UniProtKB - P02671 (FIBA_HUMAN)
Fibrinogen alpha chain
FGA
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 791 | CalciumCombined sources1 Publication | 1 | |
Metal bindingi | 793 | CalciumCombined sources1 Publication | 1 | |
Metal bindingi | 795 | Calcium; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 797 | Calcium; via carbonyl oxygenCombined sources1 Publication | 1 |
GO - Molecular functioni
- extracellular matrix structural constituent Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- signaling receptor binding Source: InterPro
- structural molecule activity Source: BHF-UCL
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- blood coagulation Source: Reactome
- blood coagulation, common pathway Source: BHF-UCL
- blood coagulation, fibrin clot formation Source: UniProtKB
- cell-matrix adhesion Source: BHF-UCL
- cellular protein-containing complex assembly Source: BHF-UCL
- cellular protein metabolic process Source: Reactome
- extracellular matrix organization Source: Reactome
- fibrinolysis Source: UniProtKB
- induction of bacterial agglutination Source: CACAO
- innate immune response Source: UniProtKB-KW
- negative regulation of blood coagulation, common pathway Source: BHF-UCL
- negative regulation of endothelial cell apoptotic process Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
- plasminogen activation Source: UniProtKB
- platelet aggregation Source: BHF-UCL
- platelet degranulation Source: Reactome
- positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- positive regulation of exocytosis Source: BHF-UCL
- positive regulation of heterotypic cell-cell adhesion Source: BHF-UCL
- positive regulation of peptide hormone secretion Source: BHF-UCL
- positive regulation of protein secretion Source: BHF-UCL
- positive regulation of substrate adhesion-dependent cell spreading Source: BHF-UCL
- positive regulation of vasoconstriction Source: BHF-UCL
- post-translational protein modification Source: Reactome
- protein-containing complex assembly Source: UniProtKB
- protein polymerization Source: BHF-UCL
- response to calcium ion Source: BHF-UCL
- toll-like receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Blood coagulation, Hemostasis, Immunity, Innate immunity |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P02671 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-216083, Integrin cell surface interactions R-HSA-354192, Integrin signaling R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708, p130Cas linkage to MAPK signaling for integrins R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5674135, MAP2K and MAPK activation R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-977225, Amyloid fiber formation |
SIGNORi | P02671 |
Names & Taxonomyi
Protein namesi | Recommended name: Fibrinogen alpha chainCleaved into the following 2 chains: |
Gene namesi | Name:FGA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3661, FGA |
MIMi | 134820, gene+phenotype |
neXtProti | NX_P02671 |
VEuPathDBi | HostDB:ENSG00000171560.14 |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
- extracellular vesicle Source: UniProtKB
- fibrinogen complex Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: BHF-UCL
- plasma membrane Source: Reactome
Other locations
- cell cortex Source: Ensembl
- cell surface Source: BHF-UCL
- platelet alpha granule Source: BHF-UCL
- platelet alpha granule lumen Source: Reactome
- synapse Source: Ensembl
Keywords - Cellular componenti
Amyloid, SecretedPathology & Biotechi
Involvement in diseasei
Congenital afibrinogenemia (CAFBN)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072721 | 55 | C → R in CAFBN; hypofibrinogenemia; heterozygous; decreased fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_072722 | 129 | R → P in CAFBN; hypofibrinogenemia; heterozygous; no effect on fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_072723 | 184 | C → W in CAFBN; hypofibrinogenemia; heterozygous; impaired fibrinogen complex assembly. 1 Publication | 1 |
Amyloidosis 8 (AMYL8)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010731 | 545 | E → V in AMYL8. Corresponds to variant dbSNP:rs121909612EnsemblClinVar. | 1 | |
Natural variantiVAR_010732 | 573 | R → L in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs78506343EnsemblClinVar. | 1 |
Dysfibrinogenemia, congenital (DYSFIBRIN)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002392 | 35 | R → C in DYSFIBRIN; fibrinogen Metz 1/Hershey III. 1 PublicationCorresponds to variant dbSNP:rs121909606EnsemblClinVar. | 1 | |
Natural variantiVAR_002401 | 573 | R → C in DYSFIBRIN; fibrinogen Dusart/Paris-5. 1 PublicationCorresponds to variant dbSNP:rs121909613EnsemblClinVar. | 1 |
Keywords - Diseasei
Amyloidosis, Disease variantOrganism-specific databases
DisGeNETi | 2243 |
MalaCardsi | FGA |
MIMi | 105200, phenotype 134820, gene+phenotype 202400, phenotype 616004, phenotype |
OpenTargetsi | ENSG00000171560 |
Orphaneti | 93562, AFib amyloidosis 98880, Familial afibrinogenemia 98881, Familial dysfibrinogenemia 248408, Familial hypodysfibrinogenemia 101041, Familial hypofibrinogenemia |
PharmGKBi | PA429 |
Miscellaneous databases
Pharosi | P02671, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364709 |
DrugBanki | DB04919, Alfimeprase DB00009, Alteplase DB05099, Ancrod DB00029, Anistreplase DB13151, Anti-inhibitor coagulant complex DB05675, EP-2104R DB11571, Human thrombin DB06245, Lanoteplase DB11311, Prothrombin DB00015, Reteplase DB00364, Sucralfate DB00031, Tenecteplase DB11300, Thrombin DB11572, Thrombin alfa DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | FGA |
DMDMi | 1706799 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 3 PublicationsAdd BLAST | 19 | |
PeptideiPRO_0000009021 | 20 – 35 | Fibrinopeptide AAdd BLAST | 16 | |
ChainiPRO_0000009022 | 36 – 866 | Fibrinogen alpha chainAdd BLAST | 831 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 22 | PhosphoserineCombined sources | 1 | |
Modified residuei | 45 | Phosphoserine; by FAM20CCombined sources1 Publication | 1 | |
Disulfide bondi | 47 | Interchain1 Publication | ||
Modified residuei | 50 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 55 | Interchain (with C-95 in beta chain)1 Publication | ||
Modified residuei | 56 | Phosphoserine; by FAM20C1 Publication | 1 | |
Disulfide bondi | 64 | Interchain (with C-49 in gamma chain)1 Publication | ||
Disulfide bondi | 68 | Interchain (with C-106 in beta chain)1 Publication | ||
Disulfide bondi | 180 | Interchain (with C-165 in gamma chain)4 Publications | ||
Disulfide bondi | 184 | Interchain (with C-223 in beta chain)4 Publications | ||
Modified residuei | 281 | PhosphoserineCombined sources | 1 | |
Modified residuei | 291 | PhosphoserineCombined sources | 1 | |
Modified residuei | 294 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 320 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Cross-linki | 322 | Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-41 in alpha-2-antiplasmin) | ||
Cross-linki | 347 | Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?) | ||
Glycosylationi | 351 | O-linked (GalNAc...) serine1 Publication | 1 | |
Modified residuei | 364 | Phosphoserine; by FAM20C1 Publication | 1 | |
Cross-linki | 385 | Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?) | ||
Modified residuei | 412 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 451 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 453 | N-linked (GlcNAc...) asparagine; in variant Caracas-21 Publication | 1 | |
Disulfide bondi | 461 ↔ 491 | By similarity | ||
Modified residuei | 501 | PhosphoserineCombined sources | 1 | |
Modified residuei | 505 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 524 | Phosphoserine; by FAM20C1 Publication | 1 | |
Cross-linki | 527 | Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)Sequence analysis | ||
Cross-linki | 558 | Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)Sequence analysis | ||
Modified residuei | 560 | Phosphoserine; by FAM20C1 Publication | 1 | |
Modified residuei | 565 | 4-hydroxyproline; by P4HA11 Publication | 1 | |
Cross-linki | 575 | Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)Sequence analysis | ||
Cross-linki | 581 | Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)Sequence analysis | ||
Cross-linki | 599 | Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)Sequence analysis | ||
Modified residuei | 609 | Phosphoserine; by FAM20CCombined sources1 Publication | 1 | |
Glycosylationi | 686 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Disulfide bondi | 799 ↔ 812 | Combined sources1 Publication |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 35 – 36 | Cleavage; by thrombin; to release fibrinopeptide A | 2 | |
Sitei | 100 – 101 | Cleavage; by plasmin; to break down fibrin clots | 2 | |
Sitei | 121 – 122 | Cleavage; by hementin; to prevent blood coagulation | 2 | |
Sitei | 123 – 124 | Cleavage; by plasmin; to break down fibrin clots | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Hydroxylation, Isopeptide bond, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-1117 non-CPTAC-1118 |
jPOSTi | P02671 |
MassIVEi | P02671 |
MaxQBi | P02671 |
PaxDbi | P02671 |
PeptideAtlasi | P02671 |
PRIDEi | P02671 |
ProteomicsDBi | 51542 [P02671-1] 51543 [P02671-2] |
2D gel databases
OGPi | P02671 |
SWISS-2DPAGEi | P02671 |
PTM databases
CarbonylDBi | P02671 |
GlyConnecti | 1238, 3 N-Linked glycans (1 site) 157, 4 N-Linked glycans |
GlyGeni | P02671, 23 sites, 4 O-linked glycans (21 sites) |
iPTMneti | P02671 |
PhosphoSitePlusi | P02671 |
SwissPalmi | P02671 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000171560, Expressed in liver and 129 other tissues |
ExpressionAtlasi | P02671, baseline and differential |
Genevisiblei | P02671, HS |
Organism-specific databases
HPAi | ENSG00000171560, Tissue enriched (liver) |
Interactioni
Subunit structurei
Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
6 Publications(Microbial infection) Interacts with Staphylococcus aureus protein Fib; this interaction inhibits fibrinogen-dependent platelet aggregation and protects the bacteria form phagocytosis.
2 PublicationsBinary interactionsi
Hide detailsP02671
With | #Exp. | IntAct |
---|---|---|
APOA1 [P02647] | 2 | EBI-348571,EBI-701692 |
FAM20C [Q8IXL6] | 2 | EBI-348571,EBI-7147442 |
Isoform 2 [P02671-2]
GO - Molecular functioni
- signaling receptor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 108534, 47 interactors |
ComplexPortali | CPX-1922, Fibrinogen |
CORUMi | P02671 |
DIPi | DIP-29643N |
IntActi | P02671, 41 interactors |
MINTi | P02671 |
STRINGi | 9606.ENSP00000306361 |
Miscellaneous databases
RNActi | P02671, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P02671 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02671 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 623 – 864 | Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST | 242 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 36 – 38 | Alpha-chain polymerization, binding distal domain of another fibrin gamma chain | 3 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 68 – 631 | 1 PublicationAdd BLAST | 564 |
Domaini
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000157467 |
HOGENOMi | CLU_013807_0_0_1 |
InParanoidi | P02671 |
OMAi | WVSFRGA |
OrthoDBi | 363208at2759 |
PhylomeDBi | P02671 |
TreeFami | TF351984 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
DisProti | DP02130 |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR021996, Fibrinogen_aC IPR037579, Fibrinogen_alpha IPR020837, Fibrinogen_CS |
PANTHERi | PTHR47221, PTHR47221, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF12160, Fibrinogen_aC, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFSMRIVCLV LSVVGTAWTA DSGEGDFLAE GGGVRGPRVV ERHQSACKDS
60 70 80 90 100
DWPFCSDEDW NYKCPSGCRM KGLIDEVNQD FTNRINKLKN SLFEYQKNNK
110 120 130 140 150
DSHSLTTNIM EILRGDFSSA NNRDNTYNRV SEDLRSRIEV LKRKVIEKVQ
160 170 180 190 200
HIQLLQKNVR AQLVDMKRLE VDIDIKIRSC RGSCSRALAR EVDLKDYEDQ
210 220 230 240 250
QKQLEQVIAK DLLPSRDRQH LPLIKMKPVP DLVPGNFKSQ LQKVPPEWKA
260 270 280 290 300
LTDMPQMRME LERPGGNEIT RGGSTSYGTG SETESPRNPS SAGSWNSGSS
310 320 330 340 350
GPGSTGNRNP GSSGTGGTAT WKPGSSGPGS TGSWNSGSSG TGSTGNQNPG
360 370 380 390 400
SPRPGSTGTW NPGSSERGSA GHWTSESSVS GSTGQWHSES GSFRPDSPGS
410 420 430 440 450
GNARPNNPDW GTFEEVSGNV SPGTRREYHT EKLVTSKGDK ELRTGKEKVT
460 470 480 490 500
SGSTTTTRRS CSKTVTKTVI GPDGHKEVTK EVVTSEDGSD CPEAMDLGTL
510 520 530 540 550
SGIGTLDGFR HRHPDEAAFF DTASTGKTFP GFFSPMLGEF VSETESRGSE
560 570 580 590 600
SGIFTNTKES SSHHPGIAEF PSRGKSSSYS KQFTSSTSYN RGDSTFESKS
610 620 630 640 650
YKMADEAGSE ADHEGTHSTK RGHAKSRPVR DCDDVLQTHP SGTQSGIFNI
660 670 680 690 700
KLPGSSKIFS VYCDQETSLG GWLLIQQRMD GSLNFNRTWQ DYKRGFGSLN
710 720 730 740 750
DEGEGEFWLG NDYLHLLTQR GSVLRVELED WAGNEAYAEY HFRVGSEAEG
760 770 780 790 800
YALQVSSYEG TAGDALIEGS VEEGAEYTSH NNMQFSTFDR DADQWEENCA
810 820 830 840 850
EVYGGGWWYN NCQAANLNGI YYPGGSYDPR NNSPYEIENG VVWVSFRGAD
860
YSLRAVRMKI RPLVTQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WUA0 | A0A087WUA0_HUMAN | Fibrinopeptide A | FGA | 289 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 177 | I → V in BAF83248 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 215 – 216 | SR → RS AA sequence (Ref. 10) Curated | 2 | ||
Sequence conflicti | 299 | S → G AA sequence (Ref. 10) Curated | 1 | ||
Sequence conflicti | 304 | S → G AA sequence (Ref. 10) Curated | 1 | ||
Sequence conflicti | 317 – 318 | GT → SG AA sequence (PubMed:518846).Curated | 2 | ||
Isoform 2 (identifier: P02671-2) | |||||
Sequence conflicti | 640 – 644 | PSLSP → LPCPPRLS in AAK31372 (Ref. 3) Curated | 5 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011609 | 6 | I → V1 PublicationCorresponds to variant dbSNP:rs2070025EnsemblClinVar. | 1 | |
Natural variantiVAR_002390 | 26 | D → N in Lille-1. Corresponds to variant dbSNP:rs121909604EnsemblClinVar. | 1 | |
Natural variantiVAR_002391 | 31 | G → V in Rouen-1. Corresponds to variant dbSNP:rs121909605EnsemblClinVar. | 1 | |
Natural variantiVAR_002392 | 35 | R → C in DYSFIBRIN; fibrinogen Metz 1/Hershey III. 1 PublicationCorresponds to variant dbSNP:rs121909606EnsemblClinVar. | 1 | |
Natural variantiVAR_002393 | 35 | R → H1 PublicationCorresponds to variant dbSNP:rs121909607EnsemblClinVar. | 1 | |
Natural variantiVAR_002394 | 37 | P → L in Kyoto-2. 1 PublicationCorresponds to variant dbSNP:rs121909609EnsemblClinVar. | 1 | |
Natural variantiVAR_002397 | 38 | R → G in Aarhus-1. Corresponds to variant dbSNP:rs121909608EnsemblClinVar. | 1 | |
Natural variantiVAR_002395 | 38 | R → N in Munich-1; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_002396 | 38 | R → S in Detroit-1. Corresponds to variant dbSNP:rs1403508334Ensembl. | 1 | |
Natural variantiVAR_010730 | 39 | V → D in Canterbury. 1 PublicationCorresponds to variant dbSNP:rs121909614EnsemblClinVar. | 1 | |
Natural variantiVAR_072721 | 55 | C → R in CAFBN; hypofibrinogenemia; heterozygous; decreased fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_002398 | 66 | S → T. | 1 | |
Natural variantiVAR_072722 | 129 | R → P in CAFBN; hypofibrinogenemia; heterozygous; no effect on fibrinogen complex assembly; no effect on fibrinogen complex secretion. 1 Publication | 1 | |
Natural variantiVAR_002399 | 160 | R → S in Lima. 1 Publication | 1 | |
Natural variantiVAR_072723 | 184 | C → W in CAFBN; hypofibrinogenemia; heterozygous; impaired fibrinogen complex assembly. 1 Publication | 1 | |
Natural variantiVAR_011610 | 331 | T → A3 PublicationsCorresponds to variant dbSNP:rs6050EnsemblClinVar. | 1 | |
Natural variantiVAR_014168 | 446 | K → E1 PublicationCorresponds to variant dbSNP:rs6052Ensembl. | 1 | |
Natural variantiVAR_002400 | 453 | S → N in Caracas-2. 1 PublicationCorresponds to variant dbSNP:rs121909610EnsemblClinVar. | 1 | |
Natural variantiVAR_011611 | 456 | T → A1 PublicationCorresponds to variant dbSNP:rs2070031EnsemblClinVar. | 1 | |
Natural variantiVAR_010731 | 545 | E → V in AMYL8. Corresponds to variant dbSNP:rs121909612EnsemblClinVar. | 1 | |
Natural variantiVAR_002401 | 573 | R → C in DYSFIBRIN; fibrinogen Dusart/Paris-5. 1 PublicationCorresponds to variant dbSNP:rs121909613EnsemblClinVar. | 1 | |
Natural variantiVAR_010732 | 573 | R → L in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs78506343EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001531 | 631 – 644 | DCDDV…PSGTQ → GIHTSPLGKPSLSP in isoform 2. 3 PublicationsAdd BLAST | 14 | |
Alternative sequenceiVSP_001532 | 645 – 866 | Missing in isoform 2. 3 PublicationsAdd BLAST | 222 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64982 Genomic DNA Translation: AAA17056.1 M64982 Genomic DNA Translation: AAA17055.1 M58569 Transcribed RNA Translation: AAC97142.1 M58569 Transcribed RNA Translation: AAC97143.1 AF361104 Genomic DNA Translation: AAK31372.1 AF361104 Genomic DNA Translation: AAK31373.1 AK290559 mRNA Translation: BAF83248.1 CH471056 Genomic DNA Translation: EAX04925.1 CH471056 Genomic DNA Translation: EAX04926.1 CH471056 Genomic DNA Translation: EAX04927.1 CH471056 Genomic DNA Translation: EAX04928.1 BC098280 mRNA Translation: AAH98280.1 BC099706 mRNA Translation: AAH99706.1 BC099720 mRNA Translation: AAH99720.1 BC101935 mRNA Translation: AAI01936.1 J00128 mRNA Translation: AAA52427.1 J00127 mRNA Translation: AAA52426.1 K02272 mRNA Translation: AAA52428.1 M26878 mRNA Translation: AAA52444.1 |
CCDSi | CCDS3787.1 [P02671-1] CCDS47152.1 [P02671-2] |
PIRi | A93956, FGHUA D44234 |
RefSeqi | NP_000499.1, NM_000508.4 [P02671-1] NP_068657.1, NM_021871.3 [P02671-2] |
Genome annotation databases
Ensembli | ENST00000403106; ENSP00000385981; ENSG00000171560 [P02671-2] ENST00000651975; ENSP00000498441; ENSG00000171560 [P02671-1] |
GeneIDi | 2243 |
KEGGi | hsa:2243 |
UCSCi | uc003iod.2, human [P02671-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia Fibrinogen entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64982 Genomic DNA Translation: AAA17056.1 M64982 Genomic DNA Translation: AAA17055.1 M58569 Transcribed RNA Translation: AAC97142.1 M58569 Transcribed RNA Translation: AAC97143.1 AF361104 Genomic DNA Translation: AAK31372.1 AF361104 Genomic DNA Translation: AAK31373.1 AK290559 mRNA Translation: BAF83248.1 CH471056 Genomic DNA Translation: EAX04925.1 CH471056 Genomic DNA Translation: EAX04926.1 CH471056 Genomic DNA Translation: EAX04927.1 CH471056 Genomic DNA Translation: EAX04928.1 BC098280 mRNA Translation: AAH98280.1 BC099706 mRNA Translation: AAH99706.1 BC099720 mRNA Translation: AAH99720.1 BC101935 mRNA Translation: AAI01936.1 J00128 mRNA Translation: AAA52427.1 J00127 mRNA Translation: AAA52426.1 K02272 mRNA Translation: AAA52428.1 M26878 mRNA Translation: AAA52444.1 |
CCDSi | CCDS3787.1 [P02671-1] CCDS47152.1 [P02671-2] |
PIRi | A93956, FGHUA D44234 |
RefSeqi | NP_000499.1, NM_000508.4 [P02671-1] NP_068657.1, NM_021871.3 [P02671-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BBR | X-ray | 2.30 | F/G/I | 26-35 | [»] | |
1DM4 | X-ray | 2.50 | C | 26-35 | [»] | |
1FPH | X-ray | 2.50 | F | 26-35 | [»] | |
1FZA | X-ray | 2.90 | A/D | 130-216 | [»] | |
1FZB | X-ray | 2.90 | A/D | 130-216 | [»] | |
1FZC | X-ray | 2.30 | A/D | 130-216 | [»] | |
1FZD | X-ray | 2.10 | A/B/C/D/E/F/G/H | 666-866 | [»] | |
1FZE | X-ray | 3.00 | A/D | 130-216 | [»] | |
1FZF | X-ray | 2.70 | A/D | 130-216 | [»] | |
1FZG | X-ray | 2.50 | A/D | 130-216 | [»] | |
1LT9 | X-ray | 2.80 | A/D | 145-210 | [»] | |
1LTJ | X-ray | 2.80 | A/D | 145-210 | [»] | |
1N86 | X-ray | 3.20 | A/D | 130-216 | [»] | |
1N8E | X-ray | 4.50 | A/D | 130-218 | [»] | |
1RE3 | X-ray | 2.45 | A/D | 145-210 | [»] | |
1RE4 | X-ray | 2.70 | A/D | 145-210 | [»] | |
1RF0 | X-ray | 2.81 | A/D | 145-210 | [»] | |
1RF1 | X-ray | 2.53 | A/D | 145-210 | [»] | |
1YCP | X-ray | 2.50 | F/N | 20-42 | [»] | |
2A45 | X-ray | 3.65 | G/J | 36-92 | [»] | |
2FFD | X-ray | 2.89 | A/D | 145-210 | [»] | |
2H43 | X-ray | 2.70 | A/D | 130-216 | [»] | |
2HLO | X-ray | 2.60 | A/D | 130-216 | [»] | |
2HOD | X-ray | 2.90 | A/D/G/J | 130-216 | [»] | |
2HPC | X-ray | 2.90 | A/D/G/J | 130-216 | [»] | |
2OYH | X-ray | 2.40 | A/D | 145-210 | [»] | |
2OYI | X-ray | 2.70 | A/D | 145-210 | [»] | |
2Q9I | X-ray | 2.80 | A/D | 130-216 | [»] | |
2XNX | X-ray | 3.30 | A/D/G/J | 130-216 | [»] | |
2XNY | X-ray | 7.50 | A/D | 130-216 | [»] | |
2Z4E | X-ray | 2.70 | A/D | 130-216 | [»] | |
3AT0 | X-ray | 2.50 | B | 332-347 | [»] | |
3BVH | X-ray | 2.60 | A/D | 148-209 | [»] | |
3E1I | X-ray | 2.30 | A/D | 130-216 | [»] | |
3GHG | X-ray | 2.90 | A/D/G/J | 20-581 | [»] | |
3H32 | X-ray | 3.60 | A/D | 20-216 | [»] | |
3HUS | X-ray | 3.04 | A/D | 145-210 | [»] | |
4F27 | X-ray | 1.92 | Q | 336-347 | [»] | |
5CFA | X-ray | 1.45 | C/D | 580-594 | [»] | |
SMRi | P02671 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108534, 47 interactors |
ComplexPortali | CPX-1922, Fibrinogen |
CORUMi | P02671 |
DIPi | DIP-29643N |
IntActi | P02671, 41 interactors |
MINTi | P02671 |
STRINGi | 9606.ENSP00000306361 |
Chemistry databases
ChEMBLi | CHEMBL2364709 |
DrugBanki | DB04919, Alfimeprase DB00009, Alteplase DB05099, Ancrod DB00029, Anistreplase DB13151, Anti-inhibitor coagulant complex DB05675, EP-2104R DB11571, Human thrombin DB06245, Lanoteplase DB11311, Prothrombin DB00015, Reteplase DB00364, Sucralfate DB00031, Tenecteplase DB11300, Thrombin DB11572, Thrombin alfa DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
PTM databases
CarbonylDBi | P02671 |
GlyConnecti | 1238, 3 N-Linked glycans (1 site) 157, 4 N-Linked glycans |
GlyGeni | P02671, 23 sites, 4 O-linked glycans (21 sites) |
iPTMneti | P02671 |
PhosphoSitePlusi | P02671 |
SwissPalmi | P02671 |
Genetic variation databases
BioMutai | FGA |
DMDMi | 1706799 |
2D gel databases
OGPi | P02671 |
SWISS-2DPAGEi | P02671 |
Proteomic databases
CPTACi | non-CPTAC-1117 non-CPTAC-1118 |
jPOSTi | P02671 |
MassIVEi | P02671 |
MaxQBi | P02671 |
PaxDbi | P02671 |
PeptideAtlasi | P02671 |
PRIDEi | P02671 |
ProteomicsDBi | 51542 [P02671-1] 51543 [P02671-2] |
Protocols and materials databases
Antibodypediai | 3395, 1011 antibodies |
DNASUi | 2243 |
Genome annotation databases
Ensembli | ENST00000403106; ENSP00000385981; ENSG00000171560 [P02671-2] ENST00000651975; ENSP00000498441; ENSG00000171560 [P02671-1] |
GeneIDi | 2243 |
KEGGi | hsa:2243 |
UCSCi | uc003iod.2, human [P02671-1] |
Organism-specific databases
CTDi | 2243 |
DisGeNETi | 2243 |
GeneCardsi | FGA |
HGNCi | HGNC:3661, FGA |
HPAi | ENSG00000171560, Tissue enriched (liver) |
MalaCardsi | FGA |
MIMi | 105200, phenotype 134820, gene+phenotype 202400, phenotype 616004, phenotype |
neXtProti | NX_P02671 |
OpenTargetsi | ENSG00000171560 |
Orphaneti | 93562, AFib amyloidosis 98880, Familial afibrinogenemia 98881, Familial dysfibrinogenemia 248408, Familial hypodysfibrinogenemia 101041, Familial hypofibrinogenemia |
PharmGKBi | PA429 |
VEuPathDBi | HostDB:ENSG00000171560.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000157467 |
HOGENOMi | CLU_013807_0_0_1 |
InParanoidi | P02671 |
OMAi | WVSFRGA |
OrthoDBi | 363208at2759 |
PhylomeDBi | P02671 |
TreeFami | TF351984 |
Enzyme and pathway databases
PathwayCommonsi | P02671 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-216083, Integrin cell surface interactions R-HSA-354192, Integrin signaling R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708, p130Cas linkage to MAPK signaling for integrins R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5674135, MAP2K and MAPK activation R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-977225, Amyloid fiber formation |
SIGNORi | P02671 |
Miscellaneous databases
BioGRID-ORCSi | 2243, 5 hits in 877 CRISPR screens |
ChiTaRSi | FGA, human |
EvolutionaryTracei | P02671 |
GeneWikii | Fibrinogen_alpha_chain |
GenomeRNAii | 2243 |
Pharosi | P02671, Tbio |
PROi | PR:P02671 |
RNActi | P02671, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171560, Expressed in liver and 129 other tissues |
ExpressionAtlasi | P02671, baseline and differential |
Genevisiblei | P02671, HS |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
DisProti | DP02130 |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR021996, Fibrinogen_aC IPR037579, Fibrinogen_alpha IPR020837, Fibrinogen_CS |
PANTHERi | PTHR47221, PTHR47221, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF12160, Fibrinogen_aC, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FIBA_HUMAN | |
Accessioni | P02671Primary (citable) accession number: P02671 Secondary accession number(s): A8K3E4 Q9UCH2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 250 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants