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Protein

C-reactive protein

Gene

CRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Miscellaneous

This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.

Cofactori

Ca2+Note: Binds 2 calcium ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi78Calcium 1PROSITE-ProRule annotation1
Metal bindingi79Calcium 1PROSITE-ProRule annotation1
Metal bindingi156Calcium 1PROSITE-ProRule annotation1
Metal bindingi156Calcium 2PROSITE-ProRule annotation1
Metal bindingi157Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi158Calcium 1PROSITE-ProRule annotation1
Metal bindingi158Calcium 2PROSITE-ProRule annotation1
Metal bindingi168Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

  • calcium ion binding Source: BHF-UCL
  • choline binding Source: BHF-UCL
  • complement component C1q binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • low-density lipoprotein particle binding Source: BHF-UCL
  • low-density lipoprotein particle receptor binding Source: AgBase

GO - Biological processi

  • acute-phase response Source: BHF-UCL
  • defense response to Gram-positive bacterium Source: BHF-UCL
  • inflammatory response Source: ProtInc
  • negative regulation of blood vessel diameter Source: AgBase
  • negative regulation of lipid storage Source: BHF-UCL
  • negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • opsonization Source: BHF-UCL
  • positive regulation of gene expression Source: AgBase
  • positive regulation of superoxide anion generation Source: AgBase
  • regulation of interleukin-8 secretion Source: UniProtKB

Keywordsi

Biological processAcute phase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-173623 Classical antibody-mediated complement activation
SIGNORiP02741

Protein family/group databases

UniLectiniP02741

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Cleaved into the following chain:
Gene namesi
Name:CRP
Synonyms:PTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000132693.12
HGNCiHGNC:2367 CRP
MIMi123260 gene
neXtProtiNX_P02741

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1401
OpenTargetsiENSG00000132693
PharmGKBiPA120

Chemistry databases

DrugBankiDB05744 CRx-139

Polymorphism and mutation databases

BioMutaiCRP
DMDMi117486

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000002352619 – 224C-reactive proteinAdd BLAST206
ChainiPRO_000002352719 – 223C-reactive protein(1-205)Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi54 ↔ 115PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP02741
PeptideAtlasiP02741
PRIDEiP02741
ProteomicsDBi12625 [P02741-2]
51558
51559 [P02741-2]

2D gel databases

DOSAC-COBS-2DPAGEiP02741
SWISS-2DPAGEiP02741

PTM databases

iPTMnetiP02741
PhosphoSitePlusiP02741

Expressioni

Tissue specificityi

Found in plasma.

Inductioni

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6/interleukin-6.

Gene expression databases

BgeeiENSG00000132693
CleanExiHS_CRP
ExpressionAtlasiP02741 baseline and differential
GenevisibleiP02741 HS

Organism-specific databases

HPAiCAB005036
HPA027367
HPA027396

Interactioni

Subunit structurei

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • complement component C1q binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • low-density lipoprotein particle receptor binding Source: AgBase

Protein-protein interaction databases

BioGridi107791, 50 interactors
DIPiDIP-39125N
IntActiP02741, 12 interactors
MINTiP02741
STRINGi9606.ENSP00000255030

Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 29Combined sources5
Beta strandi37 – 40Combined sources4
Beta strandi48 – 60Combined sources13
Helixi61 – 63Combined sources3
Beta strandi67 – 74Combined sources8
Beta strandi77 – 86Combined sources10
Turni87 – 89Combined sources3
Beta strandi90 – 95Combined sources6
Beta strandi98 – 103Combined sources6
Beta strandi112 – 119Combined sources8
Turni120 – 122Combined sources3
Beta strandi124 – 129Combined sources6
Beta strandi132 – 138Combined sources7
Beta strandi150 – 155Combined sources6
Helixi166 – 168Combined sources3
Beta strandi172 – 182Combined sources11
Helixi186 – 194Combined sources9
Beta strandi201 – 203Combined sources3
Helixi205 – 207Combined sources3
Beta strandi210 – 215Combined sources6
Beta strandi217 – 220Combined sources4

3D structure databases

ProteinModelPortaliP02741
SMRiP02741
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02741

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 224Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Belongs to the pentraxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9V0 Eukaryota
ENOG410YIJN LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000247043
HOVERGENiHBG005405
InParanoidiP02741
KOiK16143
OMAiNEILIFW
OrthoDBiEOG091G0H6X
PhylomeDBiP02741
TreeFamiTF330208

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P02741-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKLLCFLVL TSLSHAFGQT DMSRKAFVFP KESDTSYVSL KAPLTKPLKA
60 70 80 90 100
FTVCLHFYTE LSSTRGYSIF SYATKRQDNE ILIFWSKDIG YSFTVGGSEI
110 120 130 140 150
LFEVPEVTVA PVHICTSWES ASGIVEFWVD GKPRVRKSLK KGYTVGAEAS
160 170 180 190 200
IILGQEQDSF GGNFEGSQSL VGDIGNVNMW DFVLSPDEIN TIYLGGPFSP
210 220
NVLNWRALKY EVQGEVFTKP QLWP
Length:224
Mass (Da):25,039
Last modified:January 1, 1988 - v1
Checksum:i669228636A8544F6
GO
Isoform 2 (identifier: P02741-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-199: Missing.

Note: No experimental confirmation available.
Show »
Length:91
Mass (Da):10,415
Checksum:iA5E24599540DAA05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49K → G AA sequence (PubMed:403526).Curated1
Sequence conflicti52T → G AA sequence (PubMed:403526).Curated1
Sequence conflicti67 – 82YSIFS…DNEIL → TVFSRMPPRDKTMRFF in CAA39671 (Ref. 4) CuratedAdd BLAST16
Sequence conflicti80 – 98Missing AA sequence (PubMed:762075).CuratedAdd BLAST19
Sequence conflicti170L → V in AAA52074 (PubMed:6857266).Curated1

Mass spectrometryi

Molecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. 1 Publication
Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00465667 – 199Missing in isoform 2. 1 PublicationAdd BLAST133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11880 Genomic DNA Translation: AAB59526.1
M11725 Genomic DNA Translation: AAA52075.1
X56692 mRNA Translation: CAA40020.1
X56214 mRNA Translation: CAA39671.1
AF442818 Genomic DNA Translation: AAL48218.2
AK289443 mRNA Translation: BAF82132.1
AF449713 Genomic DNA Translation: AAL40835.1
AL445528 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52778.1
CH471121 Genomic DNA Translation: EAW52779.1
CH471121 Genomic DNA Translation: EAW52780.1
BC020766 mRNA Translation: AAH20766.1
BC125135 mRNA Translation: AAI25136.1
M35163 mRNA Translation: AAA52076.1
K00518 mRNA Translation: AAA52074.1
CCDSiCCDS30911.1 [P02741-1]
PIRiA24515 CJHU
RefSeqiNP_000558.2, NM_000567.2 [P02741-1]
NP_001315986.1, NM_001329057.1 [P02741-1]
NP_001315987.1, NM_001329058.1 [P02741-2]
UniGeneiHs.709456
Hs.76452

Genome annotation databases

EnsembliENST00000255030; ENSP00000255030; ENSG00000132693 [P02741-1]
ENST00000368112; ENSP00000357093; ENSG00000132693 [P02741-2]
GeneIDi1401
KEGGihsa:1401
UCSCiuc001ftw.3 human [P02741-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCRP_HUMAN
AccessioniPrimary (citable) accession number: P02741
Secondary accession number(s): A8K078
, D3DVD9, D3DVE0, Q08AK3, Q8WW75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: July 18, 2018
This is version 214 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  5. SIMILARITY comments
    Index of protein domains and families

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