UniProtKB - P02675 (FIBB_HUMAN)
Protein
Fibrinogen beta chain
Gene
FGB
Organism
Homo sapiens (Human)
Status
Functioni
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.By similarity
GO - Molecular functioni
- chaperone binding Source: BHF-UCL
- extracellular matrix structural constituent Source: BHF-UCL
- signaling receptor binding Source: InterPro
- structural molecule activity Source: BHF-UCL
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- blood coagulation Source: Reactome
- blood coagulation, fibrin clot formation Source: UniProtKB
- cell adhesion Source: GO_Central
- cell-matrix adhesion Source: BHF-UCL
- cellular protein-containing complex assembly Source: BHF-UCL
- cellular response to interleukin-1 Source: Ensembl
- cellular response to leptin stimulus Source: Ensembl
- extracellular matrix organization Source: Reactome
- fibrinolysis Source: UniProtKB
- induction of bacterial agglutination Source: CACAO
- innate immune response Source: UniProtKB-KW
- negative regulation of endothelial cell apoptotic process Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
- plasminogen activation Source: UniProtKB
- platelet aggregation Source: BHF-UCL
- platelet degranulation Source: Reactome
- positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- positive regulation of exocytosis Source: BHF-UCL
- positive regulation of heterotypic cell-cell adhesion Source: BHF-UCL
- positive regulation of peptide hormone secretion Source: BHF-UCL
- positive regulation of protein secretion Source: BHF-UCL
- positive regulation of substrate adhesion-dependent cell spreading Source: BHF-UCL
- positive regulation of vasoconstriction Source: BHF-UCL
- protein polymerization Source: BHF-UCL
- response to calcium ion Source: BHF-UCL
- toll-like receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Blood coagulation, Hemostasis, Immunity, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | P02675 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-216083, Integrin cell surface interactions R-HSA-354192, Integrin signaling R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708, p130Cas linkage to MAPK signaling for integrins R-HSA-5674135, MAP2K and MAPK activation R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SIGNORi | P02675 |
Names & Taxonomyi
Protein namesi | Recommended name: Fibrinogen beta chainCleaved into the following 2 chains: |
Gene namesi | Name:FGB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3662, FGB |
MIMi | 134830, gene |
neXtProti | NX_P02675 |
VEuPathDBi | HostDB:ENSG00000171564.11 |
Subcellular locationi
Extracellular region or secreted
- Secreted 3 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
- extracellular vesicle Source: UniProtKB
- fibrinogen complex Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: BHF-UCL
- plasma membrane Source: Reactome
Other locations
- cell cortex Source: Ensembl
- cell surface Source: BHF-UCL
- platelet alpha granule Source: BHF-UCL
- platelet alpha granule lumen Source: Reactome
- synapse Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Congenital afibrinogenemia (CAFBN)4 Publications
The disease is caused by variants affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
Disease descriptionRare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072724 | 95 | C → R in CAFBN; hypofibrinogenemia; heterozygous; decreased fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_016908 | 196 | R → C in CAFBN; fibrinogen Longmont. 1 PublicationCorresponds to variant dbSNP:rs121909623EnsemblClinVar. | 1 | |
Natural variantiVAR_072620 | 202 | L → Q in CAFBN. 1 PublicationCorresponds to variant dbSNP:rs121909624EnsemblClinVar. | 1 | |
Natural variantiVAR_016909 | 383 | L → R in CAFBN; abolishes fibrinogen secretion. 1 PublicationCorresponds to variant dbSNP:rs121909621EnsemblClinVar. | 1 | |
Natural variantiVAR_072725 | 407 | T → K in CAFBN; homozygous; heterozygous; no effect on fibrinogen complex assembly; impaired fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_016910 | 430 | G → D in CAFBN; abolishes fibrinogen secretion. 1 PublicationCorresponds to variant dbSNP:rs121909622EnsemblClinVar. | 1 |
Dysfibrinogenemia, congenital (DYSFIBRIN)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia).
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002406 | 98 | A → T in DYSFIBRIN; fibrinogen Naples and Milano-2; associated with defective thrombin binding and thrombophilia. 1 PublicationCorresponds to variant dbSNP:rs121909620EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 2244 |
MalaCardsi | FGB |
MIMi | 202400, phenotype 616004, phenotype |
OpenTargetsi | ENSG00000171564 |
Orphaneti | 98880, Familial afibrinogenemia 98881, Familial dysfibrinogenemia 248408, Familial hypodysfibrinogenemia 101041, Familial hypofibrinogenemia |
PharmGKBi | PA163 |
Miscellaneous databases
Pharosi | P02675, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2048 |
DrugBanki | DB04919, Alfimeprase DB13151, Anti-inhibitor coagulant complex DB11571, Human thrombin DB11311, Prothrombin DB00364, Sucralfate DB11300, Thrombin DB11572, Thrombin alfa |
Genetic variation databases
BioMutai | FGB |
DMDMi | 399492 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | 4 PublicationsAdd BLAST | 30 | |
PeptideiPRO_0000009070 | 31 – 44 | Fibrinopeptide B1 PublicationAdd BLAST | 14 | |
ChainiPRO_0000009071 | 45 – 491 | Fibrinogen beta chainAdd BLAST | 447 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 31 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Disulfide bondi | 95 | Interchain (with C-55 in alpha chain)1 Publication | ||
Disulfide bondi | 106 | Interchain (with C-68 in alpha chain)1 Publication | ||
Disulfide bondi | 110 | Interchain (with C-45 in gamma chain)1 Publication | ||
Disulfide bondi | 223 | Interchain (with C-184 in alpha chain)Combined sources4 Publications | ||
Disulfide bondi | 227 | Interchain (with C-161 in gamma chain) | ||
Disulfide bondi | 231 ↔ 316 | Combined sources4 Publications | ||
Disulfide bondi | 241 ↔ 270 | Combined sources4 Publications | ||
Glycosylationi | 394 | N-linked (GlcNAc...) asparagine6 Publications | 1 | |
Disulfide bondi | 424 ↔ 437 | Combined sources4 Publications |
Post-translational modificationi
Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 44 – 45 | Cleavage; by thrombin; to release fibrinopeptide B | 2 | |
Sitei | 152 – 153 | Cleavage; by plasmin; to break down fibrin clots | 2 | |
Sitei | 160 – 161 | Cleavage; by hementin; to prevent blood coagulation | 2 | |
Sitei | 163 – 164 | Cleavage; by plasmin; to break down fibrin clots | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acidProteomic databases
CPTACi | non-CPTAC-1119 non-CPTAC-1120 non-CPTAC-2665 |
EPDi | P02675 |
jPOSTi | P02675 |
MassIVEi | P02675 |
PaxDbi | P02675 |
PeptideAtlasi | P02675 |
PRIDEi | P02675 |
ProteomicsDBi | 51544 |
2D gel databases
DOSAC-COBS-2DPAGEi | P02675 |
OGPi | P02675 |
REPRODUCTION-2DPAGEi | IPI00298497 P02675 |
SWISS-2DPAGEi | P02675 |
UCD-2DPAGEi | P02675 |
PTM databases
CarbonylDBi | P02675 |
GlyConnecti | 157, 4 N-Linked glycans 159, 27 N-Linked glycans (1 site) |
GlyGeni | P02675, 5 sites, 12 N-linked glycans (1 site), 2 O-linked glycans (2 sites) |
iPTMneti | P02675 |
PhosphoSitePlusi | P02675 |
SwissPalmi | P02675 |
Expressioni
Tissue specificityi
Detected in blood plasma (at protein level).3 Publications
Gene expression databases
Bgeei | ENSG00000171564, Expressed in liver and 127 other tissues |
ExpressionAtlasi | P02675, baseline and differential |
Genevisiblei | P02675, HS |
Organism-specific databases
HPAi | ENSG00000171564, Tissue enriched (liver) |
Interactioni
Subunit structurei
Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
4 PublicationsBinary interactionsi
P02675
With | #Exp. | IntAct |
---|---|---|
Core protein precursor (PRO_0000037566) from Hepatitis C virus genotype 1a (isolate H77). | 4 | EBI-1034445,EBI-6377335 |
GO - Molecular functioni
- chaperone binding Source: BHF-UCL
- signaling receptor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 108535, 136 interactors |
ComplexPortali | CPX-1922, Fibrinogen |
CORUMi | P02675 |
DIPi | DIP-385N |
IntActi | P02675, 115 interactors |
MINTi | P02675 |
STRINGi | 9606.ENSP00000306099 |
Miscellaneous databases
RNActi | P02675, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P02675 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02675 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 232 – 488 | Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST | 257 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 45 – 47 | Beta-chain polymerization, binding distal domain of another fibrin | 3 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 157 – 222 | 3 PublicationsAdd BLAST | 66 |
Domaini
A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.3 Publications
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000158122 |
HOGENOMi | CLU_038628_13_0_1 |
InParanoidi | P02675 |
OMAi | VYPDAGG |
OrthoDBi | 357340at2759 |
PhylomeDBi | P02675 |
TreeFami | TF336658 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR037580, Fibrinogen_beta IPR020837, Fibrinogen_CS |
PANTHERi | PTHR19143:SF332, PTHR19143:SF332, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P02675-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRMVSWSFH KLKTMKHLLL LLLCVFLVKS QGVNDNEEGF FSARGHRPLD
60 70 80 90 100
KKREEAPSLR PAPPPISGGG YRARPAKAAA TQKKVERKAP DAGGCLHADP
110 120 130 140 150
DLGVLCPTGC QLQEALLQQE RPIRNSVDEL NNNVEAVSQT SSSSFQYMYL
160 170 180 190 200
LKDLWQKRQK QVKDNENVVN EYSSELEKHQ LYIDETVNSN IPTNLRVLRS
210 220 230 240 250
ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE
260 270 280 290 300
TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK
310 320 330 340 350
QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD
360 370 380 390 400
KVKAHYGGFT VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH
410 420 430 440 450
NGMFFSTYDR DNDGWLTSDP RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG
460 470 480 490
QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM SMKIRPFFPQ Q
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6REL8 | D6REL8_HUMAN | Fibrinogen beta chain | FGB | 272 | Annotation score: | ||
F8W6P4 | F8W6P4_HUMAN | Fibrinogen beta chain | FGB | 45 | Annotation score: |
Sequence cautioni
The sequence AAH07030 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 138 – 139 | SQ → QS AA sequence (Ref. 11) Curated | 2 | |
Sequence conflicti | 138 – 139 | SQ → QS AA sequence (PubMed:936108).Curated | 2 | |
Sequence conflicti | 145 – 146 | FQ → QF AA sequence (PubMed:420779).Curated | 2 | |
Sequence conflicti | 145 – 146 | FQ → QF AA sequence (Ref. 11) Curated | 2 | |
Sequence conflicti | 145 – 146 | FQ → QF AA sequence (PubMed:936108).Curated | 2 | |
Sequence conflicti | 192 | P → A in AAA52429 (PubMed:6688356).Curated | 1 | |
Sequence conflicti | 245 | I → T in AAI07767 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014169 | 2 | K → E1 PublicationCorresponds to variant dbSNP:rs6053EnsemblClinVar. | 1 | |
Natural variantiVAR_002402 | 39 – 102 | Missing in New York-1. 1 PublicationAdd BLAST | 64 | |
Natural variantiVAR_002403 | 44 | R → C in Christchurch-2, Seattle-1 and Ijmuiden. 1 PublicationCorresponds to variant dbSNP:rs121909616EnsemblClinVar. | 1 | |
Natural variantiVAR_002404 | 45 | G → R in Ise. 1 Publication | 1 | |
Natural variantiVAR_002405 | 74 | R → C in Nijmegen. 1 PublicationCorresponds to variant dbSNP:rs121909619EnsemblClinVar. | 1 | |
Natural variantiVAR_072724 | 95 | C → R in CAFBN; hypofibrinogenemia; heterozygous; decreased fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_002406 | 98 | A → T in DYSFIBRIN; fibrinogen Naples and Milano-2; associated with defective thrombin binding and thrombophilia. 1 PublicationCorresponds to variant dbSNP:rs121909620EnsemblClinVar. | 1 | |
Natural variantiVAR_013091 | 100 | P → S1 PublicationCorresponds to variant dbSNP:rs2227434EnsemblClinVar. | 1 | |
Natural variantiVAR_013092 | 170 | N → H1 PublicationCorresponds to variant dbSNP:rs2227409Ensembl. | 1 | |
Natural variantiVAR_016908 | 196 | R → C in CAFBN; fibrinogen Longmont. 1 PublicationCorresponds to variant dbSNP:rs121909623EnsemblClinVar. | 1 | |
Natural variantiVAR_072620 | 202 | L → Q in CAFBN. 1 PublicationCorresponds to variant dbSNP:rs121909624EnsemblClinVar. | 1 | |
Natural variantiVAR_013093 | 265 | P → L2 PublicationsCorresponds to variant dbSNP:rs6054EnsemblClinVar. | 1 | |
Natural variantiVAR_002407 | 365 | A → T in Pontoise-2. Corresponds to variant dbSNP:rs121909617EnsemblClinVar. | 1 | |
Natural variantiVAR_016909 | 383 | L → R in CAFBN; abolishes fibrinogen secretion. 1 PublicationCorresponds to variant dbSNP:rs121909621EnsemblClinVar. | 1 | |
Natural variantiVAR_072725 | 407 | T → K in CAFBN; homozygous; heterozygous; no effect on fibrinogen complex assembly; impaired fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_016910 | 430 | G → D in CAFBN; abolishes fibrinogen secretion. 1 PublicationCorresponds to variant dbSNP:rs121909622EnsemblClinVar. | 1 | |
Natural variantiVAR_002408 | 478 | R → K in Baltimore-2. 3 PublicationsCorresponds to variant dbSNP:rs4220EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00129 mRNA Translation: AAA52429.1 J00131, J00130 Genomic DNA Translation: AAA98115.1 J00132 Genomic DNA Translation: AAA98116.1 J00133 mRNA No translation available. M64983 Genomic DNA Translation: AAA18024.2 AF388026 Genomic DNA Translation: AAK62470.1 AK312972 mRNA Translation: BAG35810.1 CH471056 Genomic DNA Translation: EAX04932.1 BC007030 mRNA Translation: AAH07030.1 Sequence problems. BC106760 mRNA Translation: AAI06761.1 BC107766 mRNA Translation: AAI07767.1 AH002694 Genomic DNA Translation: AAA52445.1 X05018 Genomic DNA Translation: CAA28674.1 |
CCDSi | CCDS3786.1 |
PIRi | B43568, FGHUB |
RefSeqi | NP_001171670.1, NM_001184741.1 NP_005132.2, NM_005141.4 |
Genome annotation databases
Ensembli | ENST00000302068; ENSP00000306099; ENSG00000171564 |
GeneIDi | 2244 |
KEGGi | hsa:2244 |
Similar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia Fibrinogen entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00129 mRNA Translation: AAA52429.1 J00131, J00130 Genomic DNA Translation: AAA98115.1 J00132 Genomic DNA Translation: AAA98116.1 J00133 mRNA No translation available. M64983 Genomic DNA Translation: AAA18024.2 AF388026 Genomic DNA Translation: AAK62470.1 AK312972 mRNA Translation: BAG35810.1 CH471056 Genomic DNA Translation: EAX04932.1 BC007030 mRNA Translation: AAH07030.1 Sequence problems. BC106760 mRNA Translation: AAI06761.1 BC107766 mRNA Translation: AAI07767.1 AH002694 Genomic DNA Translation: AAA52445.1 X05018 Genomic DNA Translation: CAA28674.1 |
CCDSi | CCDS3786.1 |
PIRi | B43568, FGHUB |
RefSeqi | NP_001171670.1, NM_001184741.1 NP_005132.2, NM_005141.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FZA | X-ray | 2.90 | B/E | 164-491 | [»] | |
1FZB | X-ray | 2.90 | B/E | 164-491 | [»] | |
1FZC | X-ray | 2.30 | B/E | 164-491 | [»] | |
1FZE | X-ray | 3.00 | B/E | 164-491 | [»] | |
1FZF | X-ray | 2.70 | B/E | 164-491 | [»] | |
M/N/S/T | 45-48 | [»] | ||||
1FZG | X-ray | 2.50 | B/E | 164-491 | [»] | |
1LT9 | X-ray | 2.80 | B/E | 179-491 | [»] | |
1LTJ | X-ray | 2.80 | B/E | 179-491 | [»] | |
1N86 | X-ray | 3.20 | B/E | 164-491 | [»] | |
I/J | 45-51 | [»] | ||||
1N8E | X-ray | 4.50 | B/E | 164-491 | [»] | |
1RE3 | X-ray | 2.45 | B/E | 179-491 | [»] | |
1RE4 | X-ray | 2.70 | B/E | 179-491 | [»] | |
1RF0 | X-ray | 2.81 | B/E | 179-491 | [»] | |
1RF1 | X-ray | 2.53 | B/E | 179-491 | [»] | |
2A45 | X-ray | 3.65 | H/K | 45-135 | [»] | |
2FFD | X-ray | 2.89 | B/E | 179-491 | [»] | |
2H43 | X-ray | 2.70 | B/E | 164-491 | [»] | |
2HLO | X-ray | 2.60 | B/E | 164-491 | [»] | |
2HOD | X-ray | 2.90 | B/E/H/K | 164-491 | [»] | |
2HPC | X-ray | 2.90 | B/E/H/K | 164-491 | [»] | |
2OYH | X-ray | 2.40 | B/E | 179-491 | [»] | |
2OYI | X-ray | 2.70 | B/E | 179-491 | [»] | |
2Q9I | X-ray | 2.80 | B/E | 164-491 | [»] | |
2XNX | X-ray | 3.30 | B/E/H/K | 164-491 | [»] | |
2XNY | X-ray | 7.50 | B/E | 164-491 | [»] | |
2Z4E | X-ray | 2.70 | B/E | 164-489 | [»] | |
3BVH | X-ray | 2.60 | B/E | 191-488 | [»] | |
3E1I | X-ray | 2.30 | B/E | 164-491 | [»] | |
3GHG | X-ray | 2.90 | B/E/H/K | 31-491 | [»] | |
3H32 | X-ray | 3.60 | B/E | 31-488 | [»] | |
3HUS | X-ray | 3.04 | B/E | 179-491 | [»] | |
6ATZ | X-ray | 2.70 | E/F | 69-79 | [»] | |
6BIJ | X-ray | 2.10 | C | 69-81 | [»] | |
6BIL | X-ray | 2.40 | C | 69-81 | [»] | |
SMRi | P02675 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108535, 136 interactors |
ComplexPortali | CPX-1922, Fibrinogen |
CORUMi | P02675 |
DIPi | DIP-385N |
IntActi | P02675, 115 interactors |
MINTi | P02675 |
STRINGi | 9606.ENSP00000306099 |
Chemistry databases
ChEMBLi | CHEMBL2048 |
DrugBanki | DB04919, Alfimeprase DB13151, Anti-inhibitor coagulant complex DB11571, Human thrombin DB11311, Prothrombin DB00364, Sucralfate DB11300, Thrombin DB11572, Thrombin alfa |
PTM databases
CarbonylDBi | P02675 |
GlyConnecti | 157, 4 N-Linked glycans 159, 27 N-Linked glycans (1 site) |
GlyGeni | P02675, 5 sites, 12 N-linked glycans (1 site), 2 O-linked glycans (2 sites) |
iPTMneti | P02675 |
PhosphoSitePlusi | P02675 |
SwissPalmi | P02675 |
Genetic variation databases
BioMutai | FGB |
DMDMi | 399492 |
2D gel databases
DOSAC-COBS-2DPAGEi | P02675 |
OGPi | P02675 |
REPRODUCTION-2DPAGEi | IPI00298497 P02675 |
SWISS-2DPAGEi | P02675 |
UCD-2DPAGEi | P02675 |
Proteomic databases
CPTACi | non-CPTAC-1119 non-CPTAC-1120 non-CPTAC-2665 |
EPDi | P02675 |
jPOSTi | P02675 |
MassIVEi | P02675 |
PaxDbi | P02675 |
PeptideAtlasi | P02675 |
PRIDEi | P02675 |
ProteomicsDBi | 51544 |
Protocols and materials databases
ABCDi | P02675, 2 sequenced antibodies |
Antibodypediai | 855, 570 antibodies |
Genome annotation databases
Ensembli | ENST00000302068; ENSP00000306099; ENSG00000171564 |
GeneIDi | 2244 |
KEGGi | hsa:2244 |
Organism-specific databases
CTDi | 2244 |
DisGeNETi | 2244 |
GeneCardsi | FGB |
HGNCi | HGNC:3662, FGB |
HPAi | ENSG00000171564, Tissue enriched (liver) |
MalaCardsi | FGB |
MIMi | 134830, gene 202400, phenotype 616004, phenotype |
neXtProti | NX_P02675 |
OpenTargetsi | ENSG00000171564 |
Orphaneti | 98880, Familial afibrinogenemia 98881, Familial dysfibrinogenemia 248408, Familial hypodysfibrinogenemia 101041, Familial hypofibrinogenemia |
PharmGKBi | PA163 |
VEuPathDBi | HostDB:ENSG00000171564.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000158122 |
HOGENOMi | CLU_038628_13_0_1 |
InParanoidi | P02675 |
OMAi | VYPDAGG |
OrthoDBi | 357340at2759 |
PhylomeDBi | P02675 |
TreeFami | TF336658 |
Enzyme and pathway databases
PathwayCommonsi | P02675 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-216083, Integrin cell surface interactions R-HSA-354192, Integrin signaling R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708, p130Cas linkage to MAPK signaling for integrins R-HSA-5674135, MAP2K and MAPK activation R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SIGNORi | P02675 |
Miscellaneous databases
BioGRID-ORCSi | 2244, 5 hits in 873 CRISPR screens |
ChiTaRSi | FGB, human |
EvolutionaryTracei | P02675 |
GeneWikii | Fibrinogen_beta_chain |
GenomeRNAii | 2244 |
Pharosi | P02675, Tbio |
PROi | PR:P02675 |
RNActi | P02675, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171564, Expressed in liver and 127 other tissues |
ExpressionAtlasi | P02675, baseline and differential |
Genevisiblei | P02675, HS |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR037580, Fibrinogen_beta IPR020837, Fibrinogen_CS |
PANTHERi | PTHR19143:SF332, PTHR19143:SF332, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FIBB_HUMAN | |
Accessioni | P02675Primary (citable) accession number: P02675 Secondary accession number(s): A0JLR9 Q3KPF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 10, 2021 | |
This is version 238 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references