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Protein

Serum amyloid P-component

Gene

APCS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+Note: Binds 2 calcium ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi77Calcium 1PROSITE-ProRule annotation1
Metal bindingi78Calcium 1PROSITE-ProRule annotation1
Metal bindingi155Calcium 1PROSITE-ProRule annotation1
Metal bindingi155Calcium 2PROSITE-ProRule annotation1
Metal bindingi156Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi157Calcium 1PROSITE-ProRule annotation1
Metal bindingi157Calcium 2PROSITE-ProRule annotation1
Metal bindingi167Calcium 2PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: BHF-UCL
  • carbohydrate binding Source: UniProtKB-KW
  • complement component C1q binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • low-density lipoprotein particle binding Source: GO_Central
  • unfolded protein binding Source: ProtInc
  • virion binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-977225 Amyloid fiber formation

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.92.1.2 the pentraxin (pentraxin) family

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
P02743

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serum amyloid P-component
Short name:
SAP
Alternative name(s):
9.5S alpha-1-glycoprotein
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APCS
Synonyms:PTX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132703.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:584 APCS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
104770 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02743

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

Organism-specific databases

DisGeNET

More...
DisGeNETi
325

Open Targets

More...
OpenTargetsi
ENSG00000132703

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24877

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4929

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2839

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APCS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
730704

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 192 PublicationsAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002354020 – 223Serum amyloid P-componentAdd BLAST204
ChainiPRO_000002354120 – 222Serum amyloid P-component(1-203)Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00016951N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi55 ↔ 114PROSITE-ProRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P02743

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P02743

PeptideAtlas

More...
PeptideAtlasi
P02743

PRoteomics IDEntifications database

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PRIDEi
P02743

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51560

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P02743

USC-OGP 2-DE database

More...
OGPi
P02743

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00022391
P02743

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P02743

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P02743

GlyConnect protein glycosylation platform

More...
GlyConnecti
560

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02743

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P02743

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P02743

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in serum and urine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132703 Expressed in 70 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

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CleanExi
HS_APCS

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P02743 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P02743 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB007817
HPA053294

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-2115799,EBI-2115799

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106822, 13 interactors

Database of interacting proteins

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DIPi
DIP-46911N

Protein interaction database and analysis system

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IntActi
P02743, 6 interactors

Molecular INTeraction database

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MINTi
P02743

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000255040

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GYKX-ray2.20A/B/C/D/E20-223[»]
1LGNX-ray2.80A/B/C/D/E20-223[»]
1SACX-ray2.00A/B/C/D/E20-223[»]
2A3WX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T20-223[»]
2A3XX-ray3.00A/B/C/D/E/F/G/H/I/J20-223[»]
2A3YX-ray2.00A/B/C/D/E20-223[»]
2W08X-ray1.70A/B/C/D/E20-223[»]
3D5OX-ray2.80A/B/C/D/E20-223[»]
3KQRX-ray1.50A/B/C/D/E20-223[»]
4AVSX-ray1.40A/B/C/D/E20-223[»]
4AVTX-ray3.20A/B/C/D/E/F/G/H/I/J20-223[»]
4AVVX-ray1.60A/B/C/D/E20-223[»]
4AYUX-ray1.50A/B/C/D/E20-223[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P02743

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02743

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02743

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 223Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST200

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pentraxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1FD Eukaryota
ENOG410YN8S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153549

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247043

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005405

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P02743

Identification of Orthologs from Complete Genome Data

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OMAi
MDKLLLW

Database of Orthologous Groups

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OrthoDBi
1088298at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P02743

TreeFam database of animal gene trees

More...
TreeFami
TF330208

Family and domain databases

Conserved Domains Database

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CDDi
cd00152 PTX, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00354 Pentaxin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00895 PENTAXIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00159 PTX, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02743-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ
60 70 80 90 100
NFTLCFRAYS DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT
110 120 130 140 150
SKVIEKFPAP VHICVSWESS SGIAEFWING TPLVKKGLRQ GYFVEAQPKI
160 170 180 190 200
VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD SVLPPENILS AYQGTPLPAN
210 220
ILDWQALNYE IRGYVIIKPL VWV
Length:223
Mass (Da):25,387
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C88A515FE88B393
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101S → P in AAA60302 (PubMed:2987268).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 25462.5±1.1 Da from positions 20 - 223. Determined by ESI. 2 Publications
Molecular mass is 25463±3 Da from positions 20 - 223. Determined by MALDI. 2 Publications
Molecular mass is 1285.78 Da from positions 213 - 223. Determined by MALDI. 1 Publication
Molecular mass is 1186.71 Da from positions 213 - 222. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035814141G → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_006054155E → G. 1
Natural variantiVAR_006055158S → G. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D00097 Genomic DNA Translation: BAA00060.1
M10944 mRNA Translation: AAA60302.1
X04608 mRNA Translation: CAA28275.1
CR450313 mRNA Translation: CAG29309.1
AL445528 Genomic DNA No translation available.
BT006750 mRNA Translation: AAP35396.1
BC007039 mRNA Translation: AAH07039.1
BC007058 mRNA Translation: AAH07058.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1186.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A25503 YLHUP

NCBI Reference Sequences

More...
RefSeqi
NP_001630.1, NM_001639.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.507080

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000255040; ENSP00000255040; ENSG00000132703

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
325

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:325

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Serum amyloid P component entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00097 Genomic DNA Translation: BAA00060.1
M10944 mRNA Translation: AAA60302.1
X04608 mRNA Translation: CAA28275.1
CR450313 mRNA Translation: CAG29309.1
AL445528 Genomic DNA No translation available.
BT006750 mRNA Translation: AAP35396.1
BC007039 mRNA Translation: AAH07039.1
BC007058 mRNA Translation: AAH07058.1
CCDSiCCDS1186.1
PIRiA25503 YLHUP
RefSeqiNP_001630.1, NM_001639.3
UniGeneiHs.507080

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GYKX-ray2.20A/B/C/D/E20-223[»]
1LGNX-ray2.80A/B/C/D/E20-223[»]
1SACX-ray2.00A/B/C/D/E20-223[»]
2A3WX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T20-223[»]
2A3XX-ray3.00A/B/C/D/E/F/G/H/I/J20-223[»]
2A3YX-ray2.00A/B/C/D/E20-223[»]
2W08X-ray1.70A/B/C/D/E20-223[»]
3D5OX-ray2.80A/B/C/D/E20-223[»]
3KQRX-ray1.50A/B/C/D/E20-223[»]
4AVSX-ray1.40A/B/C/D/E20-223[»]
4AVTX-ray3.20A/B/C/D/E/F/G/H/I/J20-223[»]
4AVVX-ray1.60A/B/C/D/E20-223[»]
4AYUX-ray1.50A/B/C/D/E20-223[»]
ProteinModelPortaliP02743
SMRiP02743
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106822, 13 interactors
DIPiDIP-46911N
IntActiP02743, 6 interactors
MINTiP02743
STRINGi9606.ENSP00000255040

Chemistry databases

ChEMBLiCHEMBL4929
GuidetoPHARMACOLOGYi2839

Protein family/group databases

TCDBi1.C.92.1.2 the pentraxin (pentraxin) family
UniLectiniP02743

PTM databases

CarbonylDBiP02743
GlyConnecti560
iPTMnetiP02743
PhosphoSitePlusiP02743
UniCarbKBiP02743

Polymorphism and mutation databases

BioMutaiAPCS
DMDMi730704

2D gel databases

DOSAC-COBS-2DPAGEiP02743
OGPiP02743
REPRODUCTION-2DPAGEiIPI00022391
P02743
SWISS-2DPAGEiP02743

Proteomic databases

jPOSTiP02743
PaxDbiP02743
PeptideAtlasiP02743
PRIDEiP02743
ProteomicsDBi51560

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
325
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255040; ENSP00000255040; ENSG00000132703
GeneIDi325
KEGGihsa:325

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
325
DisGeNETi325
EuPathDBiHostDB:ENSG00000132703.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
APCS
HGNCiHGNC:584 APCS
HPAiCAB007817
HPA053294
MIMi104770 gene
neXtProtiNX_P02743
OpenTargetsiENSG00000132703
PharmGKBiPA24877

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J1FD Eukaryota
ENOG410YN8S LUCA
GeneTreeiENSGT00940000153549
HOGENOMiHOG000247043
HOVERGENiHBG005405
InParanoidiP02743
OMAiMDKLLLW
OrthoDBi1088298at2759
PhylomeDBiP02743
TreeFamiTF330208

Enzyme and pathway databases

ReactomeiR-HSA-977225 Amyloid fiber formation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
APCS human
EvolutionaryTraceiP02743

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Serum_amyloid_P_component

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
325

Protein Ontology

More...
PROi
PR:P02743

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132703 Expressed in 70 organ(s), highest expression level in right lobe of liver
CleanExiHS_APCS
ExpressionAtlasiP02743 baseline and differential
GenevisibleiP02743 HS

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAMP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02743
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1995
Last modified: January 16, 2019
This is version 207 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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