Fatty acid-binding protein, liver

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• antioxidant activity Source: RGDInferred from sequence orthologyⁱ
  • "Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells."
    Wang G., Gong Y., Anderson J., Sun D., Minuk G., Roberts M.S., Burczynski F.J.
    Hepatology 42:871-879(2005) [PubMed] [Europe PMC] [Abstract]
• bile acid binding Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The effect of charge reversal mutations in the alpha-helical region of liver fatty acid binding protein on the binding of fatty-acyl CoAs, lysophospholipids and bile acids."
    Hagan R.M., Davies J.K., Wilton D.C.
    Mol. Cell. Biochem. 239:55-60(2002) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins."
    Wang L., Zheng A., Yi L., Xu C., Ding M., Deng H.
    Biochem. Biophys. Res. Commun. 325:302-307(2004) [PubMed] [Europe PMC] [Abstract]
• drug binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.10

    "Identification by photoaffinity labeling of fatty acid-binding protein as a potential warfarin receptor in rat liver."
    Myszka D.G., Swenson R.P.
    J. Biol. Chem. 266:20725-20731(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: PROTEIN SEQUENCE OF 1-20.
• fatty acid binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.8

    "Liver fatty acid binding protein is the mitosis-associated polypeptide target of a carcinogen in rat hepatocytes."
    Bassuk J.A., Tsichlis P.N., Sorof S.
    Proc. Natl. Acad. Sci. U.S.A. 84:7547-7551(1987) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-102.
• long-chain fatty acid transporter activity Source: RGDInferred from mutant phenotypeⁱ
  • "The alpha-helical domain of liver fatty acid binding protein is responsible for the diffusion-mediated transfer of fatty acids to phospholipid membranes."
    Corsico B., Liou H.L., Storch J.
    Biochemistry 43:3600-3607(2004) [PubMed] [Europe PMC] [Abstract]
• lysophospholipid:sodium symporter activity Source: RGD <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "The effect of charge reversal mutations in the alpha-helical region of liver fatty acid binding protein on the binding of fatty-acyl CoAs, lysophospholipids and bile acids."
    Hagan R.M., Davies J.K., Wilton D.C.
    Mol. Cell. Biochem. 239:55-60(2002) [PubMed] [Europe PMC] [Abstract]
• phospholipid binding Source: RGDInferred from mutant phenotypeⁱ
  • "The effect of charge reversal mutations in the alpha-helical region of liver fatty acid binding protein on the binding of fatty-acyl CoAs, lysophospholipids and bile acids."
    Hagan R.M., Davies J.K., Wilton D.C.
    Mol. Cell. Biochem. 239:55-60(2002) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to hydrogen peroxide Source: RGDInferred from sequence orthologyⁱ
  • "Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells."
    Wang G., Gong Y., Anderson J., Sun D., Minuk G., Roberts M.S., Burczynski F.J.
    Hepatology 42:871-879(2005) [PubMed] [Europe PMC] [Abstract]
• cellular response to hypoxia Source: RGDInferred from sequence orthologyⁱ
  • "Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells."
    Wang G., Gong Y., Anderson J., Sun D., Minuk G., Roberts M.S., Burczynski F.J.
    Hepatology 42:871-879(2005) [PubMed] [Europe PMC] [Abstract]
• intestinal absorption Source: RGDInferred from direct assayⁱ
  • "Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine."
    Alpers D.H., Bass N.M., Engle M.J., DeSchryver-Kecskemeti K.
    Biochim. Biophys. Acta 1483:352-362(2000) [PubMed] [Europe PMC] [Abstract]
• long-chain fatty acid transport Source: RGDInferred from mutant phenotypeⁱ
  • "The alpha-helical domain of liver fatty acid binding protein is responsible for the diffusion-mediated transfer of fatty acids to phospholipid membranes."
    Corsico B., Liou H.L., Storch J.
    Biochemistry 43:3600-3607(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells."
    Wang G., Gong Y., Anderson J., Sun D., Minuk G., Roberts M.S., Burczynski F.J.
    Hepatology 42:871-879(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells."
    Wang G., Gong Y., Anderson J., Sun D., Minuk G., Roberts M.S., Burczynski F.J.
    Hepatology 42:871-879(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fatty acid beta-oxidation Source: RGDInferred from direct assayⁱ
  • "Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes."
    Antonenkov V.D., Sormunen R.T., Ohlmeier S., Amery L., Fransen M., Mannaerts G.P., Hiltunen J.K.
    Biochem. J. 394:475-484(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of hydrolase activity Source: RGDInferred from direct assayⁱ
  • "Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes."
    Antonenkov V.D., Sormunen R.T., Ohlmeier S., Amery L., Fransen M., Mannaerts G.P., Hiltunen J.K.
    Biochem. J. 394:475-484(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MNFSGKYQVQ SQENFEPFMK AMGLPEDLIQ KGKDIKGVSE IVHEGKKVKL 
        60         70         80         90        100
TITYGSKVIH NEFTLGEECE LETMTGEKVK AVVKMEGDNK MVTTFKGIKS 
       110        120 
VTEFNGDTIT NTMTLGDIVY KRVSKRI                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families