C1QA

Functionⁱ

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca²⁺-dependent C1r₂C1s₂ proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

GO - Molecular functionⁱ

serine-type endopeptidase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 9461517
complement activation Source: Reactome
complement activation, classical pathway Source: Reactome
innate immune response Source: UniProtKB-KW
regulation of complement activation Source: Reactome
response to iron ion Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Complement pathway, Immunity, Innate immunity

Biological process

Complement pathway, Immunity, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-977606 Regulation of Complement cascade

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-977606 Regulation of Complement cascade

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Complement C1q subcomponent subunit A
Gene namesⁱ	Name:C1QA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173372.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1241 C1QA
MIMⁱ	120550 gene
neXtProtⁱ	NX_P02745

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Complement component C1q deficiency (C1QD)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	712
MalaCards human disease database More...MalaCardsⁱ	C1QA
MIMⁱ	613652 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000173372
Orphanetⁱ	300345 Autosomal systemic lupus erythematosus 169147 Immunodeficiency due to a classical component pathway complement deficiency
PharmGKBⁱ	PA25622

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00054 Abciximab DB00051 Adalimumab DB00092 Alefacept DB00087 Alemtuzumab DB00074 Basiliximab DB00112 Bevacizumab DB00002 Cetuximab DB00111 Daclizumab DB00095 Efalizumab DB00005 Etanercept DB00056 Gemtuzumab ozogamicin DB00078 Ibritumomab tiuxetan DB00075 Muromonab DB00108 Natalizumab DB00110 Palivizumab DB00073 Rituximab DB00081 Tositumomab DB00072 Trastuzumab

DrugBankⁱ

DB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

Polymorphism and mutation databases

BioMutaⁱ	C1QA
DMDMⁱ	399138

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	1 PublicationAdd BLAST		22
ChainⁱPRO_0000003517	23 – 245	Complement C1q subcomponent subunit AAdd BLAST		223

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	26	Interchain (with C-29 in B chain)
Modified residueⁱ	33	5-hydroxylysine1 Publication	1
Glycosylationⁱ	33	O-linked (Gal...) hydroxylysine1 Publication	1
Modified residueⁱ	39	4-hydroxyproline1 Publication	1
Modified residueⁱ	45	4-hydroxyproline1 Publication	1
Modified residueⁱ	48	5-hydroxylysine1 Publication	1
Glycosylationⁱ	48	O-linked (Gal...) hydroxylysine1 Publication	1
Modified residueⁱ	54	4-hydroxyproline1 Publication	1
Modified residueⁱ	57	4-hydroxyproline1 Publication	1
Modified residueⁱ	67	5-hydroxylysine1 Publication	1
Glycosylationⁱ	67	O-linked (Gal...) hydroxylysine1 Publication	1
Modified residueⁱ	73	4-hydroxyproline1 Publication	1
Modified residueⁱ	79	4-hydroxyproline1 Publication	1
Modified residueⁱ	85	4-hydroxyproline1 Publication	1
Modified residueⁱ	100	5-hydroxylysine1 Publication	1
Glycosylationⁱ	100	O-linked (Gal...) hydroxylysine1 Publication	1
Glycosylationⁱ	146	N-linked (GlcNAc...) asparagine2 Publications	1

Post-translational modificationⁱ

O-linked glycans are assumed to be the Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbⁱ	P02745
PeptideAtlas More...PeptideAtlasⁱ	P02745
PRIDEⁱ	P02745
ProteomicsDBⁱ	51561

PTM databases

GlyConnectⁱ	1142
iPTMnetⁱ	P02745

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173372 Expressed in 209 organ(s), highest expression level in spleen
CleanExⁱ	HS_C1QA
ExpressionAtlasⁱ	P02745 baseline and differential
Genevisibleⁱ	P02745 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009823 HPA002350

HPAⁱ

CAB009823
HPA002350

Interactionⁱ

Subunit structureⁱ

C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
C1QB	P02746	4	EBI-1220209,EBI-2813376
C1QBP	Q07021	5	EBI-1220209,EBI-14032968
UBQLN2	Q9UHD9	3	EBI-1220209,EBI-947187

Protein-protein interaction databases

BioGridⁱ	107173, 19 interactors
ComplexPortalⁱ	CPX-1919 Complement component C1q complex
CORUMⁱ	P02745
IntActⁱ	P02745, 20 interactors
Molecular INTeraction database More...MINTⁱ	P02745
STRINGⁱ	9606.ENSP00000363773

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	116 – 120	Combined sources	5
Beta strandⁱ	128 – 130	Combined sources	3
Beta strandⁱ	135 – 140	Combined sources	6
Turnⁱ	146 – 148	Combined sources	3
Beta strandⁱ	150 – 152	Combined sources	3
Beta strandⁱ	157 – 169	Combined sources	13
Beta strandⁱ	171 – 179	Combined sources	9
Beta strandⁱ	182 – 184	Combined sources	3
Beta strandⁱ	188 – 191	Combined sources	4
Beta strandⁱ	195 – 197	Combined sources	3
Beta strandⁱ	199 – 209	Combined sources	11
Beta strandⁱ	214 – 224	Combined sources	11
Beta strandⁱ	229 – 232	Combined sources	4
Beta strandⁱ	235 – 243	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P02745
SMRⁱ	P02745
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02745

EvolutionaryTraceⁱ

P02745

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	31 – 109	Collagen-likeAdd BLAST		79
Domainⁱ	110 – 245	C1qPROSITE-ProRule annotationAdd BLAST		136

Keywords - Domainⁱ

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IK45 Eukaryota ENOG410YJJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140911
HOGENOMⁱ	HOG000085653
HOVERGENⁱ	HBG108220
InParanoidⁱ	P02745
KEGG Orthology (KO) More...KOⁱ	K03986
OMAⁱ	YYYFTFQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L3Y
PhylomeDBⁱ	P02745
TreeFamⁱ	TF329591

Family and domain databases

Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR001073 C1q_dom IPR008160 Collagen IPR037572 Complement_C1q_A IPR008983 Tumour_necrosis_fac-like_dom
PANTHERⁱ	PTHR45066 PTHR45066, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00386 C1q, 1 hit PF01391 Collagen, 1 hit
PRINTSⁱ	PR00007 COMPLEMNTC1Q
SMARTⁱ	View protein in SMART SM00110 C1Q, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS50871 C1Q, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P02745-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGPRGWLVL CVLAISLASM VTEDLCRAPD GKKGEAGRPG RRGRPGLKGE 
        60         70         80         90        100
QGEPGAPGIR TGIQGLKGDQ GEPGPSGNPG KVGYPGPSGP LGARGIPGIK 
       110        120        130        140        150
GTKGSPGNIK DQPRPAFSAI RRNPPMGGNV VIFDTVITNQ EEPYQNHSGR 
       160        170        180        190        200
FVCTVPGYYY FTFQVLSQWE ICLSIVSSSR GQVRRSLGFC DTTNKGLFQV 
       210        220        230        240 
VSGGMVLQLQ QGDQVWVEKD PKKGHIYQGS EADSVFSGFL IFPSA

Length:245

Mass (Da):26,017

Last modified:July 1, 1993 - v2

Checksum:ⁱ8FF6B6AE02D49C4C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	X6RLJ0	X6RLJ0_HUMAN		Complement C1q subcomponent subunit... Complement C1q subcomponent subunit A	C1QA	220	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	97	P → K AA sequence (PubMed:486087).Curated	1
Sequence conflictⁱ	103	K → P AA sequence (PubMed:486087).Curated	1
Sequence conflictⁱ	172	C → N AA sequence (PubMed:6981411).Curated	1
Sequence conflictⁱ	178	S → W AA sequence (PubMed:6981411).Curated	1
Sequence conflictⁱ	240 – 243	LIFP → ILPGF AA sequence (PubMed:6981411).Curated	4

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_021090	23	E → K1 PublicationCorresponds to variant dbSNP:rs17887074EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF135157 mRNA Translation: AAD32626.1 AY789471 Genomic DNA Translation: AAV40828.1 AL158086 Genomic DNA Translation: CAI22892.1 AK311980 mRNA Translation: BAG34919.1 AL158086 Genomic DNA Translation: CAI22893.1 CH471134 Genomic DNA Translation: EAW95014.1 BC030153 mRNA Translation: AAH30153.1 BC071986 mRNA Translation: AAH71986.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS226.1
PIRⁱ	S14350 C1HUQA
NCBI Reference Sequences More...RefSeqⁱ	NP_001334394.1, NM_001347465.1 NP_001334395.1, NM_001347466.1 NP_057075.1, NM_015991.3
UniGeneⁱ	Hs.632379

Genome annotation databases

Ensemblⁱ	ENST00000374642; ENSP00000363773; ENSG00000173372 ENST00000402322; ENSP00000385564; ENSG00000173372
GeneIDⁱ	712
KEGGⁱ	hsa:712
UCSC genome browser More...UCSCⁱ	uc001bfy.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P02745	Complement component 1, q subcomponent, A chain, isoform CRA_a		HUMAN		245	UniRef100_P02745
Complement C1q subcomponent subunit A (Fragment)		HUMAN		220

Protein	Similar proteins		Species	Score	Length	Source
P02745	Complement component 1, q subcomponent, A chain, isoform CRA_a		HUMAN		245	UniRef90_P02745
Uncharacterized protein		COLAP		245
Uncharacterized protein		RHIRO		245
Uncharacterized protein		MANLE		245
Uncharacterized protein		NOMLE		245
+8

Protein	Similar proteins		Species	Score	Length	Source
P02745	Complement C1q subcomponent subunit A		RAT		245	UniRef50_P02745
Complement C1q subcomponent subunit A		MOUSE		245
Complement component 1, q subcomponent, A chain, isoform CRA_a		HUMAN		245
Uncharacterized protein		NOMLE		245
Uncharacterized protein		MANLE		245
+140

Cross-referencesⁱ

Web resourcesⁱ

C1QAbase

C1QA mutation db

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF135157 mRNA Translation: AAD32626.1 AY789471 Genomic DNA Translation: AAV40828.1 AL158086 Genomic DNA Translation: CAI22892.1 AK311980 mRNA Translation: BAG34919.1 AL158086 Genomic DNA Translation: CAI22893.1 CH471134 Genomic DNA Translation: EAW95014.1 BC030153 mRNA Translation: AAH30153.1 BC071986 mRNA Translation: AAH71986.1
CCDSⁱ	CCDS226.1
PIRⁱ	S14350 C1HUQA
RefSeqⁱ	NP_001334394.1, NM_001347465.1 NP_001334395.1, NM_001347466.1 NP_057075.1, NM_015991.3
UniGeneⁱ	Hs.632379

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1PK6	X-ray	1.85	A	112-244	[»]
	2JG8	X-ray	2.05	A/D	112-245	[»]
	2JG9	X-ray	1.90	A/D	112-245	[»]
	2WNU	X-ray	2.30	A/D	112-245	[»]
	2WNV	X-ray	1.25	A/D	112-245	[»]
	5HKJ	X-ray	1.35	A	110-245	[»]
	5HZF	X-ray	1.55	A	110-245	[»]
	6FCZ	electron microscopy	10.00	A	112-244	[»]
ProteinModelPortalⁱ	P02745
SMRⁱ	P02745
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107173, 19 interactors
ComplexPortalⁱ	CPX-1919 Complement component C1q complex
CORUMⁱ	P02745
IntActⁱ	P02745, 20 interactors
MINTⁱ	P02745
STRINGⁱ	9606.ENSP00000363773

Chemistry databases

DrugBankⁱ	DB00054 Abciximab DB00051 Adalimumab DB00092 Alefacept DB00087 Alemtuzumab DB00074 Basiliximab DB00112 Bevacizumab DB00002 Cetuximab DB00111 Daclizumab DB00095 Efalizumab DB00005 Etanercept DB00056 Gemtuzumab ozogamicin DB00078 Ibritumomab tiuxetan DB00075 Muromonab DB00108 Natalizumab DB00110 Palivizumab DB00073 Rituximab DB00081 Tositumomab DB00072 Trastuzumab

DrugBankⁱ

DB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

PTM databases

GlyConnectⁱ	1142
iPTMnetⁱ	P02745

Polymorphism and mutation databases

BioMutaⁱ	C1QA
DMDMⁱ	399138

Proteomic databases

PaxDbⁱ	P02745
PeptideAtlasⁱ	P02745
PRIDEⁱ	P02745
ProteomicsDBⁱ	51561

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	712
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000374642; ENSP00000363773; ENSG00000173372 ENST00000402322; ENSP00000385564; ENSG00000173372
GeneIDⁱ	712
KEGGⁱ	hsa:712
UCSCⁱ	uc001bfy.4 human

Organism-specific databases

CTDⁱ	712
DisGeNETⁱ	712
EuPathDBⁱ	HostDB:ENSG00000173372.16
GeneCardsⁱ	C1QA
HGNCⁱ	HGNC:1241 C1QA
HPAⁱ	CAB009823 HPA002350
MalaCardsⁱ	C1QA
MIMⁱ	120550 gene 613652 phenotype
neXtProtⁱ	NX_P02745
OpenTargetsⁱ	ENSG00000173372
Orphanetⁱ	300345 Autosomal systemic lupus erythematosus 169147 Immunodeficiency due to a classical component pathway complement deficiency
PharmGKBⁱ	PA25622
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IK45 Eukaryota ENOG410YJJD LUCA
GeneTreeⁱ	ENSGT00900000140911
HOGENOMⁱ	HOG000085653
HOVERGENⁱ	HBG108220
InParanoidⁱ	P02745
KOⁱ	K03986
OMAⁱ	YYYFTFQ
OrthoDBⁱ	EOG091G0L3Y
PhylomeDBⁱ	P02745
TreeFamⁱ	TF329591

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-977606 Regulation of Complement cascade

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRSⁱ	C1QA human
EvolutionaryTraceⁱ	P02745
GeneWikiⁱ	C1QA
GenomeRNAiⁱ	712
Protein Ontology More...PROⁱ	PR:P02745
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173372 Expressed in 209 organ(s), highest expression level in spleen
CleanExⁱ	HS_C1QA
ExpressionAtlasⁱ	P02745 baseline and differential
Genevisibleⁱ	P02745 HS

Family and domain databases

Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR001073 C1q_dom IPR008160 Collagen IPR037572 Complement_C1q_A IPR008983 Tumour_necrosis_fac-like_dom
PANTHERⁱ	PTHR45066 PTHR45066, 1 hit
Pfamⁱ	View protein in Pfam PF00386 C1q, 1 hit PF01391 Collagen, 1 hit
PRINTSⁱ	PR00007 COMPLEMNTC1Q
SMARTⁱ	View protein in SMART SM00110 C1Q, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS50871 C1Q, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	C1QA_HUMAN
Accessionⁱ	P02745Primary (citable) accession number: P02745 Secondary accession number(s): B2R4X2, Q5T963
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 1, 1993
	Last modified:	November 7, 2018
	This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P02745 (C1QA_HUMAN)

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Complement C1q subcomponent subunit A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Complement component C1q deficiency (C1QD)

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ