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Protein

Colipase A

Gene

CLPS1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63Bile salt micelles1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDigestion, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase A
Gene namesi
Name:CLPS1
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 113 PublicationsAdd BLAST›11
PropeptideiPRO_000000569212 – 16Enterostatin, activation peptide5
ChainiPRO_000000569317 – 106Colipase AAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 39PROSITE-ProRule annotation
Disulfide bondi34 ↔ 50PROSITE-ProRule annotation
Disulfide bondi38 ↔ 72PROSITE-ProRule annotation
Disulfide bondi60 ↔ 80PROSITE-ProRule annotation
Disulfide bondi74 ↔ 98PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the pancreas.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.

Structurei

3D structure databases

ProteinModelPortaliP02704
SMRiP02704
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZJ Eukaryota
ENOG410YQC6 LUCA
HOVERGENiHBG005373
InParanoidiP02704

Family and domain databases

CDDicd00039 COLIPASE, 1 hit
InterProiView protein in InterPro
IPR001981 Colipase
IPR017914 Colipase_C
IPR017915 Colipase_CS
IPR017913 Colipase_N
PANTHERiPTHR10041 PTHR10041, 1 hit
PfamiView protein in Pfam
PF01114 Colipase, 1 hit
PF02740 Colipase_C, 1 hit
PRINTSiPR00128 COLIPASE
SMARTiView protein in SMART
SM00023 COLIPASE, 1 hit
PROSITEiView protein in PROSITE
PS00121 COLIPASE_1, 1 hit
PS51342 COLIPASE_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02704-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LLLVALAVAY AVPDPRGVII NLEAGEICLN SAQCKSECCH QESSLSLARC
60 70 80 90 100
AAKASENSEC SAWTLYGVYY KCPCERGLTC QVDKTLVGSI MNTNFGICFD

AARSEE
Length:106
Mass (Da):11,388
Last modified:November 1, 1995 - v2
Checksum:iC0DC26747D94810C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti33Q → E AA sequence (PubMed:6691986).Curated1
Sequence conflicti33Q → E AA sequence (PubMed:7075593).Curated1
Sequence conflicti43S → E AA sequence (PubMed:6691986).Curated1
Sequence conflicti43S → E AA sequence (PubMed:7075593).Curated1
Sequence conflicti43S → E AA sequence (PubMed:7417313).Curated1
Sequence conflicti100D → N AA sequence (PubMed:7075593).Curated1
Sequence conflicti103R → K AA sequence (PubMed:7075593).Curated1
Sequence conflicti106E → ER AA sequence (PubMed:7075593).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74503 mRNA Translation: CAA52611.1
PIRiA03164 XLHOA
UniGeneiEca.12632

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74503 mRNA Translation: CAA52611.1
PIRiA03164 XLHOA
UniGeneiEca.12632

3D structure databases

ProteinModelPortaliP02704
SMRiP02704
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IYZJ Eukaryota
ENOG410YQC6 LUCA
HOVERGENiHBG005373
InParanoidiP02704

Family and domain databases

CDDicd00039 COLIPASE, 1 hit
InterProiView protein in InterPro
IPR001981 Colipase
IPR017914 Colipase_C
IPR017915 Colipase_CS
IPR017913 Colipase_N
PANTHERiPTHR10041 PTHR10041, 1 hit
PfamiView protein in Pfam
PF01114 Colipase, 1 hit
PF02740 Colipase_C, 1 hit
PRINTSiPR00128 COLIPASE
SMARTiView protein in SMART
SM00023 COLIPASE, 1 hit
PROSITEiView protein in PROSITE
PS00121 COLIPASE_1, 1 hit
PS51342 COLIPASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOLA_HORSE
AccessioniPrimary (citable) accession number: P02704
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1995
Last modified: January 31, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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