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UniProtKB - P02724 (GLPA_HUMAN)

Entry version 221 (25 May 2022)
Sequence version 2 (22 Sep 2009)
Previous versions | rss
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Protein

Glycophorin-A

Gene

GYPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).

6 Publications

Miscellaneous

Involved in several unequal homologous recombinations or gene conversion events, predominantly with GYPB and more rarely with GYPE. The resulting fusion proteins are observed in different phenotypes and encode low incidence bloodgroup antigens.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen, Host cell receptor for virus entry, Receptor
Biological processHost-virus interaction
LigandSialic acid

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P02724

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-202733, Cell surface interactions at the vascular wall

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P02724

SIGNOR Signaling Network Open Resource

More...SIGNORi		P02724

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.168.1.1, the glycophorin (gp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycophorin-A
Alternative name(s):
MN sialoglycoprotein
PAS-2
Sialoglycoprotein alpha
CD_antigen: CD235a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GYPA
Synonyms:GPA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4702, GYPA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617922, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P02724

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170180

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 91ExtracellularAdd BLAST72
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei92 – 114HelicalAdd BLAST23
Topological domaini115 – 150CytoplasmicAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi87F → C: Diminishes dimerization. 1 Publication1
Mutagenesisi88S → C: Diminishes dimerization. 1 Publication1
Mutagenesisi90P → C: Diminishes dimerization. 1 Publication1
Mutagenesisi91E → C: Diminishes dimerization. 1 Publication1
Mutagenesisi94L → I: Diminishes dimerization. 1 Publication1
Mutagenesisi95I → A: Diminishes dimerization. 1 Publication1
Mutagenesisi98G → L: Diminishes dimerization. 1 Publication1
Mutagenesisi102G → L: Abolishes dimerization. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		2993

MalaCards human disease database

More...MalaCardsi		GYPA
MIMi111300, phenotype
611162, phenotype

Open Targets

More...OpenTargetsi		ENSG00000170180

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29080

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P02724, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5806

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GYPA

Domain mapping of disease mutations (DMDM)

More...DMDMi		259016238

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001213420 – 150Glycophorin-AAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi21O-linked (GalNAc...) serine2 Publications1
Glycosylationi22O-linked (GalNAc...) threonine2 Publications1
Glycosylationi23O-linked (GalNAc...) threonine2 Publications1
Glycosylationi29O-linked (GalNAc...) threonine2 Publications1
Glycosylationi30O-linked (GalNAc...) serine2 Publications1
Glycosylationi31O-linked (GalNAc...) threonine2 Publications1
Glycosylationi32O-linked (GalNAc...) serine2 Publications1
Glycosylationi36O-linked (GalNAc...) threonine1 Publication1
Glycosylationi38O-linked (GalNAc...) serine1 Publication1
Glycosylationi41O-linked (GalNAc...) serine2 Publications1
Glycosylationi44O-linked (GalNAc...) threonine2 Publications1
Glycosylationi45N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi52O-linked (GalNAc...) threonine1 Publication1
Glycosylationi56O-linked (GalNAc...) threonine2 Publications1
Glycosylationi63O-linked (GalNAc...) serine2 Publications1
Glycosylationi66O-linked (GalNAc...) serine2 Publications1
Glycosylationi69O-linked (GalNAc...) threonine2 Publications1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei133PhosphothreonineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The major O-linked glycan are NeuAc-alpha-2-3-Gal-beta-1-3-[NeuAc-alpha-2-6]-GalNAcOH (about 78 %) and NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-2-3-Gal-beta-1-3-[NeuAc-alpha-2-6]-GalNAcOH NeuAc-alpha-2-8-NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH-6-1-GlcNAc-beta-4-1-[Fuc-alpha-1-2]-Gal-beta-3-1-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH-6-1-GlcNAc-beta-4-1-[Fuc-alpha-1-2]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).5 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P02724

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P02724

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02724

PeptideAtlas

More...PeptideAtlasi		P02724

PRoteomics IDEntifications database

More...PRIDEi		P02724

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51556 [P02724-1]
7281
7282

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		187, 2 N-Linked glycans, 14 O-Linked glycans (1 site)
188, 4 O-Linked glycans
189, 7 O-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P02724, 19 sites, 4 N-linked glycans (1 site), 25 O-linked glycans (18 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P02724

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P02724

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170180, Expressed in trabecular bone tissue and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P02724, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P02724, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170180, Tissue enriched (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

(Microbial infection) Interacts with Streptococcus gordonii hsa protein.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109248, 185 interactors

Protein interaction database and analysis system

More...IntActi		P02724, 43 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354003

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P02724

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P02724, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P02724

Biological Magnetic Resonance Data Bank

More...BMRBi		P02724

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P02724

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P02724

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni121 – 150DisorderedSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycophorin A family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502THAT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000075214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_154690_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02724

Database of Orthologous Groups

More...OrthoDBi		1548637at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P02724

TreeFam database of animal gene trees

More...TreeFami		TF338555

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001195, Glycophorin
IPR018938, Glycophorin_CS

The PANTHER Classification System

More...PANTHERi		PTHR13813, PTHR13813, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002466, Glycophorin, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00312, GLYCOPHORIN_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P02724-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYGKIIFVLL LSEIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNDTHKR 
        60         70         80         90        100
DTYAATPRAH EVSEISVRTV YPPEEETGER VQLAHHFSEP EITLIIFGVM 
       110        120        130        140        150
AGVIGTILLI SYGIRRLIKK SPSDVKPLPS PDTDVPLSSV EIENPETSDQ
Length:150
Mass (Da):16,331
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48A5450E22FA99C9
GO
Isoform 2 (identifier: P02724-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.

Show »
Length:124
Mass (Da):13,649
Checksum:iD257CA020BB42AFD
GO
Isoform 3 (identifier: P02724-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-45: Missing.

Show »
Length:117
Mass (Da):13,000
Checksum:i3F1878ED9D7ADB29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFT7A0A0C4DFT7_HUMAN
Glycophorin
GYPA
150Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU29A0A087WU29_HUMAN
Glycophorin
GYPA
148Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7F9A0A2R8Y7F9_HUMAN
Glycophorin-A
GYPA
145Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PD10E9PD10_HUMAN
Glycophorin
GYPA
137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQF3E7EQF3_HUMAN
Glycophorin
GYPA
118Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PH25E9PH25_HUMAN
Glycophorin-A
GYPA
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q13030Q13030_HUMAN
Glycophorin Erik I-IV
GYPA GPErik, hCG_2026259
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K9JIK7K9JIK7_HUMAN
Glycophorin-A
GYPA
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K9JI14K9JI14_HUMAN
Glycophorin-A
GYPA
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJD8D6RJD8_HUMAN
Glycophorin-A
GYPA
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA52624 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30S → T AA sequence (PubMed:1059087).Curated1
Sequence conflicti36T → S AA sequence (PubMed:1059087).Curated1
Sequence conflicti133T → R in AAA88044 (PubMed:3456608).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Along with GYPB, GYPA is responsible for the MNS blood group system [MIMi:111300]. The molecular basis of the GPA M/N bloodgroup antigen is a variation at positions 20 and 24. Ser-20 and Gly-24 correspond to M (shown); 'Leu-20' and 'Glu-24' correspond to N.
GYPA polymorphisms are involved in resistance to malaria [MIMi:611162].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05891113E → A7 PublicationsCorresponds to variant dbSNP:rs4449373Ensembl.1
Natural variantiVAR_05997713E → G. Corresponds to variant dbSNP:rs4449373Ensembl.1
Natural variantiVAR_00319020S → L in N antigen and M(g) antigen. 3 PublicationsCorresponds to variant dbSNP:rs7682260Ensembl.1
Natural variantiVAR_05891223T → N in M(g) antigen. 1 Publication1
Natural variantiVAR_05891324G → D. Corresponds to variant dbSNP:rs7658293Ensembl.1
Natural variantiVAR_00319124G → E in N antigen, M(c) antigen and M(g) antigen. 4 PublicationsCorresponds to variant dbSNP:rs7687256Ensembl.1
Natural variantiVAR_05891446D → E in Ny(a) antigen. 1 Publication1
Natural variantiVAR_05891547T → K in ENEH/Hut antigen. 1 Publication1
Natural variantiVAR_05891647T → M in ENEH/Vw antigen. 1 Publication1
Natural variantiVAR_05891750R → W in Or antigen. 1
Natural variantiVAR_05891866S → Y in Vr antigen. 1 PublicationCorresponds to variant dbSNP:rs56077914Ensembl.1
Natural variantiVAR_05891973P → S in Os(a) antigen. 1 Publication1
Natural variantiVAR_05892076E → K in Ri(a) antigen. 1
Natural variantiVAR_05892177T → I in Mt(a) antigen. 1 PublicationCorresponds to variant dbSNP:rs56172553Ensembl.1
Natural variantiVAR_05892278G → R in ERIK antigen. 1 PublicationCorresponds to variant dbSNP:rs1800582EnsemblClinVar.1
Natural variantiVAR_05892382Q → K in ENAV/MARS antigen. 1
Natural variantiVAR_05892484A → P in ENEP/HAG antigen. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0478221 – 26Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_04782313 – 45Missing in isoform 3. CuratedAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M12857 mRNA Translation: AAA88044.1
X08054 mRNA Translation: CAA30843.1
M24128 M24127 Genomic DNA Translation: AAA52768.1
X51798 mRNA Translation: CAA36095.1
L31860 mRNA Translation: AAA88051.1
EU338231 mRNA Translation: ACA96789.1
EU338233 mRNA Translation: ACA96791.1
EU338234 mRNA Translation: ACA96792.1
GU347002 mRNA Translation: ADU25340.1
GU347003 mRNA Translation: ADU25341.1
AK290561 mRNA Translation: BAF83250.1
AC107223 Genomic DNA No translation available.
BC005319 mRNA Translation: AAH05319.1
BC013328 mRNA Translation: AAH13328.1
M36281 mRNA Translation: AAA52624.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34069.1 [P02724-1]
CCDS82959.1 [P02724-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A33931, A25131

NCBI Reference Sequences

More...RefSeqi		NP_001295119.1, NM_001308190.1 [P02724-3]
NP_002090.4, NM_002099.7
XP_016863624.1, XM_017008135.1 [P02724-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324022.14; ENSP00000324483.10; ENSG00000170180.22 [P02724-3]
ENST00000642713.1; ENSP00000494092.1; ENSG00000170180.22 [P02724-2]
ENST00000646447.1; ENSP00000495922.1; ENSG00000170180.22 [P02724-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2993

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2993

UCSC genome browser

More...UCSCi		uc003ijo.5, human [P02724-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12857 mRNA Translation: AAA88044.1
X08054 mRNA Translation: CAA30843.1
M24128 M24127 Genomic DNA Translation: AAA52768.1
X51798 mRNA Translation: CAA36095.1
L31860 mRNA Translation: AAA88051.1
EU338231 mRNA Translation: ACA96789.1
EU338233 mRNA Translation: ACA96791.1
EU338234 mRNA Translation: ACA96792.1
GU347002 mRNA Translation: ADU25340.1
GU347003 mRNA Translation: ADU25341.1
AK290561 mRNA Translation: BAF83250.1
AC107223 Genomic DNA No translation available.
BC005319 mRNA Translation: AAH05319.1
BC013328 mRNA Translation: AAH13328.1
M36281 mRNA Translation: AAA52624.1 Different initiation.
CCDSiCCDS34069.1 [P02724-1]
CCDS82959.1 [P02724-3]
PIRiA33931, A25131
RefSeqiNP_001295119.1, NM_001308190.1 [P02724-3]
NP_002090.4, NM_002099.7
XP_016863624.1, XM_017008135.1 [P02724-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AFONMR-A/B81-120[»]
2KPENMR-A/B89-117[»]
2KPFNMR-A/B80-117[»]
5EH4X-ray2.81A/B/C/D89-117[»]
5EH6X-ray1.92A89-117[»]
AlphaFoldDBiP02724
BMRBiP02724
SMRiP02724
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109248, 185 interactors
IntActiP02724, 43 interactors
STRINGi9606.ENSP00000354003

Chemistry databases

BindingDBiP02724
ChEMBLiCHEMBL5806

Protein family/group databases

TCDBi8.A.168.1.1, the glycophorin (gp) family

PTM databases

GlyConnecti187, 2 N-Linked glycans, 14 O-Linked glycans (1 site)
188, 4 O-Linked glycans
189, 7 O-Linked glycans (1 site)
GlyGeniP02724, 19 sites, 4 N-linked glycans (1 site), 25 O-linked glycans (18 sites)
iPTMnetiP02724
PhosphoSitePlusiP02724

Genetic variation databases

BioMutaiGYPA
DMDMi259016238

Proteomic databases

jPOSTiP02724
MassIVEiP02724
PaxDbiP02724
PeptideAtlasiP02724
PRIDEiP02724
ProteomicsDBi51556 [P02724-1]
7281
7282

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P02724, 17 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3054, 2084 antibodies from 47 providers

The DNASU plasmid repository

More...DNASUi		2993

Genome annotation databases

EnsembliENST00000324022.14; ENSP00000324483.10; ENSG00000170180.22 [P02724-3]
ENST00000642713.1; ENSP00000494092.1; ENSG00000170180.22 [P02724-2]
ENST00000646447.1; ENSP00000495922.1; ENSG00000170180.22 [P02724-2]
GeneIDi2993
KEGGihsa:2993
UCSCiuc003ijo.5, human [P02724-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2993
DisGeNETi2993

GeneCards: human genes, protein and diseases

More...GeneCardsi		GYPA
HGNCiHGNC:4702, GYPA
HPAiENSG00000170180, Tissue enriched (bone)
MalaCardsiGYPA
MIMi111300, phenotype
611162, phenotype
617922, gene
neXtProtiNX_P02724
OpenTargetsiENSG00000170180
PharmGKBiPA29080
VEuPathDBiHostDB:ENSG00000170180

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502THAT, Eukaryota
GeneTreeiENSGT00550000075214
HOGENOMiCLU_154690_2_1_1
InParanoidiP02724
OrthoDBi1548637at2759
PhylomeDBiP02724
TreeFamiTF338555

Enzyme and pathway databases

PathwayCommonsiP02724
ReactomeiR-HSA-202733, Cell surface interactions at the vascular wall
SignaLinkiP02724
SIGNORiP02724

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2993, 8 hits in 1065 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GYPA, human
EvolutionaryTraceiP02724

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GYPA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2993
PharosiP02724, Tbio

Protein Ontology

More...PROi		PR:P02724
RNActiP02724, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170180, Expressed in trabecular bone tissue and 116 other tissues
ExpressionAtlasiP02724, baseline and differential
GenevisibleiP02724, HS

Family and domain databases

InterProiView protein in InterPro
IPR001195, Glycophorin
IPR018938, Glycophorin_CS
PANTHERiPTHR13813, PTHR13813, 1 hit
PIRSFiPIRSF002466, Glycophorin, 1 hit
PROSITEiView protein in PROSITE
PS00312, GLYCOPHORIN_A, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLPA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02724
Secondary accession number(s): A8K3E6
, B8Q182, B8Q185, Q9BS51
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 22, 2009
Last modified: May 25, 2022
This is version 221 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
  5. Human variants curated from literature reports
    Index of human variants curated from literature reports
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families
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