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Protein

Colipase

Gene

CLPS

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDigestion, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-SSC-192456 Digestion of dietary lipid
R-SSC-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Alternative name(s):
Procolipase II
Gene namesi
Name:CLPS
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
PropeptideiPRO_000000570218 – 22Enterostatin, activation peptide1 Publication5
ChainiPRO_000000570323 – 112ColipaseAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 45
Disulfide bondi40 ↔ 56
Disulfide bondi44 ↔ 78
Disulfide bondi66 ↔ 86
Disulfide bondi80 ↔ 104

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP02703
PRIDEiP02703

Expressioni

Tissue specificityi

Expressed by the pancreas.

Gene expression databases

BgeeiENSSSCG00000001552
ExpressionAtlasiP02703 baseline
GenevisibleiP02703 SS

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.PROSITE-ProRule annotation4 Publications

Protein-protein interaction databases

MINTiP02703
STRINGi9823.ENSSSCP00000001686

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 28Combined sources4
Beta strandi30 – 33Combined sources4
Helixi37 – 39Combined sources3
Beta strandi40 – 43Combined sources4
Beta strandi48 – 52Combined sources5
Beta strandi64 – 67Combined sources4
Beta strandi71 – 77Combined sources7
Beta strandi84 – 88Combined sources5
Helixi92 – 97Combined sources6
Beta strandi101 – 106Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ETHX-ray2.80B/D18-110[»]
1LPAX-ray3.04A18-110[»]
1LPBX-ray2.46A18-110[»]
1N8SX-ray3.04C18-110[»]
1PCNNMR-A18-110[»]
1PCONMR-A18-110[»]
ProteinModelPortaliP02703
SMRiP02703
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02703

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZJ Eukaryota
ENOG410YQC6 LUCA
GeneTreeiENSGT00390000012644
HOGENOMiHOG000059253
HOVERGENiHBG005373
InParanoidiP02703
KOiK14460
OMAiCSAKTLY
OrthoDBiEOG091G0Z2E
TreeFamiTF336178

Family and domain databases

CDDicd00039 COLIPASE, 1 hit
InterProiView protein in InterPro
IPR001981 Colipase
IPR017914 Colipase_C
IPR017915 Colipase_CS
IPR017913 Colipase_N
PANTHERiPTHR10041 PTHR10041, 1 hit
PfamiView protein in Pfam
PF01114 Colipase, 1 hit
PF02740 Colipase_C, 1 hit
PRINTSiPR00128 COLIPASE
SMARTiView protein in SMART
SM00023 COLIPASE, 1 hit
PROSITEiView protein in PROSITE
PS00121 COLIPASE_1, 1 hit
PS51342 COLIPASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVLALLLV TLTVAYAVPD PRGIIINLDE GELCLNSAQC KSNCCQHDTI
60 70 80 90 100
LSLSRCALKA RENSECSAFT LYGVYYKCPC ERGLTCEGDK SLVGSITNTN
110
FGICHDVGRS SD
Length:112
Mass (Da):12,140
Last modified:October 25, 2002 - v3
Checksum:iAE0AE89956E5A846
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54Missing AA sequence (PubMed:4858821).Curated1
Sequence conflicti67Missing AA sequence (PubMed:4858821).Curated1
Sequence conflicti106D → N AA sequence (PubMed:6691986).Curated1
Sequence conflicti106D → N AA sequence (PubMed:4858821).Curated1
Sequence conflicti111 – 112SD → DS AA sequence (PubMed:6691986).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148567 mRNA Translation: AAF67823.1
DQ073448 Genomic DNA Translation: AAZ22441.1
PIRiA03162 XLPG2
RefSeqiNP_999368.1, NM_214203.1
XP_013833274.1, XM_013977820.1
XP_013833275.1, XM_013977821.1
XP_013833276.1, XM_013977822.1
UniGeneiSsc.514

Genome annotation databases

EnsembliENSSSCT00000001730; ENSSSCP00000001686; ENSSSCG00000001552
GeneIDi397407
KEGGissc:397407

Similar proteinsi

Entry informationi

Entry nameiCOL_PIG
AccessioniPrimary (citable) accession number: P02703
Secondary accession number(s): Q3I5G6, Q9N1T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 25, 2002
Last modified: May 23, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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