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Protein

Myelin P2 protein

Gene

PMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in lipid transport protein in Schwann cells. May bind cholesterol.1 Publication

Miscellaneous

P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei107Fatty acid1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cholesterol binding Source: UniProtKB
  • fatty acid binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin P2 protein
Alternative name(s):
Peripheral myelin protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PMP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147588.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9117 PMP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
170715 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02689

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5375

MalaCards human disease database

More...
MalaCardsi
PMP2

Open Targets

More...
OpenTargetsi
ENSG00000147588

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
476394 PMP2-related Charcot-Marie-Tooth disease type 1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33443

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3826864

Drug and drug target database

More...
DrugBanki
DB04147 Lauryl Dimethylamine-N-Oxide
DB04224 Oleic Acid
DB03796 Palmitic Acid
DB01915 S-Hydroxycysteine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PMP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
127725

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000673882 – 132Myelin P2 proteinAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi118 ↔ 1251 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P02689

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P02689

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02689

PeptideAtlas

More...
PeptideAtlasi
P02689

PRoteomics IDEntifications database

More...
PRIDEi
P02689

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51553

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02689

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02689

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P02689

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147588 Expressed in 174 organ(s), highest expression level in ventral tegmental area

CleanEx database of gene expression profiles

More...
CleanExi
HS_PMP2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P02689 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02689 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10193858,EBI-748961

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111388, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P02689, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000256103

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WUTX-ray1.85A1-132[»]
3NR3X-ray1.95A3-132[»]
4A1HX-ray2.20A/B/C1-132[»]
4A1YX-ray1.20A/B/C/D1-132[»]
4A8ZX-ray1.80A1-132[»]
4BVMX-ray0.93A1-132[»]
4D6AX-ray1.45A1-132[»]
4D6BX-ray2.12A1-132[»]
5N4MX-ray1.59A1-132[»]
5N4PX-ray1.53A1-132[»]
5N4QX-ray1.72A1-132[»]
6EW2X-ray1.59A1-132[»]
6EW4X-ray1.27A1-132[»]
6EW5X-ray1.95A/B/C/D1-132[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P02689

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02689

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02689

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni127 – 129Fatty acid binding3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4015 Eukaryota
ENOG4111US8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160445

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000004829

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005633

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02689

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCNRFVG

Database of Orthologous Groups

More...
OrthoDBi
1417203at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02689

TreeFam database of animal gene trees

More...
TreeFami
TF316894

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR031256 Myelin_P2

The PANTHER Classification System

More...
PANTHERi
PTHR11955 PTHR11955, 1 hit
PTHR11955:SF64 PTHR11955:SF64, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00061 Lipocalin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00178 FATTYACIDBP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50814 SSF50814, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00214 FABP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02689-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNKFLGTWK LVSSENFDDY MKALGVGLAT RKLGNLAKPT VIISKKGDII
60 70 80 90 100
TIRTESTFKN TEISFKLGQE FEETTADNRK TKSIVTLQRG SLNQVQRWDG
110 120 130
KETTIKRKLV NGKMVAECKM KGVVCTRIYE KV
Length:132
Mass (Da):14,909
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D515D32695899D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RH45E5RH45_HUMAN
Myelin P2 protein
PMP2
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25G → GG AA sequence (PubMed:6183401).Curated1
Sequence conflicti99D → N AA sequence (PubMed:6183401).Curated1
Sequence conflicti111N → D AA sequence (PubMed:6183401).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D16181 Genomic DNA Translation: BAA03726.1
X62167 mRNA Translation: CAA44096.1
AK311758 mRNA Translation: BAG34701.1
CR541649 mRNA Translation: CAG46450.1
CR541738 mRNA Translation: CAG46538.1
AC018616 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87090.1
BC034997 mRNA Translation: AAH34997.1
AH004648 Genomic DNA Translation: AAB32592.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6229.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JT0977 MPHU2

NCBI Reference Sequences

More...
RefSeqi
NP_002668.1, NM_002677.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.571512

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000256103; ENSP00000256103; ENSG00000147588

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5375

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5375

UCSC genome browser

More...
UCSCi
uc003ycb.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16181 Genomic DNA Translation: BAA03726.1
X62167 mRNA Translation: CAA44096.1
AK311758 mRNA Translation: BAG34701.1
CR541649 mRNA Translation: CAG46450.1
CR541738 mRNA Translation: CAG46538.1
AC018616 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87090.1
BC034997 mRNA Translation: AAH34997.1
AH004648 Genomic DNA Translation: AAB32592.2
CCDSiCCDS6229.1
PIRiJT0977 MPHU2
RefSeqiNP_002668.1, NM_002677.4
UniGeneiHs.571512

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WUTX-ray1.85A1-132[»]
3NR3X-ray1.95A3-132[»]
4A1HX-ray2.20A/B/C1-132[»]
4A1YX-ray1.20A/B/C/D1-132[»]
4A8ZX-ray1.80A1-132[»]
4BVMX-ray0.93A1-132[»]
4D6AX-ray1.45A1-132[»]
4D6BX-ray2.12A1-132[»]
5N4MX-ray1.59A1-132[»]
5N4PX-ray1.53A1-132[»]
5N4QX-ray1.72A1-132[»]
6EW2X-ray1.59A1-132[»]
6EW4X-ray1.27A1-132[»]
6EW5X-ray1.95A/B/C/D1-132[»]
ProteinModelPortaliP02689
SMRiP02689
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111388, 7 interactors
IntActiP02689, 1 interactor
STRINGi9606.ENSP00000256103

Chemistry databases

ChEMBLiCHEMBL3826864
DrugBankiDB04147 Lauryl Dimethylamine-N-Oxide
DB04224 Oleic Acid
DB03796 Palmitic Acid
DB01915 S-Hydroxycysteine

PTM databases

iPTMnetiP02689
PhosphoSitePlusiP02689
SwissPalmiP02689

Polymorphism and mutation databases

BioMutaiPMP2
DMDMi127725

Proteomic databases

jPOSTiP02689
MaxQBiP02689
PaxDbiP02689
PeptideAtlasiP02689
PRIDEiP02689
ProteomicsDBi51553

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5375
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256103; ENSP00000256103; ENSG00000147588
GeneIDi5375
KEGGihsa:5375
UCSCiuc003ycb.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5375
DisGeNETi5375
EuPathDBiHostDB:ENSG00000147588.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PMP2
HGNCiHGNC:9117 PMP2
MalaCardsiPMP2
MIMi170715 gene
neXtProtiNX_P02689
OpenTargetsiENSG00000147588
Orphaneti476394 PMP2-related Charcot-Marie-Tooth disease type 1
PharmGKBiPA33443

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00940000160445
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP02689
OMAiMCNRFVG
OrthoDBi1417203at2759
PhylomeDBiP02689
TreeFamiTF316894

Miscellaneous databases

EvolutionaryTraceiP02689

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PMP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5375

Protein Ontology

More...
PROi
PR:P02689

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147588 Expressed in 174 organ(s), highest expression level in ventral tegmental area
CleanExiHS_PMP2
ExpressionAtlasiP02689 baseline and differential
GenevisibleiP02689 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR031256 Myelin_P2
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF64 PTHR11955:SF64, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02689
Secondary accession number(s): Q6FHL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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