UniProtKB - P02747 (C1QC_HUMAN)
Complement C1q subcomponent subunit C
C1QC
Functioni
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
GO - Biological processi
- complement activation, classical pathway Source: ComplexPortal
- immune response Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- negative regulation of granulocyte differentiation Source: BHF-UCL
- negative regulation of macrophage differentiation Source: BHF-UCL
- synapse pruning Source: ARUK-UCL
Keywordsi
Biological process | Complement pathway, Immunity, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | P02747 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-977606, Regulation of Complement cascade |
SignaLinki | P02747 |
SIGNORi | P02747 |
Names & Taxonomyi
Protein namesi | Recommended name: Complement C1q subcomponent subunit C |
Gene namesi | Name:C1QC Synonyms:C1QG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1245, C1QC |
MIMi | 120575, gene |
neXtProti | NX_P02747 |
VEuPathDBi | HostDB:ENSG00000159189 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- complement component C1 complex Source: ComplexPortal
- complement component C1q complex Source: ComplexPortal
- extracellular region Source: ComplexPortal
- extracellular space Source: UniProtKB
Other locations
- collagen trimer Source: UniProtKB-KW
- collagen-containing extracellular matrix Source: BHF-UCL
- postsynapse Source: ARUK-UCL
- synapse Source: ARUK-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Complement component C1q deficiency (C1QD)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_008542 | 34 | G → R in C1QD. 1 PublicationCorresponds to variant dbSNP:rs200206736EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 714 |
MalaCardsi | C1QC |
MIMi | 613652, phenotype |
OpenTargetsi | ENSG00000159189 |
Orphaneti | 169147, Immunodeficiency due to a classical component pathway complement deficiency |
PharmGKBi | PA25626 |
Miscellaneous databases
Pharosi | P02747, Tbio |
Chemistry databases
DrugBanki | DB00112, Bevacizumab DB00002, Cetuximab DB09130, Copper DB00111, Daclizumab DB00005, Etanercept DB00110, Palivizumab DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | C1QC |
DMDMi | 20178281 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | 1 PublicationAdd BLAST | 28 | |
ChainiPRO_0000003524 | 29 – 245 | Complement C1q subcomponent subunit CAdd BLAST | 217 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 | Interchain | ||
Modified residuei | 36 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 39 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 42 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 45 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 54 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 63 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 75 | 5-hydroxylysine1 Publication | 1 | |
Glycosylationi | 75 | O-linked (Gal...) hydroxylysine | 1 | |
Modified residuei | 81 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 93 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 96 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 99 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 105 | 4-hydroxyproline1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, HydroxylationProteomic databases
CPTACi | non-CPTAC-2652 |
jPOSTi | P02747 |
MassIVEi | P02747 |
PaxDbi | P02747 |
PeptideAtlasi | P02747 |
PRIDEi | P02747 |
ProteomicsDBi | 51563 |
PTM databases
GlyGeni | P02747, 1 site |
PhosphoSitePlusi | P02747 |
Expressioni
Gene expression databases
Bgeei | ENSG00000159189, Expressed in layer of synovial tissue and 208 other tissues |
ExpressionAtlasi | P02747, baseline and differential |
Genevisiblei | P02747, HS |
Organism-specific databases
HPAi | ENSG00000159189, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.
Binary interactionsi
P02747
Protein-protein interaction databases
BioGRIDi | 107175, 137 interactors |
ComplexPortali | CPX-1919, Complement component C1q complex |
CORUMi | P02747 |
IntActi | P02747, 12 interactors |
MINTi | P02747 |
STRINGi | 9606.ENSP00000363770 |
Miscellaneous databases
RNActi | P02747, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P02747 |
SASBDBi | P02747 |
SMRi | P02747 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02747 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 112 | Collagen-likeAdd BLAST | 82 | |
Domaini | 115 – 245 | C1qPROSITE-ProRule annotationAdd BLAST | 131 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 45 – 113 | DisorderedSequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 85 – 103 | Pro residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502RZM2, Eukaryota |
GeneTreei | ENSGT00940000161227 |
HOGENOMi | CLU_001074_0_2_1 |
InParanoidi | P02747 |
OMAi | RGTNEYP |
OrthoDBi | 1258047at2759 |
PhylomeDBi | P02747 |
TreeFami | TF329591 |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR008160, Collagen IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MDVGPSSLPH LGLKLLLLLL LLPLRGQANT GCYGIPGMPG LPGAPGKDGY
60 70 80 90 100
DGLPGPKGEP GIPAIPGIRG PKGQKGEPGL PGHPGKNGPM GPPGMPGVPG
110 120 130 140 150
PMGIPGEPGE EGRYKQKFQS VFTVTRQTHQ PPAPNSLIRF NAVLTNPQGD
160 170 180 190 200
YDTSTGKFTC KVPGLYYFVY HASHTANLCV LLYRSGVKVV TFCGHTSKTN
210 220 230 240
QVNSGGVLLR LQVGEEVWLA VNDYYDMVGI QGSDSVFSGF LLFPD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | K → R in BAB71575 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 23 | P → A no nucleotide entry (PubMed:1706597).Curated | 1 | |
Sequence conflicti | 26 – 27 | GQ → AK in AAP97191 (Ref. 2) Curated | 2 | |
Sequence conflicti | 57 | K → P AA sequence (PubMed:486087).Curated | 1 | |
Sequence conflicti | 66 | P → K AA sequence (PubMed:486087).Curated | 1 | |
Sequence conflicti | 72 | K → P AA sequence (PubMed:486087).Curated | 1 | |
Sequence conflicti | 84 | P → K AA sequence (PubMed:486087).Curated | 1 | |
Sequence conflicti | 87 | N → D AA sequence (PubMed:486087).Curated | 1 | |
Sequence conflicti | 90 | M → N AA sequence (PubMed:486087).Curated | 1 | |
Sequence conflicti | 104 | I → F in AAP97191 (Ref. 2) Curated | 1 | |
Sequence conflicti | 149 | G → E in AAP97191 (Ref. 2) Curated | 1 | |
Sequence conflicti | 215 | E → G in BAB71575 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_008542 | 34 | G → R in C1QD. 1 PublicationCorresponds to variant dbSNP:rs200206736EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087892 mRNA Translation: AAP97191.1 AK057792 mRNA Translation: BAB71575.1 AL158086 Genomic DNA No translation available. BC009016 mRNA Translation: AAH09016.1 |
CCDSi | CCDS227.1 |
PIRi | S14351, C1HUQC |
RefSeqi | NP_001107573.1, NM_001114101.2 NP_001334548.1, NM_001347619.1 NP_758957.2, NM_172369.4 |
Genome annotation databases
Ensembli | ENST00000374637.1; ENSP00000363768.1; ENSG00000159189.12 ENST00000374639.7; ENSP00000363770.3; ENSG00000159189.12 ENST00000374640.9; ENSP00000363771.4; ENSG00000159189.12 |
GeneIDi | 714 |
KEGGi | hsa:714 |
MANE-Selecti | ENST00000374640.9; ENSP00000363771.4; NM_172369.5; NP_758957.2 |
UCSCi | uc001bga.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087892 mRNA Translation: AAP97191.1 AK057792 mRNA Translation: BAB71575.1 AL158086 Genomic DNA No translation available. BC009016 mRNA Translation: AAH09016.1 |
CCDSi | CCDS227.1 |
PIRi | S14351, C1HUQC |
RefSeqi | NP_001107573.1, NM_001114101.2 NP_001334548.1, NM_001347619.1 NP_758957.2, NM_172369.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PK6 | X-ray | 1.85 | C | 117-245 | [»] | |
2JG8 | X-ray | 2.05 | C/F | 115-245 | [»] | |
2JG9 | X-ray | 1.90 | C/F | 115-245 | [»] | |
2WNU | X-ray | 2.30 | C/F | 115-245 | [»] | |
2WNV | X-ray | 1.25 | C/F | 115-245 | [»] | |
5HKJ | X-ray | 1.35 | A | 115-245 | [»] | |
5HZF | X-ray | 1.55 | A | 115-245 | [»] | |
6FCZ | electron microscopy | 10.00 | C | 117-245 | [»] | |
6Z6V | X-ray | 2.19 | C/F | 115-245 | [»] | |
AlphaFoldDBi | P02747 | |||||
SASBDBi | P02747 | |||||
SMRi | P02747 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107175, 137 interactors |
ComplexPortali | CPX-1919, Complement component C1q complex |
CORUMi | P02747 |
IntActi | P02747, 12 interactors |
MINTi | P02747 |
STRINGi | 9606.ENSP00000363770 |
Chemistry databases
DrugBanki | DB00112, Bevacizumab DB00002, Cetuximab DB09130, Copper DB00111, Daclizumab DB00005, Etanercept DB00110, Palivizumab DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
PTM databases
GlyGeni | P02747, 1 site |
PhosphoSitePlusi | P02747 |
Genetic variation databases
BioMutai | C1QC |
DMDMi | 20178281 |
Proteomic databases
CPTACi | non-CPTAC-2652 |
jPOSTi | P02747 |
MassIVEi | P02747 |
PaxDbi | P02747 |
PeptideAtlasi | P02747 |
PRIDEi | P02747 |
ProteomicsDBi | 51563 |
Protocols and materials databases
Antibodypediai | 691, 295 antibodies from 34 providers |
DNASUi | 714 |
Genome annotation databases
Ensembli | ENST00000374637.1; ENSP00000363768.1; ENSG00000159189.12 ENST00000374639.7; ENSP00000363770.3; ENSG00000159189.12 ENST00000374640.9; ENSP00000363771.4; ENSG00000159189.12 |
GeneIDi | 714 |
KEGGi | hsa:714 |
MANE-Selecti | ENST00000374640.9; ENSP00000363771.4; NM_172369.5; NP_758957.2 |
UCSCi | uc001bga.5, human |
Organism-specific databases
CTDi | 714 |
DisGeNETi | 714 |
GeneCardsi | C1QC |
HGNCi | HGNC:1245, C1QC |
HPAi | ENSG00000159189, Tissue enhanced (lymphoid) |
MalaCardsi | C1QC |
MIMi | 120575, gene 613652, phenotype |
neXtProti | NX_P02747 |
OpenTargetsi | ENSG00000159189 |
Orphaneti | 169147, Immunodeficiency due to a classical component pathway complement deficiency |
PharmGKBi | PA25626 |
VEuPathDBi | HostDB:ENSG00000159189 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZM2, Eukaryota |
GeneTreei | ENSGT00940000161227 |
HOGENOMi | CLU_001074_0_2_1 |
InParanoidi | P02747 |
OMAi | RGTNEYP |
OrthoDBi | 1258047at2759 |
PhylomeDBi | P02747 |
TreeFami | TF329591 |
Enzyme and pathway databases
PathwayCommonsi | P02747 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-977606, Regulation of Complement cascade |
SignaLinki | P02747 |
SIGNORi | P02747 |
Miscellaneous databases
BioGRID-ORCSi | 714, 8 hits in 1070 CRISPR screens |
ChiTaRSi | C1QC, human |
EvolutionaryTracei | P02747 |
GenomeRNAii | 714 |
Pharosi | P02747, Tbio |
PROi | PR:P02747 |
RNActi | P02747, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159189, Expressed in layer of synovial tissue and 208 other tissues |
ExpressionAtlasi | P02747, baseline and differential |
Genevisiblei | P02747, HS |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR008160, Collagen IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | C1QC_HUMAN | |
Accessioni | P02747Primary (citable) accession number: P02747 Secondary accession number(s): Q7Z502, Q96DL2, Q96H05 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | April 16, 2002 | |
Last modified: | May 25, 2022 | |
This is version 214 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references