Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP/ATP translocase 1

Gene

SLC25A4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ADP1 Publication1
Binding sitei92ADP1 Publication1
Binding sitei235ADP1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-BTA-1268020 Mitochondrial protein import
R-BTA-422356 Regulation of insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 1
Alternative name(s):
ADP,ATP carrier protein 1
ADP,ATP carrier protein, heart isoform T11 Publication
Adenine nucleotide translocator 1
Short name:
ANT 1
Solute carrier family 25 member 4
Gene namesi
Name:SLC25A4
Synonyms:ANT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 27

Organism-specific databases

VGNCiVGNC:34765 SLC25A4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 37Helical; Name=12 PublicationsAdd BLAST30
Transmembranei75 – 99Helical; Name=22 PublicationsAdd BLAST25
Transmembranei110 – 130Helical; Name=32 PublicationsAdd BLAST21
Transmembranei179 – 199Helical; Name=42 PublicationsAdd BLAST21
Transmembranei211 – 231Helical; Name=52 PublicationsAdd BLAST21
Transmembranei274 – 291Helical; Name=62 PublicationsAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000905732 – 298ADP/ATP translocase 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei7PhosphoserineBy similarity1
Modified residuei52N6-methyllysineSequence analysis1
Modified residuei147N6-succinyllysineBy similarity1
Modified residuei160S-nitrosocysteineBy similarity1
Modified residuei245N6-succinyllysineBy similarity1
Modified residuei272N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiP02722
PeptideAtlasiP02722
PRIDEiP02722

PTM databases

iPTMnetiP02722

Expressioni

Tissue specificityi

Detected in heart muscle (at protein level). Detected in heart (PubMed:2540808).3 Publications

Gene expression databases

BgeeiENSBTAG00000013208

Interactioni

Subunit structurei

Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP (By similarity). Homodimer.By similarity1 Publication

Protein-protein interaction databases

IntActiP02722, 1 interactor
STRINGi9913.ENSBTAP00000017580

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 25Combined sources21
Helixi27 – 38Combined sources12
Helixi39 – 41Combined sources3
Helixi47 – 49Combined sources3
Helixi54 – 65Combined sources12
Helixi67 – 71Combined sources5
Turni72 – 74Combined sources3
Helixi75 – 100Combined sources26
Turni105 – 107Combined sources3
Helixi109 – 143Combined sources35
Turni149 – 151Combined sources3
Helixi157 – 168Combined sources12
Helixi170 – 173Combined sources4
Turni174 – 176Combined sources3
Helixi177 – 200Combined sources24
Helixi204 – 206Combined sources3
Helixi210 – 239Combined sources30
Turni240 – 243Combined sources4
Helixi246 – 248Combined sources3
Helixi254 – 265Combined sources12
Helixi267 – 271Combined sources5
Helixi274 – 292Combined sources19

3D structure databases

ProteinModelPortaliP02722
SMRiP02722
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02722

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 240Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Nucleotide carrier signature motifCurated6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.2 Publications

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiP02722
KOiK05863
OMAiECFKRTA
OrthoDBiEOG091G0ULB
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQALSFLK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQISAEKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA
160 170 180 190 200
QREFTGLGNC ITKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNVHI IVSWMIAQTV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWRK IAKDEGPKAF FKGAWSNVLR GMGGAFVLVL YDEIKKFV
Length:298
Mass (Da):32,967
Last modified:January 23, 2007 - v3
Checksum:iAAE851F8406479C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13783 mRNA Translation: AAA30363.1
M24102 mRNA Translation: AAA30768.1
PIRiA43646 XWBO
RefSeqiNP_777083.1, NM_174658.2
UniGeneiBt.49723

Genome annotation databases

EnsembliENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208
GeneIDi282478
KEGGibta:282478

Similar proteinsi

Entry informationi

Entry nameiADT1_BOVIN
AccessioniPrimary (citable) accession number: P02722
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health