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Entry version 178 (07 Apr 2021)
Sequence version 3 (23 Jan 2007)
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Protein

Myelin P2 protein

Gene

PMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in lipid transport protein in Schwann cells. May bind cholesterol.1 Publication

Miscellaneous

P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei107Fatty acid1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P02689

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin P2 protein
Alternative name(s):
Peripheral myelin protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PMP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9117, PMP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
170715, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02689

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000147588.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Charcot-Marie-Tooth disease, demyelinating, 1G (CMT1G)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1G is characterized by distal muscle weakness and atrophy with onset in the first or second decade.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08189743I → N in CMT1G. 2 PublicationsCorresponds to variant dbSNP:rs879253869EnsemblClinVar.1
Natural variantiVAR_08189851T → P in CMT1G. 1 PublicationCorresponds to variant dbSNP:rs1563518390EnsemblClinVar.1
Natural variantiVAR_08189952I → T in CMT1G. 2 PublicationsCorresponds to variant dbSNP:rs1563518388EnsemblClinVar.1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
5375

MalaCards human disease database

More...
MalaCardsi
PMP2
MIMi618279, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000147588

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
476394, PMP2-related Charcot-Marie-Tooth disease type 1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33443

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P02689, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3826864

Drug and drug target database

More...
DrugBanki
DB04147, Dodecyldimethylamine N-oxide
DB04224, Oleic Acid
DB03796, Palmitic Acid
DB01915, S-Hydroxycysteine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PMP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
127725

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000673882 – 132Myelin P2 proteinAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi118 ↔ 1251 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P02689

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P02689

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P02689

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02689

PeptideAtlas

More...
PeptideAtlasi
P02689

PRoteomics IDEntifications database

More...
PRIDEi
P02689

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51553

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02689

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02689

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P02689

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147588, Expressed in ventral tegmental area and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P02689, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02689, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000147588, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
111388, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P02689, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000256103

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P02689, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02689

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02689

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni127 – 129Fatty acid binding3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4015, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160445

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_113772_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02689

Identification of Orthologs from Complete Genome Data

More...
OMAi
VECKMKD

Database of Orthologous Groups

More...
OrthoDBi
1417203at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P02689

TreeFam database of animal gene trees

More...
TreeFami
TF316894

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012674, Calycin
IPR000463, Fatty_acid-bd
IPR031259, ILBP
IPR000566, Lipocln_cytosolic_FA-bd_dom
IPR031256, Myelin_P2

The PANTHER Classification System

More...
PANTHERi
PTHR11955, PTHR11955, 1 hit
PTHR11955:SF64, PTHR11955:SF64, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00061, Lipocalin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00178, FATTYACIDBP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50814, SSF50814, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00214, FABP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P02689-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNKFLGTWK LVSSENFDDY MKALGVGLAT RKLGNLAKPT VIISKKGDII
60 70 80 90 100
TIRTESTFKN TEISFKLGQE FEETTADNRK TKSIVTLQRG SLNQVQRWDG
110 120 130
KETTIKRKLV NGKMVAECKM KGVVCTRIYE KV
Length:132
Mass (Da):14,909
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D515D32695899D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RH45E5RH45_HUMAN
Myelin P2 protein
PMP2
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25G → GG AA sequence (PubMed:6183401).Curated1
Sequence conflicti99D → N AA sequence (PubMed:6183401).Curated1
Sequence conflicti111N → D AA sequence (PubMed:6183401).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08189743I → N in CMT1G. 2 PublicationsCorresponds to variant dbSNP:rs879253869EnsemblClinVar.1
Natural variantiVAR_08189851T → P in CMT1G. 1 PublicationCorresponds to variant dbSNP:rs1563518390EnsemblClinVar.1
Natural variantiVAR_08189952I → T in CMT1G. 2 PublicationsCorresponds to variant dbSNP:rs1563518388EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D16181 Genomic DNA Translation: BAA03726.1
X62167 mRNA Translation: CAA44096.1
AK311758 mRNA Translation: BAG34701.1
CR541649 mRNA Translation: CAG46450.1
CR541738 mRNA Translation: CAG46538.1
AC018616 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87090.1
BC034997 mRNA Translation: AAH34997.1
AH004648 Genomic DNA Translation: AAB32592.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6229.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JT0977, MPHU2

NCBI Reference Sequences

More...
RefSeqi
NP_002668.1, NM_002677.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000256103; ENSP00000256103; ENSG00000147588

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5375

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5375

UCSC genome browser

More...
UCSCi
uc003ycb.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16181 Genomic DNA Translation: BAA03726.1
X62167 mRNA Translation: CAA44096.1
AK311758 mRNA Translation: BAG34701.1
CR541649 mRNA Translation: CAG46450.1
CR541738 mRNA Translation: CAG46538.1
AC018616 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87090.1
BC034997 mRNA Translation: AAH34997.1
AH004648 Genomic DNA Translation: AAB32592.2
CCDSiCCDS6229.1
PIRiJT0977, MPHU2
RefSeqiNP_002668.1, NM_002677.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WUTX-ray1.85A1-132[»]
3NR3X-ray1.95A3-132[»]
4A1HX-ray2.20A/B/C1-132[»]
4A1YX-ray1.20A/B/C/D1-132[»]
4A8ZX-ray1.80A1-132[»]
4BVMX-ray0.93A1-132[»]
4D6AX-ray1.45A1-132[»]
4D6BX-ray2.12A1-132[»]
5N4MX-ray1.59A1-132[»]
5N4PX-ray1.53A1-132[»]
5N4QX-ray1.72A1-132[»]
6EW2X-ray1.59A1-132[»]
6EW4X-ray1.27A1-132[»]
6EW5X-ray1.95A/B/C/D1-132[»]
6S2MX-ray0.72A1-132[»]
6S2SX-ray0.86A1-132[»]
6STSX-ray3.00A/B1-132[»]
6XU5X-ray1.65A1-132[»]
6XU9X-ray2.70A1-132[»]
6XUAX-ray2.30B1-132[»]
6XUWX-ray2.31A1-132[»]
6XVQX-ray1.80A1-132[»]
6XVRX-ray2.00A1-132[»]
6XVSX-ray1.80A/B1-132[»]
6XVYX-ray1.80B/C/D/E1-132[»]
6XW9X-ray2.90A1-132[»]
SMRiP02689
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111388, 7 interactors
IntActiP02689, 3 interactors
STRINGi9606.ENSP00000256103

Chemistry databases

ChEMBLiCHEMBL3826864
DrugBankiDB04147, Dodecyldimethylamine N-oxide
DB04224, Oleic Acid
DB03796, Palmitic Acid
DB01915, S-Hydroxycysteine

PTM databases

iPTMnetiP02689
PhosphoSitePlusiP02689
SwissPalmiP02689

Genetic variation databases

BioMutaiPMP2
DMDMi127725

Proteomic databases

jPOSTiP02689
MassIVEiP02689
MaxQBiP02689
PaxDbiP02689
PeptideAtlasiP02689
PRIDEiP02689
ProteomicsDBi51553

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
25321, 166 antibodies

The DNASU plasmid repository

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DNASUi
5375

Genome annotation databases

EnsembliENST00000256103; ENSP00000256103; ENSG00000147588
GeneIDi5375
KEGGihsa:5375
UCSCiuc003ycb.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5375
DisGeNETi5375

GeneCards: human genes, protein and diseases

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GeneCardsi
PMP2
HGNCiHGNC:9117, PMP2
HPAiENSG00000147588, Tissue enriched (brain)
MalaCardsiPMP2
MIMi170715, gene
618279, phenotype
neXtProtiNX_P02689
OpenTargetsiENSG00000147588
Orphaneti476394, PMP2-related Charcot-Marie-Tooth disease type 1
PharmGKBiPA33443
VEuPathDBiHostDB:ENSG00000147588.6

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4015, Eukaryota
GeneTreeiENSGT00940000160445
HOGENOMiCLU_113772_0_0_1
InParanoidiP02689
OMAiVECKMKD
OrthoDBi1417203at2759
PhylomeDBiP02689
TreeFamiTF316894

Enzyme and pathway databases

PathwayCommonsiP02689

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
5375, 6 hits in 977 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PMP2, human
EvolutionaryTraceiP02689

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PMP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5375
PharosiP02689, Tbio

Protein Ontology

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PROi
PR:P02689
RNActiP02689, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000147588, Expressed in ventral tegmental area and 188 other tissues
ExpressionAtlasiP02689, baseline and differential
GenevisibleiP02689, HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674, Calycin
IPR000463, Fatty_acid-bd
IPR031259, ILBP
IPR000566, Lipocln_cytosolic_FA-bd_dom
IPR031256, Myelin_P2
PANTHERiPTHR11955, PTHR11955, 1 hit
PTHR11955:SF64, PTHR11955:SF64, 1 hit
PfamiView protein in Pfam
PF00061, Lipocalin, 1 hit
PRINTSiPR00178, FATTYACIDBP
SUPFAMiSSF50814, SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214, FABP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02689
Secondary accession number(s): Q6FHL4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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