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Protein

Acetylcholine receptor subunit alpha

Gene

CHRNA1

Organism
Torpedo marmorata (Marbled electric ray)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit alpha
Gene namesi
Name:CHRNA1
OrganismiTorpedo marmorata (Marbled electric ray)
Taxonomic identifieri7788 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaTorpediniformesTorpedinidaeTorpedo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 234ExtracellularAdd BLAST210
Transmembranei235 – 259HelicalAdd BLAST25
Transmembranei267 – 285HelicalAdd BLAST19
Transmembranei301 – 320HelicalAdd BLAST20
Topological domaini321 – 432CytoplasmicAdd BLAST112
Transmembranei433 – 451HelicalAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000000031125 – 461Acetylcholine receptor subunit alphaAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi152 ↔ 166
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 217Associated with receptor activation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP02711

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma chains.1 Publication

Protein-protein interaction databases

ComplexPortaliCPX-2635 Acetylcholine receptor, alpha1-beta1-gamma-delta

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02711
SMRiP02711
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02711

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003756

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02711-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILCSYWHVG LVLLLFSCCG LVLGSEHETR LVANLLENYN KVIRPVEHHT
60 70 80 90 100
HFVDITVGLQ LIQLINVDEV NQIVETNVRL RQQWIDVRLR WNPADYGGIK
110 120 130 140 150
KIRLPSDDVW LPDLVLYNNA DGDFAIVHMT KLLLDYTGKI MWTPPAIFKS
160 170 180 190 200
YCEIIVTHFP FDQQNCTMKL GIWTYDGTKV SISPESDRPD LSTFMESGEW
210 220 230 240 250
VMKDYRGWKH WVYYTCCPDT PYLDITYHFI MQRIPLYFVV NVIIPCLLFS
260 270 280 290 300
FLTVLVFYLP TDSGEKMTLS ISVLLSLTVF LLVIVELIPS TSSAVPLIGK
310 320 330 340 350
YMLFTMIFVI SSIIVTVVVI NTHHRSPSTH TMPQWVRKIF INTIPNVMFF
360 370 380 390 400
STMKRASKEK QENKIFADDI DISDISGKQV TGEVIFQTPL IKNPDVKSAI
410 420 430 440 450
EGVKYIAEHM KSDEESSNAA EEWKYVAMVI DHILLCVFML ICIIGTVSVF
460
AGRLIELSQE G
Length:461
Mass (Da):52,795
Last modified:July 21, 1986 - v1
Checksum:i5354B3F8451D4F8C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti347V → L in AAA96704 (PubMed:6549423).Curated1
Sequence conflicti448S → C in AAA96704 (PubMed:6549423).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00963 mRNA No translation available.
M25893 mRNA Translation: AAA96704.1
M14807 mRNA Translation: AAA49273.1
PIRiA93440
I50548
I50549

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00963 mRNA No translation available.
M25893 mRNA Translation: AAA96704.1
M14807 mRNA Translation: AAA49273.1
PIRiA93440
I50548
I50549

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L4WNMR-B206-226[»]
1LJZNMR-B206-226[»]
1OEDelectron microscopy4.00A/D235-461[»]
2BG9electron microscopy4.00A/D25-461[»]
4AQ5electron microscopy6.20A/D1-461[»]
4AQ9electron microscopy6.20A/D1-461[»]
4BOGelectron microscopy50.002/A/D/F/I/K/N/P/S/U/X/Z1-461[»]
4BOIelectron microscopy41.00A/D1-461[»]
4BONelectron microscopy40.00A/D1-461[»]
4BOOelectron microscopy42.00A/D1-461[»]
4BORelectron microscopy42.00A/D1-461[»]
4BOTelectron microscopy42.00A/D1-461[»]
ProteinModelPortaliP02711
SMRiP02711
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2635 Acetylcholine receptor, alpha1-beta1-gamma-delta

Proteomic databases

PRIDEiP02711

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG003756

Miscellaneous databases

EvolutionaryTraceiP02711

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHA_TORMA
AccessioniPrimary (citable) accession number: P02711
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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