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Protein

Retinol-binding protein 1

Gene

Rbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoplasmic retinol-binding protein (PubMed:7683727, PubMed:12850148). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41RetinolBy similarity1
Binding sitei63RetinolCombined sources1
Binding sitei109RetinolCombined sources1

GO - Molecular functioni

  • all-trans-retinol binding Source: UniProtKB
  • retinal binding Source: UniProtKB-KW
  • retinol binding Source: RGD

GO - Biological processi

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-RNO-2453902 The canonical retinoid cycle in rods (twilight vision)
R-RNO-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 1
Alternative name(s):
Cellular retinol-binding protein
Short name:
CRBP
Cellular retinol-binding protein I
Short name:
CRBP-I
Gene namesi
Name:Rbp1
Synonyms:Rbp-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3543 Rbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lipid droplet

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00000673942 – 135Retinol-binding protein 1Add BLAST134

Proteomic databases

PaxDbiP02696
PRIDEiP02696

PTM databases

iPTMnetiP02696
PhosphoSitePlusiP02696

Expressioni

Gene expression databases

BgeeiENSRNOG00000013794 Expressed in 10 organ(s), highest expression level in liver
GenevisibleiP02696 RN

Interactioni

Subunit structurei

Interacts (only as retinol-free apoprotein) with STRA6.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018622

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02696
SMRiP02696
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02696

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 32Important for interaction with STRA6By similarityAdd BLAST11

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.2 Publications

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiP02696
OMAiGDEMHLE
OrthoDBiEOG091G0QSV
PhylomeDBiP02696
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031264 CRBP1
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF56 PTHR11955:SF56, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02696-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVDFNGYWK MLSNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM
60 70 80 90 100
IIRTLSTFRN YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG
110 120 130
EKEGRGWTQW IEGDELHLEM RAEGVTCKQV FKKVH
Length:135
Mass (Da):15,834
Last modified:January 23, 2007 - v2
Checksum:i680CCE3284BD28B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16459 mRNA Translation: AAA42021.1
M19257 mRNA Translation: AAA40962.1
PIRiA29570 RJRTO
RefSeqiNP_036865.1, NM_012733.4
UniGeneiRn.902

Genome annotation databases

EnsembliENSRNOT00000018622; ENSRNOP00000018622; ENSRNOG00000013794
GeneIDi25056
KEGGirno:25056
UCSCiRGD:3543 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16459 mRNA Translation: AAA42021.1
M19257 mRNA Translation: AAA40962.1
PIRiA29570 RJRTO
RefSeqiNP_036865.1, NM_012733.4
UniGeneiRn.902

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CRBX-ray2.10A2-135[»]
1JBHNMR-A1-135[»]
1KGLNMR-A1-135[»]
1MX7NMR-A2-135[»]
1MX8NMR-A2-135[»]
ProteinModelPortaliP02696
SMRiP02696
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018622

PTM databases

iPTMnetiP02696
PhosphoSitePlusiP02696

Proteomic databases

PaxDbiP02696
PRIDEiP02696

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018622; ENSRNOP00000018622; ENSRNOG00000013794
GeneIDi25056
KEGGirno:25056
UCSCiRGD:3543 rat

Organism-specific databases

CTDi5947
RGDi3543 Rbp1

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiP02696
OMAiGDEMHLE
OrthoDBiEOG091G0QSV
PhylomeDBiP02696
TreeFamiTF316894

Enzyme and pathway databases

ReactomeiR-RNO-2453902 The canonical retinoid cycle in rods (twilight vision)
R-RNO-975634 Retinoid metabolism and transport

Miscellaneous databases

EvolutionaryTraceiP02696
PROiPR:P02696

Gene expression databases

BgeeiENSRNOG00000013794 Expressed in 10 organ(s), highest expression level in liver
GenevisibleiP02696 RN

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031264 CRBP1
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF56 PTHR11955:SF56, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRET1_RAT
AccessioniPrimary (citable) accession number: P02696
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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