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Protein

Myelin basic protein

Gene

Mbp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural constituent of myelin sheath Source: RGD

GO - Biological processi

  • aging Source: RGD
  • myelination Source: RGD
  • negative regulation of axonogenesis Source: RGD
  • response to fatty acid Source: RGD
  • response to mercury ion Source: RGD
  • response to progesterone Source: RGD
  • response to tumor necrosis factor Source: RGD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin basic protein
Short name:
MBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mbp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Rat genome database

More...
RGDi
3054 Mbp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Autoimmune encephalomyelitis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001589952 – 195Myelin basic proteinAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei8PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei15PhosphotyrosineCombined sources1
Modified residuei18PhosphothreonineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei21PhosphothreonineCombined sources1
Modified residuei26CitrullineBy similarity1
Modified residuei32CitrullineBy similarity1
Modified residuei36PhosphothreonineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei44Omega-N-methylarginineBy similarity1
Modified residuei50Omega-N-methylarginineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei92PhosphothreonineBy similarity1
Modified residuei94PhosphotyrosineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei104PhosphothreonineBy similarity1
Modified residuei119Phosphothreonine1 Publication1
Modified residuei122PhosphothreonineBy similarity1
Modified residuei127Deamidated glutamineBy similarity1
Modified residuei131Omega-N-methylarginine; alternate1 Publication1
Modified residuei131Symmetric dimethylarginine; alternate1 Publication1
Modified residuei139PhosphoserineBy similarity1
Modified residuei146N6-acetyllysineBy similarity1
Modified residuei154CitrullineBy similarity1
Modified residuei172Deamidated glutamineBy similarity1
Modified residuei184CitrullineBy similarity1
Modified residuei186PhosphoserineBy similarity1
Modified residuei190Phosphoserine; by UHMK1By similarity1
Modified residuei195CitrullineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

As in other animals, several charge isomers may be produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.2 Publications
Arg-131 was found to be 44% monomethylated and 11% symmetrically dimethylated.
Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.By similarity

Keywords - PTMi

Acetylation, Citrullination, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02688

PRoteomics IDEntifications database

More...
PRIDEi
P02688

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P02688

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02688

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P02688

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P02688

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P02688

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in both the central and the peripheral nervous system.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000016516 Expressed in 10 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P02688 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P02688 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q629764EBI-1638296,EBI-1638146

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
246698, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P02688, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000022303

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P02688

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P02688

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the myelin basic protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIUJ Eukaryota
ENOG4111PMJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014772

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293395

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG008347

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02688

KEGG Orthology (KO)

More...
KOi
K17269

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMASQKR

Database of Orthologous Groups

More...
OrthoDBi
872191at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000548 Myelin_BP

The PANTHER Classification System

More...
PANTHERi
PTHR11429 PTHR11429, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01669 Myelin_MBP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00212 MYELINMBP

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00569 MYELIN_MBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P02688-1) [UniParc]FASTAAdd to basket
Also known as: 21.5 kDa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASQKRPSQR HGSKYLATAS TMDHARHGFL PRHRDTGILD SIGRFFSGDR
60 70 80 90 100
GAPKRGSGKV PWLKQSRSPL PSHARSRPGL CHMYKDSHTR TTHYGSLPQK
110 120 130 140 150
SQRTQDENPV VHFFKNIVTP RTPPPSQGKG RGLSLSRFSW GAEGQKPGFG
160 170 180 190
YGGRASDYKS AHKGFKGAYD AQGTLSKIFK LGGRDSRSGS PMARR
Length:195
Mass (Da):21,502
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1A43933EC9D4CFF
GO
Isoform 2 (identifier: P02688-2) [UniParc]FASTAAdd to basket
Also known as: 18.5 kDa, MBP L

The sequence of this isoform differs from the canonical sequence as follows:
     60-85: Missing.

Show »
Length:169
Mass (Da):18,488
Checksum:iB2D67AB198FC7D11
GO
Isoform 3 (identifier: P02688-3) [UniParc]FASTAAdd to basket
Also known as: 17 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     141-181: Missing.

Show »
Length:154
Mass (Da):17,225
Checksum:iEFB722E97213E17A
GO
Isoform 4 (identifier: P02688-4) [UniParc]FASTAAdd to basket
Also known as: 14 kDa, MBP S, smaller myelin basic protein

The sequence of this isoform differs from the canonical sequence as follows:
     60-85: Missing.
     141-181: Missing.

Show »
Length:128
Mass (Da):14,211
Checksum:i2DAF033C19CF111C
GO
Isoform 5 (identifier: P02688-5) [UniParc]FASTAAdd to basket
Also known as: 17 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     60-85: Missing.
     130-140: Missing.

Show »
Length:158
Mass (Da):17,240
Checksum:i3256580242ECC3E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5XFW1Q5XFW1_RAT
Myelin basic protein
Mbp rCG_20541
197Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47 – 48SG → GS AA sequence (PubMed:4122324).Curated2
Sequence conflicti192M → I in CAA10804 (Ref. 1) Curated1
Sequence conflicti192M → I in CAA10805 (Ref. 1) Curated1
Sequence conflicti192M → I in CAA10806 (Ref. 1) Curated1
Sequence conflicti192M → I in CAA10807 (Ref. 1) Curated1
Sequence conflicti192M → I (PubMed:6194889).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00332160 – 85Missing in isoform 2, isoform 4 and isoform 5. 5 PublicationsAdd BLAST26
Alternative sequenceiVSP_025711130 – 140Missing in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_003322141 – 181Missing in isoform 3 and isoform 4. 4 PublicationsAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ132895 mRNA Translation: CAA10804.1
AJ132896 mRNA Translation: CAA10805.1
AJ132897 mRNA Translation: CAA10806.1
AJ132898 mRNA Translation: CAA10807.1
M25889 mRNA Translation: AAA41575.1
K00512 mRNA No translation available.
AF439750 mRNA Translation: AAL84189.1
BC094522 mRNA Translation: AAH94522.1
X72392 mRNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
B24351 MBRTS

NCBI Reference Sequences

More...
RefSeqi
NP_001020462.1, NM_001025291.1 [P02688-1]
NP_001020463.1, NM_001025292.1 [P02688-2]
NP_001020464.1, NM_001025293.1 [P02688-3]
NP_001020465.1, NM_001025294.1 [P02688-5]
NP_058722.1, NM_017026.2 [P02688-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.203146
Rn.63285

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000022280; ENSRNOP00000022280; ENSRNOG00000016516 [P02688-3]
ENSRNOT00000022303; ENSRNOP00000022303; ENSRNOG00000016516 [P02688-1]
ENSRNOT00000058295; ENSRNOP00000055097; ENSRNOG00000016516 [P02688-2]
ENSRNOT00000058296; ENSRNOP00000055098; ENSRNOG00000016516 [P02688-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24547

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:24547

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132895 mRNA Translation: CAA10804.1
AJ132896 mRNA Translation: CAA10805.1
AJ132897 mRNA Translation: CAA10806.1
AJ132898 mRNA Translation: CAA10807.1
M25889 mRNA Translation: AAA41575.1
K00512 mRNA No translation available.
AF439750 mRNA Translation: AAL84189.1
BC094522 mRNA Translation: AAH94522.1
X72392 mRNA No translation available.
PIRiB24351 MBRTS
RefSeqiNP_001020462.1, NM_001025291.1 [P02688-1]
NP_001020463.1, NM_001025292.1 [P02688-2]
NP_001020464.1, NM_001025293.1 [P02688-3]
NP_001020465.1, NM_001025294.1 [P02688-5]
NP_058722.1, NM_017026.2 [P02688-4]
UniGeneiRn.203146
Rn.63285

3D structure databases

ProteinModelPortaliP02688
SMRiP02688
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246698, 7 interactors
IntActiP02688, 2 interactors
STRINGi10116.ENSRNOP00000022303

PTM databases

CarbonylDBiP02688
iPTMnetiP02688
PhosphoSitePlusiP02688
SwissPalmiP02688

Proteomic databases

PaxDbiP02688
PRIDEiP02688

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022280; ENSRNOP00000022280; ENSRNOG00000016516 [P02688-3]
ENSRNOT00000022303; ENSRNOP00000022303; ENSRNOG00000016516 [P02688-1]
ENSRNOT00000058295; ENSRNOP00000055097; ENSRNOG00000016516 [P02688-2]
ENSRNOT00000058296; ENSRNOP00000055098; ENSRNOG00000016516 [P02688-5]
GeneIDi24547
KEGGirno:24547

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4155
RGDi3054 Mbp

Phylogenomic databases

eggNOGiENOG410IIUJ Eukaryota
ENOG4111PMJ LUCA
GeneTreeiENSGT00390000014772
HOGENOMiHOG000293395
HOVERGENiHBG008347
InParanoidiP02688
KOiK17269
OMAiLMASQKR
OrthoDBi872191at2759

Miscellaneous databases

PMAP-CutDBiP02688

Protein Ontology

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PROi
PR:P02688

Gene expression databases

BgeeiENSRNOG00000016516 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasiP02688 baseline and differential
GenevisibleiP02688 RN

Family and domain databases

InterProiView protein in InterPro
IPR000548 Myelin_BP
PANTHERiPTHR11429 PTHR11429, 1 hit
PfamiView protein in Pfam
PF01669 Myelin_MBP, 1 hit
PRINTSiPR00212 MYELINMBP
PROSITEiView protein in PROSITE
PS00569 MYELIN_MBP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBP_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02688
Secondary accession number(s): Q505J1
, Q8R4K6, Q9Z1J4, Q9Z1J5, Q9Z1J6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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