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Protein

Acetylcholine receptor subunit alpha

Gene

CHRNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.1 Publication

GO - Molecular functioni

  • acetylcholine binding Source: Ensembl
  • acetylcholine-gated cation-selective channel activity Source: MGI
  • acetylcholine receptor activity Source: ProtInc
  • ion channel activity Source: ProtInc
  • ligand-gated ion channel activity Source: Reactome
  • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: SynGO

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors
SIGNORiP02708

Protein family/group databases

TCDBi1.A.9.1.1 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit alpha
Gene namesi
Name:CHRNA1
Synonyms:ACHRA, CHNRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138435.14
HGNCiHGNC:1955 CHRNA1
MIMi100690 gene
neXtProtiNX_P02708

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 255ExtracellularAdd BLAST235
Transmembranei256 – 280HelicalAdd BLAST25
Transmembranei288 – 306HelicalAdd BLAST19
Transmembranei322 – 341HelicalAdd BLAST20
Topological domaini342 – 453CytoplasmicAdd BLAST112
Transmembranei454 – 472HelicalAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Multiple pterygium syndrome, lethal type (LMPS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionMultiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent.
See also OMIM:253290
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043904254R → L in LMPS. 1 PublicationCorresponds to variant dbSNP:rs137852809EnsemblClinVar.1
The alpha subunit is the main focus for antibody binding in myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
Myasthenic syndrome, congenital, 1A, slow-channel (CMS1A)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS1A is a slow-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in prolonged AChR channel opening episodes, prolonged endplate currents, and depolarization block. This is associated with calcium overload, which may contribute to subsequent degeneration of the endplate and postsynaptic membrane.
See also OMIM:601462
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_000282198G → S in CMS1A. 2 PublicationsCorresponds to variant dbSNP:rs137852801Ensembl.1
Natural variantiVAR_000283201V → M in CMS1A. 1 PublicationCorresponds to variant dbSNP:rs137852799EnsemblClinVar.1
Natural variantiVAR_000284262N → K in CMS1A. 1 PublicationCorresponds to variant dbSNP:rs137852798EnsemblClinVar.1
Natural variantiVAR_021207294V → F in CMS1A; causes increased channel opening in absence of ACh; prolonged opening in presence of ACh; increased affinity for ACh and enhanced desensitization. 1 PublicationCorresponds to variant dbSNP:rs137852803Ensembl.1
Natural variantiVAR_000285299T → I in CMS1A. 1 PublicationCorresponds to variant dbSNP:rs137852800EnsemblClinVar.1
Natural variantiVAR_000286314S → I in CMS1A. 1 PublicationCorresponds to variant dbSNP:rs137852802EnsemblClinVar.1
Natural variantiVAR_038601463C → W in CMS1A; increases the rate of channel opening and slows the rate of channel closing but has no effect on agonist binding. 1 PublicationCorresponds to variant dbSNP:rs137852808EnsemblClinVar.1
Myasthenic syndrome, congenital, 1B, fast-channel (CMS1B)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS1B is a fast-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in brief opening and activity of the channel, with a rapid decay in endplate current, failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential.
See also OMIM:608930
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038599177V → L in CMS1B; mutant channel shows an approximately 30-fold decrease of ACh binding affinity for the second of 2 closed-state binding sites but only a 2-fold decrease in gating efficiency. 1 PublicationCorresponds to variant dbSNP:rs137852807EnsemblClinVar.1
Natural variantiVAR_021206278F → V in CMS1B; markedly reduced protein expression. 1 PublicationCorresponds to variant dbSNP:rs137852805EnsemblClinVar.1
Natural variantiVAR_021208301F → L in CMS1B; fewer and shorter ion channel activations with decreased channel opening rate and increased channel closing rate. 1 PublicationCorresponds to variant dbSNP:rs137852806EnsemblClinVar.1
Natural variantiVAR_021209330V → I in CMS1B; abnormally slow channel opening and closing resulting in abnormally brief current. 1 PublicationCorresponds to variant dbSNP:rs137852804EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi300V → A: Increased length of channel opening. 1 Publication1

Keywords - Diseasei

Congenital myasthenic syndrome, Disease mutation

Organism-specific databases

DisGeNETi1134
GeneReviewsiCHRNA1
MalaCardsiCHRNA1
MIMi253290 phenotype
254200 phenotype
601462 phenotype
608930 phenotype
OpenTargetsiENSG00000138435
Orphaneti33108 Lethal multiple pterygium syndrome
98913 Postsynaptic congenital myasthenic syndromes
PharmGKBiPA26487

Chemistry databases

ChEMBLiCHEMBL4808
DrugBankiDB08838 Agmatine
DB00674 Galantamine
GuidetoPHARMACOLOGYi462

Polymorphism and mutation databases

BioMutaiCHRNA1
DMDMi113071

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000000030521 – 482Acetylcholine receptor subunit alphaAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi173 ↔ 187
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi237 ↔ 238Associated with receptor activation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP02708
PeptideAtlasiP02708
PRIDEiP02708
ProteomicsDBi51554
51555 [P02708-2]

PTM databases

iPTMnetiP02708
PhosphoSitePlusiP02708

Expressioni

Tissue specificityi

Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.

Gene expression databases

BgeeiENSG00000138435 Expressed in 84 organ(s), highest expression level in quadriceps femoris
CleanExiHS_CHRNA1
ExpressionAtlasiP02708 baseline and differential
GenevisibleiP02708 HS

Organism-specific databases

HPAiHPA071554

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (PubMed:15609996).1 Publication

Protein-protein interaction databases

BioGridi107556, 4 interactors
ComplexPortaliCPX-2179 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma
CPX-255 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon
IntActiP02708, 3 interactors
STRINGi9606.ENSP00000261007

Chemistry databases

BindingDBiP02708

Structurei

Secondary structure

1482
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02708
SMRiP02708
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP02708
KOiK04803
OMAiDFAIIHE
OrthoDBiEOG091G0R20
PhylomeDBiP02708
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 2 hits
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 2 hits
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: P02708-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPWPLLLLF SLCSAGLVLG SEHETRLVAK LFKDYSSVVR PVEDHRQVVE
60 70 80 90 100
VTVGLQLIQL INVDEVNQIV TTNVRLKQGD MVDLPRPSCV TLGVPLFSHL
110 120 130 140 150
QNEQWVDYNL KWNPDDYGGV KKIHIPSEKI WRPDLVLYNN ADGDFAIVKF
160 170 180 190 200
TKVLLQYTGH ITWTPPAIFK SYCEIIVTHF PFDEQNCSMK LGTWTYDGSV
210 220 230 240 250
VAINPESDQP DLSNFMESGE WVIKESRGWK HSVTYSCCPD TPYLDITYHF
260 270 280 290 300
VMQRLPLYFI VNVIIPCLLF SFLTGLVFYL PTDSGEKMTL SISVLLSLTV
310 320 330 340 350
FLLVIVELIP STSSAVPLIG KYMLFTMVFV IASIIITVIV INTHHRSPST
360 370 380 390 400
HVMPNWVRKV FIDTIPNIMF FSTMKRPSRE KQDKKIFTED IDISDISGKP
410 420 430 440 450
GPPPMGFHSP LIKHPEVKSA IEGIKYIAET MKSDQESNNA AAEWKYVAMV
460 470 480
MDHILLGVFM LVCIIGTLAV FAGRLIELNQ QG
Length:482
Mass (Da):54,546
Last modified:August 1, 1990 - v2
Checksum:i8B307AD69B91A28B
GO
Isoform 1 (identifier: P02708-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-103: Missing.

Show »
Length:457
Mass (Da):51,839
Checksum:i89480567D85C15B8
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ENE5E7ENE5_HUMAN
Acetylcholine receptor subunit alph...
CHRNA1
377Annotation score:
G5E9G9G5E9G9_HUMAN
Acetylcholine receptor subunit alph...
CHRNA1 hCG_1811440
269Annotation score:
A0A1B0GV17A0A1B0GV17_HUMAN
Acetylcholine receptor subunit alph...
CHRNA1
470Annotation score:
B8ZZD3B8ZZD3_HUMAN
Acetylcholine receptor subunit alph...
CHRNA1
375Annotation score:
F8WDS3F8WDS3_HUMAN
Acetylcholine receptor subunit alph...
CHRNA1
81Annotation score:

Sequence cautioni

The sequence CAA49705 differs from that shown. Reason: Frameshift at position 104.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti415P → F in AAD14247 (PubMed:7725386).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038599177V → L in CMS1B; mutant channel shows an approximately 30-fold decrease of ACh binding affinity for the second of 2 closed-state binding sites but only a 2-fold decrease in gating efficiency. 1 PublicationCorresponds to variant dbSNP:rs137852807EnsemblClinVar.1
Natural variantiVAR_000282198G → S in CMS1A. 2 PublicationsCorresponds to variant dbSNP:rs137852801Ensembl.1
Natural variantiVAR_000283201V → M in CMS1A. 1 PublicationCorresponds to variant dbSNP:rs137852799EnsemblClinVar.1
Natural variantiVAR_043904254R → L in LMPS. 1 PublicationCorresponds to variant dbSNP:rs137852809EnsemblClinVar.1
Natural variantiVAR_000284262N → K in CMS1A. 1 PublicationCorresponds to variant dbSNP:rs137852798EnsemblClinVar.1
Natural variantiVAR_021206278F → V in CMS1B; markedly reduced protein expression. 1 PublicationCorresponds to variant dbSNP:rs137852805EnsemblClinVar.1
Natural variantiVAR_021207294V → F in CMS1A; causes increased channel opening in absence of ACh; prolonged opening in presence of ACh; increased affinity for ACh and enhanced desensitization. 1 PublicationCorresponds to variant dbSNP:rs137852803Ensembl.1
Natural variantiVAR_000285299T → I in CMS1A. 1 PublicationCorresponds to variant dbSNP:rs137852800EnsemblClinVar.1
Natural variantiVAR_021208301F → L in CMS1B; fewer and shorter ion channel activations with decreased channel opening rate and increased channel closing rate. 1 PublicationCorresponds to variant dbSNP:rs137852806EnsemblClinVar.1
Natural variantiVAR_000286314S → I in CMS1A. 1 PublicationCorresponds to variant dbSNP:rs137852802EnsemblClinVar.1
Natural variantiVAR_021209330V → I in CMS1B; abnormally slow channel opening and closing resulting in abnormally brief current. 1 PublicationCorresponds to variant dbSNP:rs137852804EnsemblClinVar.1
Natural variantiVAR_038600383D → V. Corresponds to variant dbSNP:rs6739001Ensembl.1
Natural variantiVAR_038601463C → W in CMS1A; increases the rate of channel opening and slows the rate of channel closing but has no effect on agonist binding. 1 PublicationCorresponds to variant dbSNP:rs137852808EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00007179 – 103Missing in isoform 1. 2 PublicationsAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02502
, X02503, X02504, X02505, X02506, X02507, X02508 Genomic DNA Translation: CAA26344.1
Y00762 mRNA Translation: CAA68731.1
X17104 Genomic DNA Translation: CAA34960.1
AK299445 mRNA Translation: BAG61418.1
CH471058 Genomic DNA Translation: EAX11125.1
CH471058 Genomic DNA Translation: EAX11127.1
S77094 mRNA Translation: AAD14247.1
X70108 Genomic DNA Translation: CAA49705.1 Frameshift.
CCDSiCCDS2261.1 [P02708-2]
CCDS33331.1 [P02708-1]
PIRiA03168 ACHUA1
S10148
RefSeqiNP_000070.1, NM_000079.3 [P02708-2]
NP_001034612.1, NM_001039523.2 [P02708-1]
UniGeneiHs.434479

Genome annotation databases

EnsembliENST00000261007; ENSP00000261007; ENSG00000138435 [P02708-1]
ENST00000348749; ENSP00000261008; ENSG00000138435 [P02708-2]
GeneIDi1134
KEGGihsa:1134
UCSCiuc002ujd.3 human [P02708-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02502
, X02503, X02504, X02505, X02506, X02507, X02508 Genomic DNA Translation: CAA26344.1
Y00762 mRNA Translation: CAA68731.1
X17104 Genomic DNA Translation: CAA34960.1
AK299445 mRNA Translation: BAG61418.1
CH471058 Genomic DNA Translation: EAX11125.1
CH471058 Genomic DNA Translation: EAX11127.1
S77094 mRNA Translation: AAD14247.1
X70108 Genomic DNA Translation: CAA49705.1 Frameshift.
CCDSiCCDS2261.1 [P02708-2]
CCDS33331.1 [P02708-1]
PIRiA03168 ACHUA1
S10148
RefSeqiNP_000070.1, NM_000079.3 [P02708-2]
NP_001034612.1, NM_001039523.2 [P02708-1]
UniGeneiHs.434479

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y5Pmodel-B230-235[»]
1Y5Tmodel-B230-235[»]
1Y6Cmodel-B230-235[»]
4ZJSX-ray2.23A/B/C/D/E21-50[»]
A/B/C/D/E106-126[»]
5HBTX-ray2.61B21-256[»]
ProteinModelPortaliP02708
SMRiP02708
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107556, 4 interactors
ComplexPortaliCPX-2179 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma
CPX-255 Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon
IntActiP02708, 3 interactors
STRINGi9606.ENSP00000261007

Chemistry databases

BindingDBiP02708
ChEMBLiCHEMBL4808
DrugBankiDB08838 Agmatine
DB00674 Galantamine
GuidetoPHARMACOLOGYi462

Protein family/group databases

TCDBi1.A.9.1.1 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

PTM databases

iPTMnetiP02708
PhosphoSitePlusiP02708

Polymorphism and mutation databases

BioMutaiCHRNA1
DMDMi113071

Proteomic databases

PaxDbiP02708
PeptideAtlasiP02708
PRIDEiP02708
ProteomicsDBi51554
51555 [P02708-2]

Protocols and materials databases

DNASUi1134
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261007; ENSP00000261007; ENSG00000138435 [P02708-1]
ENST00000348749; ENSP00000261008; ENSG00000138435 [P02708-2]
GeneIDi1134
KEGGihsa:1134
UCSCiuc002ujd.3 human [P02708-1]

Organism-specific databases

CTDi1134
DisGeNETi1134
EuPathDBiHostDB:ENSG00000138435.14
GeneCardsiCHRNA1
GeneReviewsiCHRNA1
HGNCiHGNC:1955 CHRNA1
HPAiHPA071554
MalaCardsiCHRNA1
MIMi100690 gene
253290 phenotype
254200 phenotype
601462 phenotype
608930 phenotype
neXtProtiNX_P02708
OpenTargetsiENSG00000138435
Orphaneti33108 Lethal multiple pterygium syndrome
98913 Postsynaptic congenital myasthenic syndromes
PharmGKBiPA26487
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP02708
KOiK04803
OMAiDFAIIHE
OrthoDBiEOG091G0R20
PhylomeDBiP02708
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors
SIGNORiP02708

Miscellaneous databases

GeneWikiiCholinergic_receptor,_nicotinic,_alpha_1
GenomeRNAii1134
PROiPR:P02708
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138435 Expressed in 84 organ(s), highest expression level in quadriceps femoris
CleanExiHS_CHRNA1
ExpressionAtlasiP02708 baseline and differential
GenevisibleiP02708 HS

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 2 hits
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 2 hits
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHA_HUMAN
AccessioniPrimary (citable) accession number: P02708
Secondary accession number(s): B4DRV6, D3DPE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: November 7, 2018
This is version 206 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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