UniProtKB - P02722 (ADT1_BOVIN)

BLAST

>sp|P02722|ADT1_BOVIN ADP/ATP translocase 1 OS=Bos taurus OX=9913 GN=SLC25A4 PE=1 SV=3
MSDQALSFLKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVR
IPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDRHKQFWRYFAGNLASG
GAAGATSLCFVYPLDFARTRLAADVGKGAAQREFTGLGNCITKIFKSDGLRGLYQGFNVS
VQGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQTVTAVAGLVSYPFDTVRRRMMM
QSGRKGADIMYTGTVDCWRKIAKDEGPKAFFKGAWSNVLRGMGGAFVLVLYDEIKKFV

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History
Entry version 155 (07 Nov 2018)
Sequence version 3 (23 Jan 2007)
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Protein

ADP/ATP translocase 1

Gene

SLC25A4

Organism

Bos taurus (Bovine)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	80	ADP1 Publication	1
Binding siteⁱ	92	ADP1 Publication	1
Binding siteⁱ	235	ADP1 Publication	1

GO - Molecular functionⁱ

ATP:ADP antiporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ADP transport Source: UniProtKB
apoptotic mitochondrial changes Source: Ensembl
negative regulation of necroptotic process Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

Reactomeⁱ	R-BTA-1268020 Mitochondrial protein import

Reactomeⁱ

R-BTA-1268020 Mitochondrial protein import

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ADP/ATP translocase 1 Alternative name(s): ADP,ATP carrier protein 1 ADP,ATP carrier protein, heart isoform T11 Publication Adenine nucleotide translocator 1 Short name: ANT 1 Solute carrier family 25 member 4
Gene namesⁱ	Name:SLC25A4 Synonyms:ANT1
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 27

Organism-specific databases

VGNCⁱ	VGNC:34765 SLC25A4

VGNCⁱ

VGNC:34765 SLC25A4

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	8 – 37	Helical; Name=12 PublicationsAdd BLAST	30
Transmembraneⁱ	75 – 99	Helical; Name=22 PublicationsAdd BLAST	25
Transmembraneⁱ	110 – 130	Helical; Name=32 PublicationsAdd BLAST	21
Transmembraneⁱ	179 – 199	Helical; Name=42 PublicationsAdd BLAST	21
Transmembraneⁱ	211 – 231	Helical; Name=52 PublicationsAdd BLAST	21
Transmembraneⁱ	274 – 291	Helical; Name=62 PublicationsAdd BLAST	18

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000090573	2 – 298	ADP/ATP translocase 1Add BLAST		297

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserine1 Publication	1
Modified residueⁱ	7	PhosphoserineBy similarity	1
Modified residueⁱ	52	N6-methyllysineSequence analysis	1
Modified residueⁱ	147	N6-succinyllysineBy similarity	1
Modified residueⁱ	160	S-nitrosocysteineBy similarity	1
Modified residueⁱ	245	N6-succinyllysineBy similarity	1
Modified residueⁱ	272	N6-succinyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbⁱ	P02722
PeptideAtlas More...PeptideAtlasⁱ	P02722
PRIDEⁱ	P02722

PTM databases

iPTMnetⁱ	P02722

iPTMnetⁱ

P02722

Expressionⁱ

Tissue specificityⁱ

Detected in heart muscle (at protein level). Detected in heart (PubMed:2540808).3 Publications

Gene expression databases

Bgeeⁱ	ENSBTAG00000013208 Expressed in 10 organ(s), highest expression level in heart

Bgeeⁱ

ENSBTAG00000013208 Expressed in 10 organ(s), highest expression level in heart

Interactionⁱ

Subunit structureⁱ

Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP (By similarity). Homodimer.By similarity1 Publication

Protein-protein interaction databases

IntActⁱ	P02722, 1 interactor
STRINGⁱ	9913.ENSBTAP00000017580

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 25	Combined sources	21
Helixⁱ	27 – 38	Combined sources	12
Helixⁱ	39 – 41	Combined sources	3
Helixⁱ	47 – 49	Combined sources	3
Helixⁱ	54 – 65	Combined sources	12
Helixⁱ	67 – 71	Combined sources	5
Turnⁱ	72 – 74	Combined sources	3
Helixⁱ	75 – 100	Combined sources	26
Turnⁱ	105 – 107	Combined sources	3
Helixⁱ	109 – 143	Combined sources	35
Turnⁱ	149 – 151	Combined sources	3
Helixⁱ	157 – 168	Combined sources	12
Helixⁱ	170 – 173	Combined sources	4
Turnⁱ	174 – 176	Combined sources	3
Helixⁱ	177 – 200	Combined sources	24
Helixⁱ	204 – 206	Combined sources	3
Helixⁱ	210 – 239	Combined sources	30
Turnⁱ	240 – 243	Combined sources	4
Helixⁱ	246 – 248	Combined sources	3
Helixⁱ	254 – 265	Combined sources	12
Helixⁱ	267 – 271	Combined sources	5
Helixⁱ	274 – 292	Combined sources	19

Show more details

3D structure databases

ProteinModelPortalⁱ	P02722
SMRⁱ	P02722
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02722

EvolutionaryTraceⁱ

P02722

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	6 – 98	Solcar 1Add BLAST	93
Repeatⁱ	111 – 201	Solcar 2Add BLAST	91
Repeatⁱ	212 – 297	Solcar 3Add BLAST	86

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	235 – 240	Important for transport activityBy similarity		6

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	235 – 240	Nucleotide carrier signature motifCurated		6

Domainⁱ

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.2 Publications

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0749 Eukaryota ENOG410XNW0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011543
HOGENOMⁱ	HOG000165727
HOVERGENⁱ	HBG108348
InParanoidⁱ	P02722
KEGG Orthology (KO) More...KOⁱ	K05863
OMAⁱ	QVMFGKV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ULB
TreeFamⁱ	TF300743

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002113 Aden_trnslctor IPR002067 Mit_carrier IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00927 ADPTRNSLCASE PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P02722-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDQALSFLK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQISAEKQ 
        60         70         80         90        100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL 
       110        120        130        140        150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA 
       160        170        180        190        200
QREFTGLGNC ITKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG 
       210        220        230        240        250
MLPDPKNVHI IVSWMIAQTV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM 
       260        270        280        290 
YTGTVDCWRK IAKDEGPKAF FKGAWSNVLR GMGGAFVLVL YDEIKKFV

Length:298

Mass (Da):32,967

Last modified:January 23, 2007 - v3

Checksum:ⁱAAE851F8406479C2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M13783 mRNA Translation: AAA30363.1 M24102 mRNA Translation: AAA30768.1
PIRⁱ	A43646 XWBO
NCBI Reference Sequences More...RefSeqⁱ	NP_777083.1, NM_174658.2
UniGeneⁱ	Bt.49723

Genome annotation databases

Ensemblⁱ	ENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208
GeneIDⁱ	282478
KEGGⁱ	bta:282478

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P02722	ADP/ATP translocase 1		wild yak		298	UniRef100_P02722
SLC25A4		CEREH		298
UPI0000125610		BOVIN		297

Protein	Similar proteins		Species	Score	Length	Source
P02722	ADP/ATP translocase 1		HUMAN		298	UniRef90_P12235
ADP/ATP translocase 1		MOUSE		298
ADP/ATP translocase 1		RABIT		298
ADP/ATP translocase 1		RAT		298
SLC25A4 isoform 1		PANTR		298
+120

Protein	Similar proteins		Species	Score	Length	Source
P02722	ADP/ATP translocase 1		HUMAN		298	UniRef50_P12235
ADP/ATP translocase 1		RAT		298
ADP/ATP translocase 1		RABIT		298
ADP/ATP translocase 1		MOUSE		298
ADP/ATP translocase 3		PIG		298
+597

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M13783 mRNA Translation: AAA30363.1 M24102 mRNA Translation: AAA30768.1
PIRⁱ	A43646 XWBO
RefSeqⁱ	NP_777083.1, NM_174658.2
UniGeneⁱ	Bt.49723

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1OKC	X-ray	2.20	A	2-298	[»]
	1YM6	model	-	A	1-298	[»]
	1YMJ	model	-	A	1-298	[»]
	2C3E	X-ray	2.80	A	2-298	[»]
ProteinModelPortalⁱ	P02722
SMRⁱ	P02722
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P02722, 1 interactor
STRINGⁱ	9913.ENSBTAP00000017580

PTM databases

iPTMnetⁱ	P02722

iPTMnetⁱ

P02722

Proteomic databases

PaxDbⁱ	P02722
PeptideAtlasⁱ	P02722
PRIDEⁱ	P02722

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208
GeneIDⁱ	282478
KEGGⁱ	bta:282478

Organism-specific databases

CTDⁱ	291
VGNCⁱ	VGNC:34765 SLC25A4

Phylogenomic databases

eggNOGⁱ	KOG0749 Eukaryota ENOG410XNW0 LUCA
GeneTreeⁱ	ENSGT00390000011543
HOGENOMⁱ	HOG000165727
HOVERGENⁱ	HBG108348
InParanoidⁱ	P02722
KOⁱ	K05863
OMAⁱ	QVMFGKV
OrthoDBⁱ	EOG091G0ULB
TreeFamⁱ	TF300743

Enzyme and pathway databases

Reactomeⁱ	R-BTA-1268020 Mitochondrial protein import

Reactomeⁱ

R-BTA-1268020 Mitochondrial protein import

Miscellaneous databases

EvolutionaryTraceⁱ	P02722

EvolutionaryTraceⁱ

P02722

Gene expression databases

Bgeeⁱ	ENSBTAG00000013208 Expressed in 10 organ(s), highest expression level in heart

Bgeeⁱ

ENSBTAG00000013208 Expressed in 10 organ(s), highest expression level in heart

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002113 Aden_trnslctor IPR002067 Mit_carrier IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00927 ADPTRNSLCASE PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADT1_BOVIN
Accessionⁱ	P02722Primary (citable) accession number: P02722
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

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Proteomes

Annotation systems

Supporting data

UniProtKB - P02722 (ADT1_BOVIN)

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ADP/ATP translocase 1

SLC25A4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ