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UniProtKB - P02680 (FIBG_RAT)

Entry version 158 (02 Dec 2020)
Sequence version 3 (09 Jan 2007)
Previous versions | rss
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Protein

Fibrinogen gamma chain

Gene

Fgg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi344CalciumBy similarity1
Metal bindingi346CalciumBy similarity1
Metal bindingi350Calcium; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-114608, Platelet degranulation
R-RNO-140875, Common Pathway of Fibrin Clot Formation
R-RNO-216083, Integrin cell surface interactions
R-RNO-354192, Integrin signaling
R-RNO-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins
R-RNO-372708, p130Cas linkage to MAPK signaling for integrins
R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-5674135, MAP2K and MAPK activation
R-RNO-8957275, Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibrinogen gamma chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fgg
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...RGDi		2613, Fgg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Add BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000910126 – 445Fibrinogen gamma chainAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi35Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi45Interchain (with beta chain)PROSITE-ProRule annotation
Disulfide bondi49Interchain (with alpha chain)PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161Interchain (with beta chain)PROSITE-ProRule annotation
Disulfide bondi165Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi179 ↔ 208PROSITE-ProRule annotation
Disulfide bondi352 ↔ 365PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki424Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-432)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei431PhosphoserineCombined sources1
Cross-linki432Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-424)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P02680

PRoteomics IDEntifications database

More...PRIDEi		P02680

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P02680, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P02680

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P02680

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000025074, Expressed in liver and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P02680, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		246539, 1 interactor

Protein interaction database and analysis system

More...IntActi		P02680, 2 interactors

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000032735

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P02680

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini170 – 416Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST247

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni400 – 422Gamma-chain polymerization, binding amino end of another fibrin alpha chainBy similarityAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.By similarity

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2579, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158467

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_038628_13_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P02680

Identification of Orthologs from Complete Genome Data

More...OMAi		MNRCHAG

Database of Orthologous Groups

More...OrthoDBi		523014at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P02680

TreeFam database of animal gene trees

More...TreeFami		TF336658

Family and domain databases

Conserved Domains Database

More...CDDi		cd00087, FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.215.10, 1 hit
4.10.530.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036056, Fibrinogen-like_C
IPR014716, Fibrinogen_a/b/g_C_1
IPR014715, Fibrinogen_a/b/g_C_2
IPR002181, Fibrinogen_a/b/g_C_dom
IPR012290, Fibrinogen_a/b/g_coil_dom
IPR020837, Fibrinogen_CS
IPR037581, Fibrinogen_gamma

The PANTHER Classification System

More...PANTHERi		PTHR19143:SF338, PTHR19143:SF338, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08702, Fib_alpha, 1 hit
PF00147, Fibrinogen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00186, FBG, 1 hit
SM01212, Fib_alpha, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56496, SSF56496, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00514, FIBRINOGEN_C_1, 1 hit
PS51406, FIBRINOGEN_C_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Gamma-B (identifier: P02680-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNWSLQLRSF ILCWALLLLS PTGLAQYTAT RDNCCILDER FGSYCPTTCG 
        60         70         80         90        100
ISDFLNSYQT DVDTDLQTLE NILQRAENRT TEAKELIKAI QVYYNPDQPP 
       110        120        130        140        150
KPGMIEGATQ KSKKMVEEIL KYEALLLTHE SSIRYLQDIY TSNKQKITNL 
       160        170        180        190        200
KQKVAQLEAQ CQEPCKDSVR IHDTTGKDCQ DIANKGAKES GLYFIRPLKA 
       210        220        230        240        250
TQQFLVYCEI DGSGNGWTVL QKRLDGSVDF KKNWIQYKEG FGHLSPTGTT 
       260        270        280        290        300
EFWLGNEKIH LISMQSTIPY ALRIQLKDWS GRTSTADYAM FRVGPESDKY 
       310        320        330        340        350
RLTYAYFIGG DAGDAFDGYD FGDDPSDKFF TSHNGMHFST WDNDNDKFEG 
       360        370        380        390        400
NCAEQDGSGW WMNKCHAGHL NGVYYQGGTY SKSSTPNGYD NGIIWATWKT 
       410        420        430        440 
RWYSMKETTM KIIPFNRLSI GDGQQHHMGG SKQVSVEHEV DVEYP
Length:445
Mass (Da):50,633
Last modified:January 9, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB6F4FF7A7812054
GO
Isoform Gamma-A (identifier: P02680-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-437: SVE → GDM
     438-445: Missing.

Show »
Length:437
Mass (Da):49,652
Checksum:iDB58661DF73A0C06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti160Q → L in J00734 (PubMed:6897622).Curated1
Sequence conflicti160Q → L in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti162Q → K in J00734 (PubMed:6897622).Curated1
Sequence conflicti172 – 174HDT → YDI in J00734 (PubMed:6897622).Curated3
Sequence conflicti172 – 174HDT → YDI in CAA29289 (PubMed:3562236).Curated3
Sequence conflicti182I → T in J00734 (PubMed:6897622).Curated1
Sequence conflicti182I → T in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti194F → S in J00734 (PubMed:6897622).Curated1
Sequence conflicti194F → S in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti202Q → E in J00734 (PubMed:6897622).Curated1
Sequence conflicti202Q → E in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti204F → S in J00734 (PubMed:6897622).Curated1
Sequence conflicti210I → T in J00734 (PubMed:6897622).Curated1
Sequence conflicti210I → T in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti213S → P in J00734 (PubMed:6897622).Curated1
Sequence conflicti213S → P in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti219 – 221VLQ → EFK in J00734 (PubMed:6897622).Curated3
Sequence conflicti219 – 221VLQ → EFK in CAA29289 (PubMed:3562236).Curated3
Sequence conflicti231K → L in J00734 (PubMed:6897622).Curated1
Sequence conflicti231K → L in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti259I → N in J00734 (PubMed:6897622).Curated1
Sequence conflicti259I → N in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti296E → G in J00734 (PubMed:6897622).Curated1
Sequence conflicti373V → G in J00735 (PubMed:6897622).Curated1
Sequence conflicti401R → S in J00735 (PubMed:6897622).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001538435 – 437SVE → GDM in isoform Gamma-A. 2 Publications3
Alternative sequenceiVSP_001539438 – 445Missing in isoform Gamma-A. 2 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J00733 Genomic DNA No translation available.
J00734 mRNA No translation available.
J00735 mRNA No translation available.
X05860, X05861 Genomic DNA Translation: CAA29289.1
BC078893 mRNA Translation: AAH78893.1
K01337 Genomic DNA Translation: AAA98626.1

Protein sequence database of the Protein Information Resource

More...PIRi		A03128, FGRTGB
A90828, FGRTGA

NCBI Reference Sequences

More...RefSeqi		NP_036691.2, NM_012559.2 [P02680-2]
XP_006232587.1, XM_006232525.1 [P02680-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000034521; ENSRNOP00000032735; ENSRNOG00000025074 [P02680-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		24367

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:24367

UCSC genome browser

More...UCSCi		RGD:2613, rat [P02680-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00733 Genomic DNA No translation available.
J00734 mRNA No translation available.
J00735 mRNA No translation available.
X05860, X05861 Genomic DNA Translation: CAA29289.1
BC078893 mRNA Translation: AAH78893.1
K01337 Genomic DNA Translation: AAA98626.1
PIRiA03128, FGRTGB
A90828, FGRTGA
RefSeqiNP_036691.2, NM_012559.2 [P02680-2]
XP_006232587.1, XM_006232525.1 [P02680-1]

3D structure databases

SMRiP02680
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi246539, 1 interactor
IntActiP02680, 2 interactors
STRINGi10116.ENSRNOP00000032735

PTM databases

GlyGeniP02680, 1 site
iPTMnetiP02680
PhosphoSitePlusiP02680

Proteomic databases

PaxDbiP02680
PRIDEiP02680

Genome annotation databases

EnsembliENSRNOT00000034521; ENSRNOP00000032735; ENSRNOG00000025074 [P02680-2]
GeneIDi24367
KEGGirno:24367
UCSCiRGD:2613, rat [P02680-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2266
RGDi2613, Fgg

Phylogenomic databases

eggNOGiKOG2579, Eukaryota
GeneTreeiENSGT00940000158467
HOGENOMiCLU_038628_13_0_1
InParanoidiP02680
OMAiMNRCHAG
OrthoDBi523014at2759
PhylomeDBiP02680
TreeFamiTF336658

Enzyme and pathway databases

ReactomeiR-RNO-114608, Platelet degranulation
R-RNO-140875, Common Pathway of Fibrin Clot Formation
R-RNO-216083, Integrin cell surface interactions
R-RNO-354192, Integrin signaling
R-RNO-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins
R-RNO-372708, p130Cas linkage to MAPK signaling for integrins
R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-5674135, MAP2K and MAPK activation
R-RNO-8957275, Post-translational protein phosphorylation

Miscellaneous databases

Protein Ontology

More...PROi		PR:P02680

Gene expression databases

BgeeiENSRNOG00000025074, Expressed in liver and 20 other tissues
GenevisibleiP02680, RN

Family and domain databases

CDDicd00087, FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR036056, Fibrinogen-like_C
IPR014716, Fibrinogen_a/b/g_C_1
IPR014715, Fibrinogen_a/b/g_C_2
IPR002181, Fibrinogen_a/b/g_C_dom
IPR012290, Fibrinogen_a/b/g_coil_dom
IPR020837, Fibrinogen_CS
IPR037581, Fibrinogen_gamma
PANTHERiPTHR19143:SF338, PTHR19143:SF338, 1 hit
PfamiView protein in Pfam
PF08702, Fib_alpha, 1 hit
PF00147, Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186, FBG, 1 hit
SM01212, Fib_alpha, 1 hit
SUPFAMiSSF56496, SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514, FIBRINOGEN_C_1, 1 hit
PS51406, FIBRINOGEN_C_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFIBG_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02680
Secondary accession number(s): Q68FY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 9, 2007
Last modified: December 2, 2020
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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