UniProtKB - P02722 (ADT1_BOVIN)
Protein
ADP/ATP translocase 1
Gene
SLC25A4
Organism
Bos taurus (Bovine)
Status
Functioni
Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 80 | ADP1 Publication | 1 | |
Binding sitei | 92 | ADP1 Publication | 1 | |
Binding sitei | 235 | ADP1 Publication | 1 |
GO - Molecular functioni
- ATP:ADP antiporter activity Source: InterPro
GO - Biological processi
- ADP transport Source: UniProtKB
- mitochondrial ADP transmembrane transport Source: InterPro
- mitochondrial ATP transmembrane transport Source: InterPro
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-BTA-1268020, Mitochondrial protein import R-BTA-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
Names & Taxonomyi
Protein namesi | Recommended name: ADP/ATP translocase 1Alternative name(s): ADP,ATP carrier protein 1 ADP,ATP carrier protein, heart isoform T11 Publication Adenine nucleotide translocator 1 Short name: ANT 1 Solute carrier family 25 member 4 |
Gene namesi | Name:SLC25A4 Synonyms:ANT1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:34765, SLC25A4 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 2 Publications; Multi-pass membrane protein 2 Publications
Other locations
- Membrane By similarity
Note: The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (By similarity).By similarity
Mitochondrion
- integral component of mitochondrial membrane Source: UniProtKB
- mitochondrial inner membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 37 | Helical; Name=12 PublicationsAdd BLAST | 30 | |
Transmembranei | 75 – 99 | Helical; Name=22 PublicationsAdd BLAST | 25 | |
Transmembranei | 110 – 130 | Helical; Name=32 PublicationsAdd BLAST | 21 | |
Transmembranei | 179 – 199 | Helical; Name=42 PublicationsAdd BLAST | 21 | |
Transmembranei | 211 – 231 | Helical; Name=52 PublicationsAdd BLAST | 21 | |
Transmembranei | 274 – 291 | Helical; Name=62 PublicationsAdd BLAST | 18 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000090573 | 2 – 298 | ADP/ATP translocase 1Add BLAST | 297 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserine1 Publication | 1 | |
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 52 | N6,N6,N6-trimethyllysineBy similarity | 1 | |
Modified residuei | 52 | N6-methyllysineSequence analysis | 1 | |
Modified residuei | 147 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 160 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 245 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 272 | N6-succinyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Methylation, Phosphoprotein, S-nitrosylationProteomic databases
PaxDbi | P02722 |
PeptideAtlasi | P02722 |
PRIDEi | P02722 |
PTM databases
iPTMneti | P02722 |
Expressioni
Tissue specificityi
Detected in heart muscle (at protein level). Detected in heart (PubMed:2540808).3 Publications
Gene expression databases
Bgeei | ENSBTAG00000013208, Expressed in heart and 19 other tissues |
Interactioni
Subunit structurei
Homodimer (By similarity).
Found in a complex with ARL2, ARL2BP and SLC25A4 (By similarity).
Interacts with ARL2BP (By similarity).
By similarityProtein-protein interaction databases
IntActi | P02722, 1 interactor |
STRINGi | 9913.ENSBTAP00000017580 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P02722 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02722 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 6 – 98 | Solcar 1Add BLAST | 93 | |
Repeati | 111 – 201 | Solcar 2Add BLAST | 91 | |
Repeati | 212 – 297 | Solcar 3Add BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 235 – 240 | Important for transport activityBy similarity | 6 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 235 – 240 | Nucleotide carrier signature motifCurated | 6 |
Domaini
The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.2 Publications
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0749, Eukaryota |
GeneTreei | ENSGT00940000154622 |
HOGENOMi | CLU_015166_12_0_1 |
InParanoidi | P02722 |
OMAi | LGWIVTT |
OrthoDBi | 870903at2759 |
TreeFami | TF300743 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P02722-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDQALSFLK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQISAEKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA
160 170 180 190 200
QREFTGLGNC ITKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNVHI IVSWMIAQTV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWRK IAKDEGPKAF FKGAWSNVLR GMGGAFVLVL YDEIKKFV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13783 mRNA Translation: AAA30363.1 M24102 mRNA Translation: AAA30768.1 |
PIRi | A43646, XWBO |
RefSeqi | NP_777083.1, NM_174658.2 |
Genome annotation databases
Ensembli | ENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208 |
GeneIDi | 282478 |
KEGGi | bta:282478 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13783 mRNA Translation: AAA30363.1 M24102 mRNA Translation: AAA30768.1 |
PIRi | A43646, XWBO |
RefSeqi | NP_777083.1, NM_174658.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OKC | X-ray | 2.20 | A | 2-298 | [»] | |
1YM6 | model | - | A | 1-298 | [»] | |
1YMJ | model | - | A | 1-298 | [»] | |
2C3E | X-ray | 2.80 | A | 2-298 | [»] | |
SMRi | P02722 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P02722, 1 interactor |
STRINGi | 9913.ENSBTAP00000017580 |
PTM databases
iPTMneti | P02722 |
Proteomic databases
PaxDbi | P02722 |
PeptideAtlasi | P02722 |
PRIDEi | P02722 |
Genome annotation databases
Ensembli | ENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208 |
GeneIDi | 282478 |
KEGGi | bta:282478 |
Organism-specific databases
CTDi | 291 |
VGNCi | VGNC:34765, SLC25A4 |
Phylogenomic databases
eggNOGi | KOG0749, Eukaryota |
GeneTreei | ENSGT00940000154622 |
HOGENOMi | CLU_015166_12_0_1 |
InParanoidi | P02722 |
OMAi | LGWIVTT |
OrthoDBi | 870903at2759 |
TreeFami | TF300743 |
Enzyme and pathway databases
Reactomei | R-BTA-1268020, Mitochondrial protein import R-BTA-83936, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
Miscellaneous databases
EvolutionaryTracei | P02722 |
Gene expression databases
Bgeei | ENSBTAG00000013208, Expressed in heart and 19 other tissues |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADT1_BOVIN | |
Accessioni | P02722Primary (citable) accession number: P02722 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families