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Protein

Avidin

Gene

AVD

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The biological function of avidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of avidin).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57Biotin1

GO - Molecular functioni

  • biotin binding Source: AgBase

GO - Biological processi

  • antibacterial humoral response Source: AgBase

Keywordsi

LigandBiotin

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-5341

Names & Taxonomyi

Protein namesi
Recommended name:
Avidin
Gene namesi
Name:AVD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2189156

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 242 PublicationsAdd BLAST24
ChainiPRO_000000272225 – 152AvidinAdd BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 107
GlycosylationiCAR_00023041N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N-linked glycan at Asn-41 consists of GlcNAc(beta1-2)Man(alpha1-3)[GlcNAc(beta1-4)][Man(alpha1-?)Man(alpha1-6)] Man(beta1-4)GlcNAc(beta1-4)GlcNAc.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP02701
PRIDEiP02701

PTM databases

GlyConnecti65
UniCarbKBiP02701

Expressioni

Tissue specificityi

Synthesized in hen oviduct and concentrated in egg white (where it represent 0.05% of the total protein).

Gene expression databases

BgeeiENSGALG00000023622

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

DIPiDIP-60471N
STRINGi9031.ENSGALP00000003846

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 36Combined sources5
Beta strandi41 – 44Combined sources4
Beta strandi51 – 58Combined sources8
Beta strandi63 – 66Combined sources4
Beta strandi71 – 77Combined sources7
Helixi80 – 82Combined sources3
Beta strandi87 – 93Combined sources7
Beta strandi95 – 98Combined sources4
Beta strandi100 – 109Combined sources10
Beta strandi111 – 113Combined sources3
Beta strandi115 – 124Combined sources10
Helixi130 – 135Combined sources6
Beta strandi137 – 146Combined sources10

3D structure databases

ProteinModelPortaliP02701
SMRiP02701
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02701

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 149Avidin-likePROSITE-ProRule annotationAdd BLAST124

Sequence similaritiesi

Belongs to the avidin/streptavidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7T6 Eukaryota
ENOG410Y0CU LUCA
GeneTreeiENSGT00390000001847
HOGENOMiHOG000034237
HOVERGENiHBG004323
InParanoidiP02701
OMAiWKFSEST
OrthoDBiEOG091G0Z5X
PhylomeDBiP02701
TreeFamiTF336756

Family and domain databases

Gene3Di2.40.128.30, 1 hit
InterProiView protein in InterPro
IPR005469 Avidin
IPR017889 Avidin-like_CS
IPR036896 Avidin-like_sf
IPR005468 Avidin/str
PfamiView protein in Pfam
PF01382 Avidin, 1 hit
PRINTSiPR00709 AVIDIN
SUPFAMiSSF50876 SSF50876, 1 hit
PROSITEiView protein in PROSITE
PS00577 AVIDIN_1, 1 hit
PS51326 AVIDIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHATSPLLL LLLLSLALVA PGLSARKCSL TGKWTNDLGS NMTIGAVNSR
60 70 80 90 100
GEFTGTYITA VTATSNEIKE SPLHGTQNTI NKRTQPTFGF TVNWKFSEST
110 120 130 140 150
TVFTGQCFID RNGKEVLKTM WLLRSSVNDI GDDWKATRVG INIFTRLRTQ

KE
Length:152
Mass (Da):16,768
Last modified:September 11, 2007 - v3
Checksum:i7795A458481AEC09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22G → S in AAB59733 (PubMed:7665080).Curated1
Sequence conflicti35T → D in CAC34569 (PubMed:11167523).Curated1
Sequence conflicti50R → K in CAC34569 (PubMed:11167523).Curated1
Sequence conflicti77Q → E AA sequence (PubMed:5100763).Curated1
Sequence conflicti77Q → E AA sequence (PubMed:5100762).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti58I → T in about 50% of the molecules. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05343 mRNA Translation: CAA28954.1
L27818 Genomic DNA Translation: AAB59733.1
AJ311647 Genomic DNA Translation: CAC34569.1
PIRiA54975 VICH
RefSeqiNP_990651.1, NM_205320.1
UniGeneiGga.729

Genome annotation databases

EnsembliENSGALT00000003855; ENSGALP00000003846; ENSGALG00000023622
GeneIDi396260
KEGGigga:396260

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAVID_CHICK
AccessioniPrimary (citable) accession number: P02701
Secondary accession number(s): Q91958, Q98SH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 11, 2007
Last modified: April 25, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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