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Protein

Acetylcholine receptor subunit delta

Gene

Chrnd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-629587 Highly sodium permeable acetylcholine nicotinic receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit delta
Gene namesi
Name:Chrnd
Synonyms:Acrd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:87893 Chrnd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 248ExtracellularAdd BLAST224
Transmembranei249 – 273HelicalAdd BLAST25
Transmembranei281 – 299HelicalAdd BLAST19
Transmembranei315 – 336HelicalAdd BLAST22
Topological domaini337 – 474CytoplasmicAdd BLAST138
Transmembranei475 – 493HelicalAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3137264

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000000032325 – 520Acetylcholine receptor subunit deltaAdd BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 168By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei393Phosphotyrosine; by Tyr-kinasesBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP02716
PRIDEiP02716

PTM databases

iPTMnetiP02716
PhosphoSitePlusiP02716
SwissPalmiP02716

Expressioni

Gene expression databases

BgeeiENSMUSG00000026251 Expressed in 13 organ(s), highest expression level in vertebral axis musculature (mouse)
ExpressionAtlasiP02716 baseline and differential
GenevisibleiP02716 MM

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (By similarity).By similarity

Protein-protein interaction databases

BioGridi197937, 1 interactor
ComplexPortaliCPX-252 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma
CPX-257 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon
STRINGi10090.ENSMUSP00000072983

Chemistry databases

BindingDBiP02716

Structurei

3D structure databases

ProteinModelPortaliP02716
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006757
HOVERGENiHBG003756
InParanoidiP02716
KOiK04816
OMAiWIFLQGA
OrthoDBiEOG091G0R20
PhylomeDBiP02716
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02716-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPVLTLGL LAALVVCALP GSWGLNEEQR LIQHLFNEKG YDKDLRPVAR
60 70 80 90 100
KEDKVDVALS LTLSNLISLK EVEETLTTNV WIDHAWVDSR LQWDANDFGN
110 120 130 140 150
ITVLRLPPDM VWLPEIVLEN NNDGSFQISY ACNVLVYDSG YVTWLPPAIF
160 170 180 190 200
RSSCPISVTY FPFDWQNCSL KFSSLKYTAK EITLSLKQEE ENNRSYPIEW
210 220 230 240 250
IIIDPEGFTE NGEWEIVHRA AKLNVDPSVP MDSTNHQDVT FYLIIRRKPL
260 270 280 290 300
FYIINILVPC VLISFMINLV FYLPGDCGEK TSVAISVLLA QSVFLLLISK
310 320 330 340 350
RLPATSMAIP LVGKFLLFGM VLVTMVVVIC VIVLNIHFRT PSTHVLSEGV
360 370 380 390 400
KKFFLETLPK LLHMSRPAEE DPGPRALIRR SSSLGYICKA EEYFSLKSRS
410 420 430 440 450
DLMFEKQSER HGLARRLTTA RRPPASSEQV QQELFNEMKP AVDGANFIVN
460 470 480 490 500
HMRDQNSYNE EKDNWNQVAR TVDRLCLFVV TPVMVVGTAW IFLQGVYNQP
510 520
PLQPFPGDPF SYSEQDKRFI
Length:520
Mass (Da):59,143
Last modified:July 21, 1986 - v1
Checksum:iC46177ACA4A9B4A9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WNX8A0A087WNX8_MOUSE
Acetylcholine receptor subunit delt...
Chrnd mCG_16196
411Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti387 – 388IC → TA in AAA39803 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02582 mRNA Translation: AAA37157.1
L10076 mRNA Translation: AAA39803.1
M22380 Genomic DNA Translation: AAA37155.1
X13959 Genomic DNA Translation: CAA32140.1
CCDSiCCDS15129.1
PIRiA03175 ACMSD1
I49459
RefSeqiNP_067611.2, NM_021600.3
UniGeneiMm.2811

Genome annotation databases

EnsembliENSMUST00000073252; ENSMUSP00000072983; ENSMUSG00000026251
GeneIDi11447
KEGGimmu:11447
UCSCiuc007bwf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02582 mRNA Translation: AAA37157.1
L10076 mRNA Translation: AAA39803.1
M22380 Genomic DNA Translation: AAA37155.1
X13959 Genomic DNA Translation: CAA32140.1
CCDSiCCDS15129.1
PIRiA03175 ACMSD1
I49459
RefSeqiNP_067611.2, NM_021600.3
UniGeneiMm.2811

3D structure databases

ProteinModelPortaliP02716
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197937, 1 interactor
ComplexPortaliCPX-252 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma
CPX-257 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon
STRINGi10090.ENSMUSP00000072983

Chemistry databases

BindingDBiP02716
ChEMBLiCHEMBL3137264

PTM databases

iPTMnetiP02716
PhosphoSitePlusiP02716
SwissPalmiP02716

Proteomic databases

PaxDbiP02716
PRIDEiP02716

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073252; ENSMUSP00000072983; ENSMUSG00000026251
GeneIDi11447
KEGGimmu:11447
UCSCiuc007bwf.2 mouse

Organism-specific databases

CTDi1144
MGIiMGI:87893 Chrnd

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006757
HOVERGENiHBG003756
InParanoidiP02716
KOiK04816
OMAiWIFLQGA
OrthoDBiEOG091G0R20
PhylomeDBiP02716
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-MMU-629587 Highly sodium permeable acetylcholine nicotinic receptors

Miscellaneous databases

PROiPR:P02716
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026251 Expressed in 13 organ(s), highest expression level in vertebral axis musculature (mouse)
ExpressionAtlasiP02716 baseline and differential
GenevisibleiP02716 MM

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHD_MOUSE
AccessioniPrimary (citable) accession number: P02716
Secondary accession number(s): Q61267
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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