UniProtKB - P02723 (ADT_NEUCR)
Protein
ADP,ATP carrier protein
Gene
aac
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Functioni
Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 86 | ADPBy similarity | 1 | |
Binding sitei | 98 | ADPBy similarity | 1 | |
Binding sitei | 243 | ADPBy similarity | 1 |
GO - Molecular functioni
- ATP:ADP antiporter activity Source: GO_Central
GO - Biological processi
- mitochondrial ADP transmembrane transport Source: EnsemblFungi
- mitochondrial ATP transmembrane transport Source: EnsemblFungi
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: ADP,ATP carrier proteinAlternative name(s): ADP/ATP translocase Adenine nucleotide translocator Short name: ANT |
Gene namesi | Name:aac Synonyms:acp ORF Names:B22K18.180, NCU09477 |
Organismi | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Taxonomic identifieri | 367110 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:NCU09477 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 13 – 40 | Helical; Name=1By similarityAdd BLAST | 28 | |
Transmembranei | 81 – 105 | Helical; Name=2By similarityAdd BLAST | 25 | |
Transmembranei | 114 – 134 | Helical; Name=3By similarityAdd BLAST | 21 | |
Transmembranei | 184 – 205 | Helical; Name=4By similarityAdd BLAST | 22 | |
Transmembranei | 219 – 239 | Helical; Name=5By similarityAdd BLAST | 21 | |
Transmembranei | 279 – 299 | Helical; Name=6By similarityAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090591 | 1 – 313 | ADP,ATP carrier proteinAdd BLAST | 313 |
Proteomic databases
PRIDEi | P02723 |
Interactioni
Subunit structurei
Homodimer.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 11 – 104 | Solcar 1Add BLAST | 94 | |
Repeati | 116 – 208 | Solcar 2Add BLAST | 93 | |
Repeati | 216 – 302 | Solcar 3Add BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 243 – 248 | Important for transport activityBy similarity | 6 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 243 – 248 | Nucleotide carrier signature motifBy similarity | 6 |
Domaini
The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_015166_12_0_1 |
InParanoidi | P02723 |
OMAi | LGWIVTT |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P02723-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEQQKVLGM PPFVADFLMG GVSAAVSKTA AAPIERIKLL VQNQDEMIRA
60 70 80 90 100
GRLDRRYNGI IDCFKRTTAD EGVMALWRGN TANVIRYFPT QALNFAFRDK
110 120 130 140 150
FKKMFGYKKD VDGYWKWMAG NLASGGAAGA TSLLFVYSLD YARTRLANDA
160 170 180 190 200
KSAKKGGERQ FNGLVDVYRK TIASDGIAGL YRGFGPSVAG IVVYRGLYFG
210 220 230 240 250
LYDSIKPVLL VGDLKNNFLA SFALGWCVTT AAGIASYPLD TIRRRMMMTS
260 270 280 290 300
GEAVKYKSSF DAASQIVAKE GVKSLFKGAG ANILRGVAGA GVLSIYDQLQ
310
VLLFGKAFKG GSG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketV5INM6 | V5INM6_NEUCR | ADP/ATP carrier protein, variant | aac NCU09477 | 220 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00363 Transcribed RNA Translation: CAA25104.1 BX842597 Genomic DNA Translation: CAE75740.1 CM002237 Genomic DNA Translation: ESA43737.1 |
PIRi | A03182, XWNC |
RefSeqi | XP_011393638.1, XM_011395336.1 |
Genome annotation databases
EnsemblFungii | ESA43737; ESA43737; NCU09477 |
GeneIDi | 3879355 |
KEGGi | ncr:NCU09477 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00363 Transcribed RNA Translation: CAA25104.1 BX842597 Genomic DNA Translation: CAE75740.1 CM002237 Genomic DNA Translation: ESA43737.1 |
PIRi | A03182, XWNC |
RefSeqi | XP_011393638.1, XM_011395336.1 |
3D structure databases
SMRi | P02723 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P02723 |
Genome annotation databases
EnsemblFungii | ESA43737; ESA43737; NCU09477 |
GeneIDi | 3879355 |
KEGGi | ncr:NCU09477 |
Organism-specific databases
EuPathDBi | FungiDB:NCU09477 |
Phylogenomic databases
HOGENOMi | CLU_015166_12_0_1 |
InParanoidi | P02723 |
OMAi | LGWIVTT |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADT_NEUCR | |
Accessioni | P02723Primary (citable) accession number: P02723 Secondary accession number(s): Q7RVI0, V5INU6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families