C1QC

Functionⁱ

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca²⁺-dependent C1r₂C1s₂ proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

GO - Molecular functionⁱ

serine-type endopeptidase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

complement activation Source: Reactome
complement activation, classical pathway Source: Reactome
immune response
Source: UniProtKB
Non-traceable author statementⁱ
- 9777412
innate immune response Source: UniProtKB-KW
negative regulation of granulocyte differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10961870
negative regulation of macrophage differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10961870
regulation of complement activation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Complement pathway, Immunity, Innate immunity

Biological process

Complement pathway, Immunity, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-977606 Regulation of Complement cascade

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-977606 Regulation of Complement cascade

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Complement C1q subcomponent subunit C
Gene namesⁱ	Name:C1QC Synonyms:C1QG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000159189.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1245 C1QC
MIMⁱ	120575 gene
neXtProtⁱ	NX_P02747

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Complement component C1q deficiency (C1QD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	714
MalaCards human disease database More...MalaCardsⁱ	C1QC
MIMⁱ	613652 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000159189
Orphanetⁱ	169147 Immunodeficiency due to a classical component pathway complement deficiency
PharmGKBⁱ	PA25626

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00054 Abciximab DB00051 Adalimumab DB00092 Alefacept DB00087 Alemtuzumab DB00074 Basiliximab DB00112 Bevacizumab DB00002 Cetuximab DB00111 Daclizumab DB00095 Efalizumab DB00005 Etanercept DB00056 Gemtuzumab ozogamicin DB00078 Ibritumomab tiuxetan DB00075 Muromonab DB00108 Natalizumab DB00110 Palivizumab DB00073 Rituximab DB00081 Tositumomab DB00072 Trastuzumab

DrugBankⁱ

DB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

Polymorphism and mutation databases

BioMutaⁱ	C1QC
DMDMⁱ	20178281

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	1 PublicationAdd BLAST		28
ChainⁱPRO_0000003524	29 – 245	Complement C1q subcomponent subunit CAdd BLAST		217

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	32	Interchain
Modified residueⁱ	36	4-hydroxyproline1 Publication	1
Modified residueⁱ	39	4-hydroxyproline1 Publication	1
Modified residueⁱ	42	4-hydroxyproline1 Publication	1
Modified residueⁱ	45	4-hydroxyproline1 Publication	1
Modified residueⁱ	54	4-hydroxyproline1 Publication	1
Modified residueⁱ	63	4-hydroxyproline1 Publication	1
Modified residueⁱ	75	5-hydroxylysine1 Publication	1
Glycosylationⁱ	75	O-linked (Gal...) hydroxylysine	1
Modified residueⁱ	81	4-hydroxyproline1 Publication	1
Modified residueⁱ	93	4-hydroxyproline1 Publication	1
Modified residueⁱ	96	4-hydroxyproline1 Publication	1
Modified residueⁱ	99	4-hydroxyproline1 Publication	1
Modified residueⁱ	105	4-hydroxyproline1 Publication	1

Post-translational modificationⁱ

O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbⁱ	P02747
PeptideAtlas More...PeptideAtlasⁱ	P02747
PRIDEⁱ	P02747
ProteomicsDBⁱ	51563

PTM databases

PhosphoSitePlusⁱ	P02747

PhosphoSitePlusⁱ

P02747

Miscellaneous databases

PMAP-CutDBⁱ	P02747

PMAP-CutDBⁱ

P02747

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000159189 Expressed in 191 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_C1QC
ExpressionAtlasⁱ	P02747 baseline and differential
Genevisibleⁱ	P02747 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009828 HPA001471

HPAⁱ

CAB009828
HPA001471

Interactionⁱ

Subunit structureⁱ

C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
C1QBP	Q07021	4	EBI-1220222,EBI-14032968

With

Entry

#Exp.

IntAct

Notes

C1QBP

Q07021

4

EBI-1220222,EBI-14032968

Protein-protein interaction databases

BioGridⁱ	107175, 2 interactors
ComplexPortalⁱ	CPX-1919 Complement component C1q complex
CORUMⁱ	P02747
IntActⁱ	P02747, 9 interactors
Molecular INTeraction database More...MINTⁱ	P02747
STRINGⁱ	9606.ENSP00000363768

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	116 – 118	Combined sources	3
Beta strandⁱ	121 – 125	Combined sources	5
Beta strandⁱ	142 – 145	Combined sources	4
Turnⁱ	153 – 155	Combined sources	3
Beta strandⁱ	157 – 159	Combined sources	3
Beta strandⁱ	164 – 176	Combined sources	13
Beta strandⁱ	178 – 184	Combined sources	7
Beta strandⁱ	187 – 194	Combined sources	8
Beta strandⁱ	197 – 199	Combined sources	3
Beta strandⁱ	201 – 211	Combined sources	11
Beta strandⁱ	216 – 225	Combined sources	10
Beta strandⁱ	236 – 244	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P02747
SMRⁱ	P02747
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02747

EvolutionaryTraceⁱ

P02747

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	31 – 112	Collagen-likeAdd BLAST		82
Domainⁱ	115 – 245	C1qPROSITE-ProRule annotationAdd BLAST		131

Keywords - Domainⁱ

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IWVM Eukaryota ENOG4111MQB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118830
HOGENOMⁱ	HOG000085653
HOVERGENⁱ	HBG108220
InParanoidⁱ	P02747
KEGG Orthology (KO) More...KOⁱ	K03988
OMAⁱ	YKQKHQS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L3Y
PhylomeDBⁱ	P02747
TreeFamⁱ	TF329591

Family and domain databases

Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR001073 C1q_dom IPR008160 Collagen IPR008983 Tumour_necrosis_fac-like_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00386 C1q, 1 hit PF01391 Collagen, 1 hit
PRINTSⁱ	PR00007 COMPLEMNTC1Q
SMARTⁱ	View protein in SMART SM00110 C1Q, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS50871 C1Q, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P02747-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDVGPSSLPH LGLKLLLLLL LLPLRGQANT GCYGIPGMPG LPGAPGKDGY 
        60         70         80         90        100
DGLPGPKGEP GIPAIPGIRG PKGQKGEPGL PGHPGKNGPM GPPGMPGVPG 
       110        120        130        140        150
PMGIPGEPGE EGRYKQKFQS VFTVTRQTHQ PPAPNSLIRF NAVLTNPQGD 
       160        170        180        190        200
YDTSTGKFTC KVPGLYYFVY HASHTANLCV LLYRSGVKVV TFCGHTSKTN 
       210        220        230        240 
QVNSGGVLLR LQVGEEVWLA VNDYYDMVGI QGSDSVFSGF LLFPD

Length:245

Mass (Da):25,774

Last modified:April 16, 2002 - v3

Checksum:ⁱFA17117EB7ABFC12

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	14	K → R in BAB71575 (PubMed:14702039).Curated	1
Sequence conflictⁱ	23	P → A no nucleotide entry (PubMed:1706597).Curated	1
Sequence conflictⁱ	26 – 27	GQ → AK in AAP97191 (Ref. 2) Curated	2
Sequence conflictⁱ	57	K → P AA sequence (PubMed:486087).Curated	1
Sequence conflictⁱ	66	P → K AA sequence (PubMed:486087).Curated	1
Sequence conflictⁱ	72	K → P AA sequence (PubMed:486087).Curated	1
Sequence conflictⁱ	84	P → K AA sequence (PubMed:486087).Curated	1
Sequence conflictⁱ	87	N → D AA sequence (PubMed:486087).Curated	1
Sequence conflictⁱ	90	M → N AA sequence (PubMed:486087).Curated	1
Sequence conflictⁱ	104	I → F in AAP97191 (Ref. 2) Curated	1
Sequence conflictⁱ	149	G → E in AAP97191 (Ref. 2) Curated	1
Sequence conflictⁱ	215	E → G in BAB71575 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_008542	34	G → R in C1QD. 1 PublicationCorresponds to variant dbSNP:rs200206736EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087892 mRNA Translation: AAP97191.1 AK057792 mRNA Translation: BAB71575.1 AL158086 Genomic DNA No translation available. BC009016 mRNA Translation: AAH09016.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS227.1
PIRⁱ	S14351 C1HUQC
NCBI Reference Sequences More...RefSeqⁱ	NP_001107573.1, NM_001114101.2 NP_001334548.1, NM_001347619.1 NP_758957.2, NM_172369.4
UniGeneⁱ	Hs.467753

Genome annotation databases

Ensemblⁱ	ENST00000374637; ENSP00000363768; ENSG00000159189 ENST00000374639; ENSP00000363770; ENSG00000159189 ENST00000374640; ENSP00000363771; ENSG00000159189
GeneIDⁱ	714
KEGGⁱ	hsa:714
UCSC genome browser More...UCSCⁱ	uc001bga.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P02747	Complement component 1, q subcomponent, C chain, isoform CRA_a		HUMAN		245	UniRef100_P02747

Protein	Similar proteins		Species	Score	Length	Source
P02747	Complement component 1, q subcomponent, C chain, isoform CRA_a		HUMAN		245	UniRef90_P02747
Uncharacterized protein		NOMLE		246
Complement C1q C chain		GORGO		245
Complement C1q subcomponent subunit C		MACMU		245
Complement C1q C chain		MACFA		245
+10

Protein	Similar proteins		Species	Score	Length	Source
P02747	Complement C1q subcomponent subunit C		MOUSE		246	UniRef50_P02747
Complement C1q subcomponent subunit C		RAT		245
Complement component 1, q subcomponent, C chain, isoform CRA_a		HUMAN		245
Uncharacterized protein		NOMLE		246
Complement C1q C chain		GORGO		245
+161

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087892 mRNA Translation: AAP97191.1 AK057792 mRNA Translation: BAB71575.1 AL158086 Genomic DNA No translation available. BC009016 mRNA Translation: AAH09016.1
CCDSⁱ	CCDS227.1
PIRⁱ	S14351 C1HUQC
RefSeqⁱ	NP_001107573.1, NM_001114101.2 NP_001334548.1, NM_001347619.1 NP_758957.2, NM_172369.4
UniGeneⁱ	Hs.467753

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1PK6	X-ray	1.85	C	117-245	[»]
	2JG8	X-ray	2.05	C/F	115-245	[»]
	2JG9	X-ray	1.90	C/F	115-245	[»]
	2WNU	X-ray	2.30	C/F	115-245	[»]
	2WNV	X-ray	1.25	C/F	115-245	[»]
	5HKJ	X-ray	1.35	A	115-245	[»]
	5HZF	X-ray	1.55	A	115-245	[»]
	6FCZ	electron microscopy	10.00	C	117-245	[»]
ProteinModelPortalⁱ	P02747
SMRⁱ	P02747
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107175, 2 interactors
ComplexPortalⁱ	CPX-1919 Complement component C1q complex
CORUMⁱ	P02747
IntActⁱ	P02747, 9 interactors
MINTⁱ	P02747
STRINGⁱ	9606.ENSP00000363768

Chemistry databases

DrugBankⁱ	DB00054 Abciximab DB00051 Adalimumab DB00092 Alefacept DB00087 Alemtuzumab DB00074 Basiliximab DB00112 Bevacizumab DB00002 Cetuximab DB00111 Daclizumab DB00095 Efalizumab DB00005 Etanercept DB00056 Gemtuzumab ozogamicin DB00078 Ibritumomab tiuxetan DB00075 Muromonab DB00108 Natalizumab DB00110 Palivizumab DB00073 Rituximab DB00081 Tositumomab DB00072 Trastuzumab

DrugBankⁱ

DB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

PTM databases

PhosphoSitePlusⁱ	P02747

PhosphoSitePlusⁱ

P02747

Polymorphism and mutation databases

BioMutaⁱ	C1QC
DMDMⁱ	20178281

Proteomic databases

PaxDbⁱ	P02747
PeptideAtlasⁱ	P02747
PRIDEⁱ	P02747
ProteomicsDBⁱ	51563

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	714
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000374637; ENSP00000363768; ENSG00000159189 ENST00000374639; ENSP00000363770; ENSG00000159189 ENST00000374640; ENSP00000363771; ENSG00000159189
GeneIDⁱ	714
KEGGⁱ	hsa:714
UCSCⁱ	uc001bga.5 human

Organism-specific databases

CTDⁱ	714
DisGeNETⁱ	714
EuPathDBⁱ	HostDB:ENSG00000159189.11
GeneCardsⁱ	C1QC
HGNCⁱ	HGNC:1245 C1QC
HPAⁱ	CAB009828 HPA001471
MalaCardsⁱ	C1QC
MIMⁱ	120575 gene 613652 phenotype
neXtProtⁱ	NX_P02747
OpenTargetsⁱ	ENSG00000159189
Orphanetⁱ	169147 Immunodeficiency due to a classical component pathway complement deficiency
PharmGKBⁱ	PA25626
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWVM Eukaryota ENOG4111MQB LUCA
GeneTreeⁱ	ENSGT00760000118830
HOGENOMⁱ	HOG000085653
HOVERGENⁱ	HBG108220
InParanoidⁱ	P02747
KOⁱ	K03988
OMAⁱ	YKQKHQS
OrthoDBⁱ	EOG091G0L3Y
PhylomeDBⁱ	P02747
TreeFamⁱ	TF329591

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-977606 Regulation of Complement cascade

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRSⁱ	C1QC human
EvolutionaryTraceⁱ	P02747
GenomeRNAiⁱ	714
PMAP-CutDBⁱ	P02747
Protein Ontology More...PROⁱ	PR:P02747
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159189 Expressed in 191 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_C1QC
ExpressionAtlasⁱ	P02747 baseline and differential
Genevisibleⁱ	P02747 HS

Family and domain databases

Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR001073 C1q_dom IPR008160 Collagen IPR008983 Tumour_necrosis_fac-like_dom
Pfamⁱ	View protein in Pfam PF00386 C1q, 1 hit PF01391 Collagen, 1 hit
PRINTSⁱ	PR00007 COMPLEMNTC1Q
SMARTⁱ	View protein in SMART SM00110 C1Q, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS50871 C1Q, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	C1QC_HUMAN
Accessionⁱ	P02747Primary (citable) accession number: P02747 Secondary accession number(s): Q7Z502, Q96DL2, Q96H05
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	April 16, 2002
	Last modified:	November 7, 2018
	This is version 193 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P02747 (C1QC_HUMAN)

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Complement C1q subcomponent subunit C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ