UniProtKB - P02724 (GLPA_HUMAN)
Glycophorin-A
GYPA
Functioni
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
6 PublicationsMiscellaneous
GO - Molecular functioni
- identical protein binding Source: IntAct
- virus receptor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Blood group antigen, Host cell receptor for virus entry, Receptor |
Biological process | Host-virus interaction |
Ligand | Sialic acid |
Enzyme and pathway databases
PathwayCommonsi | P02724 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall |
SignaLinki | P02724 |
SIGNORi | P02724 |
Protein family/group databases
TCDBi | 8.A.168.1.1, the glycophorin (gp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Glycophorin-AAlternative name(s): MN sialoglycoprotein PAS-2 Sialoglycoprotein alpha CD_antigen: CD235a |
Gene namesi | Name:GYPA Synonyms:GPA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4702, GYPA |
MIMi | 617922, gene |
neXtProti | NX_P02724 |
VEuPathDBi | HostDB:ENSG00000170180 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: Appears to be colocalized with SLC4A1.
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: HPA
Other locations
- membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 91 | ExtracellularAdd BLAST | 72 | |
Transmembranei | 92 – 114 | HelicalAdd BLAST | 23 | |
Topological domaini | 115 – 150 | CytoplasmicAdd BLAST | 36 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 87 | F → C: Diminishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 88 | S → C: Diminishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 90 | P → C: Diminishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 91 | E → C: Diminishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 94 | L → I: Diminishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 95 | I → A: Diminishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 98 | G → L: Diminishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 102 | G → L: Abolishes dimerization. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2993 |
MalaCardsi | GYPA |
MIMi | 111300, phenotype 611162, phenotype |
OpenTargetsi | ENSG00000170180 |
PharmGKBi | PA29080 |
Miscellaneous databases
Pharosi | P02724, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5806 |
Genetic variation databases
BioMutai | GYPA |
DMDMi | 259016238 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000012134 | 20 – 150 | Glycophorin-AAdd BLAST | 131 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 21 | O-linked (GalNAc...) serine2 Publications | 1 | |
Glycosylationi | 22 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Glycosylationi | 23 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Glycosylationi | 29 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Glycosylationi | 30 | O-linked (GalNAc...) serine2 Publications | 1 | |
Glycosylationi | 31 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Glycosylationi | 32 | O-linked (GalNAc...) serine2 Publications | 1 | |
Glycosylationi | 36 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 38 | O-linked (GalNAc...) serine1 Publication | 1 | |
Glycosylationi | 41 | O-linked (GalNAc...) serine2 Publications | 1 | |
Glycosylationi | 44 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Glycosylationi | 45 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 52 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 56 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Glycosylationi | 63 | O-linked (GalNAc...) serine2 Publications | 1 | |
Glycosylationi | 66 | O-linked (GalNAc...) serine2 Publications | 1 | |
Glycosylationi | 69 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Modified residuei | 133 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 138 | PhosphoserineCombined sources | 1 | |
Modified residuei | 148 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | P02724 |
MassIVEi | P02724 |
PaxDbi | P02724 |
PeptideAtlasi | P02724 |
PRIDEi | P02724 |
ProteomicsDBi | 51556 [P02724-1] 7281 7282 |
PTM databases
GlyConnecti | 187, 2 N-Linked glycans, 14 O-Linked glycans (1 site) 188, 4 O-Linked glycans 189, 7 O-Linked glycans (1 site) |
GlyGeni | P02724, 19 sites, 4 N-linked glycans (1 site), 25 O-linked glycans (18 sites) |
iPTMneti | P02724 |
PhosphoSitePlusi | P02724 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170180, Expressed in trabecular bone tissue and 116 other tissues |
ExpressionAtlasi | P02724, baseline and differential |
Genevisiblei | P02724, HS |
Organism-specific databases
HPAi | ENSG00000170180, Tissue enriched (bone) |
Interactioni
Subunit structurei
Homodimer.
2 Publications(Microbial infection) Interacts with Streptococcus gordonii hsa protein.
1 PublicationBinary interactionsi
P02724
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 109248, 185 interactors |
IntActi | P02724, 43 interactors |
STRINGi | 9606.ENSP00000354003 |
Chemistry databases
BindingDBi | P02724 |
Miscellaneous databases
RNActi | P02724, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P02724 |
BMRBi | P02724 |
SMRi | P02724 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02724 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 121 – 150 | DisorderedSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502THAT, Eukaryota |
GeneTreei | ENSGT00550000075214 |
HOGENOMi | CLU_154690_2_1_1 |
InParanoidi | P02724 |
OrthoDBi | 1548637at2759 |
PhylomeDBi | P02724 |
TreeFami | TF338555 |
Family and domain databases
InterProi | View protein in InterPro IPR001195, Glycophorin IPR018938, Glycophorin_CS |
PANTHERi | PTHR13813, PTHR13813, 1 hit |
PIRSFi | PIRSF002466, Glycophorin, 1 hit |
PROSITEi | View protein in PROSITE PS00312, GLYCOPHORIN_A, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYGKIIFVLL LSEIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNDTHKR
60 70 80 90 100
DTYAATPRAH EVSEISVRTV YPPEEETGER VQLAHHFSEP EITLIIFGVM
110 120 130 140 150
AGVIGTILLI SYGIRRLIKK SPSDVKPLPS PDTDVPLSSV EIENPETSDQ
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DFT7 | A0A0C4DFT7_HUMAN | Glycophorin | GYPA | 150 | Annotation score: | ||
A0A087WU29 | A0A087WU29_HUMAN | Glycophorin | GYPA | 148 | Annotation score: | ||
A0A2R8Y7F9 | A0A2R8Y7F9_HUMAN | Glycophorin-A | GYPA | 145 | Annotation score: | ||
E9PD10 | E9PD10_HUMAN | Glycophorin | GYPA | 137 | Annotation score: | ||
E7EQF3 | E7EQF3_HUMAN | Glycophorin | GYPA | 118 | Annotation score: | ||
E9PH25 | E9PH25_HUMAN | Glycophorin-A | GYPA | 105 | Annotation score: | ||
Q13030 | Q13030_HUMAN | Glycophorin Erik I-IV | GYPA GPErik, hCG_2026259 | 85 | Annotation score: | ||
K9JIK7 | K9JIK7_HUMAN | Glycophorin-A | GYPA | 72 | Annotation score: | ||
K9JI14 | K9JI14_HUMAN | Glycophorin-A | GYPA | 104 | Annotation score: | ||
D6RJD8 | D6RJD8_HUMAN | Glycophorin-A | GYPA | 42 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | S → T AA sequence (PubMed:1059087).Curated | 1 | |
Sequence conflicti | 36 | T → S AA sequence (PubMed:1059087).Curated | 1 | |
Sequence conflicti | 133 | T → R in AAA88044 (PubMed:3456608).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058911 | 13 | E → A7 PublicationsCorresponds to variant dbSNP:rs4449373Ensembl. | 1 | |
Natural variantiVAR_059977 | 13 | E → G. Corresponds to variant dbSNP:rs4449373Ensembl. | 1 | |
Natural variantiVAR_003190 | 20 | S → L in N antigen and M(g) antigen. 3 PublicationsCorresponds to variant dbSNP:rs7682260Ensembl. | 1 | |
Natural variantiVAR_058912 | 23 | T → N in M(g) antigen. 1 Publication | 1 | |
Natural variantiVAR_058913 | 24 | G → D. Corresponds to variant dbSNP:rs7658293Ensembl. | 1 | |
Natural variantiVAR_003191 | 24 | G → E in N antigen, M(c) antigen and M(g) antigen. 4 PublicationsCorresponds to variant dbSNP:rs7687256Ensembl. | 1 | |
Natural variantiVAR_058914 | 46 | D → E in Ny(a) antigen. 1 Publication | 1 | |
Natural variantiVAR_058915 | 47 | T → K in ENEH/Hut antigen. 1 Publication | 1 | |
Natural variantiVAR_058916 | 47 | T → M in ENEH/Vw antigen. 1 Publication | 1 | |
Natural variantiVAR_058917 | 50 | R → W in Or antigen. | 1 | |
Natural variantiVAR_058918 | 66 | S → Y in Vr antigen. 1 PublicationCorresponds to variant dbSNP:rs56077914Ensembl. | 1 | |
Natural variantiVAR_058919 | 73 | P → S in Os(a) antigen. 1 Publication | 1 | |
Natural variantiVAR_058920 | 76 | E → K in Ri(a) antigen. | 1 | |
Natural variantiVAR_058921 | 77 | T → I in Mt(a) antigen. 1 PublicationCorresponds to variant dbSNP:rs56172553Ensembl. | 1 | |
Natural variantiVAR_058922 | 78 | G → R in ERIK antigen. 1 PublicationCorresponds to variant dbSNP:rs1800582EnsemblClinVar. | 1 | |
Natural variantiVAR_058923 | 82 | Q → K in ENAV/MARS antigen. | 1 | |
Natural variantiVAR_058924 | 84 | A → P in ENEP/HAG antigen. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047822 | 1 – 26 | Missing in isoform 2. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_047823 | 13 – 45 | Missing in isoform 3. CuratedAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M12857 mRNA Translation: AAA88044.1 X08054 mRNA Translation: CAA30843.1 M24128 , M24123, M24134, M24124, M24126, M24127 Genomic DNA Translation: AAA52768.1 X51798 mRNA Translation: CAA36095.1 L31860 mRNA Translation: AAA88051.1 EU338231 mRNA Translation: ACA96789.1 EU338233 mRNA Translation: ACA96791.1 EU338234 mRNA Translation: ACA96792.1 GU347002 mRNA Translation: ADU25340.1 GU347003 mRNA Translation: ADU25341.1 AK290561 mRNA Translation: BAF83250.1 AC107223 Genomic DNA No translation available. BC005319 mRNA Translation: AAH05319.1 BC013328 mRNA Translation: AAH13328.1 M36281 mRNA Translation: AAA52624.1 Different initiation. |
CCDSi | CCDS34069.1 [P02724-1] CCDS82959.1 [P02724-3] |
PIRi | A33931, A25131 |
RefSeqi | NP_001295119.1, NM_001308190.1 [P02724-3] NP_002090.4, NM_002099.7 XP_016863624.1, XM_017008135.1 [P02724-2] |
Genome annotation databases
Ensembli | ENST00000324022.14; ENSP00000324483.10; ENSG00000170180.22 [P02724-3] ENST00000642713.1; ENSP00000494092.1; ENSG00000170180.22 [P02724-2] ENST00000646447.1; ENSP00000495922.1; ENSG00000170180.22 [P02724-2] |
GeneIDi | 2993 |
KEGGi | hsa:2993 |
UCSCi | uc003ijo.5, human [P02724-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
dbRBC/BGMUT Blood group antigen gene mutation database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M12857 mRNA Translation: AAA88044.1 X08054 mRNA Translation: CAA30843.1 M24128 , M24123, M24134, M24124, M24126, M24127 Genomic DNA Translation: AAA52768.1 X51798 mRNA Translation: CAA36095.1 L31860 mRNA Translation: AAA88051.1 EU338231 mRNA Translation: ACA96789.1 EU338233 mRNA Translation: ACA96791.1 EU338234 mRNA Translation: ACA96792.1 GU347002 mRNA Translation: ADU25340.1 GU347003 mRNA Translation: ADU25341.1 AK290561 mRNA Translation: BAF83250.1 AC107223 Genomic DNA No translation available. BC005319 mRNA Translation: AAH05319.1 BC013328 mRNA Translation: AAH13328.1 M36281 mRNA Translation: AAA52624.1 Different initiation. |
CCDSi | CCDS34069.1 [P02724-1] CCDS82959.1 [P02724-3] |
PIRi | A33931, A25131 |
RefSeqi | NP_001295119.1, NM_001308190.1 [P02724-3] NP_002090.4, NM_002099.7 XP_016863624.1, XM_017008135.1 [P02724-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AFO | NMR | - | A/B | 81-120 | [»] | |
2KPE | NMR | - | A/B | 89-117 | [»] | |
2KPF | NMR | - | A/B | 80-117 | [»] | |
5EH4 | X-ray | 2.81 | A/B/C/D | 89-117 | [»] | |
5EH6 | X-ray | 1.92 | A | 89-117 | [»] | |
AlphaFoldDBi | P02724 | |||||
BMRBi | P02724 | |||||
SMRi | P02724 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109248, 185 interactors |
IntActi | P02724, 43 interactors |
STRINGi | 9606.ENSP00000354003 |
Chemistry databases
BindingDBi | P02724 |
ChEMBLi | CHEMBL5806 |
Protein family/group databases
TCDBi | 8.A.168.1.1, the glycophorin (gp) family |
PTM databases
GlyConnecti | 187, 2 N-Linked glycans, 14 O-Linked glycans (1 site) 188, 4 O-Linked glycans 189, 7 O-Linked glycans (1 site) |
GlyGeni | P02724, 19 sites, 4 N-linked glycans (1 site), 25 O-linked glycans (18 sites) |
iPTMneti | P02724 |
PhosphoSitePlusi | P02724 |
Genetic variation databases
BioMutai | GYPA |
DMDMi | 259016238 |
Proteomic databases
jPOSTi | P02724 |
MassIVEi | P02724 |
PaxDbi | P02724 |
PeptideAtlasi | P02724 |
PRIDEi | P02724 |
ProteomicsDBi | 51556 [P02724-1] 7281 7282 |
Protocols and materials databases
ABCDi | P02724, 17 sequenced antibodies |
Antibodypediai | 3054, 2084 antibodies from 47 providers |
DNASUi | 2993 |
Genome annotation databases
Ensembli | ENST00000324022.14; ENSP00000324483.10; ENSG00000170180.22 [P02724-3] ENST00000642713.1; ENSP00000494092.1; ENSG00000170180.22 [P02724-2] ENST00000646447.1; ENSP00000495922.1; ENSG00000170180.22 [P02724-2] |
GeneIDi | 2993 |
KEGGi | hsa:2993 |
UCSCi | uc003ijo.5, human [P02724-1] |
Organism-specific databases
CTDi | 2993 |
DisGeNETi | 2993 |
GeneCardsi | GYPA |
HGNCi | HGNC:4702, GYPA |
HPAi | ENSG00000170180, Tissue enriched (bone) |
MalaCardsi | GYPA |
MIMi | 111300, phenotype 611162, phenotype 617922, gene |
neXtProti | NX_P02724 |
OpenTargetsi | ENSG00000170180 |
PharmGKBi | PA29080 |
VEuPathDBi | HostDB:ENSG00000170180 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502THAT, Eukaryota |
GeneTreei | ENSGT00550000075214 |
HOGENOMi | CLU_154690_2_1_1 |
InParanoidi | P02724 |
OrthoDBi | 1548637at2759 |
PhylomeDBi | P02724 |
TreeFami | TF338555 |
Enzyme and pathway databases
PathwayCommonsi | P02724 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall |
SignaLinki | P02724 |
SIGNORi | P02724 |
Miscellaneous databases
BioGRID-ORCSi | 2993, 8 hits in 1065 CRISPR screens |
ChiTaRSi | GYPA, human |
EvolutionaryTracei | P02724 |
GeneWikii | GYPA |
GenomeRNAii | 2993 |
Pharosi | P02724, Tbio |
PROi | PR:P02724 |
RNActi | P02724, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170180, Expressed in trabecular bone tissue and 116 other tissues |
ExpressionAtlasi | P02724, baseline and differential |
Genevisiblei | P02724, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001195, Glycophorin IPR018938, Glycophorin_CS |
PANTHERi | PTHR13813, PTHR13813, 1 hit |
PIRSFi | PIRSF002466, Glycophorin, 1 hit |
PROSITEi | View protein in PROSITE PS00312, GLYCOPHORIN_A, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GLPA_HUMAN | |
Accessioni | P02724Primary (citable) accession number: P02724 Secondary accession number(s): A8K3E6 Q9BS51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | September 22, 2009 | |
Last modified: | May 25, 2022 | |
This is version 221 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Blood group antigen proteins
Nomenclature of blood group antigens and list of entries - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families