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Protein

Fatty acid-binding protein, intestinal

Gene

Fabp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83Fatty acid1
Binding sitei107Fatty acid1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, intestinal
Alternative name(s):
Fatty acid-binding protein 2
Intestinal-type fatty acid-binding protein
Short name:
I-FABP
Gene namesi
Name:Fabp2
Synonyms:Fabpi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2591 Fabp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi45G → V: Small reduction in stability, impaired ligand binding. 1 Publication1
Mutagenesisi55N → V: No reduction in stability. 1 Publication1
Mutagenesisi61V → N: Reduced thermodynamic stability. 1 Publication1
Mutagenesisi66G → V: Large reduction in stability. 1 Publication1
Mutagenesisi76G → V: Reduced stability. 1 Publication1
Mutagenesisi81G → V: Large reduction in stability. 1 Publication1
Mutagenesisi87G → V: No reduction in stability, impaired ligand binding. 1 Publication1
Mutagenesisi98D → V: Reduced stability. 1 Publication1
Mutagenesisi100G → V: Large reduction in stability. 1 Publication1
Mutagenesisi111G → V: Small reduction in stability, impaired ligand binding. 1 Publication1
Mutagenesisi122G → V: Large reduction in stability. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000673302 – 132Fatty acid-binding protein, intestinalAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP02693

PTM databases

iPTMnetiP02693
PhosphoSitePlusiP02693

Expressioni

Tissue specificityi

Expressed in the small intestine. Expression in the mucosal cells of the ileum extends from the midvillar region to the villus tips.1 Publication

Inductioni

By peptide YY.1 Publication

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00263
ProteinModelPortaliP02693
SMRiP02693
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02693

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP02693
KOiK08751
PhylomeDBiP02693
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031272 FABP2
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF89 PTHR11955:SF89, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02693-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFDGTWKVD RNENYEKFME KMGINVVKRK LGAHDNLKLT ITQEGNKFTV
60 70 80 90 100
KESSNFRNID VVFELGVDFA YSLADGTELT GTWTMEGNKL VGKFKRVDNG
110 120 130
KELIAVREIS GNELIQTYTY EGVEAKRIFK KE
Length:132
Mass (Da):15,124
Last modified:January 23, 2007 - v4
Checksum:iA652B8494FE8A71E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MY01A0A0A0MY01_RAT
Fatty acid-binding protein, intesti...
Fabp2
132Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10D → Y in AAA41138 (PubMed:6582489).Curated1
Sequence conflicti83W → L in AAA41138 (PubMed:6582489).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01180 mRNA Translation: AAA41138.1
M35992 mRNA Translation: AAA41141.1
M18080 Genomic DNA Translation: AAA41133.1
PIRiI65761 FZRTI
RefSeqiNP_037200.1, NM_013068.1
UniGeneiRn.91358

Genome annotation databases

GeneIDi25598
KEGGirno:25598
UCSCiRGD:2591 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01180 mRNA Translation: AAA41138.1
M35992 mRNA Translation: AAA41141.1
M18080 Genomic DNA Translation: AAA41133.1
PIRiI65761 FZRTI
RefSeqiNP_037200.1, NM_013068.1
UniGeneiRn.91358

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A57NMR-A2-132[»]
1AELNMR-A2-132[»]
1DC9X-ray2.10A2-132[»]
1ICMX-ray1.50A2-132[»]
1ICNX-ray1.74A2-132[»]
1IFBX-ray1.96A2-132[»]
1IFCX-ray1.19A1-132[»]
1SA8NMR-A2-9[»]
A37-132[»]
1T8VNMR-A2-132[»]
1URENMR-A2-132[»]
2IFBX-ray2.00A2-132[»]
3AKNX-ray1.60A2-132[»]
DisProtiDP00263
ProteinModelPortaliP02693
SMRiP02693
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP02693
PhosphoSitePlusiP02693

Proteomic databases

PRIDEiP02693

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25598
KEGGirno:25598
UCSCiRGD:2591 rat

Organism-specific databases

CTDi2169
RGDi2591 Fabp2

Phylogenomic databases

HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP02693
KOiK08751
PhylomeDBiP02693
TreeFamiTF316894

Miscellaneous databases

EvolutionaryTraceiP02693
PROiPR:P02693

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031272 FABP2
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF89 PTHR11955:SF89, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFABPI_RAT
AccessioniPrimary (citable) accession number: P02693
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 158 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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