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Entry version 212 (13 Feb 2019)
Sequence version 3 (01 Jun 1994)
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Protein

Beta-2-glycoprotein 1

Gene

APOH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • lipid binding Source: BHF-UCL
  • lipoprotein lipase activator activity Source: BHF-UCL
  • phospholipid binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-2-glycoprotein 1
Alternative name(s):
APC inhibitor
Activated protein C-binding protein
Anticardiolipin cofactor
Apolipoprotein H
Short name:
Apo-H
Beta-2-glycoprotein I
Short name:
B2GPI
Short name:
Beta(2)GPI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOH
Synonyms:B2G1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000091583.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:616 APOH

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
138700 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02749

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
350

Open Targets

More...
OpenTargetsi
ENSG00000091583

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24903

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB05446 LJP 1082

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APOH

Domain mapping of disease mutations (DMDM)

More...
DMDMi
543826

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 194 PublicationsAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000205920 – 345Beta-2-glycoprotein 1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi23 ↔ 66
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi33O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi51 ↔ 79
Disulfide bondi84 ↔ 124
Disulfide bondi110 ↔ 137
Disulfide bondi142 ↔ 188
Glycosylationi149O-linked (GalNAc...) threonine1
Glycosylationi162N-linked (GlcNAc...) (complex) asparagine8 Publications1
Disulfide bondi174 ↔ 200
Glycosylationi183N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi193N-linked (GlcNAc...) asparagine4 Publications1
Disulfide bondi205 ↔ 248
Disulfide bondi234 ↔ 260
Glycosylationi253N-linked (GlcNAc...) asparagine5 Publications1
Disulfide bondi264 ↔ 315
Disulfide bondi300 ↔ 325
Disulfide bondi307 ↔ 345

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele.8 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P02749

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P02749

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P02749

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02749

PeptideAtlas

More...
PeptideAtlasi
P02749

PRoteomics IDEntifications database

More...
PRIDEi
P02749

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51565

Consortium for Top Down Proteomics

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TopDownProteomicsi
P02749

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
678

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02749

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02749

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P02749

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000091583 Expressed in 109 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P02749 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P02749 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022214
HPA001654
HPA003732

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106847, 13 interactors

Database of interacting proteins

More...
DIPi
DIP-46878N

Protein interaction database and analysis system

More...
IntActi
P02749, 15 interactors

Molecular INTeraction database

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MINTi
P02749

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000205948

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C1ZX-ray2.87A20-345[»]
1G4FNMR-A261-345[»]
1G4GNMR-A261-345[»]
1QUBX-ray2.70A20-345[»]
2KRINMR-A263-345[»]
3OP8X-ray1.90A/B263-345[»]
4JHSX-ray3.00A203-345[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P02749

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02749

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02749

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 81Sushi 1PROSITE-ProRule annotationAdd BLAST61
Domaini82 – 139Sushi 2PROSITE-ProRule annotationAdd BLAST58
Domaini140 – 202Sushi 3PROSITE-ProRule annotationAdd BLAST63
Domaini203 – 262Sushi 4PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni263 – 345Sushi-likeAdd BLAST83

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297 Eukaryota
ENOG410XPJ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157228

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034008

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004271

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02749

KEGG Orthology (KO)

More...
KOi
K17305

Identification of Orthologs from Complete Genome Data

More...
OMAi
EKKCSYT

Database of Orthologous Groups

More...
OrthoDBi
1541140at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02749

TreeFam database of animal gene trees

More...
TreeFami
TF334137

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR015104 Sushi_2
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 4 hits
PF09014 Sushi_2, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD012422 Sushi_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535 SSF57535, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P02749-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISPVLILFS SFLCHVAIAG RTCPKPDDLP FSTVVPLKTF YEPGEEITYS
60 70 80 90 100
CKPGYVSRGG MRKFICPLTG LWPINTLKCT PRVCPFAGIL ENGAVRYTTF
110 120 130 140 150
EYPNTISFSC NTGFYLNGAD SAKCTEEGKW SPELPVCAPI ICPPPSIPTF
160 170 180 190 200
ATLRVYKPSA GNNSLYRDTA VFECLPQHAM FGNDTITCTT HGNWTKLPEC
210 220 230 240 250
REVKCPFPSR PDNGFVNYPA KPTLYYKDKA TFGCHDGYSL DGPEEIECTK
260 270 280 290 300
LGNWSAMPSC KASCKVPVKK ATVVYQGERV KIQEKFKNGM LHGDKVSFFC
310 320 330 340
KNKEKKCSYT EDAQCIDGTI EVPKCFKEHS SLAFWKTDAS DVKPC
Length:345
Mass (Da):38,298
Last modified:June 1, 1994 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63101704F8EDFE3F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRN2J3QRN2_HUMAN
Beta-2-glycoprotein 1
APOH
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS17J3KS17_HUMAN
Beta-2-glycoprotein 1
APOH
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLI0J3QLI0_HUMAN
Beta-2-glycoprotein 1
APOH
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121S → C AA sequence (PubMed:6587378).Curated1
Sequence conflicti188C → N AA sequence (PubMed:6587378).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0483165V → A. Corresponds to variant dbSNP:rs3826358Ensembl.1
Natural variantiVAR_008169107S → N in allele APOH*1. 3 PublicationsCorresponds to variant dbSNP:rs1801692Ensembl.1
Natural variantiVAR_019155154R → H1 PublicationCorresponds to variant dbSNP:rs8178847Ensembl.1
Natural variantiVAR_000673266V → L in 23% of the population. 2 PublicationsCorresponds to variant dbSNP:rs4581EnsemblClinVar.1
Natural variantiVAR_008170325C → G Loss of phosphatidylserine-binding. 1 PublicationCorresponds to variant dbSNP:rs1801689Ensembl.1
Natural variantiVAR_008171335W → S in allele APOH*3W; loss of phosphatidylserine-binding. 2 PublicationsCorresponds to variant dbSNP:rs1801690Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X58100 mRNA Translation: CAA41113.1
X53595 mRNA Translation: CAA37664.1
X57847 mRNA Translation: CAA40977.1
M62839 mRNA Translation: AAA51766.1
S80305 mRNA Translation: AAB21330.1
Y11493
, Y11494, Y11495, X53595, Y11496, Y11497, Y11498 Genomic DNA Translation: CAA72279.1
Y17754 Genomic DNA Translation: CAA76845.1
AK313838 mRNA Translation: BAG36570.1
AY322156 Genomic DNA Translation: AAP72014.1
BC020703 mRNA Translation: AAH20703.1
BC026283 mRNA Translation: AAH26283.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11663.1

Protein sequence database of the Protein Information Resource

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PIRi
S17178 NBHU

NCBI Reference Sequences

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RefSeqi
NP_000033.2, NM_000042.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.445358

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000205948; ENSP00000205948; ENSG00000091583

Database of genes from NCBI RefSeq genomes

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GeneIDi
350

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:350

UCSC genome browser

More...
UCSCi
uc002jfn.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58100 mRNA Translation: CAA41113.1
X53595 mRNA Translation: CAA37664.1
X57847 mRNA Translation: CAA40977.1
M62839 mRNA Translation: AAA51766.1
S80305 mRNA Translation: AAB21330.1
Y11493
, Y11494, Y11495, X53595, Y11496, Y11497, Y11498 Genomic DNA Translation: CAA72279.1
Y17754 Genomic DNA Translation: CAA76845.1
AK313838 mRNA Translation: BAG36570.1
AY322156 Genomic DNA Translation: AAP72014.1
BC020703 mRNA Translation: AAH20703.1
BC026283 mRNA Translation: AAH26283.1
CCDSiCCDS11663.1
PIRiS17178 NBHU
RefSeqiNP_000033.2, NM_000042.2
UniGeneiHs.445358

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C1ZX-ray2.87A20-345[»]
1G4FNMR-A261-345[»]
1G4GNMR-A261-345[»]
1QUBX-ray2.70A20-345[»]
2KRINMR-A263-345[»]
3OP8X-ray1.90A/B263-345[»]
4JHSX-ray3.00A203-345[»]
ProteinModelPortaliP02749
SMRiP02749
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106847, 13 interactors
DIPiDIP-46878N
IntActiP02749, 15 interactors
MINTiP02749
STRINGi9606.ENSP00000205948

Chemistry databases

DrugBankiDB05446 LJP 1082

PTM databases

GlyConnecti678
iPTMnetiP02749
PhosphoSitePlusiP02749

Polymorphism and mutation databases

BioMutaiAPOH
DMDMi543826

Proteomic databases

EPDiP02749
jPOSTiP02749
MaxQBiP02749
PaxDbiP02749
PeptideAtlasiP02749
PRIDEiP02749
ProteomicsDBi51565
TopDownProteomicsiP02749

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
350
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000205948; ENSP00000205948; ENSG00000091583
GeneIDi350
KEGGihsa:350
UCSCiuc002jfn.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
350
DisGeNETi350
EuPathDBiHostDB:ENSG00000091583.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
APOH
HGNCiHGNC:616 APOH
HPAiCAB022214
HPA001654
HPA003732
MIMi138700 gene
neXtProtiNX_P02749
OpenTargetsiENSG00000091583
PharmGKBiPA24903

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00940000157228
HOGENOMiHOG000034008
HOVERGENiHBG004271
InParanoidiP02749
KOiK17305
OMAiEKKCSYT
OrthoDBi1541140at2759
PhylomeDBiP02749
TreeFamiTF334137

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
APOH human
EvolutionaryTraceiP02749

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Apolipoprotein_H

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
350
PMAP-CutDBiP02749

Protein Ontology

More...
PROi
PR:P02749

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000091583 Expressed in 109 organ(s), highest expression level in liver
ExpressionAtlasiP02749 baseline and differential
GenevisibleiP02749 HS

Family and domain databases

CDDicd00033 CCP, 4 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR015104 Sushi_2
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 4 hits
PF09014 Sushi_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012422 Sushi_2, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SUPFAMiSSF57535 SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPOH_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02749
Secondary accession number(s): B2R9M3, Q9UCN7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 1, 1994
Last modified: February 13, 2019
This is version 212 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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