GYPA

Functionⁱ

Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).6 Publications

Miscellaneous

Involved in several unequal homologous recombinations or gene conversion events, predominantly with GYPB and more rarely with GYPE. The resulting fusion proteins are observed in different phenotypes and encode low incidence bloodgroup antigens.

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
virus receptor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

leukocyte migration Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Blood group antigen, Host cell receptor for virus entry, Receptor
Biological process	Host-virus interaction
Ligand	Sialic acid

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall

Reactomeⁱ

R-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycophorin-A Alternative name(s): MN sialoglycoprotein PAS-2 Sialoglycoprotein alpha CD_antigen: CD235a
Gene namesⁱ	Name:GYPA Synonyms:GPA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170180.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4702 GYPA
MIMⁱ	617922 gene
neXtProtⁱ	NX_P02724

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 91	ExtracellularAdd BLAST	72
Transmembraneⁱ	92 – 114	HelicalAdd BLAST	23
Topological domainⁱ	115 – 150	CytoplasmicAdd BLAST	36

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	87	F → C: Diminishes dimerization. 1 Publication	1
Mutagenesisⁱ	88	S → C: Diminishes dimerization. 1 Publication	1
Mutagenesisⁱ	90	P → C: Diminishes dimerization. 1 Publication	1
Mutagenesisⁱ	91	E → C: Diminishes dimerization. 1 Publication	1
Mutagenesisⁱ	94	L → I: Diminishes dimerization. 1 Publication	1
Mutagenesisⁱ	95	I → A: Diminishes dimerization. 1 Publication	1
Mutagenesisⁱ	98	G → L: Diminishes dimerization. 1 Publication	1
Mutagenesisⁱ	102	G → L: Abolishes dimerization. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2993
MalaCards human disease database More...MalaCardsⁱ	GYPA
MIMⁱ	111300 phenotype 611162 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000170180
PharmGKBⁱ	PA29080

Chemistry databases

ChEMBLⁱ	CHEMBL5806

ChEMBLⁱ

CHEMBL5806

Polymorphism and mutation databases

BioMutaⁱ	GYPA
DMDMⁱ	259016238

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	1 PublicationAdd BLAST		19
ChainⁱPRO_0000012134	20 – 150	Glycophorin-AAdd BLAST		131

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	21	O-linked (GalNAc...) serine2 Publications	1
Glycosylationⁱ	22	O-linked (GalNAc...) threonine2 Publications	1
Glycosylationⁱ	23	O-linked (GalNAc...) threonine2 Publications	1
Glycosylationⁱ	29	O-linked (GalNAc...) threonine2 Publications	1
Glycosylationⁱ	30	O-linked (GalNAc...) serine2 Publications	1
Glycosylationⁱ	31	O-linked (GalNAc...) threonine2 Publications	1
Glycosylationⁱ	32	O-linked (GalNAc...) serine2 Publications	1
Glycosylationⁱ	36	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	38	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	41	O-linked (GalNAc...) serine2 Publications	1
Glycosylationⁱ	44	O-linked (GalNAc...) threonine2 Publications	1
Glycosylationⁱ	45	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	52	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	56	O-linked (GalNAc...) threonine2 Publications	1
Glycosylationⁱ	63	O-linked (GalNAc...) serine2 Publications	1
Glycosylationⁱ	66	O-linked (GalNAc...) serine2 Publications	1
Glycosylationⁱ	69	O-linked (GalNAc...) threonine2 Publications	1
Modified residueⁱ	133	PhosphothreonineCombined sources	1
Modified residueⁱ	138	PhosphoserineCombined sources	1
Modified residueⁱ	148	PhosphoserineCombined sources	1

Post-translational modificationⁱ

The major O-linked glycan are NeuAc-alpha-_2-3-Gal-beta-_1-3-[NeuAc-alpha-_2-6]-GalNAcOH (about 78 %) and NeuAc-alpha-_2-3-Gal-beta-_1-3-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-_2-3-Gal-beta-_1-3-[NeuAc-alpha-_2-6]-GalNAcOH NeuAc-alpha-_2-8-NeuAc-alpha-_2-3-Gal-beta-_1-3-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-_2-3-Gal-beta-_1-3-GalNAcOH-_6-1-GlcNAc-beta-_4-1-[Fuc-alpha-_1-2]-Gal-beta-_3-1-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-_2-3-Gal-beta-_1-3-GalNAcOH-_6-1-GlcNAc-beta-_4-1-[Fuc-alpha-_1-2]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).5 Publications

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P02724
PeptideAtlas More...PeptideAtlasⁱ	P02724
PRIDEⁱ	P02724
ProteomicsDBⁱ	51556

PTM databases

GlyConnectⁱ	187 188 189
iPTMnetⁱ	P02724
PhosphoSitePlusⁱ	P02724
UniCarbKBⁱ	P02724

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170180 Expressed in 87 organ(s), highest expression level in trabecular bone tissue
CleanExⁱ	HS_GYPA
ExpressionAtlasⁱ	P02724 baseline and differential
Genevisibleⁱ	P02724 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002658 HPA014811

HPAⁱ

CAB002658
HPA014811

Interactionⁱ

Subunit structureⁱ

(Microbial infection) Interacts with Streptococcus gordonii hsa protein.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-702665,EBI-702665
SLC4A1	P02730	5	EBI-702665,EBI-7576138

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109248, 13 interactors
IntActⁱ	P02724, 24 interactors
STRINGⁱ	9606.ENSP00000354003

Chemistry databases

BindingDBⁱ

P02724

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	84 – 86	Combined sources		3
Helixⁱ	92 – 115	Combined sources		24

Show more details

3D structure databases

ProteinModelPortalⁱ	P02724
SMRⁱ	P02724
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P02724

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycophorin A family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410JM5B Eukaryota ENOG4111AH6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075214
HOGENOMⁱ	HOG000089933
HOVERGENⁱ	HBG005850
InParanoidⁱ	P02724
KEGG Orthology (KO) More...KOⁱ	K06575
PhylomeDBⁱ	P02724
TreeFamⁱ	TF338555

Family and domain databases

InterProⁱ	View protein in InterPro IPR001195 Glycophorin IPR018938 Glycophorin_CS
PANTHERⁱ	PTHR13813 PTHR13813, 1 hit
PIRSFⁱ	PIRSF002466 Glycophorin, 1 hit
PROSITEⁱ	View protein in PROSITE PS00312 GLYCOPHORIN_A, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P02724-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYGKIIFVLL LSEIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNDTHKR 
        60         70         80         90        100
DTYAATPRAH EVSEISVRTV YPPEEETGER VQLAHHFSEP EITLIIFGVM 
       110        120        130        140        150
AGVIGTILLI SYGIRRLIKK SPSDVKPLPS PDTDVPLSSV EIENPETSDQ

Length:150

Mass (Da):16,331

Last modified:September 22, 2009 - v2

Checksum:ⁱ48A5450E22FA99C9

GO

Isoform 2 (identifier: P02724-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-26: Missing.

« Hide

        10         20         30         40         50
MHTSTSSSVT KSYISSQTND THKRDTYAAT PRAHEVSEIS VRTVYPPEEE 
        60         70         80         90        100
TGERVQLAHH FSEPEITLII FGVMAGVIGT ILLISYGIRR LIKKSPSDVK 
       110        120 
PLPSPDTDVP LSSVEIENPE TSDQ

Show »

Length:124

Mass (Da):13,649

Checksum:ⁱD257CA020BB42AFD

GO

Isoform 3 (identifier: P02724-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
13-45: Missing.

« Hide

        10         20         30         40         50
MYGKIIFVLL LSDTHKRDTY AATPRAHEVS EISVRTVYPP EEETGERVQL 
        60         70         80         90        100
AHHFSEPEIT LIIFGVMAGV IGTILLISYG IRRLIKKSPS DVKPLPSPDT 
       110 
DVPLSSVEIE NPETSDQ

Show »

Length:117

Mass (Da):13,000

Checksum:ⁱ3F1878ED9D7ADB29

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DFT7	A0A0C4DFT7_HUMAN	Glycophorin Glycophorin	GYPA	150	Annotation score:
E9PD10	E9PD10_HUMAN	Glycophorin Glycophorin	GYPA	137	Annotation score:
E7EQF3	E7EQF3_HUMAN	Glycophorin Glycophorin	GYPA	118	Annotation score:
A0A2R8Y7F9	A0A2R8Y7F9_HUMAN	Glycophorin Glycophorin	GYPA	145	Annotation score:
A0A087WU29	A0A087WU29_HUMAN	Glycophorin Glycophorin	GYPA	148	Annotation score:
E9PH25	E9PH25_HUMAN	Glycophorin-A Glycophorin-A	GYPA	105	Annotation score:
Q13030	Q13030_HUMAN	Glycophorin Erik I-IV Glycophorin Erik I-IV (Glycophorin-A) (HCG2026259, isoform CRA_g)	GYPA GPErik, hCG_2026259	85	Annotation score:
K9JIK7	K9JIK7_HUMAN	Glycophorin-A Glycophorin-A	GYPA	72	Annotation score:
K9JI14	K9JI14_HUMAN	Glycophorin-A Glycophorin-A	GYPA	104	Annotation score:
D6RJD8	D6RJD8_HUMAN	Glycophorin-A Glycophorin-A	GYPA	42	Annotation score:

Sequence cautionⁱ

The sequence AAA52624 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	30	S → T AA sequence (PubMed:1059087).Curated	1
Sequence conflictⁱ	36	T → S AA sequence (PubMed:1059087).Curated	1
Sequence conflictⁱ	133	T → R in AAA88044 (PubMed:3456608).Curated	1

Polymorphismⁱ

Along with GYPB, GYPA is responsible for the MNS blood group system [MIMⁱ:111300]. The molecular basis of the GPA M/N bloodgroup antigen is a variation at positions 20 and 24. Ser-20 and Gly-24 correspond to M (shown); 'Leu-20' and 'Glu-24' correspond to N.

GYPA polymorphisms are involved in resistance to malaria [MIMⁱ:611162].

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_058911	13	E → A7 PublicationsCorresponds to variant dbSNP:rs4449373Ensembl.	1
Natural variantⁱVAR_059977	13	E → G. Corresponds to variant dbSNP:rs4449373Ensembl.	1
Natural variantⁱVAR_003190	20	S → L in N antigen and M(g) antigen. 3 PublicationsCorresponds to variant dbSNP:rs7682260Ensembl.	1
Natural variantⁱVAR_058912	23	T → N in M(g) antigen. 1 Publication	1
Natural variantⁱVAR_058913	24	G → D. Corresponds to variant dbSNP:rs7658293Ensembl.	1
Natural variantⁱVAR_003191	24	G → E in N antigen, M(c) antigen and M(g) antigen. 4 PublicationsCorresponds to variant dbSNP:rs7687256Ensembl.	1
Natural variantⁱVAR_058914	46	D → E in Ny(a) antigen. 1 Publication	1
Natural variantⁱVAR_058915	47	T → K in ENEH/Hut antigen. 1 Publication	1
Natural variantⁱVAR_058916	47	T → M in ENEH/Vw antigen. 1 Publication	1
Natural variantⁱVAR_058917	50	R → W in Or antigen.	1
Natural variantⁱVAR_058918	66	S → Y in Vr antigen. 1 PublicationCorresponds to variant dbSNP:rs56077914Ensembl.	1
Natural variantⁱVAR_058919	73	P → S in Os(a) antigen. 1 Publication	1
Natural variantⁱVAR_058920	76	E → K in Ri(a) antigen.	1
Natural variantⁱVAR_058921	77	T → I in Mt(a) antigen. 1 PublicationCorresponds to variant dbSNP:rs56172553Ensembl.	1
Natural variantⁱVAR_058922	78	G → R in ERIK antigen. 1 PublicationCorresponds to variant dbSNP:rs1800582EnsemblClinVar.	1
Natural variantⁱVAR_058923	82	Q → K in ENAV/MARS antigen.	1
Natural variantⁱVAR_058924	84	A → P in ENEP/HAG antigen. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047822	1 – 26	Missing in isoform 2. 1 PublicationAdd BLAST		26
Alternative sequenceⁱVSP_047823	13 – 45	Missing in isoform 3. CuratedAdd BLAST		33

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12857 mRNA Translation: AAA88044.1 X08054 mRNA Translation: CAA30843.1 M24128 M24127 Genomic DNA Translation: AAA52768.1 X51798 mRNA Translation: CAA36095.1 L31860 mRNA Translation: AAA88051.1 EU338231 mRNA Translation: ACA96789.1 EU338233 mRNA Translation: ACA96791.1 EU338234 mRNA Translation: ACA96792.1 GU347002 mRNA Translation: ADU25340.1 GU347003 mRNA Translation: ADU25341.1 AK290561 mRNA Translation: BAF83250.1 AC107223 Genomic DNA No translation available. BC005319 mRNA Translation: AAH05319.1 BC013328 mRNA Translation: AAH13328.1 M36281 mRNA Translation: AAA52624.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34069.1 [P02724-1] CCDS82959.1 [P02724-3]
PIRⁱ	A33931 A25131
NCBI Reference Sequences More...RefSeqⁱ	NP_001295119.1, NM_001308190.1 [P02724-3] NP_002090.4, NM_002099.7 XP_016863624.1, XM_017008135.1 [P02724-2]
UniGeneⁱ	Hs.434973

Genome annotation databases

Ensemblⁱ	ENST00000324022; ENSP00000324483; ENSG00000170180 [P02724-3] ENST00000642713; ENSP00000494092; ENSG00000170180 [P02724-2] ENST00000646447; ENSP00000495922; ENSG00000170180 [P02724-2]
GeneIDⁱ	2993
KEGGⁱ	hsa:2993
UCSC genome browser More...UCSCⁱ	uc003ijo.5 human [P02724-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P02724	Glycophorin		HUMAN		150	UniRef100_P02724
Glycophorin A (Fragment)		HUMAN		28
Homo sapiens Mi.V glycoprotein (exon P3A) (Fragment)		HUMAN		24
Glycophorin A (Fragment)		HUMAN		44
Glycophorin A (Fragment)		HUMAN		12
+3

Protein	Similar proteins		Species	Score	Length	Source
P02724	Glycophorin		HUMAN		150	UniRef90_P02724
Glycophorin A (Fragment)		HUMAN		28
Homo sapiens Mi.V glycoprotein (exon P3A) (Fragment)		HUMAN		24
Glycophorin A (Fragment)		HUMAN		44
Glycophorin A (Fragment)		HUMAN		12
+18

Protein	Similar proteins		Species	Score	Length	Source
P02724	Glycophorin-A		PANTR		149	UniRef50_P02724
Glycophorin-A		MACFU		144
Glycophorin		HUMAN		150
Glycophorin		GORGO		148
Glycophorin		PANPA		150
+107
P02724-3	Glycophorin		COLAP		118	UniRef50_P02724-3
Uncharacterized protein		SAIBB		117
Uncharacterized protein		RHIBE		116
Uncharacterized protein		CALJA		117
Uncharacterized protein		Cebus capucinus imitator		115
+35

Cross-referencesⁱ

Web resourcesⁱ

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12857 mRNA Translation: AAA88044.1 X08054 mRNA Translation: CAA30843.1 M24128 M24127 Genomic DNA Translation: AAA52768.1 X51798 mRNA Translation: CAA36095.1 L31860 mRNA Translation: AAA88051.1 EU338231 mRNA Translation: ACA96789.1 EU338233 mRNA Translation: ACA96791.1 EU338234 mRNA Translation: ACA96792.1 GU347002 mRNA Translation: ADU25340.1 GU347003 mRNA Translation: ADU25341.1 AK290561 mRNA Translation: BAF83250.1 AC107223 Genomic DNA No translation available. BC005319 mRNA Translation: AAH05319.1 BC013328 mRNA Translation: AAH13328.1 M36281 mRNA Translation: AAA52624.1 Different initiation.
CCDSⁱ	CCDS34069.1 [P02724-1] CCDS82959.1 [P02724-3]
PIRⁱ	A33931 A25131
RefSeqⁱ	NP_001295119.1, NM_001308190.1 [P02724-3] NP_002090.4, NM_002099.7 XP_016863624.1, XM_017008135.1 [P02724-2]
UniGeneⁱ	Hs.434973

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1AFO	NMR	-	A/B	81-120	[»]
	1MSR	model	-	A/B	93-110	[»]
	2KPE	NMR	-	A/B	89-117	[»]
	2KPF	NMR	-	A/B	80-117	[»]
	5EH4	X-ray	2.81	A/B/C/D	89-117	[»]
	5EH6	X-ray	1.92	A	89-117	[»]
ProteinModelPortalⁱ	P02724
SMRⁱ	P02724
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109248, 13 interactors
IntActⁱ	P02724, 24 interactors
STRINGⁱ	9606.ENSP00000354003

Chemistry databases

BindingDBⁱ	P02724
ChEMBLⁱ	CHEMBL5806

PTM databases

GlyConnectⁱ	187 188 189
iPTMnetⁱ	P02724
PhosphoSitePlusⁱ	P02724
UniCarbKBⁱ	P02724

Polymorphism and mutation databases

BioMutaⁱ	GYPA
DMDMⁱ	259016238

Proteomic databases

PaxDbⁱ	P02724
PeptideAtlasⁱ	P02724
PRIDEⁱ	P02724
ProteomicsDBⁱ	51556

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2993
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000324022; ENSP00000324483; ENSG00000170180 [P02724-3] ENST00000642713; ENSP00000494092; ENSG00000170180 [P02724-2] ENST00000646447; ENSP00000495922; ENSG00000170180 [P02724-2]
GeneIDⁱ	2993
KEGGⁱ	hsa:2993
UCSCⁱ	uc003ijo.5 human [P02724-1]

Organism-specific databases

CTDⁱ	2993
DisGeNETⁱ	2993
EuPathDBⁱ	HostDB:ENSG00000170180.19
GeneCardsⁱ	GYPA
HGNCⁱ	HGNC:4702 GYPA
HPAⁱ	CAB002658 HPA014811
MalaCardsⁱ	GYPA
MIMⁱ	111300 phenotype 611162 phenotype 617922 gene
neXtProtⁱ	NX_P02724
OpenTargetsⁱ	ENSG00000170180
PharmGKBⁱ	PA29080
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JM5B Eukaryota ENOG4111AH6 LUCA
GeneTreeⁱ	ENSGT00550000075214
HOGENOMⁱ	HOG000089933
HOVERGENⁱ	HBG005850
InParanoidⁱ	P02724
KOⁱ	K06575
PhylomeDBⁱ	P02724
TreeFamⁱ	TF338555

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall

Reactomeⁱ

R-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

EvolutionaryTraceⁱ	P02724
GeneWikiⁱ	GYPA
GenomeRNAiⁱ	2993
Protein Ontology More...PROⁱ	PR:P02724
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170180 Expressed in 87 organ(s), highest expression level in trabecular bone tissue
CleanExⁱ	HS_GYPA
ExpressionAtlasⁱ	P02724 baseline and differential
Genevisibleⁱ	P02724 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001195 Glycophorin IPR018938 Glycophorin_CS
PANTHERⁱ	PTHR13813 PTHR13813, 1 hit
PIRSFⁱ	PIRSF002466 Glycophorin, 1 hit
PROSITEⁱ	View protein in PROSITE PS00312 GLYCOPHORIN_A, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLPA_HUMAN
Accessionⁱ	P02724Primary (citable) accession number: P02724 Secondary accession number(s): A8K3E6 , B8Q182, B8Q185, Q9BS51
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	September 22, 2009
	Last modified:	October 10, 2018
	This is version 199 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Blood group antigen proteins
Nomenclature of blood group antigens and list of entries
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P02724 (GLPA_HUMAN)

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Glycophorin-A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ