenevisibleiP02753 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR022271 Lipocalin_ApoD
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002449 Retinol-bd/Purpurin
PANTHERiPTHR11873 PTHR11873, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PIRSFiPIRSF036893 Lipocalin_ApoD, 1 hit
PIRSF500204 RBP_purpurin, 1 hit
PRINTSiPR01174 RETINOLBNDNG
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRET4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02753
Secondary accession number(s): D3DR38
, O43478, O43479, Q5VY24, Q8WWA3, Q9P178
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 29, 2005
Last modified: December 5, 2018
This is version 212 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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