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Protein

Myelin P2 protein

Gene

PMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in lipid transport protein in Schwann cells. May bind cholesterol.1 Publication

Miscellaneous

P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107Fatty acid1

GO - Molecular functioni

  • cholesterol binding Source: UniProtKB
  • fatty acid binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin P2 protein
Alternative name(s):
Peripheral myelin protein 2
Gene namesi
Name:PMP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147588.6
HGNCiHGNC:9117 PMP2
MIMi170715 gene
neXtProtiNX_P02689

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5375
MalaCardsiPMP2
OpenTargetsiENSG00000147588
Orphaneti476394 PMP2-related Charcot-Marie-Tooth disease type 1
PharmGKBiPA33443

Chemistry databases

ChEMBLiCHEMBL3826864
DrugBankiDB04147 Lauryl Dimethylamine-N-Oxide
DB04224 Oleic Acid
DB03796 Palmitic Acid
DB01915 S-Hydroxycysteine

Polymorphism and mutation databases

BioMutaiPMP2
DMDMi127725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000673882 – 132Myelin P2 proteinAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Disulfide bondi118 ↔ 1251 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

MaxQBiP02689
PaxDbiP02689
PeptideAtlasiP02689
PRIDEiP02689
ProteomicsDBi51553

PTM databases

iPTMnetiP02689
PhosphoSitePlusiP02689
SwissPalmiP02689

Expressioni

Gene expression databases

BgeeiENSG00000147588 Expressed in 174 organ(s), highest expression level in ventral tegmental area
CleanExiHS_PMP2
ExpressionAtlasiP02689 baseline and differential
GenevisibleiP02689 HS

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10193858,EBI-748961

Protein-protein interaction databases

BioGridi111388, 7 interactors
IntActiP02689, 1 interactor
STRINGi9606.ENSP00000256103

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02689
SMRiP02689
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02689

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Fatty acid binding3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP02689
OMAiMCNRFVG
OrthoDBiEOG091G0QSV
PhylomeDBiP02689
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR031256 Myelin_P2
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF64 PTHR11955:SF64, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02689-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNKFLGTWK LVSSENFDDY MKALGVGLAT RKLGNLAKPT VIISKKGDII
60 70 80 90 100
TIRTESTFKN TEISFKLGQE FEETTADNRK TKSIVTLQRG SLNQVQRWDG
110 120 130
KETTIKRKLV NGKMVAECKM KGVVCTRIYE KV
Length:132
Mass (Da):14,909
Last modified:January 23, 2007 - v3
Checksum:i3D515D32695899D2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RH45E5RH45_HUMAN
Myelin P2 protein
PMP2
60Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25G → GG AA sequence (PubMed:6183401).Curated1
Sequence conflicti99D → N AA sequence (PubMed:6183401).Curated1
Sequence conflicti111N → D AA sequence (PubMed:6183401).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16181 Genomic DNA Translation: BAA03726.1
X62167 mRNA Translation: CAA44096.1
AK311758 mRNA Translation: BAG34701.1
CR541649 mRNA Translation: CAG46450.1
CR541738 mRNA Translation: CAG46538.1
AC018616 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87090.1
BC034997 mRNA Translation: AAH34997.1
AH004648 Genomic DNA Translation: AAB32592.2
CCDSiCCDS6229.1
PIRiJT0977 MPHU2
RefSeqiNP_002668.1, NM_002677.4
UniGeneiHs.571512

Genome annotation databases

EnsembliENST00000256103; ENSP00000256103; ENSG00000147588
GeneIDi5375
KEGGihsa:5375
UCSCiuc003ycb.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16181 Genomic DNA Translation: BAA03726.1
X62167 mRNA Translation: CAA44096.1
AK311758 mRNA Translation: BAG34701.1
CR541649 mRNA Translation: CAG46450.1
CR541738 mRNA Translation: CAG46538.1
AC018616 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87090.1
BC034997 mRNA Translation: AAH34997.1
AH004648 Genomic DNA Translation: AAB32592.2
CCDSiCCDS6229.1
PIRiJT0977 MPHU2
RefSeqiNP_002668.1, NM_002677.4
UniGeneiHs.571512

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WUTX-ray1.85A1-132[»]
3NR3X-ray1.95A3-132[»]
4A1HX-ray2.20A/B/C1-132[»]
4A1YX-ray1.20A/B/C/D1-132[»]
4A8ZX-ray1.80A1-132[»]
4BVMX-ray0.93A1-132[»]
4D6AX-ray1.45A1-132[»]
4D6BX-ray2.12A1-132[»]
5N4MX-ray1.59A1-132[»]
5N4PX-ray1.53A1-132[»]
5N4QX-ray1.72A1-132[»]
6EW2X-ray1.59A1-132[»]
6EW4X-ray1.27A1-132[»]
6EW5X-ray1.95A/B/C/D1-132[»]
ProteinModelPortaliP02689
SMRiP02689
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111388, 7 interactors
IntActiP02689, 1 interactor
STRINGi9606.ENSP00000256103

Chemistry databases

ChEMBLiCHEMBL3826864
DrugBankiDB04147 Lauryl Dimethylamine-N-Oxide
DB04224 Oleic Acid
DB03796 Palmitic Acid
DB01915 S-Hydroxycysteine

PTM databases

iPTMnetiP02689
PhosphoSitePlusiP02689
SwissPalmiP02689

Polymorphism and mutation databases

BioMutaiPMP2
DMDMi127725

Proteomic databases

MaxQBiP02689
PaxDbiP02689
PeptideAtlasiP02689
PRIDEiP02689
ProteomicsDBi51553

Protocols and materials databases

DNASUi5375
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256103; ENSP00000256103; ENSG00000147588
GeneIDi5375
KEGGihsa:5375
UCSCiuc003ycb.3 human

Organism-specific databases

CTDi5375
DisGeNETi5375
EuPathDBiHostDB:ENSG00000147588.6
GeneCardsiPMP2
HGNCiHGNC:9117 PMP2
MalaCardsiPMP2
MIMi170715 gene
neXtProtiNX_P02689
OpenTargetsiENSG00000147588
Orphaneti476394 PMP2-related Charcot-Marie-Tooth disease type 1
PharmGKBiPA33443
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP02689
OMAiMCNRFVG
OrthoDBiEOG091G0QSV
PhylomeDBiP02689
TreeFamiTF316894

Miscellaneous databases

EvolutionaryTraceiP02689
GeneWikiiPMP2
GenomeRNAii5375
PROiPR:P02689
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147588 Expressed in 174 organ(s), highest expression level in ventral tegmental area
CleanExiHS_PMP2
ExpressionAtlasiP02689 baseline and differential
GenevisibleiP02689 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR031256 Myelin_P2
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF64 PTHR11955:SF64, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYP2_HUMAN
AccessioniPrimary (citable) accession number: P02689
Secondary accession number(s): Q6FHL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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