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Protein

ADP/ATP translocase 1

Gene

SLC25A4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ADP1 Publication1
Binding sitei92ADP1 Publication1
Binding sitei235ADP1 Publication1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-BTA-1268020 Mitochondrial protein import

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 1
Alternative name(s):
ADP,ATP carrier protein 1
ADP,ATP carrier protein, heart isoform T11 Publication
Adenine nucleotide translocator 1
Short name:
ANT 1
Solute carrier family 25 member 4
Gene namesi
Name:SLC25A4
Synonyms:ANT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 27

Organism-specific databases

VGNCiVGNC:34765 SLC25A4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 37Helical; Name=12 PublicationsAdd BLAST30
Transmembranei75 – 99Helical; Name=22 PublicationsAdd BLAST25
Transmembranei110 – 130Helical; Name=32 PublicationsAdd BLAST21
Transmembranei179 – 199Helical; Name=42 PublicationsAdd BLAST21
Transmembranei211 – 231Helical; Name=52 PublicationsAdd BLAST21
Transmembranei274 – 291Helical; Name=62 PublicationsAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000905732 – 298ADP/ATP translocase 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei7PhosphoserineBy similarity1
Modified residuei52N6-methyllysineSequence analysis1
Modified residuei147N6-succinyllysineBy similarity1
Modified residuei160S-nitrosocysteineBy similarity1
Modified residuei245N6-succinyllysineBy similarity1
Modified residuei272N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiP02722
PeptideAtlasiP02722
PRIDEiP02722

PTM databases

iPTMnetiP02722

Expressioni

Tissue specificityi

Detected in heart muscle (at protein level). Detected in heart (PubMed:2540808).3 Publications

Gene expression databases

BgeeiENSBTAG00000013208 Expressed in 10 organ(s), highest expression level in heart

Interactioni

Subunit structurei

Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP (By similarity). Homodimer.By similarity1 Publication

Protein-protein interaction databases

IntActiP02722, 1 interactor
STRINGi9913.ENSBTAP00000017580

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02722
SMRiP02722
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02722

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 240Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Nucleotide carrier signature motifCurated6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.2 Publications

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiP02722
KOiK05863
OMAiQVMFGKV
OrthoDBiEOG091G0ULB
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02722-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDQALSFLK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQISAEKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA
160 170 180 190 200
QREFTGLGNC ITKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNVHI IVSWMIAQTV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWRK IAKDEGPKAF FKGAWSNVLR GMGGAFVLVL YDEIKKFV
Length:298
Mass (Da):32,967
Last modified:January 23, 2007 - v3
Checksum:iAAE851F8406479C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13783 mRNA Translation: AAA30363.1
M24102 mRNA Translation: AAA30768.1
PIRiA43646 XWBO
RefSeqiNP_777083.1, NM_174658.2
UniGeneiBt.49723

Genome annotation databases

EnsembliENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208
GeneIDi282478
KEGGibta:282478

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13783 mRNA Translation: AAA30363.1
M24102 mRNA Translation: AAA30768.1
PIRiA43646 XWBO
RefSeqiNP_777083.1, NM_174658.2
UniGeneiBt.49723

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OKCX-ray2.20A2-298[»]
1YM6model-A1-298[»]
1YMJmodel-A1-298[»]
2C3EX-ray2.80A2-298[»]
ProteinModelPortaliP02722
SMRiP02722
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02722, 1 interactor
STRINGi9913.ENSBTAP00000017580

PTM databases

iPTMnetiP02722

Proteomic databases

PaxDbiP02722
PeptideAtlasiP02722
PRIDEiP02722

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208
GeneIDi282478
KEGGibta:282478

Organism-specific databases

CTDi291
VGNCiVGNC:34765 SLC25A4

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiP02722
KOiK05863
OMAiQVMFGKV
OrthoDBiEOG091G0ULB
TreeFamiTF300743

Enzyme and pathway databases

ReactomeiR-BTA-1268020 Mitochondrial protein import

Miscellaneous databases

EvolutionaryTraceiP02722

Gene expression databases

BgeeiENSBTAG00000013208 Expressed in 10 organ(s), highest expression level in heart

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiADT1_BOVIN
AccessioniPrimary (citable) accession number: P02722
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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