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UniProtKB - P02671 (FIBA_HUMAN)

Protein

Fibrinogen alpha chain

Gene

FGA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi791CalciumCombined sources1 Publication1
Metal bindingi793CalciumCombined sources1 Publication1
Metal bindingi795Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi797Calcium; via carbonyl oxygenCombined sources1 Publication1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processAdaptive immunity, Blood coagulation, Hemostasis, Immunity, Innate immunity
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-216083 Integrin cell surface interactions
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-977225 Amyloid fiber formation
SIGNORiP02671

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen alpha chain
Cleaved into the following 2 chains:
Fibrinopeptide A
Fibrinogen alpha chain
Gene namesi
Name:FGA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000171560.14
HGNCiHGNC:3661 FGA
MIMi134820 gene+phenotype
neXtProtiNX_P02671

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Secreted

Pathology & Biotechi

Involvement in diseasei

Congenital afibrinogenemia (CAFBN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
Disease descriptionRare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen.
See also OMIM:202400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07272155C → R in CAFBN; hypofibrinogenemia; heterozygous; decreased fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication1
Natural variantiVAR_072722129R → P in CAFBN; hypofibrinogenemia; heterozygous; no effect on fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication1
Natural variantiVAR_072723184C → W in CAFBN; hypofibrinogenemia; heterozygous; impaired fibrinogen complex assembly. 1 Publication1
Amyloidosis 8 (AMYL8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
See also OMIM:105200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010731545E → V in AMYL8. Corresponds to variant dbSNP:rs121909612EnsemblClinVar.1
Natural variantiVAR_010732573R → L in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs78506343EnsemblClinVar.1
Dysfibrinogenemia, congenital (DYSFIBRIN)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia).
See also OMIM:616004
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00239235R → C in DYSFIBRIN; fibrinogen Metz 1/Hershey III. 1 PublicationCorresponds to variant dbSNP:rs121909606EnsemblClinVar.1
Natural variantiVAR_002401573R → C in DYSFIBRIN; fibrinogen Dusart/Paris-5. 1 PublicationCorresponds to variant dbSNP:rs121909613EnsemblClinVar.1

Keywords - Diseasei

Amyloidosis, Disease mutation

Organism-specific databases

DisGeNETi2243
MalaCardsiFGA
MIMi105200 phenotype
134820 gene+phenotype
202400 phenotype
616004 phenotype
OpenTargetsiENSG00000171560
Orphaneti98880 Familial afibrinogenemia
98881 Familial dysfibrinogenemia
248408 Familial hypodysfibrinogenemia
101041 Familial hypofibrinogenemia
93562 Familial renal amyloidosis due to fibrinogen A alpha-chain variant
PharmGKBiPA429

Chemistry databases

ChEMBLiCHEMBL2364709
DrugBankiDB04919 Alfimeprase
DB00009 Alteplase
DB05099 Ancrod
DB00029 Anistreplase
DB05675 EP-2104R
DB00015 Reteplase
DB00364 Sucralfate
DB00031 Tenecteplase

Polymorphism and mutation databases

BioMutaiFGA
DMDMi1706799

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 193 PublicationsAdd BLAST19
PeptideiPRO_000000902120 – 35Fibrinopeptide AAdd BLAST16
ChainiPRO_000000902236 – 866Fibrinogen alpha chainAdd BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Modified residuei45Phosphoserine; by FAM20CCombined sources1 Publication1
Disulfide bondi47Interchain1 Publication
Modified residuei50PhosphoserineCombined sources1
Disulfide bondi55Interchain (with C-95 in beta chain)1 Publication
Modified residuei56Phosphoserine; by FAM20C1 Publication1
Disulfide bondi64Interchain (with C-49 in gamma chain)1 Publication
Disulfide bondi68Interchain (with C-106 in beta chain)1 Publication
Disulfide bondi180Interchain (with C-165 in gamma chain)4 Publications
Disulfide bondi184Interchain (with C-223 in beta chain)4 Publications
Modified residuei281PhosphoserineCombined sources1
Modified residuei291PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Glycosylationi320O-linked (GalNAc...) threonine1 Publication1
Cross-linki322Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-41 in alpha-2-antiplasmin)
Cross-linki347Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)
Glycosylationi351O-linked (GalNAc...) serine1 Publication1
Modified residuei364Phosphoserine; by FAM20C1 Publication1
Cross-linki385Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)
Modified residuei412PhosphothreonineCombined sources1
Modified residuei451PhosphoserineCombined sources1
Glycosylationi453N-linked (GlcNAc...) asparagine; in variant Caracas-21 Publication1
Disulfide bondi461 ↔ 491By similarity
Modified residuei501PhosphoserineCombined sources1
Modified residuei505PhosphothreonineCombined sources1
Modified residuei524Phosphoserine; by FAM20C1 Publication1
Cross-linki527Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)Sequence analysis
Cross-linki558Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)Sequence analysis
Modified residuei560Phosphoserine; by FAM20C1 Publication1
Modified residuei5654-hydroxyproline; by P4HA11 Publication1
Cross-linki575Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)Sequence analysis
Cross-linki581Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)Sequence analysis
Cross-linki599Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)Sequence analysis
Modified residuei609Phosphoserine; by FAM20CCombined sources1 Publication1
Glycosylationi686N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi799 ↔ 812Combined sources1 Publication

Post-translational modificationi

The alpha chain is normally not N-glycosylated (PubMed:23151259), even though glycosylation at Asn-686 was observed when a fragment of the protein was expressed in insect cells (PubMed:9689040). It is well known that heterologous expression of isolated domains can lead to adventitious protein modifications. Besides, glycosylation at Asn-686 is supported by large-scale glycoproteomics studies (PubMed:16335952 and PubMed:19159218), but the evidence is still quite tenuous. Most likely, Asn-686 is not glycosylated in the healthy human body, or only with low efficiency.Curated4 Publications
O-glycosylated.1 Publication
Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.
About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.1 Publication
Phosphorylated by FAM20C in the extracellular medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei35 – 36Cleavage; by thrombin; to release fibrinopeptide A2
Sitei100 – 101Cleavage; by plasmin; to break down fibrin clots2
Sitei121 – 122Cleavage; by hementin; to prevent blood coagulation2
Sitei123 – 124Cleavage; by plasmin; to break down fibrin clots2

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Isopeptide bond, Phosphoprotein

Proteomic databases

MaxQBiP02671
PaxDbiP02671
PeptideAtlasiP02671
PRIDEiP02671
ProteomicsDBi51542
51543 [P02671-2]

2D gel databases

OGPiP02671
SWISS-2DPAGEiP02671

PTM databases

CarbonylDBiP02671
GlyConnecti1238
157
iPTMnetiP02671
PhosphoSitePlusiP02671
SwissPalmiP02671
UniCarbKBiP02671

Miscellaneous databases

PMAP-CutDBiP02671

Expressioni

Tissue specificityi

Detected in blood plasma (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000171560 Expressed in 113 organ(s), highest expression level in liver
CleanExiHS_FGA
ExpressionAtlasiP02671 baseline and differential
GenevisibleiP02671 HS

Organism-specific databases

HPAiCAB016776
HPA051370
HPA064755

Interactioni

Subunit structurei

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.6 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi108534, 31 interactors
ComplexPortaliCPX-1922 Fibrinogen
CORUMiP02671
DIPiDIP-29643N
IntActiP02671, 23 interactors
MINTiP02671
STRINGi9606.ENSP00000306361

Structurei

Secondary structure

1866
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP02671
SMRiP02671
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02671

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini623 – 864Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 38Alpha-chain polymerization, binding distal domain of another fibrin gamma chain3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili68 – 6311 PublicationAdd BLAST564

Domaini

A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.Curated2 Publications

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00920000148942
HOGENOMiHOG000285947
HOVERGENiHBG005668
InParanoidiP02671
KOiK03903
OMAiTWNPGSS
OrthoDBiEOG091G03M1
PhylomeDBiP02671
TreeFamiTF351984

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR012290 Fibrinogen_a/b/g_coil_dom
IPR021996 Fibrinogen_aC
IPR037579 Fibrinogen_alpha
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF232 PTHR19143:SF232, 2 hits
PfamiView protein in Pfam
PF08702 Fib_alpha, 1 hit
PF12160 Fibrinogen_aC, 1 hit
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SM01212 Fib_alpha, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P02671-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-E

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSMRIVCLV LSVVGTAWTA DSGEGDFLAE GGGVRGPRVV ERHQSACKDS 
        60         70         80         90        100
DWPFCSDEDW NYKCPSGCRM KGLIDEVNQD FTNRINKLKN SLFEYQKNNK 
       110        120        130        140        150
DSHSLTTNIM EILRGDFSSA NNRDNTYNRV SEDLRSRIEV LKRKVIEKVQ 
       160        170        180        190        200
HIQLLQKNVR AQLVDMKRLE VDIDIKIRSC RGSCSRALAR EVDLKDYEDQ 
       210        220        230        240        250
QKQLEQVIAK DLLPSRDRQH LPLIKMKPVP DLVPGNFKSQ LQKVPPEWKA 
       260        270        280        290        300
LTDMPQMRME LERPGGNEIT RGGSTSYGTG SETESPRNPS SAGSWNSGSS 
       310        320        330        340        350
GPGSTGNRNP GSSGTGGTAT WKPGSSGPGS TGSWNSGSSG TGSTGNQNPG 
       360        370        380        390        400
SPRPGSTGTW NPGSSERGSA GHWTSESSVS GSTGQWHSES GSFRPDSPGS 
       410        420        430        440        450
GNARPNNPDW GTFEEVSGNV SPGTRREYHT EKLVTSKGDK ELRTGKEKVT 
       460        470        480        490        500
SGSTTTTRRS CSKTVTKTVI GPDGHKEVTK EVVTSEDGSD CPEAMDLGTL 
       510        520        530        540        550
SGIGTLDGFR HRHPDEAAFF DTASTGKTFP GFFSPMLGEF VSETESRGSE 
       560        570        580        590        600
SGIFTNTKES SSHHPGIAEF PSRGKSSSYS KQFTSSTSYN RGDSTFESKS 
       610        620        630        640        650
YKMADEAGSE ADHEGTHSTK RGHAKSRPVR DCDDVLQTHP SGTQSGIFNI 
       660        670        680        690        700
KLPGSSKIFS VYCDQETSLG GWLLIQQRMD GSLNFNRTWQ DYKRGFGSLN 
       710        720        730        740        750
DEGEGEFWLG NDYLHLLTQR GSVLRVELED WAGNEAYAEY HFRVGSEAEG 
       760        770        780        790        800
YALQVSSYEG TAGDALIEGS VEEGAEYTSH NNMQFSTFDR DADQWEENCA 
       810        820        830        840        850
EVYGGGWWYN NCQAANLNGI YYPGGSYDPR NNSPYEIENG VVWVSFRGAD 
       860 
YSLRAVRMKI RPLVTQ
Length:866
Mass (Da):94,973
Last modified:October 1, 1996 - v2
Checksum:iEA73A81204D8AEC4
GO
Isoform 2 (identifier: P02671-2) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     631-644: DCDDVLQTHPSGTQ → GIHTSPLGKPSLSP
     645-866: Missing.

Show »
Length:644
Mass (Da):69,757
Checksum:iB9035F3DD864572A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUA0A0A087WUA0_HUMAN
Fibrinogen alpha chain
FGA
289Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177I → V in BAF83248 (PubMed:14702039).Curated1
Sequence conflicti215 – 216SR → RS AA sequence (Ref. 10) Curated2
Sequence conflicti299S → G AA sequence (Ref. 10) Curated1
Sequence conflicti304S → G AA sequence (Ref. 10) Curated1
Sequence conflicti317 – 318GT → SG AA sequence (PubMed:518846).Curated2
Isoform 2 (identifier: P02671-2)
Sequence conflicti640 – 644PSLSP → LPCPPRLS in AAK31372 (Ref. 3) Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0116096I → V1 PublicationCorresponds to variant dbSNP:rs2070025EnsemblClinVar.1
Natural variantiVAR_00239026D → N in Lille-1. Corresponds to variant dbSNP:rs121909604EnsemblClinVar.1
Natural variantiVAR_00239131G → V in Rouen-1. Corresponds to variant dbSNP:rs121909605EnsemblClinVar.1
Natural variantiVAR_00239235R → C in DYSFIBRIN; fibrinogen Metz 1/Hershey III. 1 PublicationCorresponds to variant dbSNP:rs121909606EnsemblClinVar.1
Natural variantiVAR_00239335R → H1 PublicationCorresponds to variant dbSNP:rs121909607EnsemblClinVar.1
Natural variantiVAR_00239437P → L in Kyoto-2. 1 PublicationCorresponds to variant dbSNP:rs121909609EnsemblClinVar.1
Natural variantiVAR_00239738R → G in Aarhus-1. Corresponds to variant dbSNP:rs121909608EnsemblClinVar.1
Natural variantiVAR_00239538R → N in Munich-1; requires 2 nucleotide substitutions. 1
Natural variantiVAR_00239638R → S in Detroit-1. 1
Natural variantiVAR_01073039V → D in Canterbury. 1 PublicationCorresponds to variant dbSNP:rs121909614EnsemblClinVar.1
Natural variantiVAR_07272155C → R in CAFBN; hypofibrinogenemia; heterozygous; decreased fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication1
Natural variantiVAR_00239866S → T. 1
Natural variantiVAR_072722129R → P in CAFBN; hypofibrinogenemia; heterozygous; no effect on fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication1
Natural variantiVAR_002399160R → S in Lima. 1 Publication1
Natural variantiVAR_072723184C → W in CAFBN; hypofibrinogenemia; heterozygous; impaired fibrinogen complex assembly. 1 Publication1
Natural variantiVAR_011610331T → A3 PublicationsCorresponds to variant dbSNP:rs6050EnsemblClinVar.1
Natural variantiVAR_014168446K → E1 PublicationCorresponds to variant dbSNP:rs6052Ensembl.1
Natural variantiVAR_002400453S → N in Caracas-2. 1 PublicationCorresponds to variant dbSNP:rs121909610EnsemblClinVar.1
Natural variantiVAR_011611456T → A1 PublicationCorresponds to variant dbSNP:rs2070031Ensembl.1
Natural variantiVAR_010731545E → V in AMYL8. Corresponds to variant dbSNP:rs121909612EnsemblClinVar.1
Natural variantiVAR_002401573R → C in DYSFIBRIN; fibrinogen Dusart/Paris-5. 1 PublicationCorresponds to variant dbSNP:rs121909613EnsemblClinVar.1
Natural variantiVAR_010732573R → L in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs78506343EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001531631 – 644DCDDV…PSGTQ → GIHTSPLGKPSLSP in isoform 2. 3 PublicationsAdd BLAST14
Alternative sequenceiVSP_001532645 – 866Missing in isoform 2. 3 PublicationsAdd BLAST222

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64982 Genomic DNA Translation: AAA17056.1
M64982 Genomic DNA Translation: AAA17055.1
M58569 Transcribed RNA Translation: AAC97142.1
M58569 Transcribed RNA Translation: AAC97143.1
AF361104 Genomic DNA Translation: AAK31372.1
AF361104 Genomic DNA Translation: AAK31373.1
AK290559 mRNA Translation: BAF83248.1
CH471056 Genomic DNA Translation: EAX04925.1
CH471056 Genomic DNA Translation: EAX04926.1
CH471056 Genomic DNA Translation: EAX04927.1
CH471056 Genomic DNA Translation: EAX04928.1
BC098280 mRNA Translation: AAH98280.1
BC099706 mRNA Translation: AAH99706.1
BC099720 mRNA Translation: AAH99720.1
BC101935 mRNA Translation: AAI01936.1
J00128 mRNA Translation: AAA52427.1
J00127 mRNA Translation: AAA52426.1
K02272 mRNA Translation: AAA52428.1
M26878 mRNA Translation: AAA52444.1
CCDSiCCDS3787.1 [P02671-1]
CCDS47152.1 [P02671-2]
PIRiA93956 FGHUA
D44234
RefSeqiNP_000499.1, NM_000508.4 [P02671-1]
NP_068657.1, NM_021871.3 [P02671-2]
UniGeneiHs.351593
Hs.612036

Genome annotation databases

EnsembliENST00000302053; ENSP00000306361; ENSG00000171560 [P02671-1]
ENST00000403106; ENSP00000385981; ENSG00000171560 [P02671-2]
GeneIDi2243
KEGGihsa:2243
UCSCiuc003iod.2 human [P02671-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Fibrinogen entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64982 Genomic DNA Translation: AAA17056.1
M64982 Genomic DNA Translation: AAA17055.1
M58569 Transcribed RNA Translation: AAC97142.1
M58569 Transcribed RNA Translation: AAC97143.1
AF361104 Genomic DNA Translation: AAK31372.1
AF361104 Genomic DNA Translation: AAK31373.1
AK290559 mRNA Translation: BAF83248.1
CH471056 Genomic DNA Translation: EAX04925.1
CH471056 Genomic DNA Translation: EAX04926.1
CH471056 Genomic DNA Translation: EAX04927.1
CH471056 Genomic DNA Translation: EAX04928.1
BC098280 mRNA Translation: AAH98280.1
BC099706 mRNA Translation: AAH99706.1
BC099720 mRNA Translation: AAH99720.1
BC101935 mRNA Translation: AAI01936.1
J00128 mRNA Translation: AAA52427.1
J00127 mRNA Translation: AAA52426.1
K02272 mRNA Translation: AAA52428.1
M26878 mRNA Translation: AAA52444.1
CCDSiCCDS3787.1 [P02671-1]
CCDS47152.1 [P02671-2]
PIRiA93956 FGHUA
D44234
RefSeqiNP_000499.1, NM_000508.4 [P02671-1]
NP_068657.1, NM_021871.3 [P02671-2]
UniGeneiHs.351593
Hs.612036

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BBRX-ray2.30F/G/I26-35[»]
1DM4X-ray2.50C26-35[»]
1FPHX-ray2.50F26-35[»]
1FZAX-ray2.90A/D130-216[»]
1FZBX-ray2.90A/D130-216[»]
1FZCX-ray2.30A/D130-216[»]
1FZDX-ray2.10A/B/C/D/E/F/G/H666-866[»]
1FZEX-ray3.00A/D130-216[»]
1FZFX-ray2.70A/D130-216[»]
1FZGX-ray2.50A/D130-216[»]
1LT9X-ray2.80A/D145-210[»]
1LTJX-ray2.80A/D145-210[»]
1N86X-ray3.20A/D130-216[»]
1N8EX-ray4.50A/D130-218[»]
1RE3X-ray2.45A/D145-210[»]
1RE4X-ray2.70A/D145-210[»]
1RF0X-ray2.81A/D145-210[»]
1RF1X-ray2.53A/D145-210[»]
1YCPX-ray2.50F/N20-42[»]
2A45X-ray3.65G/J36-92[»]
2FFDX-ray2.89A/D145-210[»]
2H43X-ray2.70A/D130-216[»]
2HLOX-ray2.60A/D130-216[»]
2HODX-ray2.90A/D/G/J130-216[»]
2HPCX-ray2.90A/D/G/J130-216[»]
2OYHX-ray2.40A/D145-210[»]
2OYIX-ray2.70A/D145-210[»]
2Q9IX-ray2.80A/D130-216[»]
2XNXX-ray3.30A/D/G/J130-216[»]
2XNYX-ray7.50A/D130-216[»]
2Z4EX-ray2.70A/D130-216[»]
3AT0X-ray2.50B332-347[»]
3BVHX-ray2.60A/D148-209[»]
3E1IX-ray2.30A/D130-216[»]
3GHGX-ray2.90A/D/G/J20-581[»]
3H32X-ray3.60A/D20-216[»]
3HUSX-ray3.04A/D145-210[»]
4F27X-ray1.92Q336-347[»]
5CFAX-ray1.45C/D580-594[»]
ProteinModelPortaliP02671
SMRiP02671
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108534, 31 interactors
ComplexPortaliCPX-1922 Fibrinogen
CORUMiP02671
DIPiDIP-29643N
IntActiP02671, 23 interactors
MINTiP02671
STRINGi9606.ENSP00000306361

Chemistry databases

ChEMBLiCHEMBL2364709
DrugBankiDB04919 Alfimeprase
DB00009 Alteplase
DB05099 Ancrod
DB00029 Anistreplase
DB05675 EP-2104R
DB00015 Reteplase
DB00364 Sucralfate
DB00031 Tenecteplase

PTM databases

CarbonylDBiP02671
GlyConnecti1238
157
iPTMnetiP02671
PhosphoSitePlusiP02671
SwissPalmiP02671
UniCarbKBiP02671

Polymorphism and mutation databases

BioMutaiFGA
DMDMi1706799

2D gel databases

OGPiP02671
SWISS-2DPAGEiP02671

Proteomic databases

MaxQBiP02671
PaxDbiP02671
PeptideAtlasiP02671
PRIDEiP02671
ProteomicsDBi51542
51543 [P02671-2]

Protocols and materials databases

DNASUi2243
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302053; ENSP00000306361; ENSG00000171560 [P02671-1]
ENST00000403106; ENSP00000385981; ENSG00000171560 [P02671-2]
GeneIDi2243
KEGGihsa:2243
UCSCiuc003iod.2 human [P02671-1]

Organism-specific databases

CTDi2243
DisGeNETi2243
EuPathDBiHostDB:ENSG00000171560.14
GeneCardsiFGA
HGNCiHGNC:3661 FGA
HPAiCAB016776
HPA051370
HPA064755
MalaCardsiFGA
MIMi105200 phenotype
134820 gene+phenotype
202400 phenotype
616004 phenotype
neXtProtiNX_P02671
OpenTargetsiENSG00000171560
Orphaneti98880 Familial afibrinogenemia
98881 Familial dysfibrinogenemia
248408 Familial hypodysfibrinogenemia
101041 Familial hypofibrinogenemia
93562 Familial renal amyloidosis due to fibrinogen A alpha-chain variant
PharmGKBiPA429
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00920000148942
HOGENOMiHOG000285947
HOVERGENiHBG005668
InParanoidiP02671
KOiK03903
OMAiTWNPGSS
OrthoDBiEOG091G03M1
PhylomeDBiP02671
TreeFamiTF351984

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-216083 Integrin cell surface interactions
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-977225 Amyloid fiber formation
SIGNORiP02671

Miscellaneous databases

ChiTaRSiFGA human
EvolutionaryTraceiP02671
GeneWikiiFibrinogen_alpha_chain
GenomeRNAii2243
PMAP-CutDBiP02671
PROiPR:P02671
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171560 Expressed in 113 organ(s), highest expression level in liver
CleanExiHS_FGA
ExpressionAtlasiP02671 baseline and differential
GenevisibleiP02671 HS

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR012290 Fibrinogen_a/b/g_coil_dom
IPR021996 Fibrinogen_aC
IPR037579 Fibrinogen_alpha
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF232 PTHR19143:SF232, 2 hits
PfamiView protein in Pfam
PF08702 Fib_alpha, 1 hit
PF12160 Fibrinogen_aC, 1 hit
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SM01212 Fib_alpha, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFIBA_HUMAN
AccessioniPrimary (citable) accession number: P02671
Secondary accession number(s): A8K3E4
, D3DP14, D3DP15, Q4QQH7, Q9BX62, Q9UCH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: October 10, 2018
This is version 232 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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