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Protein

Beta-casein

Gene

CSN2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important role in determination of the surface properties of the casein micelles.
Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide.
Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A.
Antioxidant peptide has antioxidant activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntioxidant, Hypotensive agent, Metalloenzyme inhibitor, Metalloprotease inhibitor, Milk protein, Protease inhibitor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-casein
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:27764 CSN2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
10199 Bos d 11.0101
167 Bos d 8
2736 Bos d 11

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3313833

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 153 PublicationsAdd BLAST15
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000447016 – 224Beta-caseinAdd BLAST209
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000029203141 – 45Casoparan5
PeptideiPRO_0000320153113 – 120Antioxidant peptide8
PeptideiPRO_0000308464129 – 136Casohypotensin8

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30Phosphoserine3 Publications1
Modified residuei32Phosphoserine3 Publications1
Modified residuei33Phosphoserine3 Publications1
Modified residuei34Phosphoserine3 Publications1
Modified residuei50Phosphoserine; in variant A1, variant A2, variant A3, variant B, variant E, variant F, variant G and variant H2 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P02666

PeptideAtlas

More...
PeptideAtlasi
P02666

PRoteomics IDEntifications database

More...
PRIDEi
P02666

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P02666

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P02666

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000002632 Expressed in 1 organ(s), highest expression level in adult mammalian kidney

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-46257N

Protein interaction database and analysis system

More...
IntActi
P02666, 4 interactors

Molecular INTeraction database

More...
MINTi
P02666

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000003409

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P02666

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of protein disorder

More...
DisProti
DP00329

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P02666

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYJE Eukaryota
ENOG411197Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001890

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004973

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P02666

Identification of Orthologs from Complete Genome Data

More...
OMAi
EIMEVPK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0XI8

TreeFam database of animal gene trees

More...
TreeFami
TF336929

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001588 Casein
IPR016345 Casein_beta
IPR031305 Casein_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11500 PTHR11500, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00363 Casein, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002372 Beta-casein, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P02666-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVLILACLV ALALARELEE LNVPGEIVES LSSSEESITR INKKIEKFQS
60 70 80 90 100
EEQQQTEDEL QDKIHPFAQT QSLVYPFPGP IPNSLPQNIP PLTQTPVVVP
110 120 130 140 150
PFLQPEVMGV SKVKEAMAPK HKEMPFPKYP VEPFTESQSL TLTDVENLHL
160 170 180 190 200
PLPLLQSWMH QPHQPLPPTV MFPPQSVLSL SQSKVLPVPQ KAVPYPQRDM
210 220
PIQAFLLYQE PVLGPVRGPF PIIV
Length:224
Mass (Da):25,107
Last modified:July 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0BBDD8148A238AE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAW84270 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAW84271 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ABL74247 differs from that shown. Reason: Frameshift at positions 65 and 71.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50S → Z AA sequence (PubMed:1804413).Curated1
Sequence conflicti69Q → R in ABL74247 (Ref. 14) Curated1
Sequence conflicti112K → R in ABL74247 (Ref. 14) Curated1
Sequence conflicti208Y → V in CAC37028 (Ref. 16) Curated1
Sequence conflicti209 – 210QE → EQ AA sequence (PubMed:1804413).Curated2
Sequence conflicti210E → Q in AAA30430 (PubMed:3814153).Curated1
Sequence conflicti210E → Q no nucleotide entry (PubMed:4557764).Curated1
Sequence conflicti212V → A in ABR10906 (Ref. 15) Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 872.51 Da from positions 113 - 120. Determined by ESI. 1 Publication

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Leu-152 is present in the variants F and G; Gln-190 and Glu-210 are present in the variant H. The sequence shown is the A2 variant.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti33S → K in variant D. 1 Publication1
Natural varianti40R → C in variant H. 1
Natural varianti51E → K in variant E. 1 Publication1
Natural varianti52E → K in variant C. 1
Natural varianti82P → H in variants A1, B, C, F and G. 3 Publications1
Natural varianti103L → I in variant H. 1
Natural varianti108M → L4 Publications1
Natural varianti121H → Q in variant A3. 2 Publications1
Natural varianti132E → Q in variants A1 and G. 2 Publications1
Natural varianti137S → R in variant B. 1 Publication1
Natural varianti152L → P in variants A1 and H. 1 Publication1
Natural varianti153P → L in variants A1, G and H. 1 Publication1
Natural varianti167P → L in variant F. 1
Natural varianti190Q → E in variants A1 and G. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M15132 mRNA Translation: AAA30430.1
X06359 mRNA Translation: CAA29658.1
M16645 mRNA Translation: AAA30480.1
M55158 Genomic DNA Translation: AAA30431.1
S67277 mRNA Translation: AAB29137.1
BC111172 mRNA Translation: AAI11173.1
AY899917 mRNA Translation: AAW84270.1 Different initiation.
AY899918 mRNA Translation: AAW84271.1 Different initiation.
AH007287 Genomic DNA Translation: AAD09813.1
EF123100 Genomic DNA Translation: ABL74247.1 Frameshift.
EF628290 Genomic DNA Translation: ABR10906.1
AJ296330 Genomic DNA Translation: CAC37028.1
M64756 mRNA Translation: AAB59254.1
AY366419 Genomic DNA Translation: AAR14677.1
K01087 mRNA Translation: AAA30481.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A59068
I45873 KBBOA2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Bt.53272

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000003409; ENSBTAP00000003409; ENSBTAG00000002632

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15132 mRNA Translation: AAA30430.1
X06359 mRNA Translation: CAA29658.1
M16645 mRNA Translation: AAA30480.1
M55158 Genomic DNA Translation: AAA30431.1
S67277 mRNA Translation: AAB29137.1
BC111172 mRNA Translation: AAI11173.1
AY899917 mRNA Translation: AAW84270.1 Different initiation.
AY899918 mRNA Translation: AAW84271.1 Different initiation.
AH007287 Genomic DNA Translation: AAD09813.1
EF123100 Genomic DNA Translation: ABL74247.1 Frameshift.
EF628290 Genomic DNA Translation: ABR10906.1
AJ296330 Genomic DNA Translation: CAC37028.1
M64756 mRNA Translation: AAB59254.1
AY366419 Genomic DNA Translation: AAR14677.1
K01087 mRNA Translation: AAA30481.1
PIRiA59068
I45873 KBBOA2
UniGeneiBt.53272

3D structure databases

DisProtiDP00329
ProteinModelPortaliP02666
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46257N
IntActiP02666, 4 interactors
MINTiP02666
STRINGi9913.ENSBTAP00000003409

Chemistry databases

BindingDBiP02666
ChEMBLiCHEMBL3313833

Protein family/group databases

Allergomei10199 Bos d 11.0101
167 Bos d 8
2736 Bos d 11

PTM databases

iPTMnetiP02666

Proteomic databases

PaxDbiP02666
PeptideAtlasiP02666
PRIDEiP02666

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003409; ENSBTAP00000003409; ENSBTAG00000002632

Organism-specific databases

VGNCiVGNC:27764 CSN2

Phylogenomic databases

eggNOGiENOG410IYJE Eukaryota
ENOG411197Z LUCA
GeneTreeiENSGT00390000001890
HOVERGENiHBG004973
InParanoidiP02666
OMAiEIMEVPK
OrthoDBiEOG091G0XI8
TreeFamiTF336929

Miscellaneous databases

PMAP-CutDBiP02666

Protein Ontology

More...
PROi
PR:P02666

Gene expression databases

BgeeiENSBTAG00000002632 Expressed in 1 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR001588 Casein
IPR016345 Casein_beta
IPR031305 Casein_CS
PANTHERiPTHR11500 PTHR11500, 1 hit
PfamiView protein in Pfam
PF00363 Casein, 1 hit
PIRSFiPIRSF002372 Beta-casein, 1 hit
PROSITEiView protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASB_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P02666
Secondary accession number(s): A1YQZ8
, A6N8V0, Q2TA13, Q5EEQ6, Q5EEQ7, Q6UN63, Q9BDG5, Q9TSD5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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