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Protein

Serum amyloid A-2 protein

Gene

SAA2

Organism
Neovison vison (American mink) (Mustela vison)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

Miscellaneous

SAA2 is more amyloidogenic than SAA1.

GO - Biological processi

Keywordsi

Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-2 protein
Cleaved into the following chain:
Alternative name(s):
Amyloid fibril protein AA
Gene namesi
Name:SAA2
OrganismiNeovison vison (American mink) (Mustela vison)
Taxonomic identifieri452646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeNeovison

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000003159419 – 129Serum amyloid A-2 proteinAdd BLAST111
ChainiPRO_000003159519 – 82Amyloid protein AAdd BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1

Keywords - PTMi

Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Upon cytokine stimulation.

Structurei

3D structure databases

SMRiP02739
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG016327

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFTGLIFC SLVLGVSSQW YSFIGEAVQG AWDMYRAYSD MREANYKNSD
60 70 80 90 100
KYFHARGNYD AAQRGPGGAW AAKVISDARE RSQRVTDLFK YGDSGHGVED
110 120
SKADQAANEW GRSGKDPNHF RPSGLPDKY
Length:129
Mass (Da):14,456
Last modified:November 1, 1990 - v2
Checksum:iB79402006B34B882
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti24I → F. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34954 mRNA Translation: AAA30969.1
PIRiA03199 YLMNA
B36451

Similar proteinsi

Entry informationi

Entry nameiSAA2_NEOVI
AccessioniPrimary (citable) accession number: P02739
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: March 15, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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