Serum amyloid P-component

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium ion binding Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]
• carbohydrate binding Source: UniProtKB-KW
• complement component C1q complex binding Source: BHF-UCLInferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component."
    Kolstoe S.E., Ridha B.H., Bellotti V., Wang N., Robinson C.V., Crutch S.J., Keir G., Kukkastenvehmas R., Gallimore J.R., Hutchinson W.L., Hawkins P.N., Wood S.P., Rossor M.N., Pepys M.B.
    Proc Natl Acad Sci U S A 106:7619-7623(2009) [PubMed] [Europe PMC] [Abstract]
  • "Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques."
    Mencarelli C., Bode G.H., Losen M., Kulharia M., Molenaar P.C., Veerhuis R., Steinbusch H.W., De Baets M.H., Nicolaes G.A., Martinez-Martinez P.
    J Biol Chem 287:14897-14911(2012) [PubMed] [Europe PMC] [Abstract]
  • "The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes."
    Hall Z., Hernandez H., Marsh J.A., Teichmann S.A., Robinson C.V.
    Structure 21:1325-1337(2013) [PubMed] [Europe PMC] [Abstract]
• low-density lipoprotein particle binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• unfolded protein binding Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Molecular chaperone properties of serum amyloid P component."
    Coker A.R., Purvis A., Baker D., Pepys M.B., Wood S.P.
    FEBS Lett 473:199-202(2000) [PubMed] [Europe PMC] [Abstract]
• virion binding Source: BHF-UCLInferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• acute-phase response Source: ProtIncTraceable author statementⁱ
  • Ref.1

    "Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1."
    Mantzouranis E.C., Dowton S.B., Whitehead A.S., Edge M.D., Bruns G.A.P., Colten H.R.
    J. Biol. Chem. 260:7752-7756(1985) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• cellular protein metabolic process Source: Reactome
• chaperone-mediated protein complex assembly Source: ProtIncTraceable author statementⁱ
  • "Human serum amyloid P component is a single uncomplexed pentamer in whole serum."
    Hutchinson W.L., Hohenester E., Pepys M.B.
    Mol Med 6:482-493(2000) [PubMed] [Europe PMC] [Abstract]
• complement activation, classical pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• innate immune response Source: BHF-UCLInferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation by host of viral exo-alpha-sialidase activity Source: BHF-UCLInferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation by host of viral glycoprotein metabolic process Source: BHF-UCLInferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation by host of viral process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of acute inflammatory response Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Inhibition of fibrocyte differentiation by serum amyloid P."
    Pilling D., Buckley C.D., Salmon M., Gomer R.H.
    J Immunol 171:5537-5546(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of exo-alpha-sialidase activity Source: BHF-UCLInferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of glycoprotein metabolic process Source: BHF-UCLInferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of monocyte differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "Inhibition of fibrocyte differentiation by serum amyloid P."
    Pilling D., Buckley C.D., Salmon M., Gomer R.H.
    J Immunol 171:5537-5546(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of viral entry into host cell Source: BHF-UCLInferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of viral process Source: BHF-UCLInferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of wound healing Source: BHF-UCLInferred by curatorⁱ
  • "Inhibition of fibrocyte differentiation by serum amyloid P."
    Pilling D., Buckley C.D., Salmon M., Gomer R.H.
    J Immunol 171:5537-5546(2003) [PubMed] [Europe PMC] [Abstract]
• protein folding Source: ProtIncTraceable author statementⁱ
  • "Molecular chaperone properties of serum amyloid P component."
    Coker A.R., Purvis A., Baker D., Pepys M.B., Wood S.P.
    FEBS Lett 473:199-202(2000) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• complement component C1q complex binding Source: BHF-UCLInferred from direct assayⁱ
  • "Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses."
    Job E.R., Bottazzi B., Gilbertson B., Edenborough K.M., Brown L.E., Mantovani A., Brooks A.G., Reading P.C.
    PLoS One 8:e59623-e59623(2013) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component."
    Kolstoe S.E., Ridha B.H., Bellotti V., Wang N., Robinson C.V., Crutch S.J., Keir G., Kukkastenvehmas R., Gallimore J.R., Hutchinson W.L., Hawkins P.N., Wood S.P., Rossor M.N., Pepys M.B.
    Proc Natl Acad Sci U S A 106:7619-7623(2009) [PubMed] [Europe PMC] [Abstract]
  • "Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques."
    Mencarelli C., Bode G.H., Losen M., Kulharia M., Molenaar P.C., Veerhuis R., Steinbusch H.W., De Baets M.H., Nicolaes G.A., Martinez-Martinez P.
    J Biol Chem 287:14897-14911(2012) [PubMed] [Europe PMC] [Abstract]
  • "The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes."
    Hall Z., Hernandez H., Marsh J.A., Teichmann S.A., Robinson C.V.
    Structure 21:1325-1337(2013) [PubMed] [Europe PMC] [Abstract]
• unfolded protein binding Source: ProtIncTraceable author statementⁱ
  • "Molecular chaperone properties of serum amyloid P component."
    Coker A.R., Purvis A., Baker D., Pepys M.B., Wood S.P.
    FEBS Lett 473:199-202(2000) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ 
        60         70         80         90        100
NFTLCFRAYS DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT 
       110        120        130        140        150
SKVIEKFPAP VHICVSWESS SGIAEFWING TPLVKKGLRQ GYFVEAQPKI 
       160        170        180        190        200
VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD SVLPPENILS AYQGTPLPAN 
       210        220 
ILDWQALNYE IRGYVIIKPL VWV                              

Experimental Info

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryⁱ

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families
5. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
6. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations