UniProtKB - P02679 (FIBG_HUMAN)
Fibrinogen gamma chain
FGG
Functioni
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 344 | CalciumCombined sources6 Publications | 1 | |
Metal bindingi | 346 | CalciumCombined sources6 Publications | 1 | |
Metal bindingi | 348 | Calcium; via carbonyl oxygenCombined sources6 Publications | 1 | |
Metal bindingi | 350 | Calcium; via carbonyl oxygenCombined sources6 Publications | 1 |
GO - Molecular functioni
- cell adhesion molecule binding Source: BHF-UCL
- extracellular matrix structural constituent Source: BHF-UCL
- identical protein binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- signaling receptor binding Source: BHF-UCL
- structural molecule activity Source: BHF-UCL
GO - Biological processi
- blood coagulation Source: Reactome
- blood coagulation, fibrin clot formation Source: UniProtKB
- cell-matrix adhesion Source: BHF-UCL
- cellular protein-containing complex assembly Source: BHF-UCL
- cellular protein metabolic process Source: Reactome
- cellular response to interleukin-1 Source: Ensembl
- cellular response to interleukin-6 Source: Ensembl
- extracellular matrix organization Source: Reactome
- fibrinolysis Source: UniProtKB
- negative regulation of endothelial cell apoptotic process Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
- negative regulation of platelet aggregation Source: Ensembl
- plasminogen activation Source: UniProtKB
- platelet aggregation Source: BHF-UCL
- platelet degranulation Source: Reactome
- platelet maturation Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- positive regulation of exocytosis Source: BHF-UCL
- positive regulation of heterotypic cell-cell adhesion Source: BHF-UCL
- positive regulation of peptide hormone secretion Source: BHF-UCL
- positive regulation of protein secretion Source: BHF-UCL
- positive regulation of substrate adhesion-dependent cell spreading Source: BHF-UCL
- positive regulation of vasoconstriction Source: BHF-UCL
- post-translational protein modification Source: Reactome
- protein polymerization Source: BHF-UCL
- protein secretion Source: UniProtKB
- response to calcium ion Source: BHF-UCL
- toll-like receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Blood coagulation, Hemostasis |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P02679 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-216083, Integrin cell surface interactions R-HSA-354192, Integrin signaling R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708, p130Cas linkage to MAPK signaling for integrins R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5674135, MAP2K and MAPK activation R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SIGNORi | P02679 |
Names & Taxonomyi
Protein namesi | Recommended name: Fibrinogen gamma chain |
Gene namesi | Name:FGG ORF Names:PRO2061 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171557.16 |
HGNCi | HGNC:3694, FGG |
MIMi | 134850, gene |
neXtProti | NX_P02679 |
Subcellular locationi
Extracellular region or secreted
- Secreted 3 Publications
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
- fibrinogen complex Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: BHF-UCL
- plasma membrane Source: Reactome
Other locations
- cell surface Source: BHF-UCL
- platelet alpha granule Source: BHF-UCL
- platelet alpha granule lumen Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Congenital afibrinogenemia (CAFBN)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072726 | 303 | T → P in CAFBN; hypofibrinogenemia; heterozygous; no effect on fibrinogen complex assembly; impaired fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_072727 | 327 | D → H in CAFBN; hypofibrinogenemia; heterozygous; no effect on fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_072728 | 345 | N → D in CAFBN; hypofibrinogenemia; heterozygous; no effect on fibrinogen complex assembly; decreased fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_072729 | 401 | R → W in CAFBN; hypofibrinogenemia; heterozygous. 1 PublicationCorresponds to variant dbSNP:rs75848804EnsemblClinVar. | 1 |
Dysfibrinogenemia, congenital (DYSFIBRIN)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002410 | 301 | R → H in DYSFIBRIN; fibrinogen Bergamo-2/Essen/Haifa/Osaka-3/Perugia/Saga/Barcelona-3/Barcelona-4. 4 PublicationsCorresponds to variant dbSNP:rs121913088EnsemblClinVar. | 1 | |
Natural variantiVAR_002411 | 318 | G → V in DYSFIBRIN; fibrinogen Baltimore-1; impaired polymerization. 1 PublicationCorresponds to variant dbSNP:rs121913089EnsemblClinVar. | 1 | |
Natural variantiVAR_002418 | 356 | D → V in DYSFIBRIN; fibrinogen Milano-1; impaired polymerization. 1 PublicationCorresponds to variant dbSNP:rs121913094EnsemblClinVar. | 1 | |
Natural variantiVAR_072621 | 404 | S → P in DYSFIBRIN; fibrinogen Philadelphia. 1 PublicationCorresponds to variant dbSNP:rs587777720EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 2266 |
MalaCardsi | FGG |
MIMi | 202400, phenotype 616004, phenotype |
OpenTargetsi | ENSG00000171557 |
Orphaneti | 98880, Familial afibrinogenemia 98881, Familial dysfibrinogenemia 248408, Familial hypodysfibrinogenemia 101041, Familial hypofibrinogenemia |
PharmGKBi | PA430 |
Miscellaneous databases
Pharosi | P02679, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364709 |
DrugBanki | DB11571, Human thrombin DB00364, Sucralfate DB11300, Thrombin DB11572, Thrombin alfa |
Polymorphism and mutation databases
BioMutai | FGG |
DMDMi | 20178280 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 2 PublicationsAdd BLAST | 26 | |
ChainiPRO_0000009099 | 27 – 453 | Fibrinogen gamma chainAdd BLAST | 427 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 | Interchain (with C-35)Combined sources1 Publication | ||
Disulfide bondi | 35 | Interchain (with C-34)Combined sources1 Publication | ||
Disulfide bondi | 45 | Interchain (with C-110 in beta chain)1 Publication | ||
Disulfide bondi | 49 | Interchain (with C-64 in alpha chain)1 Publication | ||
Modified residuei | 68 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 78 | N-linked (GlcNAc...) (complex) asparagine6 Publications | 1 | |
Disulfide bondi | 161 | Interchain (with C-227 in beta chain)1 Publication | ||
Disulfide bondi | 165 | Interchain (with C-180 in alpha chain)1 Publication | ||
Disulfide bondi | 179 ↔ 208 | Combined sources6 Publications | ||
Glycosylationi | 334 | N-linked (GlcNAc...) asparagine; in variant Asahi | 1 | |
Disulfide bondi | 352 ↔ 365 | Combined sources6 Publications | ||
Cross-linki | 424 | Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-432) | ||
Cross-linki | 432 | Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-424) | ||
Modified residuei | 444 | Sulfotyrosine1 Publication | 1 | |
Modified residuei | 448 | Sulfotyrosine1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 84 – 85 | Cleavage; by plasmin; to break down fibrin clots | 2 | |
Sitei | 88 – 89 | Cleavage; by plasmin; to break down fibrin clots | 2 | |
Sitei | 102 – 103 | Cleavage; by hementin; to prevent blood coagulation | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, SulfationProteomic databases
CPTACi | non-CPTAC-1121 |
jPOSTi | P02679 |
MassIVEi | P02679 |
MaxQBi | P02679 |
PaxDbi | P02679 |
PeptideAtlasi | P02679 |
PRIDEi | P02679 |
ProteomicsDBi | 51545 [P02679-1] 51546 [P02679-2] |
2D gel databases
DOSAC-COBS-2DPAGEi | P02679 |
OGPi | P02679 |
REPRODUCTION-2DPAGEi | IPI00219713 P02679 |
SWISS-2DPAGEi | P02679 |
PTM databases
CarbonylDBi | P02679 |
GlyConnecti | 157, 4 N-Linked glycans 160, 12 N-Linked glycans (1 site), 1 O-Linked glycan (1 site) |
GlyGeni | P02679, 4 sites, 14 N-linked glycans (1 site) |
iPTMneti | P02679 |
PhosphoSitePlusi | P02679 |
UniCarbKBi | P02679 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000171557, Expressed in liver and 118 other tissues |
ExpressionAtlasi | P02679, baseline and differential |
Genevisiblei | P02679, HS |
Organism-specific databases
HPAi | ENSG00000171557, Tissue enriched (liver) |
Interactioni
Subunit structurei
Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
7 PublicationsBinary interactionsi
P02679
With | #Exp. | IntAct |
---|---|---|
gapA [P75358] from Mycoplasma pneumoniae (strain ATCC 29342 / M129). | 2 | EBI-1034422,EBI-2259469 |
GO - Molecular functioni
- cell adhesion molecule binding Source: BHF-UCL
- identical protein binding Source: Ensembl
- signaling receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 108557, 29 interactors |
ComplexPortali | CPX-1922, Fibrinogen |
CORUMi | P02679 |
DIPi | DIP-29644N |
IntActi | P02679, 29 interactors |
MINTi | P02679 |
STRINGi | 9606.ENSP00000336829 |
Miscellaneous databases
RNActi | P02679, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P02679 |
SMRi | P02679 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02679 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 170 – 416 | Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST | 247 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 400 – 422 | Gamma-chain polymerization, binding amino end of another fibrin alpha chainAdd BLAST | 23 | |
Regioni | 423 – 437 | Platelet aggregation and Staphylococcus clumpingAdd BLAST | 15 |
Domaini
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000158467 |
HOGENOMi | CLU_038628_13_0_1 |
InParanoidi | P02679 |
OrthoDBi | 751651at2759 |
PhylomeDBi | P02679 |
TreeFami | TF336658 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit 4.10.530.10, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR014715, Fibrinogen_a/b/g_C_2 IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR020837, Fibrinogen_CS IPR037581, Fibrinogen_gamma |
PANTHERi | PTHR19143:SF338, PTHR19143:SF338, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSWSLHPRNL ILYFYALLFL SSTCVAYVAT RDNCCILDER FGSYCPTTCG
60 70 80 90 100
IADFLSTYQT KVDKDLQSLE DILHQVENKT SEVKQLIKAI QLTYNPDESS
110 120 130 140 150
KPNMIDAATL KSRKMLEEIM KYEASILTHD SSIRYLQEIY NSNNQKIVNL
160 170 180 190 200
KEKVAQLEAQ CQEPCKDTVQ IHDITGKDCQ DIANKGAKQS GLYFIKPLKA
210 220 230 240 250
NQQFLVYCEI DGSGNGWTVF QKRLDGSVDF KKNWIQYKEG FGHLSPTGTT
260 270 280 290 300
EFWLGNEKIH LISTQSAIPY ALRVELEDWN GRTSTADYAM FKVGPEADKY
310 320 330 340 350
RLTYAYFAGG DAGDAFDGFD FGDDPSDKFF TSHNGMQFST WDNDNDKFEG
360 370 380 390 400
NCAEQDGSGW WMNKCHAGHL NGVYYQGGTY SKASTPNGYD NGIIWATWKT
410 420 430 440 450
RWYSMKKTTM KIIPFNRLTI GEGQQHHLGG AKQVRPEHPA ETEYDSLYPE
DDL
The sequence of this isoform differs from the canonical sequence as follows:
434-453: VRPEHPAETEYDSLYPEDDL → AGDV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JC84 | C9JC84_HUMAN | Fibrinogen gamma chain | FGG | 461 | Annotation score: | ||
C9JEU5 | C9JEU5_HUMAN | Fibrinogen gamma chain | FGG | 445 | Annotation score: | ||
C9JU00 | C9JU00_HUMAN | Fibrinogen gamma chain | FGG | 123 | Annotation score: | ||
C9JPQ9 | C9JPQ9_HUMAN | Fibrinogen gamma chain | FGG | 119 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 | K → I in AAB59530 (PubMed:2990550).Curated | 1 | |
Sequence conflicti | 114 | K → I in AAB59531 (PubMed:2990550).Curated | 1 | |
Sequence conflicti | 435 | R → Y AA sequence (PubMed:7306501).Curated | 1 | |
Sequence conflicti | 448 | Y → R AA sequence (PubMed:7306501).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049066 | 77 | E → G. Corresponds to variant dbSNP:rs11551835Ensembl. | 1 | |
Natural variantiVAR_033930 | 140 | Y → H1 PublicationCorresponds to variant dbSNP:rs2066870EnsemblClinVar. | 1 | |
Natural variantiVAR_014170 | 191 | G → R in Milano-12. 3 PublicationsCorresponds to variant dbSNP:rs6063EnsemblClinVar. | 1 | |
Natural variantiVAR_002409 | 301 | R → C in Tochigi/Osaka-2/Milano-5/Villajoyosa. 5 PublicationsCorresponds to variant dbSNP:rs121913087EnsemblClinVar. | 1 | |
Natural variantiVAR_002410 | 301 | R → H in DYSFIBRIN; fibrinogen Bergamo-2/Essen/Haifa/Osaka-3/Perugia/Saga/Barcelona-3/Barcelona-4. 4 PublicationsCorresponds to variant dbSNP:rs121913088EnsemblClinVar. | 1 | |
Natural variantiVAR_072726 | 303 | T → P in CAFBN; hypofibrinogenemia; heterozygous; no effect on fibrinogen complex assembly; impaired fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_002411 | 318 | G → V in DYSFIBRIN; fibrinogen Baltimore-1; impaired polymerization. 1 PublicationCorresponds to variant dbSNP:rs121913089EnsemblClinVar. | 1 | |
Natural variantiVAR_072727 | 327 | D → H in CAFBN; hypofibrinogenemia; heterozygous; no effect on fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_002413 | 334 | N → I in Baltimore-3; impaired polymerization. 1 PublicationCorresponds to variant dbSNP:rs121913090EnsemblClinVar. | 1 | |
Natural variantiVAR_002412 | 334 | N → K in Kyoto-1; causes accelerated cleavage by plasmin. 2 Publications | 1 | |
Natural variantiVAR_015853 | 335 | G → D in Hillsborough; prolonged thrombin clotting time. 1 Publication | 1 | |
Natural variantiVAR_002414 | 336 | M → T in Asahi; impaired polymerization. 2 PublicationsCorresponds to variant dbSNP:rs121913091EnsemblClinVar. | 1 | |
Natural variantiVAR_002415 | 345 – 346 | Missing in Vlissingen; defective calcium binding and impaired polymerization. 1 Publication | 2 | |
Natural variantiVAR_072728 | 345 | N → D in CAFBN; hypofibrinogenemia; heterozygous; no effect on fibrinogen complex assembly; decreased fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_002416 | 355 | Q → R in Nagoya-1; impaired polymerization. 1 PublicationCorresponds to variant dbSNP:rs121913092EnsemblClinVar. | 1 | |
Natural variantiVAR_002418 | 356 | D → V in DYSFIBRIN; fibrinogen Milano-1; impaired polymerization. 1 PublicationCorresponds to variant dbSNP:rs121913094EnsemblClinVar. | 1 | |
Natural variantiVAR_002417 | 356 | D → Y in Kyoto-3; impaired polymerization. 2 PublicationsCorresponds to variant dbSNP:rs121913093EnsemblClinVar. | 1 | |
Natural variantiVAR_002419 | 363 | N → K in Bern-1; impaired polymerization. 1 Publication | 1 | |
Natural variantiVAR_002420 | 377 | G → VMCGEALPMLKDPCYS in Paris-1; impaired polymerization. 1 Publication | 1 | |
Natural variantiVAR_002421 | 384 | S → C in Milano-7; impaired polymerization. 1 Publication | 1 | |
Natural variantiVAR_002422 | 401 | R → G in Osaka-5. 1 PublicationCorresponds to variant dbSNP:rs75848804EnsemblClinVar. | 1 | |
Natural variantiVAR_072729 | 401 | R → W in CAFBN; hypofibrinogenemia; heterozygous. 1 PublicationCorresponds to variant dbSNP:rs75848804EnsemblClinVar. | 1 | |
Natural variantiVAR_072621 | 404 | S → P in DYSFIBRIN; fibrinogen Philadelphia. 1 PublicationCorresponds to variant dbSNP:rs587777720EnsemblClinVar. | 1 | |
Natural variantiVAR_014171 | 410 | M → V1 PublicationCorresponds to variant dbSNP:rs6061Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001537 | 434 – 453 | VRPEH…PEDDL → AGDV in isoform Gamma-A. 5 PublicationsAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M10014 Genomic DNA Translation: AAB59530.1 M10014 Genomic DNA Translation: AAB59531.1 AF118092 mRNA Translation: AAF22036.1 AF350254 Genomic DNA Translation: AAK19751.2 AF350254 Genomic DNA Translation: AAK19752.2 AK289422 mRNA Translation: BAF82111.1 AK290824 mRNA Translation: BAF83513.1 BT007081 mRNA Translation: AAP35744.1 CH471056 Genomic DNA Translation: EAX04917.1 CH471056 Genomic DNA Translation: EAX04919.1 BC007044 mRNA Translation: AAH07044.1 BC021674 mRNA Translation: AAH21674.1 X51473 mRNA Translation: CAA35837.1 X00086 mRNA Translation: CAA24944.1 K02569 Genomic DNA Translation: AAA52430.1 K02569 Genomic DNA Translation: AAA52431.1 |
CCDSi | CCDS3788.1 [P02679-1] CCDS47153.1 [P02679-2] |
PIRi | A90470, FGHUG A90494, FGHUGB |
RefSeqi | NP_000500.2, NM_000509.5 [P02679-2] NP_068656.2, NM_021870.2 [P02679-1] |
Genome annotation databases
Ensembli | ENST00000336098; ENSP00000336829; ENSG00000171557 [P02679-1] ENST00000404648; ENSP00000384860; ENSG00000171557 [P02679-2] |
GeneIDi | 2266 |
KEGGi | hsa:2266 |
UCSCi | uc003iog.4, human [P02679-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Fibrinogen entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M10014 Genomic DNA Translation: AAB59530.1 M10014 Genomic DNA Translation: AAB59531.1 AF118092 mRNA Translation: AAF22036.1 AF350254 Genomic DNA Translation: AAK19751.2 AF350254 Genomic DNA Translation: AAK19752.2 AK289422 mRNA Translation: BAF82111.1 AK290824 mRNA Translation: BAF83513.1 BT007081 mRNA Translation: AAP35744.1 CH471056 Genomic DNA Translation: EAX04917.1 CH471056 Genomic DNA Translation: EAX04919.1 BC007044 mRNA Translation: AAH07044.1 BC021674 mRNA Translation: AAH21674.1 X51473 mRNA Translation: CAA35837.1 X00086 mRNA Translation: CAA24944.1 K02569 Genomic DNA Translation: AAA52430.1 K02569 Genomic DNA Translation: AAA52431.1 |
CCDSi | CCDS3788.1 [P02679-1] CCDS47153.1 [P02679-2] |
PIRi | A90470, FGHUG A90494, FGHUGB |
RefSeqi | NP_000500.2, NM_000509.5 [P02679-2] NP_068656.2, NM_021870.2 [P02679-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DUG | X-ray | 1.80 | A/B | 424-433 | [»] | |
1FIB | X-ray | 2.10 | A | 169-433 | [»] | |
1FIC | X-ray | 2.50 | A/B | 169-433 | [»] | |
1FID | X-ray | 2.10 | A | 169-433 | [»] | |
1FZA | X-ray | 2.90 | C/F | 114-432 | [»] | |
1FZB | X-ray | 2.90 | C/F | 114-432 | [»] | |
1FZC | X-ray | 2.30 | C/F | 114-432 | [»] | |
1FZE | X-ray | 3.00 | C/F | 114-432 | [»] | |
1FZF | X-ray | 2.70 | C/F | 114-432 | [»] | |
1FZG | X-ray | 2.50 | C/F | 114-432 | [»] | |
1LT9 | X-ray | 2.80 | C/F | 122-432 | [»] | |
1LTJ | X-ray | 2.80 | C/F | 122-432 | [»] | |
1N86 | X-ray | 3.20 | C/F | 114-433 | [»] | |
1N8E | X-ray | 4.50 | C/F | 114-433 | [»] | |
1RE3 | X-ray | 2.45 | C/F | 122-432 | [»] | |
1RE4 | X-ray | 2.70 | C/F | 122-432 | [»] | |
1RF0 | X-ray | 2.81 | C/F | 122-432 | [»] | |
1RF1 | X-ray | 2.53 | C/F | 122-432 | [»] | |
2A45 | X-ray | 3.65 | I/L | 27-71 | [»] | |
2FFD | X-ray | 2.89 | C/F | 122-432 | [»] | |
2FIB | X-ray | 2.01 | A | 169-433 | [»] | |
2H43 | X-ray | 2.70 | C/F | 115-433 | [»] | |
2HLO | X-ray | 2.60 | C/F | 114-433 | [»] | |
2HOD | X-ray | 2.90 | C/F/I/L | 115-433 | [»] | |
2HPC | X-ray | 2.90 | C/F/I/L | 115-433 | [»] | |
2HWL | X-ray | 2.40 | P | 439-452 | [»] | |
2OYH | X-ray | 2.40 | C/F | 122-432 | [»] | |
2OYI | X-ray | 2.70 | C/F | 122-432 | [»] | |
2Q9I | X-ray | 2.80 | C/F | 114-433 | [»] | |
2VDO | X-ray | 2.51 | C | 426-433 | [»] | |
2VDP | X-ray | 2.80 | C | 428-433 | [»] | |
2VDQ | X-ray | 2.59 | C | 426-433 | [»] | |
2VDR | X-ray | 2.40 | C | 428-433 | [»] | |
2VR3 | X-ray | 1.95 | C/D | 425-433 | [»] | |
2XNX | X-ray | 3.30 | C/F/I/L | 114-432 | [»] | |
2XNY | X-ray | 7.50 | C/F | 114-432 | [»] | |
2Y7L | X-ray | 1.49 | B | 421-433 | [»] | |
2Z4E | X-ray | 2.70 | C/F | 114-433 | [»] | |
3BVH | X-ray | 2.60 | C/F | 128-420 | [»] | |
3E1I | X-ray | 2.30 | C/F | 114-432 | [»] | |
3FIB | X-ray | 2.10 | A | 170-418 | [»] | |
3GHG | X-ray | 2.90 | C/F/I/L | 27-433 | [»] | |
3H32 | X-ray | 3.60 | C/F | 121-433 | [»] | |
3HUS | X-ray | 3.04 | C/F | 122-432 | [»] | |
4B60 | X-ray | 1.83 | C/D | 421-433 | [»] | |
BMRBi | P02679 | |||||
SMRi | P02679 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108557, 29 interactors |
ComplexPortali | CPX-1922, Fibrinogen |
CORUMi | P02679 |
DIPi | DIP-29644N |
IntActi | P02679, 29 interactors |
MINTi | P02679 |
STRINGi | 9606.ENSP00000336829 |
Chemistry databases
ChEMBLi | CHEMBL2364709 |
DrugBanki | DB11571, Human thrombin DB00364, Sucralfate DB11300, Thrombin DB11572, Thrombin alfa |
PTM databases
CarbonylDBi | P02679 |
GlyConnecti | 157, 4 N-Linked glycans 160, 12 N-Linked glycans (1 site), 1 O-Linked glycan (1 site) |
GlyGeni | P02679, 4 sites, 14 N-linked glycans (1 site) |
iPTMneti | P02679 |
PhosphoSitePlusi | P02679 |
UniCarbKBi | P02679 |
Polymorphism and mutation databases
BioMutai | FGG |
DMDMi | 20178280 |
2D gel databases
DOSAC-COBS-2DPAGEi | P02679 |
OGPi | P02679 |
REPRODUCTION-2DPAGEi | IPI00219713 P02679 |
SWISS-2DPAGEi | P02679 |
Proteomic databases
CPTACi | non-CPTAC-1121 |
jPOSTi | P02679 |
MassIVEi | P02679 |
MaxQBi | P02679 |
PaxDbi | P02679 |
PeptideAtlasi | P02679 |
PRIDEi | P02679 |
ProteomicsDBi | 51545 [P02679-1] 51546 [P02679-2] |
Protocols and materials databases
ABCDi | P02679, 3 sequenced antibodies |
Antibodypediai | 16774, 637 antibodies |
DNASUi | 2266 |
Genome annotation databases
Ensembli | ENST00000336098; ENSP00000336829; ENSG00000171557 [P02679-1] ENST00000404648; ENSP00000384860; ENSG00000171557 [P02679-2] |
GeneIDi | 2266 |
KEGGi | hsa:2266 |
UCSCi | uc003iog.4, human [P02679-1] |
Organism-specific databases
CTDi | 2266 |
DisGeNETi | 2266 |
EuPathDBi | HostDB:ENSG00000171557.16 |
GeneCardsi | FGG |
HGNCi | HGNC:3694, FGG |
HPAi | ENSG00000171557, Tissue enriched (liver) |
MalaCardsi | FGG |
MIMi | 134850, gene 202400, phenotype 616004, phenotype |
neXtProti | NX_P02679 |
OpenTargetsi | ENSG00000171557 |
Orphaneti | 98880, Familial afibrinogenemia 98881, Familial dysfibrinogenemia 248408, Familial hypodysfibrinogenemia 101041, Familial hypofibrinogenemia |
PharmGKBi | PA430 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000158467 |
HOGENOMi | CLU_038628_13_0_1 |
InParanoidi | P02679 |
OrthoDBi | 751651at2759 |
PhylomeDBi | P02679 |
TreeFami | TF336658 |
Enzyme and pathway databases
PathwayCommonsi | P02679 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-216083, Integrin cell surface interactions R-HSA-354192, Integrin signaling R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708, p130Cas linkage to MAPK signaling for integrins R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5674135, MAP2K and MAPK activation R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SIGNORi | P02679 |
Miscellaneous databases
BioGRID-ORCSi | 2266, 15 hits in 842 CRISPR screens |
ChiTaRSi | FGG, human |
EvolutionaryTracei | P02679 |
GeneWikii | FGG |
GenomeRNAii | 2266 |
Pharosi | P02679, Tbio |
PROi | PR:P02679 |
RNActi | P02679, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171557, Expressed in liver and 118 other tissues |
ExpressionAtlasi | P02679, baseline and differential |
Genevisiblei | P02679, HS |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit 4.10.530.10, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR014715, Fibrinogen_a/b/g_C_2 IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR020837, Fibrinogen_CS IPR037581, Fibrinogen_gamma |
PANTHERi | PTHR19143:SF338, PTHR19143:SF338, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FIBG_HUMAN | |
Accessioni | P02679Primary (citable) accession number: P02679 Secondary accession number(s): A8K057 Q9UCF3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | April 16, 2002 | |
Last modified: | December 2, 2020 | |
This is version 250 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations