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Protein

Serum amyloid A protein

Gene
N/A
Organism
Anas platyrhynchos (Mallard) (Anas boschas)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Biological processi

Keywordsi

Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A protein
Short name:
SAA
OrganismiAnas platyrhynchos (Mallard) (Anas boschas)
Taxonomic identifieri8839 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnatinaeAnas
Proteomesi
  • UP000016666 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000003156719 – 127Serum amyloid A proteinAdd BLAST109

Post-translational modificationi

This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 3 residues from the C-terminal end.

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma. Also present in the liver and lung irrespective of induction.

Inductioni

Upon cytokine stimulation.

Structurei

3D structure databases

SMRiP02740
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG016327
KOiK17310

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02740-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLCICFVLL AVIVCASADN PFTRGGRFVL DAAGGAWDML RAYRDMREAN
60 70 80 90 100
HIGADKYFHA RGNYDAARRG PGGAWAARVI SDARENWQGG VSGRGAEDTR
110 120
ADQEANAWGR NGGDPNRYRP PGLPSKY
Length:127
Mass (Da):13,873
Last modified:November 1, 1997 - v2
Checksum:i6F61476AEAB9EB6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81 – 82SD → AN AA sequence (PubMed:845435).Curated2
Sequence conflicti93Missing AA sequence (PubMed:845435).Curated1
Sequence conflicti99T → R AA sequence (PubMed:845435).Curated1

Polymorphismi

At least two alleles exist. The sequence of the B allele is shown here.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti89G → S in allele A. 1
Natural varianti107A → V in allele A. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59909 Genomic DNA Translation: AAC60058.1
U59908 mRNA Translation: AAC60057.1
U64985 Genomic DNA Translation: AAC60059.1
PIRiA03200 YLDKA
A27227
RefSeqiNP_001297733.1, NM_001310804.1
XP_005028466.2, XM_005028409.2

Genome annotation databases

GeneIDi101798523
KEGGiapla:101798523

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59909 Genomic DNA Translation: AAC60058.1
U59908 mRNA Translation: AAC60057.1
U64985 Genomic DNA Translation: AAC60059.1
PIRiA03200 YLDKA
A27227
RefSeqiNP_001297733.1, NM_001310804.1
XP_005028466.2, XM_005028409.2

3D structure databases

SMRiP02740
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101798523
KEGGiapla:101798523

Organism-specific databases

CTDi6289

Phylogenomic databases

HOVERGENiHBG016327
KOiK17310

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAA_ANAPL
AccessioniPrimary (citable) accession number: P02740
Secondary accession number(s): Q92034
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1997
Last modified: February 28, 2018
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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