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Protein

Myelin basic protein

Gene

MBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calmodulin binding Source: CAFA
  • protease binding Source: Ensembl
  • structural constituent of myelin sheath Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P02686

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin basic protein
Short name:
MBP
Alternative name(s):
Myelin A1 protein
Myelin membrane encephalitogenic protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000197971.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6925 MBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
159430 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P02686

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).

Keywords - Diseasei

Autoimmune encephalomyelitis

Organism-specific databases

DisGeNET

More...
DisGeNETi
4155

Open Targets

More...
OpenTargetsi
ENSG00000197971

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30667

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MBP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001589901 – 304Myelin basic proteinAdd BLAST304
Isoform 3 (identifier: P02686-3)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
Isoform 4 (identifier: P02686-4)
Initiator methionineiRemoved1 Publication
Isoform 5 (identifier: P02686-5)
Initiator methionineiRemoved1 Publication
Isoform 6 (identifier: P02686-6)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei96PhosphoserineCombined sources1
Modified residuei141PhosphoserineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei148PhosphotyrosineBy similarity1
Modified residuei151PhosphothreonineBy similarity1
Modified residuei153PhosphoserineBy similarity1
Modified residuei154PhosphothreonineBy similarity1
Modified residuei159Citrulline; in form C81 Publication1
Modified residuei165Citrulline; in form C81 Publication1
Modified residuei167Citrulline1 Publication1
Modified residuei169PhosphothreonineBy similarity1
Modified residuei174PhosphoserineBy similarity1
Modified residuei177Omega-N-methylarginineBy similarity1
Modified residuei183Omega-N-methylarginineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Modified residuei199Citrulline1 Publication1
Modified residuei203PhosphotyrosineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei214PhosphothreonineBy similarity1
Modified residuei229PhosphothreonineBy similarity1
Modified residuei231Citrulline1 Publication1
Modified residuei232PhosphothreonineBy similarity1
Modified residuei237Deamidated glutamineBy similarity1
Modified residuei241Omega-N-methylarginine; alternate1 Publication1
Modified residuei241Symmetric dimethylarginine; alternate1 Publication1
Modified residuei249PhosphoserineBy similarity1
Modified residuei256Citrulline; in form C81 Publication1
Modified residuei264Citrulline; in form C82 Publications1
Modified residuei281Deamidated glutamineBy similarity1
Modified residuei293Citrulline; in form C81 Publication1
Modified residuei295PhosphoserineBy similarity1
Modified residuei296Citrulline1 Publication1
Modified residuei299Phosphoserine; by UHMK11 Publication1
Modified residuei303Citrulline1 Publication1
Modified residuei304Citrulline; in form C81 Publication1
Isoform 3 (identifier: P02686-3)
Modified residuei2N-acetylalanine1 Publication1
Isoform 4 (identifier: P02686-4)
Modified residuei2N-acetylalanine1 Publication1
Isoform 5 (identifier: P02686-5)
Modified residuei2N-acetylalanine1 Publication1
Isoform 6 (identifier: P02686-6)
Modified residuei2N-acetylalanine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.3 Publications
The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).
Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.
Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.

Keywords - PTMi

Acetylation, Citrullination, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P02686

MaxQB - The MaxQuant DataBase

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MaxQBi
P02686

PeptideAtlas

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PeptideAtlasi
P02686

PRoteomics IDEntifications database

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PRIDEi
P02686

ProteomicsDB human proteome resource

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ProteomicsDBi
51547
51548 [P02686-2]
51549 [P02686-3]
51550 [P02686-4]
51551 [P02686-5]
51552 [P02686-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02686

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P02686

SwissPalm database of S-palmitoylation events

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SwissPalmi
P02686

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P02686

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks and its relative proportion declines thereafter.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197971 Expressed in 237 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

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CleanExi
HS_MBP

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P02686 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P02686 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002300
HPA049222
HPA064368

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Isoform 3 exists as a homodimer.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110325, 89 interactors

Database of interacting proteins

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DIPi
DIP-36624N

Protein interaction database and analysis system

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IntActi
P02686, 18 interactors

Molecular INTeraction database

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MINTi
P02686

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of protein disorder

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DisProti
DP00236

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P02686

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P02686

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P02686

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni179 – 222Induces experimental autoimmune encephalomyelitis (EAE) 1Add BLAST44
Regioni246 – 256Induces experimental autoimmune encephalomyelitis (EAE) 2Add BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the myelin basic protein family.Curated

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00390000014772

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG008347

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P02686

KEGG Orthology (KO)

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KOi
K17269

Identification of Orthologs from Complete Genome Data

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OMAi
LMASQKR

Database of Orthologous Groups

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OrthoDBi
EOG091G11QQ

Database for complete collections of gene phylogenies

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PhylomeDBi
P02686

TreeFam database of animal gene trees

More...
TreeFami
TF333391

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000548 Myelin_BP

The PANTHER Classification System

More...
PANTHERi
PTHR11429 PTHR11429, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01669 Myelin_MBP, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00212 MYELINMBP

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00569 MYELIN_MBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P02686-1) [UniParc]FASTAAdd to basket
Also known as: Golli-MBP1, HOG7

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNHAGKREL NAEKASTNSE TNRGESEKKR NLGELSRTTS EDNEVFGEAD
60 70 80 90 100
ANQNNGTSSQ DTAVTDSKRT ADPKNAWQDA HPADPGSRPH LIRLFSRDAP
110 120 130 140 150
GREDNTFKDR PSESDELQTI QEDSAATSES LDVMASQKRP SQRHGSKYLA
160 170 180 190 200
TASTMDHARH GFLPRHRDTG ILDSIGRFFG GDRGAPKRGS GKDSHHPART
210 220 230 240 250
AHYGSLPQKS HGRTQDENPV VHFFKNIVTP RTPPPSQGKG RGLSLSRFSW
260 270 280 290 300
GAEGQRPGFG YGGRASDYKS AHKGFKGVDA QGTLSKIFKL GGRDSRSGSP

MARR
Length:304
Mass (Da):33,117
Last modified:October 18, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AD7305C1D5434C4
GO
Isoform 2 (identifier: P02686-2) [UniParc]FASTAAdd to basket
Also known as: Golli-MBP2, HOG5

The sequence of this isoform differs from the canonical sequence as follows:
     193-304: DSHHPARTAH...SRSGSPMARR → VSSEE

Show »
Length:197
Mass (Da):21,522
Checksum:i0B2F47BA214706F2
GO
Isoform 3 (identifier: P02686-3) [UniParc]FASTAAdd to basket
Also known as: MBP1, 21.5 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     192-192: K → KVPWLKPGRSPLPSHARSQPGLCNMYK

Note: Contains a non-traditional PY nuclear localization signal. Mutagenesis of Cys-81 to Ser prevents dimerization.1 Publication
Show »
Length:197
Mass (Da):21,493
Checksum:i230FD99ECEC75FC5
GO
Isoform 4 (identifier: P02686-4) [UniParc]FASTAAdd to basket
Also known as: MBP2, 20.2 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     192-192: K → KVPWLKPGRSPLPSHARSQPGLCNMYK
     240-250: Missing.

Show »
Length:186
Mass (Da):20,246
Checksum:i6CCF96DD90FE1CEB
GO
Isoform 5 (identifier: P02686-5) [UniParc]FASTAAdd to basket
Also known as: MBP3, 18.5 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Show »
Length:171
Mass (Da):18,591
Checksum:i8E73B56787611054
GO
Isoform 6 (identifier: P02686-6) [UniParc]FASTAAdd to basket
Also known as: MBP4, 17.2 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     240-250: Missing.

Show »
Length:160
Mass (Da):17,343
Checksum:i0107AAD603FCD876
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQK6J3QQK6_HUMAN
Myelin basic protein
MBP
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MZH3A8MZH3_HUMAN
Myelin basic protein
MBP
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYR8H7BYR8_HUMAN
Myelin basic protein
MBP
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6H1C9J6H1_HUMAN
Myelin basic protein
MBP
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF02H0YF02_HUMAN
Myelin basic protein
MBP
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEU6F8WEU6_HUMAN
Myelin basic protein
MBP
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKL5J3QKL5_HUMAN
Myelin basic protein
MBP
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7N4F5H7N4_HUMAN
Myelin basic protein
MBP
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEA2H0YEA2_HUMAN
Myelin basic protein
MBP
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ72E9PJ72_HUMAN
Myelin basic protein
MBP
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC41944 differs from that shown. Contaminating sequence. The C-terminus contains a Histidine tag.Curated
The sequence BAD92223 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH10359 differs from that shown. wrong intron-exon boundaries.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti300P → T in CAG38771 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0033081 – 133Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 7 PublicationsAdd BLAST133
Alternative sequenceiVSP_003309192K → KVPWLKPGRSPLPSHARSQP GLCNMYK in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_003311193 – 304DSHHP…PMARR → VSSEE in isoform 2. 2 PublicationsAdd BLAST112
Alternative sequenceiVSP_003310240 – 250Missing in isoform 4 and isoform 6. 4 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M30047 mRNA Translation: AAA59559.1
M20009 mRNA Translation: AAA59561.1
M13577 mRNA Translation: AAA59562.1
M30516 mRNA Translation: AAA59563.1
M30515 mRNA Translation: AAA59564.1
X17286
, X17287, X17290, X17288, X17369, X17289 Genomic DNA Translation: CAA35179.1
L18862 Genomic DNA Translation: AAA72008.1
L18864 Genomic DNA Translation: AAA72009.1
L18865 Genomic DNA Translation: AAA72010.1
L18866 Genomic DNA Translation: AAA72011.1
L41657 Genomic DNA Translation: AAC41944.1 Sequence problems.
CR536534 mRNA Translation: CAG38771.1
CR541919 mRNA Translation: CAG46717.1
CR627018 mRNA Translation: CAH10359.1 Sequence problems.
AK128770 mRNA Translation: BAG54728.1
AK128788 mRNA Translation: BAG54734.1
AB208986 mRNA Translation: BAD92223.1 Different initiation.
AC018529 Genomic DNA No translation available.
AC093330 Genomic DNA No translation available.
BC008749 mRNA Translation: AAH08749.3
BC065248 mRNA Translation: AAH65248.1
BC080654 mRNA Translation: AAH80654.1
BC101771 mRNA Translation: AAI01772.1
BC101773 mRNA Translation: AAI01774.1
BC143348 mRNA Translation: AAI43349.1
BC143350 mRNA Translation: AAI43351.1
M63599 Genomic DNA Translation: AAA59560.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12011.1 [P02686-4]
CCDS32847.1 [P02686-3]
CCDS42448.1 [P02686-6]
CCDS42449.1 [P02686-5]
CCDS42450.1 [P02686-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A49635
S10482 MBHUB

NCBI Reference Sequences

More...
RefSeqi
NP_001020252.1, NM_001025081.1 [P02686-3]
NP_001020261.1, NM_001025090.1 [P02686-5]
NP_001020263.1, NM_001025092.1 [P02686-6]
NP_001020271.1, NM_001025100.1 [P02686-2]
NP_001020272.1, NM_001025101.1 [P02686-1]
NP_002376.1, NM_002385.2 [P02686-4]
XP_016881269.1, XM_017025780.1 [P02686-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.551713

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355994; ENSP00000348273; ENSG00000197971 [P02686-1]
ENST00000359645; ENSP00000352667; ENSG00000197971 [P02686-4]
ENST00000382582; ENSP00000372025; ENSG00000197971 [P02686-3]
ENST00000397860; ENSP00000380958; ENSG00000197971 [P02686-2]
ENST00000397863; ENSP00000380961; ENSG00000197971 [P02686-2]
ENST00000397865; ENSP00000380963; ENSG00000197971 [P02686-6]
ENST00000397866; ENSP00000380964; ENSG00000197971 [P02686-5]
ENST00000580402; ENSP00000462223; ENSG00000197971 [P02686-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4155

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4155

UCSC genome browser

More...
UCSCi
uc002lml.4 human [P02686-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Myelin basic protein entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30047 mRNA Translation: AAA59559.1
M20009 mRNA Translation: AAA59561.1
M13577 mRNA Translation: AAA59562.1
M30516 mRNA Translation: AAA59563.1
M30515 mRNA Translation: AAA59564.1
X17286
, X17287, X17290, X17288, X17369, X17289 Genomic DNA Translation: CAA35179.1
L18862 Genomic DNA Translation: AAA72008.1
L18864 Genomic DNA Translation: AAA72009.1
L18865 Genomic DNA Translation: AAA72010.1
L18866 Genomic DNA Translation: AAA72011.1
L41657 Genomic DNA Translation: AAC41944.1 Sequence problems.
CR536534 mRNA Translation: CAG38771.1
CR541919 mRNA Translation: CAG46717.1
CR627018 mRNA Translation: CAH10359.1 Sequence problems.
AK128770 mRNA Translation: BAG54728.1
AK128788 mRNA Translation: BAG54734.1
AB208986 mRNA Translation: BAD92223.1 Different initiation.
AC018529 Genomic DNA No translation available.
AC093330 Genomic DNA No translation available.
BC008749 mRNA Translation: AAH08749.3
BC065248 mRNA Translation: AAH65248.1
BC080654 mRNA Translation: AAH80654.1
BC101771 mRNA Translation: AAI01772.1
BC101773 mRNA Translation: AAI01774.1
BC143348 mRNA Translation: AAI43349.1
BC143350 mRNA Translation: AAI43351.1
M63599 Genomic DNA Translation: AAA59560.1
CCDSiCCDS12011.1 [P02686-4]
CCDS32847.1 [P02686-3]
CCDS42448.1 [P02686-6]
CCDS42449.1 [P02686-5]
CCDS42450.1 [P02686-2]
PIRiA49635
S10482 MBHUB
RefSeqiNP_001020252.1, NM_001025081.1 [P02686-3]
NP_001020261.1, NM_001025090.1 [P02686-5]
NP_001020263.1, NM_001025092.1 [P02686-6]
NP_001020271.1, NM_001025100.1 [P02686-2]
NP_001020272.1, NM_001025101.1 [P02686-1]
NP_002376.1, NM_002385.2 [P02686-4]
XP_016881269.1, XM_017025780.1 [P02686-2]
UniGeneiHs.551713

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BX2X-ray2.60C/F217-231[»]
1FV1X-ray1.90C/F218-237[»]
1HQRX-ray3.20C221-233[»]
1K2DX-ray2.20P135-144[»]
1QCLmodel-A135-304[»]
1YMMX-ray3.50C217-240[»]
1ZGLX-ray2.80C/F/I/L221-233[»]
DisProtiDP00236
ProteinModelPortaliP02686
SMRiP02686
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110325, 89 interactors
DIPiDIP-36624N
IntActiP02686, 18 interactors
MINTiP02686

PTM databases

iPTMnetiP02686
PhosphoSitePlusiP02686
SwissPalmiP02686

Polymorphism and mutation databases

BioMutaiMBP

Proteomic databases

EPDiP02686
MaxQBiP02686
PeptideAtlasiP02686
PRIDEiP02686
ProteomicsDBi51547
51548 [P02686-2]
51549 [P02686-3]
51550 [P02686-4]
51551 [P02686-5]
51552 [P02686-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4155
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355994; ENSP00000348273; ENSG00000197971 [P02686-1]
ENST00000359645; ENSP00000352667; ENSG00000197971 [P02686-4]
ENST00000382582; ENSP00000372025; ENSG00000197971 [P02686-3]
ENST00000397860; ENSP00000380958; ENSG00000197971 [P02686-2]
ENST00000397863; ENSP00000380961; ENSG00000197971 [P02686-2]
ENST00000397865; ENSP00000380963; ENSG00000197971 [P02686-6]
ENST00000397866; ENSP00000380964; ENSG00000197971 [P02686-5]
ENST00000580402; ENSP00000462223; ENSG00000197971 [P02686-1]
GeneIDi4155
KEGGihsa:4155
UCSCiuc002lml.4 human [P02686-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4155
DisGeNETi4155
EuPathDBiHostDB:ENSG00000197971.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MBP
HGNCiHGNC:6925 MBP
HPAiCAB002300
HPA049222
HPA064368
MIMi159430 gene
neXtProtiNX_P02686
OpenTargetsiENSG00000197971
PharmGKBiPA30667

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000014772
HOVERGENiHBG008347
InParanoidiP02686
KOiK17269
OMAiLMASQKR
OrthoDBiEOG091G11QQ
PhylomeDBiP02686
TreeFamiTF333391

Enzyme and pathway databases

SIGNORiP02686

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MBP human
EvolutionaryTraceiP02686

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Myelin_basic_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4155
PMAP-CutDBiP02686

Protein Ontology

More...
PROi
PR:P02686

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197971 Expressed in 237 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_MBP
ExpressionAtlasiP02686 baseline and differential
GenevisibleiP02686 HS

Family and domain databases

InterProiView protein in InterPro
IPR000548 Myelin_BP
PANTHERiPTHR11429 PTHR11429, 1 hit
PfamiView protein in Pfam
PF01669 Myelin_MBP, 1 hit
PRINTSiPR00212 MYELINMBP
PROSITEiView protein in PROSITE
PS00569 MYELIN_MBP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02686
Secondary accession number(s): A4FU54
, A6NI84, A8MY86, A8MYL4, B3KY66, B7ZKS2, B7ZKS4, Q15337, Q15338, Q15339, Q15340, Q59GX3, Q65ZS4, Q6AI64, Q6FH37, Q6FI04, Q6PK23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 18, 2001
Last modified: November 7, 2018
This is version 211 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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