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UniProtKB - P02692 (FABPL_RAT)
Protein
Fatty acid-binding protein, liver
Gene
Fabp1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (By similarity).
Binds cholesterol (PubMed:25732850).
Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
By similarity1 PublicationMiscellaneous
There are three fractions of Z-protein: DE-I, DE-II and DE-III. DE-I is virtually lipid free, DE-II binds palmitic, stearic, oleic, linoleic and arachidonic acids and DE-III binds mainly arachidonic acid.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 31 | Oleate 1Combined sources1 Publication | 1 | |
Binding sitei | 39 | Oleate 2Combined sources1 Publication | 1 | |
Binding sitei | 122 | Oleate 2Combined sources1 Publication | 1 |
GO - Molecular functioni
- antioxidant activity Source: RGD
- bile acid binding Source: RGD
- chromatin binding Source: RGD
- fatty acid binding Source: RGD
- heterocyclic compound binding Source: RGD
- long-chain fatty acid transporter activity Source: RGD
- lysophospholipid:sodium symporter activity Source: RGD
- oleic acid binding Source: RGD
- phospholipid binding Source: RGD
GO - Biological processi
- cellular response to hydrogen peroxide Source: RGD
- cellular response to hypoxia Source: RGD
- fatty acid transport Source: GO_Central
- intestinal absorption Source: RGD
- long-chain fatty acid transport Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
- positive regulation of fatty acid beta-oxidation Source: RGD
- positive regulation of hydrolase activity Source: RGD
Keywordsi
Biological process | Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-RNO-163560, Triglyceride catabolism R-RNO-189483, Heme degradation R-RNO-400206, Regulation of lipid metabolism by PPARalpha R-RNO-9707564, Cytoprotection by HMOX1 |
Chemistry databases
SwissLipidsi | SLP:000001517 |
Names & Taxonomyi
Protein namesi | Recommended name: Fatty acid-binding protein, liverAlternative name(s): Fatty acid-binding protein 1 Liver-type fatty acid-binding protein Short name: L-FABP Squalene- and sterol-carrier protein Short name: SCP Z-protein p14 |
Gene namesi | Name:Fabp1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2590, Fabp1 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: RGD
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Peroxisome
- peroxisomal matrix Source: RGD
Other locations
- apical cortex Source: RGD
- cytoplasm Source: RGD
- protein-containing complex Source: RGD
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL5738 |
DrugCentrali | P02692 |
GuidetoPHARMACOLOGYi | 2531 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067337 | 1 – 127 | Fatty acid-binding protein, liverAdd BLAST | 127 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine2 Publications | 1 | |
Modified residuei | 11 | PhosphoserineCombined sources | 1 | |
Modified residuei | 31 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 36 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 39 | PhosphoserineCombined sources | 1 | |
Modified residuei | 46 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 51 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 56 | PhosphoserineCombined sources | 1 | |
Modified residuei | 57 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 78 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 84 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 84 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 90 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 100 | PhosphoserineBy similarity | 1 | |
Cross-linki | 105 ↔ 106 | Isoaspartyl glycine isopeptide (Asn-Gly); alternate | ||
Modified residuei | 105 | Deamidated asparagine; alternate1 Publication | 1 | |
Modified residuei | 121 | N6-succinyllysineBy similarity | 1 |
Post-translational modificationi
Deamidation and transpeptidation at the beta carboxyl of Asn-105 forms an isoaspartyl residue found in an isoform of the DE-III fraction. This rearrangement gives rise to an extra negative charge carried by the acid form.1 Publication
Keywords - PTMi
Acetylation, Isopeptide bond, PhosphoproteinProteomic databases
PaxDbi | P02692 |
PTM databases
CarbonylDBi | P02692 |
iPTMneti | P02692 |
PhosphoSitePlusi | P02692 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000006675, Expressed in jejunum and 18 other tissues |
Genevisiblei | P02692, RN |
Interactioni
Binary interactionsi
P02692
With | #Exp. | IntAct |
---|---|---|
Hnf4a [P22449] | 3 | EBI-1209448,EBI-5261592 |
Protein-protein interaction databases
IntActi | P02692, 4 interactors |
MINTi | P02692 |
STRINGi | 10116.ENSRNOP00000008841 |
Chemistry databases
BindingDBi | P02692 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P02692 |
PCDDBi | P02692 |
SMRi | P02692 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02692 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 54 – 56 | Oleate 1 bindingCombined sources1 Publication | 3 |
Domaini
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
GeneTreei | ENSGT00940000155135 |
HOGENOMi | CLU_113772_4_2_1 |
InParanoidi | P02692 |
OMAi | DTITNTM |
OrthoDBi | 1440574at2759 |
PhylomeDBi | P02692 |
TreeFami | TF330348 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR000463, Fatty_acid-bd IPR031259, ILBP IPR031276, Lb-FABP |
PANTHERi | PTHR11955, PTHR11955, 1 hit PTHR11955:SF96, PTHR11955:SF96, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
i Sequence
Sequence statusi: Complete.
P02692-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNFSGKYQVQ SQENFEPFMK AMGLPEDLIQ KGKDIKGVSE IVHEGKKVKL
60 70 80 90 100
TITYGSKVIH NEFTLGEECE LETMTGEKVK AVVKMEGDNK MVTTFKGIKS
110 120
VTEFNGDTIT NTMTLGDIVY KRVSKRI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01235 mRNA Translation: CAA24545.1 M13501 Genomic DNA Translation: AAA41140.1 M35991 mRNA Translation: AAA41135.1 S55929 Other DNA Translation: AAB19788.1 BC086947 mRNA Translation: AAH86947.1 M17899 mRNA Translation: AAA41134.1 M10951 mRNA Translation: AAA42119.1 |
PIRi | A92416, FZRTL I52354 I52850 I55238 |
RefSeqi | NP_036688.1, NM_012556.2 |
Genome annotation databases
Ensembli | ENSRNOT00000008840; ENSRNOP00000008841; ENSRNOG00000006675 |
GeneIDi | 24360 |
KEGGi | rno:24360 |
UCSCi | RGD:2590, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01235 mRNA Translation: CAA24545.1 M13501 Genomic DNA Translation: AAA41140.1 M35991 mRNA Translation: AAA41135.1 S55929 Other DNA Translation: AAB19788.1 BC086947 mRNA Translation: AAH86947.1 M17899 mRNA Translation: AAA41134.1 M10951 mRNA Translation: AAA42119.1 |
PIRi | A92416, FZRTL I52354 I52850 I55238 |
RefSeqi | NP_036688.1, NM_012556.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LFO | X-ray | 2.30 | A | 1-127 | [»] | |
2JU3 | NMR | - | A | 1-127 | [»] | |
2JU7 | NMR | - | A | 1-127 | [»] | |
2JU8 | NMR | - | A | 1-127 | [»] | |
BMRBi | P02692 | |||||
PCDDBi | P02692 | |||||
SMRi | P02692 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P02692, 4 interactors |
MINTi | P02692 |
STRINGi | 10116.ENSRNOP00000008841 |
Chemistry databases
BindingDBi | P02692 |
ChEMBLi | CHEMBL5738 |
DrugCentrali | P02692 |
GuidetoPHARMACOLOGYi | 2531 |
SwissLipidsi | SLP:000001517 |
PTM databases
CarbonylDBi | P02692 |
iPTMneti | P02692 |
PhosphoSitePlusi | P02692 |
Proteomic databases
PaxDbi | P02692 |
Protocols and materials databases
DNASUi | 24360 |
Genome annotation databases
Ensembli | ENSRNOT00000008840; ENSRNOP00000008841; ENSRNOG00000006675 |
GeneIDi | 24360 |
KEGGi | rno:24360 |
UCSCi | RGD:2590, rat |
Organism-specific databases
CTDi | 2168 |
RGDi | 2590, Fabp1 |
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
GeneTreei | ENSGT00940000155135 |
HOGENOMi | CLU_113772_4_2_1 |
InParanoidi | P02692 |
OMAi | DTITNTM |
OrthoDBi | 1440574at2759 |
PhylomeDBi | P02692 |
TreeFami | TF330348 |
Enzyme and pathway databases
Reactomei | R-RNO-163560, Triglyceride catabolism R-RNO-189483, Heme degradation R-RNO-400206, Regulation of lipid metabolism by PPARalpha R-RNO-9707564, Cytoprotection by HMOX1 |
Miscellaneous databases
EvolutionaryTracei | P02692 |
PROi | PR:P02692 |
Gene expression databases
Bgeei | ENSRNOG00000006675, Expressed in jejunum and 18 other tissues |
Genevisiblei | P02692, RN |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR000463, Fatty_acid-bd IPR031259, ILBP IPR031276, Lb-FABP |
PANTHERi | PTHR11955, PTHR11955, 1 hit PTHR11955:SF96, PTHR11955:SF96, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FABPL_RAT | |
Accessioni | P02692Primary (citable) accession number: P02692 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | August 13, 1987 | |
Last modified: | February 23, 2022 | |
This is version 189 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families